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Aberrant resting-state connectivity in non-psychotic individuals with auditory hallucinations

Published online by Cambridge University Press:  16 November 2012

K. M. J. Diederen ,
S. F. W. Neggers ,
A. D. de Weijer ,
R. van Lutterveld ,
K. Daalman ,
S. B. Eickhoff ,
M. Clos ,
R. S. Kahn  and
I. E. C. Sommer
K. M. J. Diederen*
Affiliation:
Neuroscience Division, University Medical Centre Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
S. F. W. Neggers
Affiliation:
Neuroscience Division, University Medical Centre Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
A. D. de Weijer
Affiliation:
Neuroscience Division, University Medical Centre Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
R. van Lutterveld
Affiliation:
Neuroscience Division, University Medical Centre Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
K. Daalman
Affiliation:
Neuroscience Division, University Medical Centre Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
S. B. Eickhoff
Affiliation:
Institute of Neuroscience and Medicine (INM-1, INM-2), Research Centre Jülich, Germany Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical School, RWTH Aachen University, Germany Institute for Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Düsseldorf, Germany
M. Clos
Affiliation:
Institute of Neuroscience and Medicine (INM-1, INM-2), Research Centre Jülich, Germany
R. S. Kahn
Affiliation:
Neuroscience Division, University Medical Centre Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
I. E. C. Sommer
Affiliation:
Neuroscience Division, University Medical Centre Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
*
*Address for correspondence: K. M. J. Diederen, Ph.D., Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Place, Cambridge CB2 3DY, UK. (Email: [email protected])
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Abstract

Background

Although auditory verbal hallucinations (AVH) are a core symptom of schizophrenia, they also occur in non-psychotic individuals, in the absence of other psychotic, affective, cognitive and negative symptoms. AVH have been hypothesized to result from deviant integration of inferior frontal, parahippocampal and superior temporal brain areas. However, a direct link between dysfunctional connectivity and AVH has not yet been established. To determine whether hallucinations are indeed related to aberrant connectivity, AVH should be studied in isolation, for example in non-psychotic individuals with AVH.

Method

Resting-state connectivity was investigated in 25 non-psychotic subjects with AVH and 25 matched control subjects using seed regression analysis with the (1) left and (2) right inferior frontal, (3) left and (4) right superior temporal and (5) left parahippocampal areas as the seed regions. To correct for cardiorespiratory (CR) pulsatility rhythms in the functional magnetic resonance imaging (fMRI) data, heartbeat and respiration were monitored during scanning and the fMRI data were corrected for these rhythms using the image-based method for retrospective correction of physiological motion effects RETROICOR.

Results

In comparison with the control group, non-psychotic individuals with AVH showed increased connectivity between the left and the right superior temporal regions and also between the left parahippocampal region and the left inferior frontal gyrus. Moreover, this group did not show a negative correlation between the left superior temporal region and the right inferior frontal region, as was observed in the healthy control group.

Conclusions

Aberrant connectivity of frontal, parahippocampal and superior temporal brain areas can be specifically related to the predisposition to hallucinate in the auditory domain.

Keywords

Functional connectivityfunctional magnetic resonance imaginghallucinationslanguagememorypsychosisschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 43 , Issue 8 , August 2013 , pp. 1685 - 1696
Copyright
Copyright © Cambridge University Press 2012 

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