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Associations between maternal depressive symptoms and risk for offspring early-life psychopathology: the role of genetic and non-genetic mechanisms

Published online by Cambridge University Press:  09 December 2019

Line C. Gjerde Open the ORCID record for Line C. Gjerde [Opens in a new window] ,
Espen M. Eilertsen ,
Laurie J. Hannigan ,
Thalia Eley ,
Espen Røysamb ,
Ted Reichborn-Kjennerud ,
Fruhling V. Rijsdijk ,
Tom A. McAdams  and
Eivind Ystrom
Line C. Gjerde*
Affiliation:
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway PROMENTA Research Center, University of Oslo, Oslo, Norway
Espen M. Eilertsen
Affiliation:
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway
Laurie J. Hannigan
Affiliation:
Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway
Thalia Eley
Affiliation:
Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Espen Røysamb
Affiliation:
PROMENTA Research Center, University of Oslo, Oslo, Norway Department of Child Development, Norwegian Institute of Public Health, Oslo, Norway
Ted Reichborn-Kjennerud
Affiliation:
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Fruhling V. Rijsdijk
Affiliation:
Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Tom A. McAdams
Affiliation:
Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Eivind Ystrom
Affiliation:
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway PROMENTA Research Center, University of Oslo, Oslo, Norway School of Pharmacy, University of Oslo, Oslo, Norway
*
Author for correspondence: Line C. Gjerde, E-mail: [email protected]
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Abstract

Background

Although maternal depressive symptoms are robustly associated with offspring early-life psychopathology symptoms, it is not clear which potential mechanisms are at play. We aimed to estimate the relative importance of genetic transmission and direct environmental exposure in these associations on three occasions in early childhood.

Methods

Biometric modeling of maternal sisters and their offspring from the Norwegian Mother and Child Cohort Study. The analyzed sample comprised 22 316 mothers and 35 589 offspring. Mothers reported their own depressive symptoms using the Symptom checklist, and offspring's concurrent symptoms of psychopathology using the Child Behavior Checklist at 1.5, 3, and 5 years postpartum.

Results

Associations between maternal symptoms of depression and offspring emotional problems were predominantly explained by passive genetic transmission at 1.5 and 3 years postpartum. At age 5, associations were more due to direct environmental exposure. For offspring behavioral problems, there was no net increase in the importance of direct environmental exposure across occasions.

Conclusions

Associations between maternal depressive symptoms and offspring psychopathology symptoms remained after accounting for shared genes, consistent with a small, causal effect. For offspring emotional problems, this effect appeared to increase in importance over time. Our findings imply that treatment of maternal depressive symptoms could also benefit the offspring, and that genetic confounding should be considered in future studies of such mother–offspring associations.

Keywords

Child psychopathology symptomsintergenerational transmission of riskmaternal depressive symptomsNorwegian Mother and Child Cohort Study
Type
Original Articles
Information
Psychological Medicine , Volume 51 , Issue 3 , February 2021 , pp. 441 - 449
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Copyright
Copyright © Cambridge University Press 2019

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References

Achenbach, T. M. (1992). Manual for the child behavior checklist/2-3 and 1992 profile. Burlington, VT: Department of Psychiatry, University of Vermont.Google Scholar
Akaike, H. (1987). Factor analysis and AIC. Psychometrica, 52, 317–332.CrossRefGoogle Scholar
Barker, E. D., Jaffee, S. R., Uher, R., & Maughan, B. (2011). The contribution of prenatal and postnatal maternal anxiety and depression to child maladjustment. Depression and Anxiety, 28, 696–702.CrossRefGoogle ScholarPubMed
Cummings, E. M., & Davies, P. T. (1994). Maternal depression and child development. Journal of Child Psychology and Psychiatry and Allied Disciplines, 35, 73–112.CrossRefGoogle ScholarPubMed
Davis, E. P., Glynn, L. M., Schetter, C. D., Hobel, C., Chicz-Demet, A., & Sandman, C. A. (2007). Prenatal exposure to maternal depression and cortisol influences infant temperament. Journal of the American Academy of Child & Adolescent Psychiatry, 46, 737–746.CrossRefGoogle ScholarPubMed
Gadermann, A. M., Guhn, M., & Zumbo, B. D. (2012). Estimating ordinal reliability for Likert-type and ordinal item response data: a conceptual, empirical, and practical guide. Practical Assessment, Research and Evaluation, 17, 1–13.Google Scholar
Gjerde, L. C., Eilertsen, E. M., Eley, T. C., McAdams, T. A., Reichborn-Kjennerud, T., Roysamb, E., & Ystrom, E. (2018). Maternal perinatal and concurrent anxiety and mental health problems in early childhood: a sibling-comparison study. Child Development. https://doi.org/10.1111/cdev.13192Google ScholarPubMed
Gjerde, L. C., Eilertsen, E. M., Reichborn-Kjennerud, T., McAdams, T. A., Zachrisson, H. D., Zambrana, I. M., … Ystrøm, E. (2017). Maternal perinatal and concurrent depressive symptoms and child behavior problems: a sibling comparison study. Journal of Child Psychology and Psychiatry, 58, 779–786.CrossRefGoogle ScholarPubMed
Gjerde, L. C., Roysamb, E., Czajkowski, N., Reichborn-Kjennerud, T., Orstavik, R. E., Kendler, K. S., & Tambs, K. (2011). Strong genetic correlation between interview-assessed internalizing disorders and a brief self-report symptom scale. Twin Research and Human Genetics, 14, 64–72.CrossRefGoogle Scholar
Golub, Y., Canneva, F., Funke, R., Frey, S., Distler, J., von Hörsten, S., … Solati, J. (2016). Effects of in utero environment and maternal behavior on neuroendocrine and behavioral alterations in a mouse model of prenatal trauma. Developmental Neurobiology, 76, 1254–1265.CrossRefGoogle Scholar
Goodman, S. H., Rouse, M. H., Connell, A. M., Broth, M. R., Hall, C. M., & Heyward, D. (2011). Maternal depression and child psychopathology: a meta-analytic review. Clinical Child and Family Psychology Review, 14, 1–27.CrossRefGoogle ScholarPubMed
Hannigan, L. J., Eilertsen, E. M., Gjerde, L. C., Reichborn-Kjennerud, T., Eley, T. C., Rijsdijk, F. V., … McAdams, T. A. (2018). Maternal prenatal depressive symptoms and risk for early-life psychopathology in offspring: genetic analyses in the Norwegian Mother and Child Birth Cohort Study. The Lancet Psychiatry, 5, 808–815.CrossRefGoogle ScholarPubMed
Helland, S. S., Røysamb, E., Wang, M. V., & Gustavson, K. (2017). Language difficulties and internalizing problems: bidirectional associations from 18 months to 8 years among boys and girls. Development and Psychopathology, 30, 1239–1252.CrossRefGoogle ScholarPubMed
Hesbacher, P. T., Rickels, K., Morris, R. J., Newman, H., & Rosenfeld, H. (1980). Psychiatric illness in family practice. Journal of Clinical Psychiatry, 41, 6–10.Google ScholarPubMed
Jinks, J. L., & Fulker, D. W. (1970). Comparison of biometrical genetical, MAVA, and classical approaches to analysis of human behavior. Psychological Bulletin, 73, 311–349.CrossRefGoogle ScholarPubMed
Kendler, K. S., Ohlsson, H., Sundquist, K., & Sundquist, J. (2018). Sources of parent-offspring resemblance for major depression in a national Swedish extended adoption study. Jama Psychiatry, 75, 194–200.CrossRefGoogle Scholar
Kerr, D. C. R., Leve, L. D., Harold, G. T., Natsuaki, M. N., Neiderhiser, J. M., Shaw, D. S., & Reiss, D. (2013). Influences of biological and adoptive mothers’ depression and antisocial behavior on adoptees’ early behavior trajectories. Journal of Abnormal Child Psychology, 41, 723–734.CrossRefGoogle ScholarPubMed
Lovejoy, M. C., Graczyk, P. A., O'Hare, E., & Neuman, G. (2000). Maternal depression and parenting behavior: a meta-analytic review. Clinical Psychology Review, 20, 561–592.CrossRefGoogle ScholarPubMed
Magnus, P., Birke, C., Vejrup, K., Haugan, A., Alsaker, E., Daltveit, A. K., … Stoltenberg, C. (2016). Cohort profile update: the Norwegian mother and child cohort study (MoBa). International Journal of Epidemiology, 45, 382–388.CrossRefGoogle Scholar
McAdams, T. A., Hannigan, L. J., Eilertsen, E. M., Gjerde, L. C., Ystrom, E., & Rijsdijk, F. V. (2018). Revisiting the children-of-twins design: improving existing models for the exploration of intergenerational associations. Behavior Genetics, 48, 397–412.CrossRefGoogle ScholarPubMed
McAdams, T. A., Neiderhiser, J. M., Rijsdijk, F. V., Narusyte, J., Lichtenstein, P., & Eley, T. C. (2014). Accounting for genetic and environmental confounds in associations between parent and child characteristics: a systematic review of children-of-twins studies. Psychological Bulletin, 140, 1138–1173.CrossRefGoogle ScholarPubMed
McAdams, T. A., Rijsdijk, F. V., Neiderhiser, J. M., Narusyte, J., Shaw, D. S., Natsuaki, M. N., … Eley, T. C. (2015). The relationship between parental depressive symptoms and offspring psychopathology: evidence from a children-of-twins study and an adoption study. Psychological Medicine, 45, 2583–2594.CrossRefGoogle Scholar
McGinnis, E., Bocknek, E., Beeghly, M., Rosenblum, K. L., & Muzik, M. (2015). Does child sex moderate vulnerability to postpartum risk among infants of mothers at risk for psychopathology? Infancy, 20, 42–69.CrossRefGoogle Scholar
Natsuaki, M. N., Shaw, D. S., Neiderhiser, J. M., Ganiban, J. M., Harold, G. T., Reiss, D., & Leve, L. D. (2014). Raised by depressed parents: is it an environmental risk? Clinical Child and Family Psychology Review, 17, 357–367.CrossRefGoogle ScholarPubMed
Neale, M. C., Hunter, M. D., Pritikin, J. N., Zahery, M., Brick, T. R., Kirkpatrick, R. M., … Boker, S. M. (2016). Openmx 2.0: extended structural equation and statistical modeling. Psychometrika, 81, 535–549.CrossRefGoogle ScholarPubMed
Nes, R. B., Roysamb, E., Reichborn-Kjennerud, T., Harris, J. R., & Tambs, K. (2007). Symptoms of anxiety and depression in young adults: genetic and environmental influences on stability and change. Twin Research & Human Genetics, 10, 450–461.CrossRefGoogle ScholarPubMed
Netsi, E., Pearson, R. M., Murray, L., Cooper, P., Craske, M. G., & Stein, A. (2018). Association of persistent and severe postnatal depression with child outcomes. JAMA Psychiatry, 75, 247–253.CrossRefGoogle ScholarPubMed
Nilsen, T. S., Knudsen, G. P., Gervin, K., Brandt, I., Roysamb, E., Tambs, K., … Harris, J. R. (2013). The Norwegian Twin Registry from a public health perspective: a research update. Twin Research and Human Genetics, 16, 285–295.CrossRefGoogle ScholarPubMed
Polderman, T. J., Benyamin, B., de Leeuw, C. A., Sullivan, P. F., van Bochoven, A., Visscher, P. M., & Posthuma, D. (2015). Meta-analysis of the heritability of human traits based on fifty years of twin studies. Nature Genetics, 47, 702–709.CrossRefGoogle ScholarPubMed
Quarini, C., Pearson, R. M., Stein, A., Ramchandani, P. G., Lewis, G., & Evans, J. (2016). Are female children more vulnerable to the long-term effects of maternal depression during pregnancy? Journal of Affective Disorders, 189, 329–335.CrossRefGoogle ScholarPubMed
Rice, F., Harold, G., & Thapar, A. (2002). The genetic aetiology of childhood depression: a review. Journal of Child Psychology and Psychiatry and Allied Disciplines, 43, 65–79.CrossRefGoogle ScholarPubMed
Sandman, C. A., Glynn, L. M., & Davis, E. P. (2013). Is there a viability-vulnerability tradeoff? Sex differences in fetal programming. Journal of Psychosomatic Research, 75, 327–335.CrossRefGoogle Scholar
Silberg, J. L., Maes, H., & Eaves, L. J. (2010). Genetic and environmental influences on the transmission of parental depression to children's depression and conduct disturbance: an extended Children of Twins study. Journal of Child Psychology and Psychiatry, 51, 734–744.CrossRefGoogle ScholarPubMed
Singh, A. L., D'Onofrio, B. M., Slutske, W. S., Turkheimer, E., Emery, R. E., Harden, K. P., … Martin, N. G. (2011). Parental depression and offspring psychopathology: a Children of Twins study. Psychological Medicine, 41, 1385–1395.CrossRefGoogle ScholarPubMed
Siu, A. L. & USPST. (2016). Screening for depression in adults: us preventive services task force recommendation statement. JAMA 315, 380–387.CrossRefGoogle ScholarPubMed
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000). Genetic epidemiology of major depression: review and meta-analysis. American Journal of Psychiatry, 157, 1552–1562.CrossRefGoogle ScholarPubMed
Tambs, K., & Røysamb, E. (2014). Selection of questions to short-form versions of original psychometric instruments in MoBa. Norwegian Journal of Epidemiology, 24, 195–201.Google Scholar
Weissman, M. M. (2018). Postpartum depression and its long-term impact on children: many new questions. JAMA Psychiatry, 75, 227–228.CrossRefGoogle ScholarPubMed
Wellman, H. M., Cross, D., & Watson, J. (2001). Meta-analysis of theory-of-mind development: the truth about false belief. Child Development, 72, 655–684.CrossRefGoogle ScholarPubMed
Young, S. E., Stallings, M. C., Corley, R. P., Krauter, K. S., & Hewitt, J. K. (2000). Genetic and environmental influences on behavioral disinhibition. American Journal of Medical Genetics, 96, 684–695.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
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