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Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort

Published online by Cambridge University Press:  02 March 2017

G. Brucato ,
M. D. Masucci ,
L. Y. Arndt ,
S. Ben-David ,
T. Colibazzi ,
C. M. Corcoran ,
A. H. Crumbley ,
F. M. Crump ,
K. E. Gill  and
D. Kimhy
...Show all authors
G. Brucato*
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
M. D. Masucci
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
L. Y. Arndt
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
S. Ben-David
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
T. Colibazzi
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
C. M. Corcoran
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
A. H. Crumbley
Affiliation:
City University of New York, New York, NY, USA
F. M. Crump
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
K. E. Gill
Affiliation:
Department of Psychology, The Catholic University of America, Washington, DC, USA
D. Kimhy
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
A. Lister
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
S. A. Schobel
Affiliation:
F. Hoffman-LaRoche A.G., Basel, Switzerland
L. H. Yang
Affiliation:
Department of Social and Behavioral Sciences, College of Global Public Health, New York University, New York, NY, USA
J. A. Lieberman
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
R. R. Girgis
Affiliation:
The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA
*
*Address for correspondence: G. Brucato, Ph.D., The Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, 1051 Riverside Drive, Room 4818, New York, NY 10032, USA. (Email: [email protected])
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Abstract

Background

DSM-5 proposes an Attenuated Psychosis Syndrome (APS) for further investigation, based upon the Attenuated Positive Symptom Syndrome (APSS) in the Structured Interview for Psychosis-Risk Syndromes (SIPS). SIPS Unusual Thought Content, Disorganized Communication and Total Disorganization scores predicted progression to psychosis in a 2015 NAPLS-2 Consortium report. We sought to independently replicate this in a large single-site high-risk cohort, and identify baseline demographic and clinical predictors beyond current APS/APSS criteria.

Method

We prospectively studied 200 participants meeting criteria for both the SIPS APSS and DSM-5 APS. SIPS scores, demographics, family history of psychosis, DSM Axis-I diagnoses, schizotypy, and social and role functioning were assessed at baseline, with follow-up every 3 months for 2 years.

Results

The conversion rate was 30% (n = 60), or 37.7% excluding participants who were followed under 2 years. This rate was stable across time. Conversion time averaged 7.97 months for 60% who developed schizophrenia and 15.68 for other psychoses. Mean conversion age was 20.3 for males and 23.5 for females. Attenuated odd ideas and thought disorder appear to be the positive symptoms which best predict psychosis in a logistic regression. Total negative symptom score, Asian/Pacific Islander and Black/African-American race were also predictive. As no Axis-I diagnosis or schizotypy predicted conversion, the APS is supported as a distinct syndrome. In addition, cannabis use disorder did not increase risk of conversion to psychosis.

Conclusions

NAPLS SIPS findings were replicated while controlling for clinical and demographic factors, strongly supporting the validity of the SIPS APSS and DSM-5 APS diagnosis.

Keywords

Attenuated psychosisclinical high-risk for psychosisfirst episode of psychosisprodromal psychosisschizotypy
Type
Original Articles
Information
Psychological Medicine , Volume 47 , Issue 11 , August 2017 , pp. 1923 - 1935
Copyright
Copyright © Cambridge University Press 2017 

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Footnotes

†

These authors contributed equally to this work.

References

Abe-Kim, J, Takeuchi, DT, Hong, S, Zane, N, Sue, S, Spencer, MS, Appel, H, Nicdao, E, Alegria, M (2007). Use of mental health-related services among immigrant and US-born Asian Americans: results from the National Latino and Asian American study. American Journal of Public Health 97, 91–98.Google Scholar
Addington, J, Cadenhead, KS, Cannon, TD, Cornblatt, B, McGlashan, TH, Perkins, DO, Seidman, LJ, Tsuang, M, Walker, EF, Woods, SW, Heinssen, R (2007). North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research. Schizophrenia Bulletin 33, 665–672.CrossRefGoogle ScholarPubMed
Addington, J, Cadenhead, KS, Cornblatt, BA, Mathalon, DH, McGlashan, TH, Perkins, DO, Seidman, LJ, Tsuang, MT, Walker, EF, Woods, SW, Addington, JA, Cannon, TD (2012). North American Prodrome Longitudinal Study (NAPLS 2): overview and recruitment. Schizophrenia Research 142, 77–82.Google Scholar
Addington, J, Liu, L, Buchy, L, Cadenhead, KS, Cannon, TD, Cornblatt, BA, Perkins, DO, Seidman, LJ, Tsuang, MT, Walker, EF, Woods, SW, Bearden, CE, Mathalon, DH, McGlashan, TH (2015). North American Prodrome Longitudinal Study (NAPLS-2): the prodromal symptoms. Journal of Nervous and Mental Disease 203, 328–335.Google Scholar
APA (1994). Diagnostic and Statistical Manual of Mental Disorders – 4th edn. American Psychiatric Association: Washington, DC.Google Scholar
APA (2013). Diagnostic and Statistical Manual of Mental Disorders – 5th edn. American Psychiatric Association: Washington, DC.Google Scholar
Andreasen, NC, Endicott, J, Spitzer, RL, Winokur, G (1977). The family history method using diagnostic criteria: reliability and validity. Archives of General Psychiatry 34, 1229–1235.Google Scholar
Anglin, DM, Lui, F, Espinosa, A, Tikhonov, A, Ellman, L (2016). Ethnic identity, racial discrimination and attenuated psychotic symptoms in an urban population of emerging adults. Early Intervention in Psychiatry, doi:10.1111/eip.12314.Google Scholar
Barajas, A, Ochoa, S, Obiols, JE, Lalucat-Jo, L (2015). Gender differences in individuals at high-risk of psychosis: a comprehensive literature review. Scientific World Journal 2015, 1–13.CrossRefGoogle ScholarPubMed
Cannon, TD, Cadenhead, K, Cornblatt, B, Woods, SJ, Addington, J, Walker, E, Seidman, LJ, Perkins, D, Tsuang, M, McGlashen, T (2008). Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Archives of General Psychiatry 65, 28–37.CrossRefGoogle ScholarPubMed
Cannon, TD, Yu, C, Addington, J, Bearden, CE, Cadenhead, KS, Cornblatt, BA, Heinssen, R, Jeffries, CD, Mathalon, DH, McGlashan, TH, Perkins, DO, Seidman, LJ, Tsuang, MT, Walker, EF, Woods, SW, Kattan, MW (2016). An individualized risk calculator for research in prodromal psychosis. American Journal of Psychiatry 173, 980–988.CrossRefGoogle ScholarPubMed
Carpenter, W, Van Os, J (2011). Should attenuated psychosis syndrome be a DSM-5 diagnosis? American Journal of Psychiatry 168, 460–463.CrossRefGoogle ScholarPubMed
Carrion, RE, Cornblatt, BA, Burton, CZ, Tso, IF, Auther, AM, Adelsheim, S, Calkins, R, Carter, CS, Neindam, T, Sale, TG, Taylor, SF, McFarlane, WR (2016). Personalized prediction of psychosis: external validation of the NAPLS-2 psychosis risk calculator with the EDIPPP project. American Journal of Psychiatry 173, 989–996.Google Scholar
Cohen, CI, Marino, L (2013). Racial and ethnic differences in the prevalence of psychotic symptoms in the general population. Psychiatric Services 64, 1103–1109.Google Scholar
Compton, MT, Kaslow, NJ, Walker, EW (2004). Observations on parent/family factors that may influence the duration of untreated psychosis among African-American first-episode schizophrenia-spectrum patients. Schizophrenia Research 68, 373–385.Google Scholar
Corcoran, CM, First, MB, Cornblatt, B (2010). The Psychosis Risk Syndrome and its proposed inclusion in the DSM-V: a risk-benefit analysis. Schizophrenia Research 120, 16–22.Google Scholar
Cornblatt, BA, Auther, AM, Niendam, T, Smith, CW, Zinberg, J, Bearden, CE, Cannon, TD (2007). Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia. Schizophrenia Bulletin 33, 688–702.Google Scholar
Cornblatt, BA, Carrión, RE, Addington, J, Seidman, L, Walker, EF, Cannon, TD, Cadenhead, KS, McGlashan, TH, Perkins, DO, Tsuang, MT, Woods, SW, Heinssen, R, Lencz, T (2012). Risk factors for psychosis: impaired social and role functioning. Schizophrenia Bulletin 38, 1247–1257.Google Scholar
Cornblatt, BA, Lencz, T, Smith, CW, Correll, CU, Auther, AM, Nakayama, E (2003). The schizophrenia prodrome revisited: a neurodevelopmental perspective. Schizophrenia Bulletin 29, 633–651.CrossRefGoogle ScholarPubMed
Correll, CU, Hauser, MH, Auther, AM, Cornblatt, BA (2010). Research in people with the psychosis risk syndrome: a review of the current evidence and future directions. Journal of Child Psychology and Psychiatry 51, 390–431.CrossRefGoogle ScholarPubMed
DeVylder, JE, Muchomba, FM, Gill, KE, Ben-David, S, Walder, DJ, Malaspina, D, Corcoran, CM (2014). Symptom trajectories and psychosis onset in a clinical high-risk cohort: the relevance of subthreshold thought disorder. Schizophrenia Research 159, 278–283.Google Scholar
Drake, RJ, Lewis, SW (2010). Valuing prodromal psychosis: what do we get and what is the price? Schizophrenia Research 120, 38–41.Google Scholar
First, MB, Spitzer, RL, Gibbon, M, Williams, JBW (2002). Structured Clinical Interview for DSM-IV-TR Axis-I Disorders, Research Version, Patient Edition. (SCID-I/P). New York State Psychiatric Institute, Biometrics Research: New York.Google Scholar
Fusar-Poli, P, Bonoldi, I, Yung, AR, Borgwardt, S, Kempton, MJ, Valmaggia, K, Barale, F, Caverzasi, E, McGuire, P (2012). Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk. Archives of General Psychiatry 69, 220–229.CrossRefGoogle ScholarPubMed
Fusar-Poli, P, Borgwardt, S, Bechdolf, A, Addington, J, Richer-Rossler, A, Schultze-Lutter, F, Keshavan, M, Wood, S, Ruhrmann, S, Seidman, LJ, Valmaggia, L, Cannon, T, Velthorst, E, De Haan, L, Cornblatt, B, Bonoldi, I, Birchwood, M, McGlashan, T, Carpenter, W, McGorry, P, Klosterkotter, J, McGuire, P, Yung, A (2013). The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry 70, 107–120.Google Scholar
Fusar-Poli, P, Cappucciati, M, Rutigliano, G, Schultze-Lutter, F, Bonoldi, I, Borgwardt, S, Richer-Rossler, A, Addington, A, Perkins, D, Woods, SW, McGlashen, TH, Lee, J, Klosterkotter, J, Yung, AR, McGuire, P (2015). At risk or not at risk? A meta-analysis of the prognostic accuracy of psychometric interviews for psychosis prediction. World Psychiatry 14, 322–332.Google Scholar
Fusar-Poli, P, Nelson, B, Valmaggia, L, Yung, AR, McGuire, PK (2014). Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis. Schizophrenia Bulletin 40, 120–131.Google Scholar
Fusar-Poli, P, Van Os, J (2013). Lost in transition: setting the psychosis threshold in prodromal research. Acta Psychiatrica Scandinavica 127, 248–252.CrossRefGoogle ScholarPubMed
Gates, G (2011). How Many People are Lesbian, Gay, Bisexual, and Transgender? Williams Institute at University of California Los Angeles School of Law.Google Scholar
Gee, GD, Cannon, TD (2011). Prediction of conversion to psychosis: review and future directions. Revista Brasileira de Psiquiatria 33, 129–142.CrossRefGoogle ScholarPubMed
Guadiano, BA, Zimmerman, M (2013). Prevalence of attenuated psychotic symptoms and their relationship with DSM-IV diagnoses in a general psychiatric outpatient clinic. Journal of Clinical Psychiatry 74, 149–155.CrossRefGoogle Scholar
Hall, R (1995). Global assessment of functioning: a modified scale. Psychosomatics 36, 267–275.Google Scholar
Haroun, N, Dunn, L, Haroun, A, Cadenhead, KS (2006). Risk and protection in prodromal schizophrenia: ethical implications for clinical practice and future research. Schizophrenia Bulletin 32, 166–178.Google Scholar
Hartmann, JA, Yuen, HP, McGorry, PD, Yung, AR, Lin, A, Wood, SJ, Lavoie, S, Nelson, B (2016). Declining transition rates to psychotic disorder in “ultra-high risk clients: investigation of a dilution effect”. Schizophrenia Research 170, 130–136.Google Scholar
Hawkins, KA, Quinlan, D, Miller, TJ, Woods, SW, Zipursky, RB, Perkins, DO, Addington, J, McGlashan, TH (2004). Factorial structure of the scale of prodromal symptoms. Schizophrenia Research 68, 339–347.CrossRefGoogle ScholarPubMed
IBM Corporation (2013). IBM SPSS Statistics for Windows, Version 22.0. IBM Corporation: Armonk, NY.Google Scholar
Kaufman, J, Birmaher, B, Brent, D, Rao, U, Ryan, N (1996). Kiddie-SADS-Present and Lifetime Version (K-SADS-PL). Department of Psychiatry: University of Pittsburgh.Google Scholar
Lemos-Giráldez, S, Vallina-Fernández, O, Fernández-Iglesias, P, Vallejo-Seco, G, Fonseco-Padrero, E, Paino-Pineiro, M, Sierra-Baigrie, S, García-Pelayo, P, Pedrejón-Molino, C, Alonso-Bada, S, Gutiérrez-Pérez, A, Ortega-Ferrández, JA (2009). Symptomatic and functional outcome in youth at ultra-high risk for psychosis: a longitudinal study. Schizophrenia Research 115, 121–129.Google Scholar
Li, H, Friedman-Yakoobian, M, Min, G, Gnong Granato, A, Seidman, LJ (2013). Working with Asian American youth at clinical high risk for psychosis: a case illustration. Journal of Nervous and Mental Disease 201, 484–489.Google Scholar
Mason, O, Startup, M, Halpin, S, Schall, U, Conrad, A, Carr, V (2004). Risk factors for transition to first episode psychosis among individuals with ‘at-risk mental states’. Schizophrenia Research 71, 227–237.Google Scholar
Masuda, A, Boone, MS (2011). Mental health stigma, self-concealment, and help-seeking attitudes among Asian American and European American college students with no help-seeking experience. International Journal of Advances Counseling 33, 266–279.Google Scholar
McGlashan, TH, Miller, TJ, Woods, SW, Hoffman, RE, Davidson, LA (2001). Scale for the assessment of prodromal symptoms and states. In Early Intervention in Psychotic Disorders (ed. Miller, T., Mednick, S. A., McGlashan, T. H., Liberger, J. and Johannessen, J. O.), pp. 135–149. Kluwer Academic Publishers: Dordrecht, The Netherlands.Google Scholar
Miller, TJ, McGlashan, TH, Rosen, JL, Cadenhead, K, Cannon, T, Ventura, J, McFarlane, W, Perkins, DO, Pearlson, GD, Woods, SW (2003). Prodromal assessment with the Sstructured Interview for Prodromal Syndromes: predictive validity, interrater reliability, and training to reliability. Schizophrenia Bulletin 29, 703–715.Google Scholar
Miller, TJ, McGlashan, TH, Rosen, JL, Somjee, L, Markovich, PJ, Stein, K, Woods, SW (2002). Prospective diagnosis of the prodrome for schizophrenia: preliminary evidence of interrater reliability and predictive validity using operational criteria and a structured interview. American Journal of Psychiatry 159, 863–865.CrossRefGoogle Scholar
Miller, TJ, McGlashan, TH, Woods, SW, Stein, K, Driesen, N, Corcoran, CM, Hoffman, R, Davidson, L (1999). Symptom assessment in schizophrenic prodromal states. Psychiatric Quarterly 70, 273–287.CrossRefGoogle ScholarPubMed
Nelson, B, Yuen, HP, Wood, SJ, Lin, A, Spiliotacopoulos, D, Bruxner, A, Broussard, C, Simmons, M, Foley, DL, Brewer, WJ, Francey, SM, Amminger, GP, Thompson, A, McGorry, PD, Yung, AR (2013). Long-term follow-up of a group at Ultra High Risk (“prodromal”) for psychosis: the PACE 400 Study. JAMA Psychiatry 70, 1–10.CrossRefGoogle ScholarPubMed
Nurnberger, JI Jr., Blejar, MC, Kaufmann, CA, York-Cooler, C, Simpson, SG, Harkavy-Friedman, J, Severe, JB, Malaspina, D, Reich, T (1994). Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Archives of General Psychiatry 51, 849–859.Google Scholar
Ochoa, S, Usall, J, Cobo, J, Labad, X, Kulkarni, J (2012). Gender differences in schizophrenia and first-episode psychosis: a comprehensive literature review. Schizophrenia Research and Treatment 2012, 1–9.Google Scholar
Piskulic, D, Addington, J, Cadenhead, KS, Cannon, TD, Cornblatt, BA, Heinssen, R, Perkins, DO, Seidman, LJ, Tsuang, MT, Walker, EF, Woods, SW, McGlashan, TH (2012). Negative symptoms in individuals at clinical high risk of psychosis. Psychiatry Research 196, 220–224.CrossRefGoogle ScholarPubMed
Rosen, JL, Woods, SW, Miller, TJ, McGlashan, TH (2002). Prospective observations of emerging psychosis. Journal of Nervous and Mental Disease 190, 133–141.Google Scholar
Ruhrmann, S, Schultze-Lutter, F, Salokangas, RK, Heinimaa, M, Linszen, D, Dingemans, P, Birchwood, M, Patterson, P, Juckel, G, Heinz, A, Morrison, A, Lewis, S, von Reventlow, HG, Klosterkotter, J (2010). Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study. Archives of General Psychiatry 67, 241–251.CrossRefGoogle Scholar
Schultze-Lutter, F, Michel, C, Ruhrmann, S, Schimmelmann, BG (2014). Prevalence and clinical significance of DSM-5-attenuated psychosis syndrome in adolescents and young adults in the general population: the Bern Epidemiological At-Risk (BEAR) study. Schizophrenia Bulletin 40, 1499–1508.Google Scholar
Shea, M, Yeh, CJ (2008). Asian American students’ cultural values, stigma, and relational self-construal: correlates and attitudes toward professional help seeking. Journal of Mental Health Counseling 30, 157–172.Google Scholar
Simon, AE, Umbricht, D (2010). High remission rates from an initial ultra-high risk state for psychosis. Schizophrenia Research 116, 168–172.Google Scholar
Simon, AE, Umbricht, D, Lang, UE, Borgwardt, S (2014). Declining transition rates to psychosis: the role of diagnostic spectra and symptom overlaps in individuals with attenuated psychosis syndrome. Schizophrenia Research 159, 292–298.Google Scholar
Stafford, MR, Jackson, H, Mayo-Wilson, E, Morrison, AP, Kendall, T (2013). Early interventions to prevent psychosis: systematic review and meta-analysis. British Medical Journal 346, f185.Google Scholar
Sue, DW (1994). Asian-American mental health and help-seeking behavior: comment on Solberg et al. (1994), Tata and Leong (1994), and Lin (1994). Journal of Counseling Psychology 41, 92–295.Google Scholar
Tsuang, MT, Van Os, J, Tandon, R, Barch, DM, Bustillo, J, Gaebel, W, Gur, RE, Heckers, S, Malaspina, D, Owen, MJ, Schultz, S, Carpenter, W (2013). Attenuated psychosis syndrome in DSM-5. Schizophrenia Research 150, 31–35.Google Scholar
Van der Gaag, M, Smit, F, Bechdolf, A, French, P, Linszen, DH, Yung, AR, McGorry, P, Cuijpers, P (2013). Preventing a first episode of psychosis: meta-analysis of randomized controlled prevention trials of 12 months and longer-term follow-ups. Schizophrenia Research 149, 56–62.Google Scholar
Van Os, J, Linscott, RJ, Myin-Germeys, I, Delespaul, P, Krabbendam, L (2009). A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychological Medicine 39, 179–195.CrossRefGoogle ScholarPubMed
Velthorst, E, Nieman, DH, Becker, HE, van de Fliert, R, Dingemans, PM, Klaassen, R, de Haan, L, van Amelsvoort, T, Linszen, DH (2009). Baseline differences in clinical symptomatology between ultra high risk subjects with and without a transition to psychosis. Schizophrenia Research 109, 60–65.Google Scholar
Waford, RN, MacDonald, A, Goines, K, Novacek, DM, Trotman, HD, Elaine, FW, Addington, J, Bearden, CE, Cadenhead, KS, Cannon, TD, Cornblatt, BA, Heinssen, R, Mathalon, DH, Tsuang, MT, Perkins, DO, Seidman, LJ, Woods, SW, McGlashan, TH (2015). Demographic correlates of attenuated positive psychotic symptoms. Schizophrenia Research 166, 31–36.Google Scholar
Walder, DJ, Holtzman, CW, Addington, J, Cadenhead, K, Tsuang, M, Cornblatt, B, Cannon, TD, McGlashan, T, Woods, SW, Perkins, DO, Seidman, LJ, Heinssen, R, Walker, E (2013). Sexual dimorphisms and prediction of conversion in the NAPLS psychosis prodrome. Schizophrenia Research 144, 43–50.Google Scholar
Woods, SW, Addington, J, Cadenhead, K, Cannon, TD, Cornblatt, BA, Heinssen, R, Perkins, DO, Seidman, LJ, Tsuang, MT, Walker, EF, McGlashan, TH (2009). Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study. Schizophrenia Bulletin 35, 894–908.Google Scholar
Woods, SW, Carlson, JP, McGlashen, TH (2010). DSM-5 and the ‘Psychosis Risk Syndrome’: the DSM-V proposal is better than DSM-IV. Psychosis 2, 187–190.Google Scholar
Yang, LH, Link, BG, Ben-David, S, Gill, KE, Girgis, RR, Brucato, G, Wonpat-Borja, AJ, Corcoran, CM (2015). Stigma related to labels and symptoms in individuals at clinical high-risk for psychosis. Schizophrenia Research 168, 9–15.CrossRefGoogle ScholarPubMed
Yung, AR, Phillips, LJ, Yuen, HP, Francey, SM, McFarlane, CA, Hallgren, M, McGorry, PD (2003). Psychosis prediction: 12-month follow up of a high-risk (‘prodromal’) group. Schizophrenia Research 60, 21–32.Google Scholar
Yung, AR, Stanford, C, Cosgrave, E, Killackey, E, Phillips, L, Nelson, B, McGorry, PD (2006). Testing the ultra high risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people. Schizophrenia Research 84, 57–66.Google Scholar
Yung, AR, Yuen, HP, Berger, G, Francey, S, Hung, TC, Nelson, B, Phillips, L, McGorry, P (2007). Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk? Schizophrenia Bulletin 33, 673–681.Google Scholar
Ziermans, TB, Schothorst, PF, Sprong, M, van Engeland, H (2011). Transition and remission in adolescents at ultra-high risk for psychosis. Schizophrenia Research 126, 58–64.Google Scholar
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