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Behavioural measurement and drug response characteristics of unipolar and bipolar depression1

Published online by Cambridge University Press:  09 July 2009

Martin M. Katz ,
Eli Robins ,
Jack Croughan ,
Steven Secunda  and
Alan Swann
Eli Robins
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA.
Jack Croughan
Affiliation:
1050 Baltimore Pike, Springfield, Pennsylvania, USA.
Steven Secunda
Affiliation:
1050 Baltimore Pike, Springfield, Pennsylvania, USA.
Alan Swann
Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
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Synopsis

This research is part of the NIMH-CRB Collaborative Study on the psychobiology of depression. The main objective of the research programme is to test hypotheses concerning the interaction of neurobiological mechanisms and behaviour in the depressive disorders. Part I of the report describes the rationale and the overall approach to measuring behavioural state and outcome in the research programme. Part II reports on the results of applying the behavioural methods to a comparison of the clinical phenomenology of unipolar and bipolar depression. The behavioural patterns expressed during the episode by the two groups are different. Further, the two types are shown to react differently to treatment with tricyclic drugs, reinforcing the thesis that they are qualitatively distinct forms of the depressive disorders.

Type
Research Article
Information
Psychological Medicine , Volume 12 , Issue 1 , February 1982 , pp. 25 - 36
Copyright
Copyright © Cambridge University Press 1982

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Footnotes

1

Based on a paper presented at the meeting of the International Collegium of Neuropsychopharmacology, Gothenburg, Sweden, June 1980.

References

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