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Childhood maltreatment and eating disorder pathology: a systematic review and dose-response meta-analysis

Published online by Cambridge University Press:  19 January 2017

M. L. Molendijk ,
H. W. Hoek ,
T. D. Brewerton  and
B. M. Elzinga
M. L. Molendijk*
Affiliation:
Institute of Psychology, Clinical Psychology Unit, Leiden University, Leiden, The Netherlands Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands
H. W. Hoek
Affiliation:
Parnassia Psychiatric Institute, The Hague, The Netherlands Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands Department of Epidemiology, Columbia University, New York, USA
T. D. Brewerton
Affiliation:
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
B. M. Elzinga
Affiliation:
Institute of Psychology, Clinical Psychology Unit, Leiden University, Leiden, The Netherlands Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands
*
*Address for correspondence: M. L. Molendijk, Ph.D., Institute of Psychology, Clinical Psychology Unit, Leiden University, Leiden, The Netherlands and Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands. (Email: [email protected])
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Abstract

Background

Meta-analyses have established a high prevalence of childhood maltreatment (CM) in patients with eating disorders (EDs) relative to the general population. Whether the prevalence of CM in EDs is also high relative to that in other mental disorders has not yet been established through meta-analyses nor to what extent CM affects defining features of EDs, such as number of binge/purge episodes or age at onset. Our aim is to provide meta-analyses on the associations between exposure to CM (i.e. emotional, physical and sexual abuse) on the occurrence of all types of EDs and its defining features.

Method

Systematic review and meta-analyses. Databases were searched until 4 June 2016.

Results

CM prevalence was high in each type of ED (total N = 13 059, prevalence rates 21–59%) relative to healthy (N = 15 092, prevalence rates 1–35%) and psychiatric (N = 7736, prevalence rates 5–46%) control groups. ED patients reporting CM were more likely to be diagnosed with a co-morbid psychiatric disorder [odds ratios (ORs) range 1.41–2.46, p < 0.05] and to be suicidal (OR 2.07, p < 0.001) relative to ED subjects who were not exposed to CM. ED subjects exposed to CM also reported an earlier age at ED onset [effect size (Hedges’ g) = −0.32, p < 0.05], to suffer a more severe form of the illness (g = 0.29, p < 0.05), and to binge-purge (g = 0.31, p < 0.001) more often compared to ED patients who did not report any CM.

Conclusion

CM, regardless of type, is associated with the presence of all types of ED and with severity parameters that characterize these illnesses in a dose dependent manner.

Keywords

Anorexiabulimiachildhood abuseeating disordersmeta-analysis
Type
Original Articles
Information
Psychological Medicine , Volume 47 , Issue 8 , June 2017 , pp. 1402 - 1416
Copyright
Copyright © Cambridge University Press 2017 

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References

Anderson, KP, Laporte, D, Brandt, H, Crawford, S (1997). Sexual abuse and bulimia: response to inpatient treatment and preliminary outcome. Journal of Psychiatric Research 31, 621–633.Google Scholar
Allison, KC, Grilo, CM, Masheb, RM, Stunkard, AJ (2007). High self-reported rates of neglect and emotional abuse, by persons with binge eating disorder and night eating syndrome. Behaviour Research and Therapy 45, 2874–2883.Google Scholar
APA (1980). Diagnostic and Statistical Manual of Mental Disorders, 3th edn. American Psychiatric Association: Washington, DC.Google Scholar
APA (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington, DC.Google Scholar
APA (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Association: Washington, DC.Google Scholar
Arcelus, J, Mitchell, AJ, Wales, J, Nielsen, S (2011). Mortality rates in patients with anorexia nervosa and other eating disorders: a meta-analysis of 36 studies. Archives of General Psychiatry 68, 724–731.CrossRefGoogle ScholarPubMed
Backholm, K, Isomaa, R, Birgegård, A (2013). The prevalence and impact of trauma history in eating disorder patients. European Journal of Psychotraumatology 4, 1–8.Google Scholar
Bardone-Cone, AM, Maldonado, CR, Crosby, RD, Mitchell, JE, Wonderlich, SA, Joiner, TE Jr. et al. (2008). Revisiting differences in individuals with bulimia nervosa with and without a history of anorexia nervosa: eating pathology, personality, and maltreatment. International Journal of Eating Disorders 41, 697–704.CrossRefGoogle ScholarPubMed
Basurte, E, Díaz-Marsá, M, Martín, O, Carrasco, JL (2004). Traumatic childhood background, impulsiveness and hypothalamus-pituitary-adrenal dysfunction in eating disorders; a pilot study. Actas Españolas Psiquiatricas 32, 149–152.Google ScholarPubMed
Becker, DF, Grilo, CM (2011). Childhood maltreatment in women with binge-eating disorder: associations with psychiatric comorbidity, psychological functioning, and eating pathology. Eating and Weight Disorders 16, 113–120.Google Scholar
Borenstein, M, Hedges, LV, Higgins, JPT (2009). Introduction to Meta-Analyses. Chichester Wiley: NH, USA.CrossRefGoogle Scholar
Brewerton, TD (2007). Eating disorders, trauma, and comorbidity: focus on PTSD. Eating Disorders 15, 285–304.Google Scholar
Brewerton, TD, Rance, SJ, Dansky, BS, O'Neil, PM, Kilpatrick, DG (2014). A comparison of women with child-adolescent versus adult onset binge eating: results from the National Women's Study. International Journal of Eating Disorders 47, 836–843.CrossRefGoogle ScholarPubMed
Brown, L, Russell, J, Thornton, C, Dunn, S (1997). Experiences of physical and sexual abuse in Australian general practice attenders and an eating disordered population. Australian and New Zealand Journal of Psychiatry 31, 398–404.Google Scholar
Carter, JC, Bewell, C, Blackmore, E, Woodside, DB (2006). The impact of childhood abuse in anorexia nervosa. Child Abuse Neglect 30, 257–269.CrossRefGoogle ScholarPubMed
Casper, RC, Lyubomirsky, S (1997). Individual psychopathology relative to reports of unwanted sexual experiences as predictor of a bulimic eating pattern. International Journal of Eating Disorders 21, 229–236.Google Scholar
Castellini, G, Lo Suaro, C, Lelli, L, Godini, L, Vignozzi, L, Rellini, AH, Faravelli, C, Maggi, M, Ricca, V (2013). Childhood sexual abuse moderates the relationship between sexual functioning and eating disorder psychopathology in anorexia nervosa: a 1-year follow-up study. International Society of Sexual Medicine 10, 2190–2200.Google Scholar
Claes, L, Vandereycken, W (2007). Is there a link between traumatic experiences and self-injurious behaviors in eating-disordered patients? Treatment and Prevention 15, 305–315.Google Scholar
Corstorphine, E, Waller, G, Lawson, R, Ganis, C (2007). Trauma and multiple-impulsivity in the eating disorders. Eating Behaviour 8, 23–30.Google Scholar
Cumella, EJ, Kally, Z (2008). Comparison of middle-age and young women inpatients with eating disorders. Eating and Weight Disorders 13, 183–190.Google Scholar
Caslini, M, Bartoli, F, Crocamo, C, Dakanalis, A, Clerici, M, Carrà, G (2016). Disentangling the association between child abuse and eating disorders: a systematic review and meta-analysis. Psychosomatic Medicine 78, 79–90.Google Scholar
Chen, LP, Murad, MH, Paras, ML, Colbenson, KM, Sattler, AL, Goranson, EN, Elamin, MB, Seime, RJ, Shinozaki, G, Prokop, LJ, Zirakzadeh, A (2010). Sexual abuse and lifetime diagnosis of psychiatric disorders: a systematic review and meta-analysis. Mayo Clinic Proceedings 85, 618–629.Google Scholar
Cochrane Community Handbook (2016) (http://community.cochrane.org/handbook). Accessed 10 February 2016).Google Scholar
Deep, AL, Lilenfeld, LR, Plotnicov, KH, Pollice, C, Kaye, WH (1999). Sexual abuse in eating disorder subtypes and control women: the role of comorbid substance dependence in bulimia nervosa. International Journal of Eating Disorders 25, 1–10.Google Scholar
Duarte, C, Ferreira, C, Pint-Gouveia, J (2016). At the core of eating disorders: overvaluation, social rank, self-criticism and shame in anorexia, bulimia and binge eating disorder. Comprehensive Psychiatry 66, 123–131.Google Scholar
Dunkley, DM, Masheb, RM, Grilo, CM (2010). Childhood maltreatment, depressive symptoms, and body dissatisfaction in patients with binge eating disorder: the mediating role of self-criticism. International Journal of Eating Disorders 43, 274–281.Google Scholar
Duval, S, Tweedie, RL (2000). A nonparametric trim and fill method of accounting for publication bias in meta-analysis. Journal of the American Statistical Society 95, 89–98.Google Scholar
Egger, M, Davey Smith, G, Schneider, M, Minder, C (1997). Bias in meta-analysis detected by a simple, graphical test. British Medical Journal 315, 629–634.CrossRefGoogle ScholarPubMed
Fairburn, CG, Welch, SL, Doll, HA, Davies, BA, O'Conner, ME (1997). Risk Factors for Bulimia Nervosa. Archives of General Psychiatry 54, 509–517.CrossRefGoogle ScholarPubMed
Fairburn, CG, Doll, HA, Welch, SL, Hay, PJ, Davies, BA, O'Connor, ME (1998). Risk factors for binge eating disorders: a community-based, case control study. Archives of General Psychiatry 55, 425–432.CrossRefGoogle ScholarPubMed
Favaro, A, Santonastaso, P (1997). Suicidality in eating disorders: clinical and psychological correlates. Acta Psychiatrica Scandinavia 95, 508–514.Google Scholar
Favaro, A, Grave, D, Santonastaso, P (1998). Impact of a history of physical and sexual abuse in eating disordered and asymptomatic subjects. Acta Psychiatrica Scandinavia 97, 358–363.CrossRefGoogle ScholarPubMed
Favaro, A, Tenconi, E, Santonastaso, P (2010). The interaction between perinatal factors and childhood abuse in the risk of developing anorexia nervosa. Psychological Medicine 40, 657–665.CrossRefGoogle ScholarPubMed
Feldman, MB, Meyer, IH (2007). Childhood abuse and eating disorders in gay and bisexual men. International Journal of Eating Disorders 49, 418–423.Google Scholar
Folsom, V, Krahn, D, Nairn, K, Gold, L, Demitrack, MA, Silk, KR (1993). The impact of sexual and physical abuse on eating disordered and psychiatric symptoms: a comparison of eating disordered and psychiatric inpatients. International of Journal Eating Disorders 13, 249–257.Google Scholar
Friedman, MA, Wilfley, DE, Welch, RR, Kunce, JT (1997). Self-directed hostility and family functioning in normal-weight bulimics and overweight binge eaters. Addictive Behaviour 22, 367–375.CrossRefGoogle ScholarPubMed
Fullerton, DT, Wonderlich, SA, Gosnell, BA (1995). Clinical characteristics of eating disorder patients who report sexual or physical abuse. International Journal of Eating Disorders 17, 243–249.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Fairburn, CG, Harrison, PJ (2003). Eating disorders. Lancet 361, 407–416.Google Scholar
Garfinkel, PE, Lin, E, Goering, P, Spegg, C, Goldbloom, DS, Kennedy, S Kaplan, AS, Woodside, D. (1995). Bulimia nervosa in a Canadian community sample: prevalence and comparison of subgroups. American Journal of Psychiatry 152, 1052–1058.Google Scholar
Grilo, CM, Masheb, RM (2001). Childhood psychological, physical, and sexual maltreatment in outpatients with binge eating disorder: frequency and associations with gender, obesity, and eating related psychopathology. Obesity Research 9, 320–325.Google Scholar
Grilo, CM, Masheb, RM (2002). Childhood maltreatment and personality disorders in adult patients with binge eating disorder. Acta Psychiatrica Scandinavia 106, 183–188.Google Scholar
Groleau, P, Joober, R, Israel, M, Zeramdini, N, DeGuzman, R, Steiger, H (2014). Methylation of the dopamine D2 receptor (DRD2) gene promotor in women with bulimia-spectrum disorder: associations with borderline personality disorder and exposure to childhood abuse. Journal of Psychiatric Research 48, 121–127.Google Scholar
Hartt, J, Waller, G (2002). Child abuse, dissociation, and core beliefs in bulimic disorders. Child Abuse and Neglect 26, 923–938.Google Scholar
Herzog, Db, Staley, JE, Carmody, S, Robbins, WM, van der Kolk, BA (1993). Childhood sexual abuse in anorexia nervosa and bulimia nervosa: a pilot study. Journal of the American Academy of Child Psychiatry 32, 962–966.Google Scholar
Henderson, M, Freeman, CP (1987). A self-rating scale for bulimia. The ‘BITE’. The British Journal of Psychiatry 150(1), 18–24.Google Scholar
Hepp, U, Spindler, A, Schnyder, U, Kraemer, B, Milos, G (2007). Post-traumatic stress disorder in women with eating disorders. Eating and Weigth Disorders 12, 24–27.Google Scholar
Jaite, C, Schneider, N, Hilbert, A, Pfeiffer, E, Lehmkuhl, U, Salbach-Andrae, H (2012). Etiological role of childhood emotional trauma and neglect in adolescent anorexia nervosa: a cross-sectional questionnaire analysis. Psychopathology 45, 61–66.Google Scholar
Haidich, AB (2010) Meta-analysis in medical research. Hippokratia 14S, 29.Google Scholar
Hedges, LV, Olkin, I (1985). Statistical Method for Meta-Analysis. Princeton, NJ, USA. Academic Press.Google Scholar
Higgins, JPT, Thompson, SG (2002). Quantifying heterogeneity in meta-analysis. Statistics in Medicine 21, 1539–1558.Google Scholar
Hill, AB (1965). The environment and disease: association or causation? Proceedings of the Royal Society of Medicine 58, 295–300.Google Scholar
Karwautz, A, Rabe-Hesketh, S, Hu, X, Zhao, J, Sham, P, Collier, DA, Treasure, JL (2001). Individual-specific risk factors for anorexia nervosa: a pilot study using a discordant sister-pair design. Psychological Medicine 31, 317–329.Google Scholar
Kaye, WH, Wierenga, CE, Bailer, UF, Simmons, AN, Bischoff-Grethe, A (2013 a). Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa. Trends in Neuroscience 36, 110–120.Google Scholar
Kaye, WH, Wierenga, CE, Bailer, UF, Simmons, AN, Wagner, A, Bischoff-Grethe, A (2013 b). Does a shared neurobiology for foods and drugs of abuse contribute to extremes of food ingestion in anorexia and bulimia nervosa? Biological Psychiatry 73, 836–842.Google Scholar
Kern, J, Hastings, T (1995). Differential family environment of bulimics and victims of childhood sexual abuse: achievement orientation. Journal of Clinical Psychology 51, 499–506.Google Scholar
Kong, S, Bernstein, K (2009). Childhood trauma as a predictor of eating psychopathology and its mediating variables in patients with eating disorders. Journal of Clinical Nursing 18, 1897–1907.Google Scholar
Kugu, N, Akyuz, G, Dogan, O, Ersan, E, Izgic, F (2006). The prevalence of eating disorders among University students and the relationship with some individual characteristics. Aus NZ Journal Psychiatry 40, 129–135.CrossRefGoogle ScholarPubMed
Kent, A, Waller, G (2000). Childhood emotional abuse and eating psychopathology. Clinical Psychology Review 20, 887–903.Google Scholar
Keski-Rahkonen, A, Mustelin, L (2016). Epidemiology of eating disorders in Europe: prevalence, incidence, comorbidity, course, consequences, and risk factors. Current Opinion in Psychiatry 29, 340–345.Google Scholar
Klump, KL, Wonderlich, S, Lehoux, P, Lilenfeld, LRR, Bulik, CM (2002). Does environment matter? A review of non-shared environment and eating disorders. International Journal of Eating Disorders 31, 118–132.Google Scholar
Léonard, S, Steiger, H, Kao, A (2003). Childhood and adulthood abuse in bulimic and nonbulimic women: prevalence and psychological correlates. International Journal of Eating Disorders 33, 397–405.Google Scholar
Lockwood, R, Lawson, R, Waller, G (2004). Compulsive features in the eating disorders: a role for trauma. Journal of Nervous and Mental Disease 192, 247–249.Google Scholar
Luce, KH, Crowther, JH, Pole, M (2008). Eating Disorder Examination Questionnaire (EDE-Q): norms for undergraduate women. International Journal of Eating Disorders 41, 273–276.Google Scholar
Mahon, J, Bradley, NS, Harvey, PK, Winston, AP, Palmer, RL (2001). Childhood trauma has dose effect relationship with dropping out from psychotherapeutic treatment for bulimia nervosa: a replication. International Journal of Eating Disorders 30, 138–148.CrossRefGoogle ScholarPubMed
Machado, BC, Gonçalves, SF, Martins, C, Hoek, HW, Machado, PP (2014). Risk factors and antecedent life events in he development of anorexia nervosa: A Portuguese case-control study. European Eating Disorders Reviews 22, 243–251.Google Scholar
Mangweth-Matzek, B, Rupp, CI, Hausmann, A, Gusmerotti, S, Kemmler, G, Biebl, W (2010). Eating disorders in men: current features and childhood factors. Eating and Weight Disorders 15, 15–22.Google Scholar
Monteleone, AM, Monteleone, P, Serino, I, Scognamiglio, P, Di Genio, M, Maj, M (2015). Childhood trauma and cortisol awakening response in symptomatic patients with anorexia nervosa and bulimia nervosa. International Journal of Eating Disorders 48(6), 615–621.Google Scholar
Matsunaga, H, Kaye, WH, McConaha, CRN, Plotonicov, K, Pollice, CBA, Rao, R, Stein, D (1999). Psychopathological characteristics of recovered bulimics who have a history of physical or sexual abuse. Journal of Nervous and Mental Disease 187, 472–477.Google Scholar
Michopoulos, V, Powers, A, Moore, C, Villarreal, S, Ressler, KJ, Bradley, B (2015). The mediating role of emotion dysregulation and depression on the relationship between childhood trauma exposure and emotional eating. Appetite 91, 129–136.CrossRefGoogle ScholarPubMed
Mintz, LB, O'halloran, MS (2000). The eating attitudes test: validation with DSM-IV eating disorder criteria. Journal of Personality Assessment 74, 489–503.Google Scholar
Mischoulon, D, Eddy, KT, Keshaviah, A, Dinescu, D, Ross, SL, Kass, AE, Franko, DL, Herzog, DB (2011). Depression and eating disorders: treatment and course. Journal of Affective Disorders 130, 470–477.Google Scholar
Mitchell, KS, Mazzeo, SE, Schlesinger, MR, Brewerton, TD, Smith, BN (2012). Comorbidity of partial and subtreshold PTSD among men and women with eating disorders in the national comorbidity survey-replication. International Journal of Eating Disorders 45, 307–315.Google Scholar
Moher, D, Liberati, A, Tetzlaff, J, Altman, DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the prisma statement. Annals of Internal Medicine 151, 264–269.Google Scholar
Moulton, SJ, Newman, E, Power, K, Swanson, V, Day, K (2015). Childhood trauma and eating psychopathology: a mediating role for dissociation and emotion dysregulation? Child Abuse and Neglect 39, 167–174.Google Scholar
Muehlenkamp, JJ, Claes, L, Smits, D, Peat, CM, Vandereycken, W (2011). Non--suicidal self-injury in eating disordered patients: a test of a conceptual model. Psychiatry Research 188, 102–108.Google Scholar
Nagata, H, Kaye, WH, Kiriki, N, Rao, R, Plotnicov, KH (2001). Physical and sexual abuse histories in patients with eating disorders: A comparison of Japanese and American patients. Psychiatry and Clinical Neuroscience 55, 333–340.Google Scholar
Nickel, C, Simek, M, Moleda, A, Muehlbacher, M, Buschmann, W, Fartacek, R Bachler, E, Egger, C, Rother, WK, Loew, TH, Nickel, MK (2006). Suicide attempts versus suicidal ideation in bulimic female adolescents. Pediatrics International 48, 374–381.Google Scholar
Nanni, V, Uher, R, Danese, A (2012). Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. American Journal of Psychiatry 169, 141–151.CrossRefGoogle ScholarPubMed
Nemeroff, CB (2016). Paradise lost: the neurobiological and clinical consequences of child abuse and neglect. Neuron 89, 892–909.Google Scholar
Norman, RE, Byambaa, M, De, R, Butchart, A, Scott, J, Vos, T (2012). The long-term health consequences of child physical abuse, emotional abuse, and neglect: a systematic review and meta-analysis. PLoS Medicine 9, e1001349.Google Scholar
Olivardia, R, Pope, HG, Mangweth, B, Hudson, JL (1995). Eating disorders in college men. American Journal of Psychiatry 152, 1279–1285.Google Scholar
Oppenheimer, R, Howells, K, Palmer, RL, Chaloner, DA (1985). Adverse sexual experience in childhood and clinical eating disorders: a preliminary description. Journal of Psychiatric Research 19, 357–361.CrossRefGoogle ScholarPubMed
Palmer, RL, Oppenheimer, R, Dignon, A, Chaloner, DA, Howells, K (1990). Childhood sexual experiences with adults reported by women with eating disorders: an extended series. British Journal of Psychiatry 156, 699–703.Google Scholar
Pitts, C, Waller, G (1993). Self-denigratory beliefs following sexual abuse: association with the symptomatology of bulimic disorders. International Journal of Eating Disorders 13, 407–410.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Pope, HG, Mangweth, B, Brooking Negrão, MA, Hudson, JI, Cordas, TA (1994). Childhood sexual abuse and bulimia nervosa: a comparison of American, Austrian, and Brazilian women. American Journal of Psychiatry 151, 732–737.Google Scholar
Preti, A, Incani, E, Camboni, MV, Petretto, DR, Masala, C (2016). Sexual and eating disorder symptoms: the mediator role of bodily dissatisfaction. Comprehensive Psychiatry 47, 475–481.Google Scholar
Racine, SE, Wildes, JE (2015). Emotion dysregulation and anorexia nervosa: an exploration of the role of childhood abuse. International Journal of Eating Disorders 48, 55–58.CrossRefGoogle ScholarPubMed
Rayworth, BB, Wise, LA, Harlow, BL (2004). Childhood abuse and risk of eating disorders in women. Epidemiology 15, 271–278.Google Scholar
Rind, B, Tromovitch, P, Bauserman, R (1998). A meta-analytic examination of assumed properties of child sexual abuse using college samples. Psychological Bulletin 124, 22–53.Google Scholar
Röhr, S, Dölemeyer, R, Klinitzke, G, Steinig, J, Wagner, B, Kersting, A (2015). Kindesmishandlung bei binge eating Störung: ein systematischer Literaturüberblick. Psychiatrische Praxis 42, 125–132.Google Scholar
Romans, SE, Gendall, KA, Martin, JL, Mullen, PE (2001). Child sexual abuse and later disordered eating: a New Zealand epidemiological study. International Journal of Eating Disorders 29, 380–392.Google Scholar
Rorty, M, Yager, J, Rossotto, E (1994). Childhood sexual, physical, and psychological abuse and their relationship to comorbid psychopathology in bulimia nervosa. International Journal of Eating Disorders 21, 317–334.Google Scholar
Richardson, J, Steiger, H, Schmitz, N, Joober, R, Bruce, KR, Israel, M, Gauvin, L, Anestin, AS, Dandurand, C, Howard, H, de Guzman, R (2008). Relevance of the 5-HTTLPR polymorphism and childhood abuse to increased psychiatric comorbidity in women with bulimia spectrum disorders. Journal of Clinical Psychiatry 69, 981–990.Google Scholar
Root, MPP, Fallon, P (1988). The incidence of victimization experiences in a bulimic sample. Journal of Interpersonal Violence 3, 161–173.Google Scholar
Sanci, L, Coffey, C, Olsson, C, Reid, S, Carlin, JB, Patton, G (2008). Childhood sexual abuse and eating disorders in females. Findings from the Victorian adolescent health cohort study. Archives of Pediatric and Adolescent Medicine 162, 261–267.Google Scholar
Steiger, H, Zanko, M (1990). Sexual traumata among eating-disordered, psychiatric, and normal female groups. Journal of Interpersonal Violence 5, 74–86.Google Scholar
Steiger, H, Richardson, J, Joober, R, Israel, M, Bruce, KR, Ying Kin, NMK, Howard, H, Anestin, A, Dandurand, C, Gauvein, L (2008). Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes. American Journal of Medical Genetics part B (Neuropsychiatric Genetics) 147B, 128–130.Google Scholar
Steiger, H, Richardson, J, Schmitz, N, Israel, M, Bruce, KR, Gauvin, L (2010). Trait-defined eating disorder subtypes and history of childhood abuse. International Journal of Eating Disorders 43, 428–423.Google Scholar
Sachs-Ericsson, N, Keel, PK, Selby, EA, Verona, E, Cougle, JR, Palmer, E (2012). Parental disorders, childhood abuse, and binge eating in a large community sample. International Journal of Eating Disorders 45, 316–325.Google Scholar
Stuart, GW, Laraia, MT, Ballenger, JC, Lydiard, RB (1990). Early family experiences of women with bulimia and depression. Archives of Psychiatric Nursing 4, 43–52.Google Scholar
Schmidt, UH, Tiller, J, Treasure, JL (1993). Setting the scene for eating disorders: childhood care, classification and course of illness. Psychological Medicine 23, 663–672.Google Scholar
Steiger, H, Léonard, S, Kin, NMK, Ladouceur, C, Ramdoyal, D, Young, SN (2000). Childhood abuse and platelet tritiated-paroxetine binding in bulimia nervosa: implications for borderline personality disorder. Journal of Clinical Psychiatry 61, 427–435.Google Scholar
Schmidt, U, Evans, K, Tiller, J, Treasure, J (1995). Puberty, sexual milestones and abuse: how are they related in eating disorder patients. Psychological Medicine 25, 413–417.Google Scholar
Sullivan, PF, Bulik, CM, Carter, FA, Joyce, PR (1995). The significance of a history of childhood sexual abuse in bulimia nervosa. British Journal of Psychiatry 167, 679–682.Google Scholar
Steiger, H, Jabalpurwala, S, Champagne, J (1996). Axis II comorbidity and developmental adversity in bulimia nervosa. Journal of Nervous and Mental Disease 184, 555–560.Google Scholar
Schoemaker, C, Smit, F, van Bijl, R, Vollebergh, WAM (2002). Bulimia Nervosa following psychological and multiple child abuse: support for the self-medication hypothesis in a population-based cohort study. International Journal of Eating Disorders 32, 381–388.CrossRefGoogle Scholar
Striegel-Moore, RH, Dohm, F-A, Pike, KM, Wifley, DE, Fairburn, CG (2002). Abuse, bullying, and discrimination as risk factors for binge eating disorder. American Journal of Psychiatry 159, 1902–1907.Google Scholar
Steiger, H, Gauvin, L, Israël, M, Kin, NMKN, Young, SN, Roussin, J (2004). Serotonin function, personality variations and childhood abuse in women with bulimia-spectrum eating disorders. Journal of Clinical Psychiatry 65, 830–837.Google Scholar
Tasca, GA, Ritchie, K, Zachariades, F, Proulx, G, Trinneer, A, Balfour, L, Demidenko, N, Hayden, G, Wong, A, Bissada, H (2013). Attachment insecurity mediates the relationship between childhood trauma and eating disorder psychopathology in a clinical sample: a structural equation model. Child Abuse and Neglect 37, 926–933.Google Scholar
Smink, FRE, Van Hoeken, D, Hoek, HW (2013). Epidemiology, course and outcome of eating disorders. Current Opinion in Psychiatry 26, 543–548.CrossRefGoogle ScholarPubMed
Smolak, L, Murnen, SK (2002). A meta-analytic examination of the relationship between child sexual abuse and eating disorders. International Journal of Eating Disorders 31, 136–150.Google Scholar
StataCorp (2013). Stata Statistical Software: Release 13. StataCorp LP: College Station, TX.Google Scholar
Trace, SE, Baker, JH, Peñas-Lledó, E, Bulik, CM (2013). The genetics of eating disorders. Annual Review of Clinical Psychology 9, 589–562.Google Scholar
Ulfvebrand, S, Birgegård, A, Norring, C, Högdahl, L, Hausswolff-Juhlin, Y (2015). Psychiatric comorbidity in women and men with eating disorders results from a large clinical database. Psychiatry Research 230, 294–299.Google Scholar
Vrabel, KR, Hoffart, A, Rø, Ø, Martinsen, EW, Rosenvinge, JH (2010). Co-occurrence of avoidant personality disorder and child sexual abuse predicts poor outcome in long-standing eating disorder. Journal of Abnormal Psychology 119, 623–629.Google Scholar
Van Gerko, K, Hughes, ML, Hamil, M, Waller, G (2005). Reported childhood sexual abuse and eating-disordered cognitions and behaviors. Child Abuse and Neglect 18, 375–382.Google Scholar
Vaz Leal, FJ, Guisado Marcias, JA, Garcia-Herraiz, MA, López Vinuesa, B, Monge Bautista, M, Bolivar Perálvarez, M (2005). History of sexual abuse in patients with bulimia nervosa: its influence on clinical status. Actas Españolas Psiquiatricas 33, 135–140.Google Scholar
Waller, G (1994). Childhood sexual abuse and borderline personality disorder in the eating disorders. Child Abuse and Neglect 18, 97–101.Google Scholar
Waller, G (1998). Perceived control in eating disorders: relationship with reported sexual abuse. International Journal of Eating Disorders 23, 213–216.Google Scholar
Waller, G (1992). Sexual abuse and the severity of bulimic symptoms. British Journal of Psychiatry 161, 90–93.Google Scholar
Waller, G, Meyer, C, Ohanian, V, Elliott, P, Dickson, C, Sellings, J (2001). The psychopathology of bulimic women who report childhood sexual abuse: the mediating role of core beliefs. Journal of Nervous and Mental Disease 189, 700–708.Google Scholar
Webster, JJ, Palmer, RL (2000). The childhood and family background of women with clinical eating disorders: a comparison with women with major depression and women without psychiatric disorder. Psychological Medicine 30, 53–60.Google Scholar
Wentz, E, Gillberg, IC, Gillberg, G, Råstman, M (2005). Fertility and history of sexual abuse at 1-year follow-up of adolescent-onset anorexia nervosa. International Journal of Eating Disorders 37, 294–298.Google Scholar
Welch, SL, Doll, HA, Fairburn, CG (1997). Life events and the onset of bulimia nervosa. Psychological Medicine 27, 515–522.Google Scholar
Wonderlich, SA, Rosenfeldt, S, Crosby, RD, Mitchell, JE, Engel, SG, Smyth, J, Miltenberger, R (2007). The effects of childhood trauma on daily mood lability and comorbid psychopathology in bulimia nervosa. Journal of Traumatic Stress 20, 77–87.Google Scholar
Wear, RW, Pratz, O (1987). Test-retest reliability for the eating disorder inventory. International Journal of Eating Disorders 6, 767–769.Google Scholar
Wells, GA, Shea, B, O'Connell, D (2016). The Newcastle-Ottawa Scale (NOS) for assessing the quality non-randomised studies in meta-analyses. Ottawa Healthcare Institute (http://www.ohri.ca). Accessed 2 February 2016.Google Scholar
WHO (2016 a). International Classification of Diseases. World Health Organization: Geneva.Google Scholar
WHO (2016 b). Childhood abuse (2016). (http://www.who.int/topics/child_abuse/en/). World Health Organization. Accessed 3 January 2016.Google Scholar
Yao, S, Kuja-Halkola, R, Thorton, LM, Runfola, CD, D'Onofrio, BM, Almqvist, C, Lichtenstein, P, Sjölander, A, Larsson, H, Bulik, CM (2016). Familial liability for eating disorders and suicide attempts: evidence from a population registry in Sweden. JAMA Psychiatry 73, 284–291.Google Scholar
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