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Aberrant myelination of the cingulum and Schneiderian delusions in schizophrenia: a 7T magnetization transfer study

Published online by Cambridge University Press:  19 September 2018

Lena Palaniyappan ,
Ali Al-Radaideh ,
Olivier Mougin ,
Tushar Das ,
Penny Gowland  and
Peter F. Liddle
Lena Palaniyappan*
Affiliation:
Robarts Research Institute, University of Western Ontario, London, Ontario, Canada Department of Psychiatry, University of Western Ontario, London, Ontario, Canada Lawson Health Research Institute, London, Ontario, Canada
Ali Al-Radaideh
Affiliation:
Department of Medical Imaging, Faculty of Allied Health Sciences, The Hashemite University, Zarqa, Jordan
Olivier Mougin
Affiliation:
Sir Peter Mansfield Imaging Centre (SPMIC), School of Physics and Astronomy, University of Nottingham, Nottingham, UK
Tushar Das
Affiliation:
Robarts Research Institute, University of Western Ontario, London, Ontario, Canada Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Penny Gowland
Affiliation:
Sir Peter Mansfield Imaging Centre (SPMIC), School of Physics and Astronomy, University of Nottingham, Nottingham, UK
Peter F. Liddle
Affiliation:
Translational Neuroimaging for Mental Health, Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, UK
*
Author for correspondence: Lena Palaniyappan, E-mail: [email protected]
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Abstract

Background

The structural integrity of the anterior cingulum has been repeatedly observed to be abnormal in patients with schizophrenia. More recently, aberrant myelination of frontal fasciculi, especially, cingulum has been proposed to underlie delayed corollary discharges that can affect sense of agency and contribute to delusions of control (Schneiderian delusions). Using the magnetization transfer phenomenon at an ultra-high field 7T MRI, we investigated the putative myelin content of cingulum bundle in patients with schizophrenia.

Methods

Seventeen clinically stable patients with schizophrenia and 20 controls were recruited for this 7T MRI study. We used a region-of-interest method and extracted magnetization transfer ratio (MTR) from left and right dorsal cingulum bundles and estimated patients v. controls differences. We also related the cingulum MTR values to the severity of Schneiderian delusions.

Results

Patients had a significant reduction in the MTR, indicating reduced myelin content, in the cingulum bundle (right cingulum Hedges’ g = 0.91; left cingulum g = 0.03). The reduced MTR of left cingulum was associated with higher severity of Schneiderian delusions (τ = −0.45, p = 0.026) but no such relationship was seen for the right cingulum MTR (τ = −0.136, p = 0.50) among patients. The association between the left cingulum MTR and Schneiderian delusions was not explained by the presence of other delusions, hallucinations, disorganization or negative symptoms.

Conclusions

Dysmyelination of the cingulum bundle is seen in a subgroup of patients with schizophrenia and may be involved in the mechanism of Schneiderian delusions.

Keywords

Cingulummagnetization transfermyelinationpassivitySchneiderianschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 11 , August 2019 , pp. 1890 - 1896
Copyright
Copyright © Cambridge University Press 2018 

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