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Abnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia

Published online by Cambridge University Press:  16 December 2010

Q. Wang ,
W. Deng ,
C. Huang ,
M. Li ,
X. Ma ,
Y. Wang ,
L. Jiang ,
S. Lui ,
X. Huang  and
S. E. Chua
...Show all authors
Q. Wang
Affiliation:
The Psychiatric Laboratory and Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
W. Deng
Affiliation:
The Psychiatric Laboratory and Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
C. Huang
Affiliation:
The Psychiatric Laboratory and Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
M. Li
Affiliation:
The Psychiatric Laboratory and Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
X. Ma
Affiliation:
The Psychiatric Laboratory and Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
Y. Wang
Affiliation:
The Psychiatric Laboratory and Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
L. Jiang
Affiliation:
The Psychiatric Laboratory and Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
S. Lui
Affiliation:
Huaxi MR Research Centre, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China
X. Huang
Affiliation:
Huaxi MR Research Centre, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China
S. E. Chua
Affiliation:
Department of Psychiatry, The University of Hong Kong, Pokfulam, S.A.R. China
C. Cheung
Affiliation:
Department of Psychiatry, The University of Hong Kong, Pokfulam, S.A.R. China
G. M. McAlonan
Affiliation:
Department of Psychiatry, The University of Hong Kong, Pokfulam, S.A.R. China
P. C. Sham
Affiliation:
Department of Psychiatry, The University of Hong Kong, Pokfulam, S.A.R. China
R. M. Murray
Affiliation:
Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, UK
D. A. Collier
Affiliation:
MRC SGDP Centre, Institute of Psychiatry, King's College London, UK
Q. Gong*
Affiliation:
Huaxi MR Research Centre, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China
T. Li*
Affiliation:
The Psychiatric Laboratory and Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, UK MRC SGDP Centre, Institute of Psychiatry, King's College London, UK
*
*Address for correspondence: Professors Tao Li or Qiyong Gong, 28 Dian Xin Nan Road, West China Hospital, Chengdu, Sichuan, 610041, P.R. China. (Email: [email protected])
*Address for correspondence: Professors Tao Li or Qiyong Gong, 28 Dian Xin Nan Road, West China Hospital, Chengdu, Sichuan, 610041, P.R. China. (Email: [email protected])
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Background

Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The aims of this study were to explore the microstructural changes in first-episode schizophrenia in a Han Chinese population and to investigate whether a family history of psychiatric disorder is related to the severity of WM tract integrity abnormalities in these patients.

Method

T1-weighted MR and DT images were collected in 68 patients with first-episode schizophrenia [22 with a positive family history (PFH) and 46 with a negative family history (NFH)] and 100 healthy controls. Voxel-based analysis was performed and WM integrity was quantified by fractional anisotropy (FA). Cluster- and voxel-level analyses were performed by using two-sample t tests between patients and controls and/or using a full factorial model with one factor and three levels among the three sample groups (patients with PFH or NFH, and controls), as appropriate.

Results

FA deficits were observed in the patient group, especially in the left temporal lobe and right corpus callosum. This effect was more severe in the non-familial schizophrenia than in the familial schizophrenia subgroup.

Conclusions

Overall, these findings support the hypothesis that loss of WM integrity may be an important pathophysiological feature of schizophrenia, with particular implications for brain dysmaturation in non-familial and familial schizophrenia.

Keywords

DTIfamily historyfirst episodefractional anisotropyschizophreniavoxel-based analysis
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 8 , August 2011 , pp. 1691 - 1700
Copyright
Copyright © Cambridge University Press 2010

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