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Associations between serotonin transporter gene (SLC6A4) methylation and clinical characteristics and cortical thickness in children with ADHD

Published online by Cambridge University Press:  28 May 2015

S. Park ,
J.-M. Lee ,
J.-W. Kim ,
D.-Y. Cho ,
H. J. Yun ,
D. H. Han ,
J. H. Cheong  and
B.-N. Kim
S. Park
Affiliation:
Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea
J.-M. Lee
Affiliation:
Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea
J.-W. Kim
Affiliation:
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
D.-Y. Cho
Affiliation:
Lab Genomics Clinical Research Institute, Seoul, Republic of Korea
H. J. Yun
Affiliation:
Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea
D. H. Han
Affiliation:
Department of Psychiatry, College of Medicine, Chung Ang University, Seoul, Republic of Korea
J. H. Cheong
Affiliation:
Uimyung Research Institute for Neuroscience, Sahmyook University, Seoul, Republic of Korea
B.-N. Kim*
Affiliation:
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
*
*Address for correspondence: Dr B.-N. Kim, Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University, College of Medicine, College of Medicine, 101 Daehakro, Chongro-Gu, Seoul, South Korea. (Email: [email protected])
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Abstract

Background.

Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Additionally, environmental factors such as perinatal stress and early adversities contribute to the occurrence and severity of ADHD. Recently, DNA methylation has emerged as a mechanism that potentially mediates gene–environmental interaction effects in the aetiology and phenomenology of psychiatric disorders. Here, we investigated whether serotonin transporter gene (SLC6A4) methylation patterns were associated with clinical characteristics and regional cortical thickness in children with ADHD.

Method.

In 102 children with ADHD (age 6–15 years), the methylation status of the SLC6A4 promoter was measured. Brain magnetic resonance imaging was obtained and ADHD symptoms were evaluated.

Results.

A higher methylation status of the SLC6A4 promoter was significantly associated with worse clinical presentations (more hyperactive-impulsive symptoms and more commission errors). Additionally, a negative correlation was observed between SLC6A4 methylation levels and cortical thickness values in the right occipito-temproral regions.

Conclusions.

Our results suggest that the SLC6A4 methylation status may be associated with certain symptoms of ADHD, such as behavioural disinhibition, and related brain changes. Future studies that use a larger sample size and a control group are required to corroborate these results.

Keywords

Attention deficit hyperactivity disorderbrain imaginggene–environment interactionneuropsychology
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 14 , October 2015 , pp. 3009 - 3017
Copyright
Copyright © Cambridge University Press 2015 

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