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Acute physical dependence in the waking dog after a single low dose of morphine

Published online by Cambridge University Press:  09 July 2009

Joseph J. Jacob  and
Gérard M. Michaud
Joseph J. Jacob*
Affiliation:
Laboratory of Pharmacology and Toxicology, Pasteur Institute, Paris, France
Gérard M. Michaud
Affiliation:
Laboratory of Pharmacology and Toxicology, Pasteur Institute, Paris, France
*
1Address for correspondence: Professor J. J. Jacob, Laboratory of Pharmacology and Toxicology, Pasteur Institute, F.75015, Paris, France.
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Sysnopsis

In the waking dog, a small dose of morphine (0·1 mg/kg intravenously) was sufficient (1) to induce a quite appreciable state of sedation which might be more closely related to clinical analgesia than experimental nociception, and (2) to allow for precipitation of clear-cut signs of abstinence (agitation, tachycardia, tachypnoea, mydriasis, hyperthermia, tremors, salivation, urination) when naloxone (3 mg/kg subcutaneously) was injected 1·5 hours later.

Type
Research Article
Information
Psychological Medicine , Volume 4 , Issue 3 , August 1974 , pp. 270 - 273
Copyright
Copyright © Cambridge University Press 1974

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References

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