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The cardiovascular effects of antidepressants

Published online by Cambridge University Press:  09 July 2009

S. J. Warrington ,
C. Padgham  and
M. Lader
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Psychological Medicine Monograph Supplement , Volume 16: The cardiovascular effects of antidepressants , 1989 , pp. 1 - 40
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Copyright © Cambridge University Press 1989

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References

Agarwal, S. L., Deepak, B. & Natu, M. V. (1968). The role of monoamine oxidase inhibitors in experimental auricular arrhythmia. Indian Journal of Medical Research 56, 57–60.Google ScholarPubMed
Ahles, S., Gwirtsman, H., Halaris, A., Shah, P., Schwarcz, G. & Hill, M. A. (1984). Comparative cardiac effects of maprotiline and doxepin in elderly depressed patients. Journal of Clinical Psychiatry 45, 460–465.Google Scholar
Albrecht, J. W. & Muller-Oerlinghausen, B. (1980). Cardiovascular side-effects of lithium. In Handbook of Lithium Therapy (ed. Johnson, F. N.), pp. 323–337. MTC Press: Lancaster.Google Scholar
Alexander, C. S. & Nino, A. (1969). Cardiovascular complications in young patients taking psychotropic drugs. American Heart Journal 78, 757–769.CrossRefGoogle ScholarPubMed
Alexanderson, B. & Sjoqvist, F. (1977). Individual differences in the pharmacokinetics of monomethylated tricyclic antidepressants: role of genetic and environment factors and clinical importance. Annals New York Academy of Sciences 179, 739–751.Google Scholar
Alexpoulos, G. S. & Shamoian, C. A. (1982). Tricyclic antidepressants and cardiac patients with pacemakers. American Journal of Psychiatry 139, 519–520.Google Scholar
Arlock, P. (1981). Actions of lofepramine, a new tricyclic antidepressant, and desipramine on electrophysiological and mechanical parameters of guinea pig atrial and papillary muscles. Acta pharmacologica et toxicologica 49, 248–258.Google Scholar
Aronson, M. D. & Hafez, H. (1986). A case of trazodone-induced ventricular tachycardia. Journal of Clinical Psychiatry 47, 388–389.Google ScholarPubMed
Arora, R. B. (1963). Mechanism of action of monoamine inhibitors in experimental myocardial infarction in pigs. Annals New York Academy of Science 107, 1152–1158.Google Scholar
Arora, R. B. & Sivappa, D. S. (1962). Ectopic ventricular rhythms and myocardial infarction in the domestic pig and their response to nialamide, a monoamine oxidase inhibitor. British Journal of Pharmacology 19, 394–404.Google ScholarPubMed
Australian Drug Evaluation Committee (1965). Adverse reactions to amitriptyline. Medical Journal of Australia 1, 741–742.CrossRefGoogle Scholar
Bailey, D. N., Van Dyke, C., Langou, R. A. & Jatlow, P. I. (1978). Tricyclic antidepressant plasma levels and clinical findings in overdose. American Journal of Psychiatry 135, 1325–1328.Google ScholarPubMed
Barnes, R. J., Kong, S. M. & Wu, R. W. Y. (1968). Electrocardiographic changes in amitriptyline poisoning. British Medical Journal iii, 222.CrossRefGoogle Scholar
Barth, N. & Muscholl, E. (1974). The effects of the tricyclic antidepressants, desipramine, doxepin and iprindole on the isolated perfused rabbit heart. Naunyn Schmiedeberg's Archives of Pharmacology 284, 215–232.CrossRefGoogle ScholarPubMed
Baum, T., Shropshire, A. T., Rowles, G. & Gluckman, M. I. (1971). Antidepressants and cardiac conduction: iprindole and imipramine. European Journal of Pharmacology 13, 287–291.Google Scholar
Baum, T., Peters, J. R., Butz, F. & Much, D. R. (1976). Tricyclic antidepressants and cardiac conduction: changes in ventricular automaticity. European Journal of Pharmacology 39, 323–326.Google Scholar
Bayle, B. J. (1979). Essai clinique d'un nouvel antidepresseur: la viloxazine. Psychologie Médicale 11, 2241–2249.Google Scholar
Bayliss, P. F. C. & Duncan, S. M. (1974). The clinical pharmacology of viloxazine hydrochloride - a new antidepressant of novel chemical structure. British Journal of Clinical Pharmacology 1, 43–437.CrossRefGoogle ScholarPubMed
Ben, M., Warren, M., Drinnon, V. & Scott, C. (1960). Cardiovascular activity of beta-phenylethylhydrazine (Phenelzine). Angiology 11, 62–66.Google Scholar
Benfield, P. & Ward, A. (1986). Fluvoxamine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32, 313–334.CrossRefGoogle ScholarPubMed
Benfield, P., Heel, R. C. & Lewis, S. P. (1986). Fluoxetine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32, 481–508.CrossRefGoogle ScholarPubMed
Bethge, K.-P., Godt, U., Bianco-Cruz, E. & Lichtlen, P. R. (1982). Incidence of cardiac arrhythmias during antidepressant therapy with maprotiline and nomifensine. Journal of Cardiovascular Pharmacology 4, 142–148.Google Scholar
Biamino, G. (1977). In vitro and in vivo studies on cardiovascular side effects of antidepressant drugs. In Symposia Medico Hoechst 13, (ed. Garattini, S.), pp. 389–399. Schattauer: Stuttgart.Google Scholar
Bianchetti, G., Bonaccorsi, A., Chiodaroli, A., Franco, R., Garattini, S., Gomeni, R. & Morselli, P. L. (1977). Plasma concentrations and cardiotoxic effects of desipramine and protriptyline in the rat. British Journal of Pharmacology 60, 11–19.Google Scholar
Biederman, J., Gastfriend, D., Jellinek, M. S. & Goldblatt, A. (1985). Cardiovascular effects of desipramine in children and adolescents with attention deficit disorder. Journal of Pediatrics 106, 1017–1020.CrossRefGoogle ScholarPubMed
Bigger, J. T., Giardina, E. G. V., Perel, J. M., Kantor, S. J. & Glassman, A. H. (1977). Cardiac antiarrhythmic effect of imipramine hydrochloride. New England Journal of Medicine 296, 206–208.CrossRefGoogle ScholarPubMed
Biggs, J. T., Spiker, D. G., Petit, J. M. & Ziegler, V. E. (1977). Tricyclic antidepressant overdose: incidence of symptoms. Journal of the American Medical Association 238, 135–138.Google Scholar
Bishop, M. P. & Briggs, J. H. (1986). QRS duration in acute overdose of tricyclic antidepressants. New England Journal of Medicine 314, 988.Google Scholar
Blackwell, B. (1963). Hypertensive crisis due to MAOI. Lancet ii, 849–851.CrossRefGoogle Scholar
Blackwell, B. (1981 a). Adverse effects of antidepressant drugs Part 1: monoamine oxidase inhibitors and tricyclics. Drugs 21, 201–219.CrossRefGoogle ScholarPubMed
Blackwell, B. (1981 b). Adverse effects of antidepressant drugs. Part 2: Second generation antidepressants and rational decision making in antidepressant therapy. Drugs 21, 273–282.CrossRefGoogle ScholarPubMed
Boakes, A. J., Lawrence, D. R., Teoh, P. C., Barar, F. S. K., Benedicter, L. T. D. & Prichard, B. N. C. (1973). Interactions between sympathomimetic amines and antidepressants in man. British Medical Journal i, 311–315.CrossRefGoogle Scholar
Bock, J. L., Cummings, K. C. & Jatlow, P. I. (1982). Amoxapine overdose: a case report. American Journal of Psychiatry 139, 1619–1620.Google Scholar
Boeck, V., Jergensen, A. & Overo, K. F. (1984). Comparative animal studies on cardiovascular toxicity of tri- and tetracyclic antidepressants and citalopram: relation to drug plasma levels. Psychopharmacology 82, 275–281.CrossRefGoogle ScholarPubMed
Boehnert, M. T. & Lovejoy, F. H. Jr (1985). Value of the QRS duration versus the serum drug level in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants. New England Journal of Medicine 313, 474–479.CrossRefGoogle ScholarPubMed
Boehnert, M. T. & Lovejoy, F. H. Jr (1986). QRS duration in acute overdose of tricyclic antidepressants. New England Journal of Medicine 314, 990.Google Scholar
Boesen, F., Andersen, E. B., Jensen, E. K. & Ladefoged, S. D. (1983). Cardiac conduction disturbances during carbamazepine therapy. Acta Neurologica Scandinavica 68 49–52.Google Scholar
Boissier, J., Simon, P. & Witchitz, S. (1965). Etude chez le cobaye de la toxicité cardiaque de l'imipramine, de l'amitriptyline et de leurs dérivés monodesmethyles. Thérapie 20, 67.Google Scholar
Boston Collaborative Drug Surveillance Program (1972). Adverse reactions to tricyclic antidepressant drugs: report from Boston Collaborative Drug Surveillance Program. Lancet i, 529–531.Google Scholar
Branconnier, R. J. & Cole, J. O. (1981). Effects of acute administration of trazodone and amitriptyline on cognition, cardiovascular function and salivation in the normal geriatric subject. Journal of Clinical Psychopharmacology 1 Suppl 82S–88S.Google Scholar
Branconnier, R. J., Cole, J. O., Ghazvinian, S. & Rosenthal, S. (1982). Treating the depressed elderly patient: the comparative behavioural pharmacology of mianserin and amitriptyline. Advances in Biochemical Psychopharmacology 32, 195–212.Google Scholar
Brennan, F. J. (1980). Electrophysiological effects of imipramine and doxepin in normal and depressed cardiac Purkinje fibers. American Journal of Cardiology 46, 599–606.Google Scholar
Briant, R. H. & George, C. F. (1974). The assessment of potential drug interactions with a new tricyclic drug. British Journal of Clinical Pharmacology 1, 113–118.CrossRefGoogle Scholar
Briant, R. H., Reid, J. L. & Dollery, C. T. (1973). Interactions between clonidine and desipramine in man. British Medical Journal i, 522–523.Google Scholar
Brion, S. (1975). Open studies with viloxazine (Vivalan). Journal of International Medical Research 3, Suppl 3, 877–891.Google Scholar
Brogden, R. N., Heel, R. C., Speight, T. M. & Avery, G. S. (1978). Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs 16, 273–301.CrossRefGoogle ScholarPubMed
Brogden, R. N., Heel, R. C., Speight, T. M. & Avery, G. S. (1979). Nomifensine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs 18, 1–24.CrossRefGoogle ScholarPubMed
Brogden, R. N., Heel, R. C., Speight, T. M. & Avery, G. S. (1981). Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs 21, 401–429.CrossRefGoogle ScholarPubMed
Brorson, L. & Wennerblom, B. (1978). Electrophysiological methods in assessing cardiac effects of the tricyclic antidepressant imipramine. Acta Medica Scandinavica 203, 429–432.CrossRefGoogle ScholarPubMed
Brosnan, R. D. & Holland, R. P. C. (1977). Overdosage attempts with viloxazine (Vivalan). International Congress on Suicide Prevention and Crisis Intervention Proceedings, abstract 20–23.Google Scholar
Brosnan, R. D., Busby, A. M. & Holland, R. P. C. (1976). Case of overdosage with viloxazine hydrochloride (Vivalan). Journal of International Medical Research 4, 83–85.CrossRefGoogle ScholarPubMed
Brown, T. C. K. & Leversha, A. (1979). Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline and doxepin. Clinical Toxicology 14, 253–256.Google Scholar
Brubakk, O. & Kalager, T. (1978). Non-invasive assessment of cardiac function in poisoning with drugs. Acta Medica Scandinavica 204, 39–42.Google Scholar
Bucknall, C., Brooks, D., Curry, P. V. L., Bridges, P. K., Bouras, N. & Ankier, S. I. (1988). Mianserin and trazodone for cardiac patients with depression. European Journal of Clinical Pharmacology 33, 565–569.CrossRefGoogle ScholarPubMed
Burckhardt, D., Raeder, E., Muller, V., Imhof, P. & Neubauer, H. (1978). Cardiovascular effects of tricyclic and tetracyclic antidepressants. Journal of the American Medical Association 239, 213–216.Google Scholar
Burgess, C. D. (1981). Effects of antidepressants on cardiac function. Acta Psychiatrica Scandinavica 63, Suppl 290, 370–379.Google Scholar
Burgess, C. D. & Hames, T. K. (1982). A comparison of the cardiovascular and anticholinergic effects of trazodone and imipramine. Trazodone Clinical Workshop - A Summary of UK Studies. Rome, June 1982, pp. 20–21. Medicine Publishing Foundation: Oxford.Google Scholar
Burgess, C. D. & Turner, P. (1980). Cardiotoxicity of antidepressant drugs. Neuropharmacology 19, 1195–1199.Google Scholar
Burgess, C. D., Turner, P. & Wadsworth, J. (1978). Cardiovascular responses to mianserin hydrochloride. A comparison with tricyclic antidepressant drugs. British Journal of Clinical Pharmacology 5, 21S–28S.CrossRefGoogle ScholarPubMed
Burgess, C. D., Montgomery, S. A., Turner, P. & Wadsworth, J. (1979). Cardiovascular effects of amitriptyline, mianserin, zimelidine and nomifensine in depressed patients. Postgraduate Medical Journal 55, 704–708.Google Scholar
Burgess, C. D., Montgomery, S. A., Montgomery, D. B. & Wadsworth, J. (1980). Cardiovascular effects of amitriptyline, mianserin and zimelidine in depressed patients. Progress in Neuropsychopharmacology 4, 523–526.CrossRefGoogle ScholarPubMed
Burgess, C. D., Mellsop, G. W. & Franzep, M. E. V. (1986). The cardiovascular effects of cianopramine and amitriptyline in depressed patients. Current Therapeutic Research 39, 51–58.Google Scholar
Burrows, G. D. & Norman, T. R. (1980). Psychotherapeutic drugs: important adverse reaction and interactions. Drugs 20, 485–493.CrossRefGoogle ScholarPubMed
Burrows, G. D., Vohra, J., Hunt, D., Sloman, J. G., Scoggins, B. A. & Davies, B. (1976). Cardiac effects of different tricyclic antidepressant drugs. British Journal of Psychiatry 129, 335–341.Google Scholar
Burrows, G. D., Vohra, J., Dumovic, P., Maguire, K., Scoggins, B. A. & Davies, B. (1977). Tricyclic antidepressant drugs and cardiac conduction. Progress in Neuropsychopharmacology 1, 329–334.Google Scholar
Burrows, G. D., Vohra, J., Dumovic, P., Scoggins, B. A. & Davies, B. (1978). Cardiological effects of nomifensine, a new antidepressant. Medical Journal of Australia 1, 341–343.Google Scholar
Burrows, G. D., Davies, B., Hamer, A. & Vohra, J. (1979). Effect of mianserin on cardiac conduction. Medical Journal of Australia 2, 97–98.Google Scholar
Burrows, G. D., Norman, T. R., Dennerstein, L. & Davies, B. M. (1985). Antidepressant therapy: benefits and risks in perspective. Acta Psychiatrica Scandinavica 72, Suppl. 320, 43–47.Google Scholar
Cairncross, K. D. (1965). On the peripheral pharmacology of amitriptyline. Archives of International Pharmacology 154, 438–448.Google Scholar
Cairncross, K. D. & Gershon, S. (1962). A pharmacologic basis for the cardiovascular complications of imipramine medication. Medical Journal of Australia 2, 372–375.Google Scholar
Callaham, M. & Kassel, D. (1985). Epidemiology of fatal tricyclic antidepressant ingestion: implications for management. Annals of Emergency Medicine (United States) 14, 1–9.CrossRefGoogle ScholarPubMed
Carney, M. W. P. (1979). Tricyclics and the heart. British Journal of Psychiatry 134, 637–639.Google Scholar
Carr, A. C. & Hobson, R. P. (1977). High serum concentrations of antidepressants in elderly patients. British Medical Journal ii, 1151.Google Scholar
Cassem, N. (1982). Cardiovascular effects of antidepressants. Journal of Clinical Psychiatry 43, 22–29.Google ScholarPubMed
Cassidy, S. & Henry, J. (1987). Fatal toxicity of antidepressant drugs in overdose. British Medical Journal 295, 1021–1024.Google Scholar
Cavanaugh, S. V. A. (1984). Use of desipramine in the medically ill. Journal of Clinical Psychiatry 45, 23–29.Google Scholar
Cavero, I., Gomeni, R., Lefevre-Borg, F. & Roach, A. G. (1980). Comparison of mianserin with desipramine, maprotiline and phentolamine on cardiac presynaptic and vascular postsynaptic alpha-adrenoceptors and noradrenaline reuptake in pithed normotensive rats. British Journal of Pharmacology 68, 321–332.Google Scholar
Cavero, I., Lefevre-Borg, F. & Roach, A. G. (1981). Effects of mianserin, desipramine and maprotiline on blood pressure responses evoked by acetylcholine, histamine and 5-hydroxytryptamine in rats. British Journal of Pharmacology 74, 143–148.Google Scholar
Chan, K.-M., Aguanno, J. J., Jansen, R. & Dietzler, D. N. (1981). Charcoal haemoperfusion for the treatment of carbamazepine poisoning. Clinical Chemistry 27, 1300–1302.Google Scholar
Chand, S., Crome, P. & Dawling, S. (1981). One hundred cases of acute intoxication with mianserin hydrochloride. Pharmakopsychiatry 14, 15–17.Google Scholar
Chapman, B. J., Proudfoot, A. T. & Dawling, S. (1983). Convulsions after self-poisoning with zimeldine. British Medical Journal 287, 1672–1673.CrossRefGoogle ScholarPubMed
Christensen, P., Thomsen, H. Y., Pedersen, O. L., Gram, L. F. & Kragh–Sørensen, P. (1985 a). Orthostatic side effects of clomipramine and citalopram during treatment for depression. Psychopharmacology 86, 383–385.Google Scholar
Christensen, P., Thomsen, H. Y., Pedersen, O. L., Thayssen, P., Oxhøj, H., Kragh-Sørensen, P. & Gram, L. F. (1985 b). Cardiovascular effects of amitriptyline in the treatment of elderly depressed patients. Psychopharmacology 87, 212–215.CrossRefGoogle ScholarPubMed
Christie, J. E. & Brown, D. (1981). Comparison of the cardiovascular effects of amitriptyline and zimelidine using thoracic impedance cardiography. Acta Psychiatrica Scandinavica 63, Suppl. 290, 385–392.Google Scholar
Chynoweth, R. (1983). Psychotherapeutic drugs. Current Therapy 24, 115–126.Google Scholar
Claghora, J. L., Schroeder, J. & Goldstein, B. J. (1984). Comparison of the electrocardiographic effect of dothiepin and amitriptyline. Journal of Clinical Psychiatry 45, 291–293.Google Scholar
Coccaro, E. F. & Siever, L. J. (1985). Second generation antidepressants: a comparative review. Journal of Clinical Pharmacology 25, 241–260.Google Scholar
Constantine, J. W., Scriabine, A., Smith, S. G., McShane, W. K. & Booher, K. D. (1964). Antispasmodic and vasodilator activities of doxepin. Journal of New Drugs 4, 149–257.Google Scholar
Coppen, A., Ghose, K., Swade, C. & Wood, K. (1978). Effect of mianserin hydrochloride on peripheral uptake mechanisms for noradrenaline and 5-hydroxytryptamine in man. British Journal of Clinical Pharmacology 5, 13S–17S.Google Scholar
Coryell, W. & Sherman, A. (1980). Slow tricyclic antidepressant metabolism, polypharmacy and cardiac arrest. American Journal of Psychiatry 137, 108–109.Google Scholar
Coull, D. C., Crooks, J., Dingwall-Fordyce, I., Scott, A. M. & Weir, R. D. (1970). Amitriptyline and cardiac disease: risk of sudden death identified by monitoring system. Lancet ii, 590–591.Google Scholar
Crome, P. (1982). Antidepressant overdosage. Drugs 23, 431–461.Google Scholar
Crome, P. & Chand, S. (1980). The clinical toxicology of nomifensine: comparison with tricyclic antidepressants. In Nomifensine (ed. Stonier, P. D. and Jenner, F. A.), pp. 55–58. Royal Society of Medicine International Congress Series No. 25: London.Google Scholar
Crome, P. & Newman, B. (1977). Poisoning with maprotiline and mianserin. British Medical Journal 2, 260.CrossRefGoogle ScholarPubMed
Crome, P. & Newman, B. (1979 a). Fatal tricyclic antidepressant poisoning. Journal of the Royal Society of Medicine 72, 649–653.CrossRefGoogle ScholarPubMed
Crome, P. & Newman, B. (1979 b). The problem of tricyclic antidepressant poisoning. Postgraduate Medicine 55, 520–532.Google Scholar
Curry, A. S. (1964). Seven fatal cases involving imipramine in man. Journal of Pharmacy and Pharmacology 16, 265–267.CrossRefGoogle ScholarPubMed
Cutler, N. R., Zavadil, A. P., Linnoila, M., Scheinin, M., Rudorfer, M. V. & Potter, W. Z. (1984). Effects of chronic desipramine on plasma norepinephrine concentrations and cardiovascular parameters in elderly depressed women: a preliminary report. Biological Psychiatry 19, 549–556.Google Scholar
Danjoux, J. & Moron, P. (1970). Experimentation de la viloxazine en psychiatrie infanto-juvenile. Psychologie Médicate 11, 191–197.Google Scholar
Davidson, W. J. (1977). Psychotropic drugs, stress and cardiomyopathies. In Stress and the Heart (ed. Wheatley, D.), pp. 43–50. Raven Press: New York.Google Scholar
Demers, R. G. & Heninger, G. R. (1971). Electrocardiographic Twave changes during lithium carbonate therapy. Journal of the American Medical Association 218, 381–386.Google Scholar
Denning, D. W., Matheson, L., Bryson, S. M., Streete, J., Berry, D. J. & Henry, J. A. (1985). Death due to carbamazepine selfpoisoning:remedies reviewed. Human Toxicology 4, 255–260.CrossRefGoogle ScholarPubMed
Desager, J. P. & Harvengt, C. (1983). Relative acute cardiovascular toxicity induced by maprotiline, mianserin and nomifensine in conscious rabbits. Journal of Toxicology – Clinical Toxicology 20, 255–269.Google Scholar
de Villiers, J. C. (1966). Intracranial haemorrhage in patients treated with monoamine oxidase inhibitors. British Journal of Psychiatry 112, 109–118.Google Scholar
DeWilde, J. E. M. & Doogan, D. P. (1982). Fluvoxamine and chlorimipramine in endogenous depression. Journal of Affective Disorders 4, 249–259.CrossRefGoogle Scholar
DeWilde, J. E., Mertens, C. & Wakelin, J. S. (1983). Clinical trials of fluvoxamine vs chlorimipramine with single and three times daily dosing. British Journal of Clinical Pharmacology 15, Suppl. 3, 427S–431S.Google Scholar
Donlon, P. T. (1982). Cardiac effects of antidepressants. Geriatrics 37, 53–59.Google Scholar
Dorman, T. (1985). Toxicity of tricyclic antidepressants: are there important differences. Journal of International Medical Research 13, 77–83.Google Scholar
Doumeix, J. J., Virot, P., Blanc, P., Bensaid, J. & Blanc, G. (1981). Severe sinus node dysfunction during a lithium intoxication. Thérapie 36, 327–331.Google Scholar
Drug and Therapeutics Bulletin (1972). Tricyclic antidepressives and cardiac deaths. Drug and Therapeutics Bulletin 10, 55–56.Google Scholar
Drug and Therapeutics Bulletin (1979). Cardiac effects of antidepressive drugs. Drug and Therapeutics Bulletin 17, 13–14.CrossRefGoogle Scholar
Duke, W. W. & Horton, J. P. (1969). Nortriptyline (Aventyl) overdosage. Southern Medical Journal 62, 1348–1349.Google Scholar
Dumovic, P., Burrows, G. D., Chamberlain, K., Vohra, J., Fuller, J. & Sloman, J. G. (1980). Effect of therapeutic dosage of lithium on the heart. British Journal of Clinical Pharmacology 9, 599–604.Google Scholar
Durelli, L., Mutani, R., Sechi, T. G. P., Monaco, F., Glorioso, N. & Gusmaroli, G. (1985). Cardiac side effects of phenytoin and carbamazepine. A dose-related phenomenon? Archives of Neurology 42, 1067–1068.Google Scholar
Echizen, H. & Freed, C. R. (1982). Long-term infusion of L-5- hydroxytryptophan increases brain serotonin turnover and decreases blood pressure in normotensive rats. Journal of Pharmacology and Experimental Therapeutics 220, 579–584.Google Scholar
Editorial (1979). Tricyclic antidepressant poisoning in children. Lancet ii, 511.Google Scholar
Editorial (1985). Adverse reactions to antidepressants. British Medical Journal 291, 1638.Google Scholar
Edwards, J. G. & Goldie, A. (1983). Mianserin, maprotiline and intracardiac conduction. British Journal of Clinical Pharmacology 15, 249S–254S.CrossRefGoogle ScholarPubMed
Elis, J., Laurence, D. R., Mattie, H. & Prichard, B. N. C. (1967). Modification by monoamine oxidase inhibitors of the effect of some sympathomimetics on blood pressure. British Medical Journal ii, 75–78.Google Scholar
Elliot, H. L., McLean, K., Reid, J. L. & Sumner, D. J. (1981). Pharmacodynamic studies on mianserin and its interaction with clonidine. British Journal of Clinical Pharmacology 11, 122P.Google Scholar
Elonen, E., Mattila, M. J. & Sarrnivaara, L. (1974). Cardiovascular effects of amitriptyline, nortriptyline, protriptyline and doxepin in conscious rabbits. European Journal of Pharmacology 28, 178–188.CrossRefGoogle ScholarPubMed
Evans, L. & Cox, J. (1981). A comparative study of the therapeutic effect and cardiotoxicity of dothiepin HC1 and doxepin HC1 in reactive depression. Progress in Neuro-Psychopharmacology 5, 389–393.Google Scholar
Fann, W. E., Davis, J. M., Janowsky, D. S., Kaufmann, J. S., Griffith, J. D. & Oates, J. A. (1972). Effect of iprindole on amine uptake in man. Archives of General Psychiatry 26, 158–162.Google Scholar
Farid, F. F., Wenger, T. L. & Tsai, S. Y. (1983). Use of bupropion in patients who exhibit orthostatic hypotension on tricyclic antidepressants. Journal of Clinical Psychiatry 44, 170–173.Google ScholarPubMed
Fasoli, R. A. & Glauser, F. L. (1981). Cardiac arrhythmias and ECG abnormalities in tricyclic antidepressant overdose. Clinical Toxicology 18, 155–163.Google Scholar
Feltkamp, H., Meurer, K. A. & Godehardt, E. (1984). Tryptophaninduced lowering of blood pressure and changes of serotonin uptake by platelets in patients with essential hypertension. Klinische Wochenschrift 62, 1115–1119.Google Scholar
Fisch, C. (1985). Effect of fluoxetine on the electrocardiogram. Journal of Clinical Psychiatry 46, 42–44.Google Scholar
Follmer, C. H. & Lum, B. K. (1982). Protective action of diazepam and of sympathomimetic amines against amitriptyline-induced toxicity. Journal of Pharmacology and Experimental Therapeutics 222, 424–429.Google Scholar
Fouron, J. C. & Chicoine, R. (1971). ECG changes in fatal imipramine (Tofranil) intoxication. Pediatrics 48, 777–781.Google Scholar
Fowler, N. O., McCall, D., Chou, T. C., Holmes, J. C. & Hanenson, I. B. (1976). Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs. American Journal of Cardiology 37, 223–230.CrossRefGoogle ScholarPubMed
Fraser, A., Paramananthan, T., Shaw, H. & Gibb, I. (1982). Nortriptyline and electroconvulsive therapy. New Zealand Medical Journal, 95, 551–552.Google Scholar
Freeman, J. W., Mundy, G. R., Beattie, R. R. & Ryan, C. (1969). Cardiac abnormalities in poisoning with tricyclic antidepressants. British Medical Journal ii, 610–611.Google Scholar
Freyschuss, U., Sjoqvist, F., Tuck, D. & Asberg, M. (1970). Circulatory effects in man of nortriptyline, a tricyclic antidepressant drug. Pharmacologia Clinica 2, 68–72.Google Scholar
Garnier, R., Delaby, F., Chabaux, Ch., Benzaken, C., Bismuth, Ch. & Efthymiou, M.-L. (1982). Intoxication aigue par la nomifensine. Journal of Toxicological Medicine 2, 141–144.Google Scholar
Geller, B., Farooki, Z. Q., Cooper, T. B., Chestnut, E. C. & Abel, A. S. (1985). Serial ECG measurements at controlled plasma levels of nortriptyline in depressed children. American Journal of Psychiatry 142, 1095–1097.Google Scholar
Georgotas, A., Mann, J., Bush, D. & Gershon, S. (1981). Safety data on zimelidine hydrochloride following an overdose. Ata Psychiatrica Scandinavica 63, Suppl 290, 257–261.Google Scholar
Gerner, R., Estabrook, W., Steuer, J. & Jarvik, L. (1980). Treatment of geriatric depression with trazodone, imipramine and placebo: a double-blind study. Journal of Clinical Psychiatry 41, 216–220.Google ScholarPubMed
Gerring, J. P. & Shields, H. M. (1982). The identification and management of patients with a high risk for cardiac arrhythmias during modified ECT. Journal of Clinical Psychiatry 43, 140–143.Google Scholar
Ghose, K., Huston, G. J., Kirby, M. J., Witts, D. J. & Turner, P. (1977). Some clinical pharmacological studies with butriptyline, an antidepressive drug. British Journal of Clinical Pharmacology 4, 91.Google ScholarPubMed
Giardina, E. C. & Bigger, J. T. Jr (1982). Antiarrhythmic effect of imipramine hydrochloride in patients with ventricular premature complexes without psychological depression. American Journal of Cardiology 50, 172–179.Google Scholar
Giardina, E. G. V., Bigger, J. T. Jr, Glassmann, A. H., Perel, J. M. & Kantor, S. J. (1979). The electrocardiographic and antiarrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations. Circulation 60, 1045–1052.Google Scholar
Giardina, E. G., Johnson, L. L., Vita, J., Bigger, J. T. Jr & Brem, R. F. (1985). Effect of imipramine and nortriptyline on left ventricular function and blood pressure in patients treated for arrhythmias. American Heart Journal 109, 992–998.Google Scholar
Giles, H. McC. (1963). Imipramine poisoning in childhood. British Medical Journal ii, 844–846.Google Scholar
Glassman, A. H. (1984 a). Cardiovascular effects of tricyclic antidepressants. Annual Review of Medicine 35, 503–511.Google Scholar
Glassman, A. H. (1984 b). The newer antidepressant drugs and their cardiovascular effects Psychopharmacology Bulletin 20, 272–279.Google ScholarPubMed
Glassman, A. H. & Bigger, J. T. Jr (1981). Cardiovascular effects of therapeutic doses of tricyclic antidepressants. A review. Archives of General Psychiatry 38, 815–820.Google Scholar
Glassman, A. H. & Perel, J. M. (1973). The clinical pharmacology of imipramine. Archives of General Psychiatry 28, 649–653.Google Scholar
Glassman, A. H., Bigger, J. T. Jr, Giardina, E. V., Kantor, S. J., Perel, J. M. & Davies, M. (1979). Clinical characteristics of imipramine-induced orthostatic hypotension. Lancet i, 468–472.Google Scholar
Glassman, A. H., Johnson, L. L. & Giardina, E. G. V. (1983). The use of imipramine in depressed patients with congestive heart failure. Journal of the American Medical Association 250, 1997–2001.Google Scholar
Glassman, A. H., Carino, J. S. & Roose, S. P. (1984). Adverse effects of tricyclic antidepressants: focus on the elderly. In: Frontiers in Biochemical and Pharmacological Research in Depression (ed. Usdin, E.), pp. 891–898. Raven Press: New York.Google Scholar
Glenn, M. & Taska, R. J. (1984). Antidepressants and lithium. In The Somatic Therapies (ed. Karasu, T. B.), pp. 85–118. American Psychiatric Association: Washington.Google Scholar
Gokelma, Y. (1983). Heart effects of lofepramine in depressed patients with and without heart diseases.VII. World Congress of Psychiatry,Vienna. (Unpublished abstract.)Google Scholar
Goldie, A. & Edwards, J. G. (1984). Electrocardiographic changes during treatment with maprotiline and mianserin. Neuropharmacology 23, 273–275.Google Scholar
Goldman, L. S., Alexander, R. C. & Luchins, D. J. (1986). Monoamine oxidase inhibitors and tricyclic antidepressants: comparison of their cardiovascular effects. Journal of Clinical Psychiatry 47, 225–229.Google ScholarPubMed
Gomoll, A. W. & Byrne, J. (1979). Trazodone and imipramine: comparative effects on canine cardiac conduction. European Journal of Pharmacology 57, 335–342.Google Scholar
Gomoll, A. W., Byrne, J. E. & Deitchman, D. (1979). Hemodynamic and cardiac actions of trazodone and imipramine in the anesthetized dog. Life Science 24, 1841–1848.Google Scholar
Green, S. D. R. & Kendall-Taylor, P. (1977). Heart block in mianserin hydrochloride overdosage. British Medical Journal ii, 1190–1191.Google Scholar
Greenberg, L. M. & Yellin, A. M. (1975). Blood pressure and pulse changes in hyperactive children treated with imipramine and methylphenidate. American Journal Psychiatry 132, 1325–1326.Google Scholar
Guelfi, J. D., Dreyfus, J. F., Pichot, P. & The Group D'Etude Pour Les Essais Cooperatifs (1983). A double-blind, controlled, clinical trial comparing fluvoxamine with imipramine. British Journal of Clinical Pharmacology 15, Suppl 3, 411S–417S.CrossRefGoogle ScholarPubMed
Gwynne, J. F. (1971). Tricyclic antidepressants and heart disease. New Zealand Medical Journal 74, 414–415.Google Scholar
Hagman, A. (1979). Syncope caused by lithium treatment. Acta Medico Scandinavica 205, 467–471.Google Scholar
Hallstrom, C. & Brooks, N. (1979). ECG changes on butriptyline. Communications in Psychopharmacology 3, 55–58.Google Scholar
Hallstrom, C. & Gifford, L. (1976). Antidepressant blood levels in acute overdose. Postgraduate Medical Journal 52, 687–688.Google Scholar
Hames, T. K., Burgess, C. D. & George, C. F. (1982). Haemodynamic responses of trazodone and imipramine. Clinical Pharmacology and Therapeutics 32, 497–502.Google Scholar
Hansen, H. E. & Amdisen, A. (1978). Lithium intoxication (report of 23 cases and review of 100 cases from the literature). Quarterly Journal of Medicine 47, 123–144.Google Scholar
Harper, B. & Hughes, I. E. (1977). A comparison in rabbit isolated hearts of the dysrhythmogenic potential of amitriptyline, maprotiline and mianserin in relation to their ability to block noradrenaline uptake. British Journal of Pharmacology 59, 651–660.Google Scholar
Hattab, J. R. (1976). The cardiovascular effects of Ludiomil in comparison with those of some tricyclic antidepressants. In Depression – The Biochemical and Physiological Role of Ludiomil (ed. Jukes, A.), pp. 191–200 Ciba Laboratories: Crawley.Google Scholar
Hayes, J. R., Born, G. F. & Rosenbaum, A. H. (1977). Incidence of orthostatic hypotension in patients with primary affective disorders treated with tricyclic antidepressants. Mayo Clinic Proceedings 52, 509–512.Google Scholar
Hayes, T. A., Panitch, M. L. & Barker, E. (1975). Imipramine dosage in children: a comment on imipramine and electrocardiographic abnormalities in hyperactive children. American Journal of Psychiatry 132, 546–547.Google Scholar
Heath, A. (1984). Suicidal overdoses of antidepressants, with special reference to lofepramine. International Medicine Supplement 10, 27–30.Google Scholar
Heath, A. & Hultén, B. A. (1983). Lofepramine toxicity in overdose.VII. World Congress of Psychiatry,Vienna. (Unpublished abstract.)Google Scholar
Hedges, J. R., Otten, E. J., Schroeder, T. & Tasset, J. J. (1986). QRS duration in acute overdose of tricyclic antidepressants. New England Journal of Medicine 314, 988.Google Scholar
Henry, J. A. & Ali, C. J. (1983). Trazodone overdosage: experience from a poisons information service. Human Toxicology 2, 353–356.Google Scholar
Hersom, A. S. & Mackenzie, J. E. (1984). Comparative cardiotoxicity of idazoxan, amitriptyline, mianserin and yohimbine in the rabbit. British Journal of Pharmacology 82, 318P.Google Scholar
Hessov, I. (1971). Hypertension during chlorimipramine therapy. British Medical Journal i, 406.Google Scholar
Himmelhoch, J. M. (1981). Cardiovascular effects of trazodone in humans. Journal of Clinical Psychopharmacology 1, Suppl. 6, 76–81.Google Scholar
Himmelhoch, J. M., Schechtman, K. & Auchenbach, R. (1984). The role of trazodone in the treatment of depressed cardiac patients. Psychopathology 17, Suppl. 2, 51–63.Google Scholar
Holland, R. P. & Brosnan, R. D. (1979). Overdosage with viloxazine (Vivalan, ICI) XV.International Congress of Therapeutics.Google Scholar
Hollister, L. E. (1978). Tricyclic antidepressants. New England Journal of Medicine 209, 1106–1109.Google Scholar
Hong, W. K., Mauer, P., Hochman, R., Caslowitz, J. G. & Paraskos, J. A. (1974). Amitriptyline cardiotoxicity. Chest 66, 304–306.Google Scholar
Horgan, J. H., Ford, G. D., Proctor, J. D. & Wasserman, A. J. (1974). The effect of prophylactic and therapeutic administration of lithium on ventricular arrhythmias. Archives Internationales de Pharmacodynamie (et de The'rapie) 207, 77–85.Google Scholar
Horn, A. S. (1976). The interaction of tricyclic antidepressants with the biogenic amine uptake systems in the central nervous system. Postgraduate Medical Journal 52, Suppl. 3, 25–30.Google Scholar
Hourdebaigt-Larrusse, P. & Perchet, H. (1985). Mianserin in acute cardiopathies - 27 cases recorded in a medical intensive care unit. Annals of Cardiology and Angiology 34, 637–641.Google Scholar
Howland, J. S., Poe, T. E. & Keith, J. F. Jr (1983). Cardiomyopathy associated with tricyclic antidepressants. Southern Medical Journal 76, 1455–1456.Google Scholar
Hughes, I. E. & Radwan, S. (1978). Relative toxicity of amitriptyline, imipramine, maprotiline and mianserin after intravenous infusion in conscious rabbits. British Journal of Clinical Pharmacology 5, 19S–20S.Google Scholar
Hughes, I. E. & Radwan, S. (1979). The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo. British Journal of Pharmacology 65, 331–338.Google Scholar
Hultén, B. A. & Heath, A. (1983). Clinical aspects of tricyclic antidepressant poisoning. Acta Medica Scandinavica 213, 275–278.Google Scholar
Irwin, M. & Spar, J. E. (1983). Reversible cardiac conduction abnormality associated with trazodone administration. American Journal of Psychiatry 140, 945–946.Google Scholar
Jaffe, C. M. (1977). First degree AV block during lithium carbonate therapy. American Journal of Psychiatry 134, 88–89.Google Scholar
Janowsky, D., Curtis, G., Zisook, S., Kuhn, K., Resovsky, K. & Le Winter, M. (1983 a). Trazodone-aggravated ventricular arrhythmias. Journal of Clinical Psychopharmacology 3, 372–376.Google Scholar
Janowsky, D., Curtis, G., Zisook, S., Kuhn, K., Resovsky, K. & Le Winter, M. (1983 b). Ventricular arrhythmias possibly aggravated by trazodone. American Journal of Psychiatry 140, 796–797.Google Scholar
Jansen, F. H. J., Drykoningen, G. & de Ridder, J. J. (1977). Poisoning with antidepressants. British Medical Journal ii, 896.Google Scholar
Jefferson, J. W. (1974). Hypotension from drugs: incidence, peril, prevention. Diseases of the Nervous System 35, 66–71.Google Scholar
Jefferson, J. W. (1975). A review of the cardiovascular effects and toxicity of tricyclic antidepressants. Psychosomatic Medicine 37, 160–179.Google Scholar
Jélinek, R., Benesova, O., Hor´k, J. & Souck, K. (1978). Cardiotoxicity of tricyclic antidepressants and maprotiline in the chick embryo. A comparative study. Activit´s Nervosa Superior (Praha) 20, 52–54.Google Scholar
Jennings, A. E., Levey, A. S. & Harrington, J. T. (1983). Amoxapine associated acute renal failure. Acute Internal Medicine 143, 1525–1527.Google Scholar
Judd, F. K., Norman, T. R. & Burrows, G. D. (1983). Safety of zimeldine in overdose. British Medical Journal 287, 1592–1593.Google Scholar
Kantor, S. J., Bigger, J. T. Jr, Glassman, A. H., Macken, D. L. & Perel, J. M. (1975). Imipramine-induced heart block. A longitudinal case study. Journal of the American Medical Association 231, 1364–1366.Google Scholar
Kantor, S. J., Glassman, A. H., Bigger, J. T., Perel, J. M. & Giardina, E. V. (1978). The cardiac effects of therapeutic plasma concentrations of imipramine. American Journal of Psychiatry 135, 534–538.Google Scholar
Kazetska, V., Zimanova, J. & Vojtechovsky, M. (1978). Cardiotoxicity of Prothiaden in clinical trials. Agressologie 19D, 203–209.Google Scholar
Kelly, D. (1985). First and second generation antidepressants. Insert to The Practitioner 229, 1407.Google Scholar
Khan, A. U. (1981). Comparison of the therapeutic and cardiovascular effects of a single nightly dose of Prothiaden (dothiepin, dosulepin) and Lentizol (sustained-release amitriptyline) in depressed elderly patients. Journal of International Medical Research 9, 108–112.Google Scholar
Khan, M. C. (1980). a review of cardiac conduction effects of maprotiline and mianserin. British Journal of Clinical Practice 7, Suppl, 96–99.Google Scholar
Klok, C. J., Brouwer, G. J., van Praag, H. M. & Doogan, D. (1981). Fluvoxamine and clomipramine in depressed patients: a double blind clinical study. Acta Psychialrica Scandinavica 64, 1–11.Google Scholar
Knudsen, K. & Heath, A. (1984). Effects of self-poisoning with maprotiline. British Medical Journal 288, 601–603.Google Scholar
Koehl, G. W. & Wenzel, J. E. (1971). Severe postural hypotension due to imipramine therapy. Pediatrics 47, 132–134.Google Scholar
Kopera, H. (1978 a). Anticholinergic and blood pressure effects of mianserin, amitriptyline and placebo. British Journal of Clinical Pharmacology 5, 29S–34S.Google Scholar
Kopera, H. (1978 b). Cardiovascular tolerance of mianserin and interactions of mianserin with other drugs. Acta Psychiatrica Belgica 78, 787–797.Google Scholar
Kopera, H. (1980). Cardiac effects of mianserin: results of clinical pharmacological investigations. Current Medical Research and Opinion 6, Suppl, 7, 36–43.Google Scholar
Kopera, H. (1981). Antidepressants in cardiac patients. In Stress and the Heart (ed. Wheatley, D.), pp. 191–205. Raven Press: New York.Google Scholar
Kopera, H. (1983). Lack of anticholinergic and cardiovascular effects of mianserin: studies in healthy subjects and heart patients. Acta Psychiatrica Scandinavica 302, 81–89.Google Scholar
Kopera, H., Schenk, H. & Stulemeijer, S. (1978). Phenprocoumon requirement, whole blood coagulation time, bleeding time and plasma gamma-GT in patients receiving mianserin. European Journal of Clinical Pharmacology 13, 351–356.Google Scholar
Kopera, H., Fluch, N., Harpf, H., Klein, W. W. & Stulemeijer, S. M. (1980 a). Cardiovascular effects of mianserin - a comparative study with amitriptyline and a placebo in healthy subjects. International Journal of Clinical Pharmacology, Therapy and Toxicology 18, 104–109.Google Scholar
Kopera, H., Klein, W. & Schenk, H. (1980a). Psychotropic drugs and the heart: clinical implications. Progress in Neuro-psychopharmacology 4, 527–535.Google Scholar
Kragh–Sørensen, P. (1982). Antidepressants: cardiovascular effects in elderly patients. Acta Pharmacologica et Toxicologica 53, 138.Google Scholar
Kristiansen, E. S. (1961). Cardiac complications during treatment with imipramine (Tofranil). Acta Psychiatrica et Neurologica Scandinavica 36, 427–429.Google Scholar
Kronig, M. H., Roose, S. P., Walsh, B. T., Woodring, S. & Glassman, A. H. (1983). Blood pressure effects of phenelzine. Journal of Clinical Psychopharmacology 3, 307–310.Google Scholar
Krstic, M. K. & Djurkovic, D. (1981). Comparison of the cardiovascular responses to intracerebroventricular administration of tryptamine, 5-hydroxytryptamine, tryptophan and 5-hydroxytryptophan in rats. Archives Internationales de Physiologie 89, 385–391.Google Scholar
Labat, J., Veillon, F. & Bardon, A. (1979). Viloxazine et depression. Bordeaux Medical 12, 613–616.Google Scholar
Ladefoged, S. D. & Møgelvang, J. C. (1982). Total atrioventricular block with syncopes complicating carbamazepine therapy. Acta Medica Scandinavica 212, 185–186.Google Scholar
Lader, M. (1982). Some newer antidepressants. Hospital Update (July), 895–902.Google Scholar
Lader, M. (1983). The problems of safety and compliance with conventional anti-depressant drugs. Acta Psychiatrica Scandinavica 68, Suppl. 308, 91–95.Google Scholar
Lake, C. R., Mikkelsen, E. J., Rapoport, J. L., Zavadil, A. P. & Kopin, I. J. (1979). Effect of imipramine on norepinephrine and blood pressure in enuretic boys. Clinical Pharmacology and Therapeutics 26, 647–653.Google Scholar
Lancaster, N. P. & Foster, A. R. (1959). Suicidal attempt by imipramine overdosage. British Medical Journal ii, 1458.Google Scholar
Langou, R. A., Van Dyke, C., Tahan, S. R. & Cohen, L. S. (1980). Cardiovascular manifestations of tricyclic antidepressant overdose. American Heart Journal 100, 458–464.Google Scholar
Langslett, A., Johansen, W. G., Ryg, M., Skomedal, T. & Øye, I. (1971). Effects of dibenzepine and imipramine on isolated rat heart. European Journal of Pharmacology 14, 333–339.Google Scholar
Larochelle, P., Hamet, P. & Enjalbert, M. (1979). Responses to tyramine and norepinephrine after imipramine and trazodone. Clinical Pharmacology and Therapeutics 26, 24–30.Google Scholar
Lee, W. C., Shin, Y. H. & Shideman, F. E. (1961). Cardiac activities of several monoamine oxidase inhibitors. Journal of Pharmacology and Experimental Therapeutics 133, 180–185.Google Scholar
Leonard, B. E. (1978). Some effects of mianserin on monoamine metabolism in the rat brain. British Journal of Clinical Pharmacology 5, 11S–12S.Google Scholar
Leslie, P. J., Heyworth, R. & Prescott, L. F. (1983). Cardiac complications of carbamazepine intoxication: treatment by haemoperfusion. British Medical Journal 286, 1018.Google Scholar
Li, H. Y., Chen, H., Chen, W. C. & Ting, K. S. (1964). Pharmacological studies of phenelzine on heart and coronary circulation. Scientia Sinica 13, 1453–1460.Google Scholar
Lindbom, L.-O., Groschinsky-Grind, M. & Forsberg, T. (1982). Comparative cardiovascular effects of antidepressants in animals and man. Journal of Clinical Psychiatry 43, 32–34.Google Scholar
Lippman, S., Bedford, P., Manshadi, N. & Mather, S. (1983). Trazodone cardiotoxicity. American Journal of Psychiatry 140, 1383.Google Scholar
Lippmann, W. (1971). Effects of butriptyline and structurally related drugs on norepinephrine uptake and gastric acid secretion in rodents. Canadian Journal of Medicine 2, 250–257.Google Scholar
Lisciani, R., Compana, A. & Scorza Barcellona, P. (1978). Comparative cardiovascular toxicity of trazodone and imipramine in the rat. Archives of Toxicology Suppl. 1, 169–172.Google Scholar
Loudon, J. B., Tiplady, B., Ashcroft, G. W. & Waddell, J. L. (1981). Zimelidine and amitriptyline in the treatment of depressive illness in general practice. Acta Psychiatrica Scandinavica 63, Suppl. 290, 454–463.CrossRefGoogle Scholar
Lown, B., Desilura, R. A., Reich, P. & Murawski, B. J. (1980). Psychophysiologic factors in sudden death. American Journal of Psychiatry 137, 1325–1335.Google Scholar
Luchins, D. J. (1983). Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. American Journal of Psychiatry 140, 1006–1009.Google Scholar
Luke, C. M. (1971). Tricyclic antidepressants and heart disease. New Zealand Medical Journal 74, 345.Google Scholar
Lundberg, G. D. (1982). Antidepressant drugs as a cause of death: a call for caution and data. Journal of the American Medical Association 248, 1879.Google Scholar
McGrath, P. J., Blood, D. K., Stewart, J. W., Harrison, W., Quitkin, F. M., Tricamo, E. & Markowitz, J. (1987). A comparative study of the electrocardiographic effects of phenelzine, tricyclic antidepressants, mianserin and placebo. Journal of Clinical Psychopharmacology 7, 335–339.Google Scholar
McIntyre, I. M., Burrows, G. D., Norman, T. R., Dumovic, P. & Vohra, J. (1980). Plasma nomifensine concentration, cardiological effects and clinicial response. International Pharmacopsychiatry 15, 325–333.Google Scholar
Mann, A. M., Catterson, A. G. & Macpherson, A. S. (1959). Toxicity of imipramine: report on serious side effects and massive overdosage. Canadian Medical Association Journal 81, 23–28.Google Scholar
Marneros, A. & Philipp, M. (1979). A double-blind trial with amitriptyline and lofepramine in the treatment of endogenous depression. International Pharmacopsychiatry 14, 300–304.Google Scholar
Marshall, J. B. & Forker, A. D. (1980). Tricyclic antidepressant overdose: clinical and cardiovascular features. Nebraska Medical Journal 65, 77–82.Google Scholar
Marshall, J. B. & Forker, A. D. (1982). Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose and management of complications. American Heart Journal 103, 401–414.Google Scholar
Martin, G. I. & Zaug, P. J. (1975). Electrocardiographic monitoring of enuretic children receiving therapeutic doses of imipramine. American Journal of Psychiatry 132, 540–542.Google ScholarPubMed
Masters, A. B. (1967). Delayed death in imipramine poisoning. British Medical Journal iii, 866–867.Google Scholar
Mattila, M. J. & Saarnivaara, L. (1970). Amitriptyline toxicity. Lancet ii, 1138–1139.Google Scholar
Meredith, T. J. & Vale, J. A. (1985). Poisoning due to psychotropic agents. Adverse Drug Reactions Acute Poisonings Reviews 4, 83–126.Google Scholar
Meyer, J. F., McAllister, C. F. & Goldberg, L. I. (1970). Insidious and prolonged antagonism of guanethidine by amitriptyline. Journal of the American Medical Association 213, 1487–1488.Google Scholar
Michaeli, J., Ben-Ishay, D., Kidron, R. & Dasberg, H. (1984). Severe hypertension and lithium intoxication. Journal of the American Medical Association 251, 1680.Google Scholar
Moir, D. C., Crooks, J., Cornwell, W. B., O'Malley, K., Dingwall-Fordyce, I. & Turnbull, M. J. (1972). Cardiotoxicity of amitriptyline. Lancet ii, 561–564.Google Scholar
Moir, D. C., Dingwall-Fordyce, I. & Weir, R. D. (1973). Medicines evaluation and monitoring group: a follow-up study of cardiac patients receiving amitriptyline. European Journal of Clinical Pharmacology 6, 98–101.Google Scholar
Mailer, M., Thayssen, P., Kragh–Sørensen, P., Pedersen, O. L., Kristensen, C. B., Bjerre, M., Benjaminsen, S. & Gram, L. F. (1983). Mianserin: cardiovascular effects in elderly patients. Psychopharmacology 80, 174–177.Google Scholar
Montalescot, G., Levy, Y. & Hatt, P. Y. (1984). Serious sinus node dysfunction caused by therapeutic doses of lithium. International Journal of Cardiology 5, 94–96.Google Scholar
Montgomery, S. (1980). The effect of mianserin on sleep and cardiac function. Current Medical Research and Opinion 6, Suppl. 7, 23–28.Google Scholar
Montgomery, S. A. (1983). Advances with antidepressants: clinical experiences with mianserin. Acta Psychiatrica Scandinavica 6, Suppl. 302, 90–94.Google Scholar
Moorhead, C. N. & Knox, S. J. (1965). Imipramine-induced auricular fibrillation. American Journal of Psychiatry 122, 216–217.Google Scholar
Mortensen, S. A. (1984). Cyclic antidepressants and cardiotoxicity. Practitioner 228, 1180–1183.Google Scholar
Muir, W. W., Strauch, S. M. & Schaal, S. F. (1982). Effects of tricyclic antidepressant drugs on the electrophysiological properties of dog Purkinje fibers. Journal of Cardiovascular Pharmacology 4, 82–90.Google Scholar
Mulgaokar, G. D., Dauchot, P. J., Duffy, P. & Anton, A. H. (1985). Non-invasive assessment of electroconvulsive-induced changes in cardiac function. Journal of Clinical Psychiatry 46, 479–482.Google Scholar
Muller, O. F., Goodma, N. & Bellet, S. (1961). The hypotensive effect of imipramine hydrochloride in patients with cardiovascular disease. Clinical Pharmacology and Therapeutics 2, 300–307.Google Scholar
Nelson, J. C., Jatlow, P. I., Bock, U., Quinlan, D. M. & Bowers, M. B. Jr (1982). Major adverse reactions during desipramine treatment: relationship to plasma drug concentration, concomitant antipsychotic treatment and patient characteristics. Archives of General Psychiatry 39, 1055–1061.Google Scholar
Němec, J. (1974). Cardiotoxic effects of tricyclic antidepressants imipramine, amitriptyline and dosulepin (Prothiaden Spofa) in an acute experiment in rats. Activitas Nervosa Superior (Praha) 16, 182–183.Google Scholar
Nicotra, M. B., Rivera, M., Pool, J. L. & Noall, M. W. (1981). Tricyclic antidepressant overdose: clinical and pharmacological observations. Clinical Toxicology 18, 599–613.Google Scholar
Nies, A., Robinson, D. S., Friedman, M. J., Green, R., Cooper, T. B., Ravaris, C. L. & Ives, J. O. (1977). Relationship between age and tricyclic antidepressant plasma levels. American Journal of Psychiatry 134, 790–793.Google Scholar
Noble, J. & Matthew, H. (1969). Acute poisoning by tricyclic antidepressants: clinical features and management of 100 patients. Clinical Toxicology 2, 403–421.Google Scholar
Norton, B. & Whalley, L. J. (1984). Mortality of a lithium-treated population. British Journal of Psychiatry 145, 277–282.Google Scholar
Office of Population Censuses and Surveys (1984). Deaths from Poisoning by Solid or Liquid Substances in England and Wales. HMSO: London.Google Scholar
Ogura, C., Kishimoto, A., Mizukawa, R., Hazama, H., Honma, H. & Kawahara, K. (1983). Age difference in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline. European Journal of Clinical Pharmacology 25, 811–814.Google Scholar
Opie, L. H. (1980). Drugs and the heart. IV. Antiarrhythmic agents Lancet i, 861–867.Google Scholar
Orme, M. L'E. (1984). Antidepressants and heart disease. British Medical Journal 289, 1–2.Google Scholar
Ortiz, A. & Josef, N. C. (1983). Premature atrial contractions and amoxapine therapy: a case report. Journal of Clinical Psychopharmacology 3, 246–249.Google Scholar
O'Shea, B. (1985). Antidepressant cardiotoxicity. Irish Medical Journal 78, 22–24.Google ScholarPubMed
Ostow, M. (1966). Orthostatic hypotension and psychic energizers: a clinical note. Psychosomatics 7, 224–225.Google Scholar
Palileo, E. V., Coelho, A., Westveer, D., Dhingra, R. & Rosen, K. M. (1983). Persistent sinus node dysfunction secondary to lithium therapy. American Heart Journal 106(b), 1443–1444.Google Scholar
Pariser, S. F., Reynolds, J. C., Falco, J. M., Jones, B. A. & Mencer, D. L. (1981). Arrhythmia induced by a tricyclic antidepressant in a patient with undiagnosed mitral valve prolapse. American Journal of Psychiatry 138, 522–523.Google Scholar
Park, J. & Proudfoot, A. T. (1977). Acute poisoning with maprotiline hydrochloride. British Medical Journal i, 1573.Google Scholar
Paykel, E. S. (1985 a). How effective are antidepressants? In Psychopharmacology: Recent Advances and Future Prospects (ed. Iversen, S. D.), pp. 4–13. Oxford University Press: Oxford.Google Scholar
Paykel, E. S. (1985 b). Management of acute depression. In Psychopharmacology: Recent Advances and Future Prospects (ed. Iversen, S. D.), pp. 235–247. Oxford University Press: Oxford.Google Scholar
Pecknold, J. C., Familamiri, P., McClure, D. J., Elie, R. & Chang, H. (1985). Trimipramine and maprotiline: antidepressant, anxiolytic and cardiotoxic comparison. Journal of Clinical Psychiatry 46, 166–171.Google Scholar
Pedersen, O. L., Gram, L. F., Kristensen, C. B., Møller, M., Thaysen, P., Bjerre, M., Kragh–Sørensen, P., Klitgaard, N. A., Sendrup, E., Hole, P. & Brinkløv, M. (1982). Overdosage of antidepressants: clinical and pharmacokinetic aspects. European Journal of Clinical Pharmacology 23, 513–521.Google Scholar
Peet, M. & Behagel, H. (1978). Mianserin: a decade of scientific development. British Journal of Clinical Pharmacology 5, 5S–9S.Google Scholar
Peet, M., Tienari, P. & Jaskari, M. O. (1977). A comparison of the cardiac effects of mianserin and amitriptyline in man. Pharmacopsychiatry 10, 309–312.Google Scholar
Penny, R. (1968). Imipramine hydrochloride poisoning in childhood. American Journal of Diseases of Children 116, 181–186.Google Scholar
Pentel, P. & Sioris, L. (1981). Incidence of late arrhythmias following tricyclic antidepressant overdose. Clinical Toxicology 18, 543–548.Google Scholar
Petersen, J. L. & Pedersen, V. (1983). The cardiotoxic effects of lithium. Ugeskrift for Laeger 14S, 3264–3265.Google Scholar
Petit, J. M., Spiker, D. G. & Biggs, J. T. (1976). Psychiatric diagnosis and tricyclic plasma levels in 36 hospitalised overdosed patients. Journal of Nervous and Mental Disease 163, 289–293.Google Scholar
Petit, J. M., Spiker, D. G., Ruwitch, J. F., Ziegler, V. E., Weiss, A. N. & Biggs, J. T. (1977). Tricyclic antidepressant plasma levels and adverse effects after overdosage. Clinical Pharmacology and Therapeutics 21, 47–51.CrossRefGoogle Scholar
Pichot, P., Dreyfus, J. F. & Pull, C. (1978). A double-blind multicentretrial comparing mianserin with imipramine. British Journal of Clinical Pharmacology 5, 87S–90S.CrossRefGoogle ScholarPubMed
Pinder, R. M. (1985). Antidepressant drugs of the future. In Psychopharmacology: Recent Advances and Future Prospects (ed. Iversen, S. D.), pp. 44–62. Oxford University Press: Oxford.Google Scholar
Pinder, R. M., Brogden, R. N., Speight, T. M. & Avery, G. S. (1977 a). Doxepin up to date. Drugs 13, 161–218.Google Scholar
Pinder, R. M., Brogden, R. N., Speight, T. M. & Avery, G. S. (1977 b). Viloxazine: a review of its pharmacological properties and therapeutic efficacy in mental depressive states. Drugs 13, 401–421.Google Scholar
Pinder, R. M., Blum, A., Stulemeijer, S. M., Barres, M., Rigaud, A., Charbaut, J., Israel, L. & Kammerer, Th. (1980). A double-blind multicenter trial comparing the efficacy and side effects of mianserin and clomipramine in depressed inpatients and outpatients. Current Medical Research and Opinion 6, Suppl. 7, 115–127.Google Scholar
Plym-Forshell, G., Siwers, B. & Tack, J. R. (1976). Pharmacokinetics of lofepramine in man: relationship to inhibition of noradrenaline uptake. European Journal of Clinical Pharmacology 9, 291–298.Google Scholar
Popova, N. K. (1966). Antifibrillatory properties of hydrazine derivates in experimental acute coronary insufficiency. Farmakol Toksikol 29, 44–45.Google Scholar
Pratila, M. G. & Pratilas, V. (1979). ST depression under anaesthesia in a patient on lithium carbonate. Mount Sinai Journal of Medicine 46, 549.Google Scholar
Preskorn, S. H. & Irwin, H. A. (1982). Toxicity of tricyclic antidepressants - kinetics, mechanism, intervention: a review. Journal of Clinical Psychiatry 43, 151–156.Google Scholar
Preskorn, S. H., Weller, E. B., Weller, R. A. & Glotzbach, E. (1983). Plasma levels of imipramine and adverse effects in children. American Journal of Psychiatry 140, 1332–1335.Google Scholar
Prien, R. F., Blaine, J. D. & Levine, J. (1985). Antidepressant drug therapy: the role of the new antidepressants. Hospital and Community Psychiatry 36, 513–516.Google Scholar
Prout, B. J., Young, J. & Goddard, P. (1965). Imipramine poisoning in childhood and suggested treatment. British Medical Journal i, 972.Google Scholar
Puisto, E. L., Mattila, M. J., Elonen, E. & Eränkö, P. (1980). Prostaglandins and the cardiotoxic effects of doxepin in rabbits and guinea pigs. Acta Pharmacologica et Toxicologica 41, 183–189.Google Scholar
Rabkin, J. G., Quitkin, F. M. & McGrath, P. (1985). Adverse reactions to monoamine oxidase inhibitors. Part II. Treatment correlates and clinical management. Journal of Clinical Psychopharmacology 5, 2–9.Google Scholar
Raeder, E., Burckhardt, D., Neubauer, H., Walter, R. & Gastpar, M. (1978). Long-term tri- and tetra-cyclic antidepressants, myocardial contractility and cardiac rhythm. British Medical Journal ii, 666–667.Google Scholar
Raeder, E. A., Zinsli, M. & Burckhardt, D. (1979). Effect of maprotiline on cardiac arrhythmias. British Medical Journal ii, 102.Google Scholar
Raisfeld, I. H. (1972). Cardiovascular complications of antidepressant therapy. Interactions at the adrenergic neuron. American Heart Journal 83, 129–133.Google Scholar
Ramanathan, K. B. & Davidson, C. (1975). Cardiac arrhythmia and imipramine therapy. British Medical Journal i, 661–662.Google Scholar
Rasmussen, J. (1965). Amitriptyline and imipramine poisoning. Lancet ii, 850.Google Scholar
Rasmussen, E. B. & Kristiansen, P. (1963). ECG changes during amitriptyline treatment. American Journal of Psychiatry 119, 781–782.CrossRefGoogle Scholar
Ravaris, C. L., Robinson, D. S., Ives, J. O., Nies, A. & Bartlett, D. (1980). Phenelzine and amitriptyline in the treatment of depression. Archives of General Psychiatry 37, 1075–1080.Google Scholar
Razani, J., White, K. L., White, J., Simpson, G., Sloane, R. B., Rebal, R. & Palmer, R. (1983). The safety and efficacy of combined amitriptyline and tranylcypromine antidepressant treatment. A controlled trial. Archives of General Psychiatry 40, 657–661.Google Scholar
Rector, W. G., Jarzobski, J. A. & Levin, H. S. (1979). Sinus node dysfunction associated with lithium therapy: report of a case and a review of the literature. Nebraska Medical Journal 64, 193–196.Google Scholar
Reed, K., Smith, R. C., Schooler, J. C., Hu, R., Leelavathi, D. E., Mann, E. & Lippman, L. (1980). Cardiovascular effects of nortriptyline in geriatric patients. American Journal of Psychiatry 137, 986–989.Google Scholar
Reisberg, B. & Gershon, S. (1979). Side effects associated with lithium therapy. Archives of General Psychiatry 36, 879–887.Google Scholar
Riboulet, G., Falcy, M., Conso, F., Efthymiou, M. L. & Bismuth, C. (1979). Intoxication aigue volontaire par chlorhydrate de viloxazine (Vivalan). Bulletin de Médecine Légate et de Toxicologie Médicale 22, 359–362.Google Scholar
Riboulet-Delmas, G., Falcy, M. & Gamier, R. (1983). Acute intoxication with viloxazine hydrochloride. International Symposium on ‘Vivalan’, Cambridge, 22–24 September, Abstract 615–754.Google Scholar
Riccioni, N., Roni, P. & Bartolomei, C. (1983). Lithium-induced sinus node dysfunction. Acta Cardiologica 38, 133–138.Google Scholar
Richardson, J. S. & Chiu, E. K. Y. (1982). The acute effects of amitriptyline, iprindole and trazodone on blood pressure and heart rate in rats. Pharmacology, Biochemistry and Behaviour 17, 1221–1223.Google Scholar
Risch, S. C., Groom, G. P. & Janowsky, D. S. (1981). Interfaces of psychopharmacology and cardiology - part one. Journal of Clinical Psychiatry 42, 23–34.Google Scholar
Robinson, D. S. & Barker, E. (1976). Tricyclic antidepressant cardiotoxicity. Journal of the American Medical Association 236, 2089–2090.Google Scholar
Robinson, D. S., Nies, A., Ravaris, L., Ives, J. O. & Bartlett, D. (1978) Clinical pharmacology of phenelzine. Archives of General Psychiatry 35, 629–635.Google Scholar
Robinson, D. S., Nies, A., Corcella, J., Cooper, T. B., Spencer, C. & Keefover, R. (1982). Cardiovascular effects of phenelzine and amitriptyline in depressed outpatients. Journal of Clinical Psychiatry 43 8–15.Google ScholarPubMed
Rodriguez, S. & Tamargo, J. (1980). Electrophysiological effects of imipramine on bovine ventricular muscle and Purkinje fibres. British Journal of Pharmacology 70, 15–23.Google Scholar
Roos, J. C. (1983). Cardiac effects of antidepressant drugs. A comparison of the tricyclic antidepressants and fluvoxamine. British Journal of Clinical Pharmacology 15, Suppl. 3, 439S–445S.Google Scholar
Roos, J. C. & Sharp, D. J. (1984). Antidepressant drugs and cardiovascular side effects. A comparison of fluvoxamine and the tricyclic antidepressant drugs. In Biological Psychiatry: Recent Studies (ed. Burrows, G. D., Norman, T. R. & Maguire, K. P.), pp. 146–158. John Libbey: London.Google Scholar
Roose, S. P., Nurnberger, J. I., Dunner, D. L., Blood, D. K. & Fieve, R. R. (1979). Cardiac sinus node dysfunction during lithium treatment. American Journal of Psychiatry 136, 804–806.Google Scholar
Roose, S. P., Glassman, A. H., Siris, S. G., Walsh, T., Bruro, R. L. & Wright, L. B. (1981). Comparison of imipramine- and nortriptyline-induced orthostatic hypotension: a meaningful difference. Journal of Clinical Psychopharmacology 1, 316–319.CrossRefGoogle ScholarPubMed
Rose, J. B. (1977). Tricyclic antidepressant toxicity. Clinical Toxicology 99, 391–402.Google Scholar
Rotrekl, J., Náhunek, K., Homola, D., Švestka, J., Srnová, V. & Ryšánek, K. (1975). The comparison of the cardiotoxic effect of prothiaden, imipramine and amitriptyline. Activitas Nervosa Superior (Praha) 17, 232–233.Google Scholar
Rudorfer, M. W. & Young, R. C. (1980). Desipramine: Cardioivascular effects and plasma levels. American Journal of Psychiatry 137, 984–986.Google Scholar
Ryšánek, K., Rotrekl, J., Homola, D., Náhunek, K., Rodová, A., Švestka, J. & Srnová, V. (1974). Mechanocardiographical comparison of the cardiotoxic effect of prothiaden and imipramine. Activitas Nervosa Superior (Praha) 16, 183–184.Google ScholarPubMed
Sacks, M. H., Bonforte, R. J., Lasser, R. P. & Dimich, I. (1968). Cardiovascular complications of imipramine intoxication. Journal of the American Medical Association 205, 588–590.Google Scholar
Saletu, B., Schjerve, M., Crünberger, J., Schanda, H. & Arnold, O. H. (1977). Fluvoxamine – a new serotonin re-uptake inhibitor: first clinical and psychometric experiences in depressed patients. Journal of Neural Transmission 41, 17–36.Google Scholar
Salzman, C. (1985 a). Clinical guidelines for the use of antidepressant drugs in geriatric patients. Journal of Clinical Psychiatry 46, 38–44.Google Scholar
Salzman, C. (1985 b). Clinical use of antidepressant blood levels and the electrocardiogram. New England Journal of Medicine 313, 512–513.Google Scholar
Saraf, K. R., Klein, D. F., Gittelman-Klein, R. & Groff, S. (1974). Imipramine side effects in children. Psychopharmacologia 37, 265–274.Google Scholar
Schwarcz, G. & Lopez-Toca, R. (1982). Continued lithium treatment after myocardial infarction. American Journal of Psychiatry 139, 2.Google Scholar
Scollins, M. J., Robinson, D. S. & Nies, A. (1972). Cardiotoxicity of amitriptyline. Lancet ii, 1202.Google Scholar
Seppala, T., Linnoila, M., Sondergaard, I., Elonen, E. & Mattila, M. J. (1981). Tyramine pressor test and cardiovascular effects of chlorimipramine and nortriptyline in healthy volunteers. Biological Psychiatry 16, 71–77.Google Scholar
Serafimovski, N., Torball, N., Asmussen, I. & Lunding, M. (1975). Tricyclic antidepressant poisoning with special reference to cardiac complications. Acta Anaesthesica Scandinavica 57, 55–63.Google Scholar
Shaw, W. L. (1980). The comparative safety of mianserin in overdose. Current Medical Research and Opinion 6, Suppl. 7, 44–51.Google Scholar
Siebel, I. (1978). Controlled Double-blind Study to Compare Lofepramine with Imipramine in Cyclothymic Depression. M.D. thesis: University of Dusseldorf, West Germany.Google Scholar
Sigg, E. B., Osborne, M. & Karol, B. (1963). Cardiovascular effects of imipramine. Journal of Pharmacology and Experimental Therapeutics 141, 237–243.Google Scholar
Simpson, R. J., Lawton, D. J., Watt, M. H. & Tiplady, B. (1981). Effect of zimelidine, a new antidepressant, on appetite and body weight. British Journal of Clinical Pharmacology 11, 96–98.Google Scholar
Singer, I. & Rotenberg, D. (1973). Mechanisms of lithium action. New England Journal of Medicine 289, 254.Google Scholar
Singh, G. (1972). Cardiac arrest with chlorimipramine. British Medical Journal iii, 698.Google Scholar
Sjögren, C. (1980). The pharmacological profile of lofepramine, a new antidepressant drug. Neuropharmacology 19, 1213–1214.CrossRefGoogle ScholarPubMed
Skinner, C., Coull, D. C. & Johnson, A. W. (1969). Antagonism of the hypotensive action of bethanidine and debrisoquine by tricyclic antidepressants. Lancet ii, 564–566.Google Scholar
Sloman, J. G., Norman, T. R. & Burrows, G. D. (1983). Clinical studies of antidepressant cardiotoxicity. In Antidepressants (ed. Burrows, G. D., Norman, T.R. and Davies, B. M.), pp. 173–186. Elsevier Science Publishers: Amsterdam.Google Scholar
Smith, R. B. & Rusbatch, B. J. (1967). Amitriptyline and heart block. British Medical Journal iii, 311.Google Scholar
Smith, R. C., Reed, K. & Leelavathi, D. E. (1980). Pharmacokinetics and the effects of nortriptyline in geriatric depressed patients. Psychopharmacology Bulletin 16, 54–57.Google ScholarPubMed
Soroko, F. E. & Maxwell, R. A. (1983). The pharmacologic basis for therapeutic interest in bupropion. Journal of Clinical Psychiatry 44, 267–273.Google Scholar
Spencer, P. S. J. (1977). Review of the pharmacology of existing antidepressants. British Journal of Clinical Pharmacology 4, Suppl. 2, 57–68.Google Scholar
Spiker, D. G. & Biggs, J. T. (1976). Tricyclic antidepressants: prolonged plasma levels after overdose. Journal of the American Medical Association 236, 1711–1712.Google Scholar
Spiker, D. G., Weiss, A. N., Chang, S. S., Ruwitch, J. F. & Biggs, J. T. (1975). Tricyclic antidepresssants overdose: clinical presentation and plasma levels. Clinical Pharmacology and Therapeutics 18, 539–546.Google Scholar
Srinivasan, D. P. and Hullin, R. P. (1980). Current concepts of lithium therapy. British Journal of Hospital Medicine 24, 466–475.Google Scholar
Staniforth, D. H. (1985). Correction equation for QT interval. British Journal of Clinical Pharmacology 19, 862.Google Scholar
Starkey, I. R. & Lawson, A. A. H. (1980). Poisoning with tricyclic and related antidepressants – a ten year review. Quarterly Journal of Medicine 49, 33–49.Google Scholar
Steel, C. M., O'Duffy, J. & Brown, S. S. (1967). Clinical effects and treatment of imipramine and amitriptyline poisoning in children. British Medical Journal iii, 663.Google Scholar
Stern, H., Konetschny, J., Herrman, L., Säwe, U. & Belz, G. G. (1985). Cardiovascular effects of single doses of the antidepressants amitriptyline and lofepramine in healthy subjects. Pharmacopsychiatry 78, 272–277.Google Scholar
Strom, J., Madsen, P. S., Nielsen, N. N. & Sørensen, M. B. (1984). Acute self-poisoning with tricyclic antidepressants in 295 consecutive patients treated in an ICU. Acta Anaesthesica Scandinavica 28, 666–670.Google Scholar
Sullivan, J. B., Rumack, B. H. & Peterson, R. G. (1981). Acute carbamazepine toxicity resulting from overdose. Neurology 31, 621–624.Google Scholar
Sved, A. F., Van Itallie, C. M. & Fernstrom, J. D. (1982). Studies on the antihypertensive action of L-tryptophan. Journal of Pharmacology and Experimental Therapeutics 221, 329–333.Google Scholar
Svedmyr, N. (1968). The influence of a tricyclic antidepressive agent (protriptyline) on some of the circulatory effects of noradrenaline and adrenaline in man. Life Science 7, 77.Google Scholar
Swedberg, K. & Winblad, B. (1974). Heart failure as a complication of lithium treatment. Acta Medica Scandinavica 196, 279–280.Google Scholar
Tangedahl, T. N. & Gau, G. T. (1972). Myocardial irritability associated with lithium carbonate therapy. New England Journal of Medicine 287, 867–869.Google Scholar
Task Force on the Use of Laboratory Tests in Psychiatry (1985). Tricyclic antidepressants – blood level measurements and clinical outcome: an APA task force report. American Journal of Psychiatry 142, 155–167.Google Scholar
Taylor, D. J. E. & Braithwaite, R. A. (1978). Cardiac effects of tricyclic antidepressant medication. A preliminary study of nortriptyline. British Heart Journal 40, 1006–1009.Google Scholar
Thayssen, P., Bjerre, M., Kragh–Sørensen, P., Møller, M., Petersen, O. L., Kristensen, C. B. & Gram, L. F. (1981). Cardiovascular effects of imipramine and nortriptyline in elderly patients. Psychopharmacology 74, 360–364.Google Scholar
Thorstrand, C. (1974). Cardiovascular effects of poisoning with tricyclic antidepressants. Acta Medica Scandinavica 195, 505–514.CrossRefGoogle ScholarPubMed
Thorstrand, C. (1976). Clinical features in poisoning by tricyclic antidepressants with special reference to the ECG. Acta Medica Scandinavica 199, 337–344.Google Scholar
Tilkian, A. G., Schroeder, J. S., Kao, J. J. & Hultgren, H. N. (1976). The cardiovascular effects of lithium in man. A review of the literature. American Journal of Medicine 61, 665–670.Google Scholar
Tobis, J. M. & Aronow, W. X. (1981). Cardiotoxicity of amitriptyline and doxepin. Clinical Pharmacology and Therapeutics 29, 359–364.Google Scholar
Todd, R. D. & Faber, R. (1983). Ventricular arrhythmias induced by doxepin and amitriptyline: case report. Journal of Clinical Psychiatry 44, 423–425.Google Scholar
Tollefson, G., Lesar, T. & Herzog, C. (1984). Atrial flutter and maprotiline: case report. Journal of Clinical Psychiatry 45, 31–33.Google Scholar
van der Merwe, T. J. (1983). A comparative study of the effects of trazodone and amitriptyline on cardiovascular function in depressed out-patients. Trazodone Second Clinical Workshop – A Summary of UK Studies, Vienna, July 1983, pp. 20–21.Google Scholar
van de Merwe, T. J., Silverstone, T. & Ankier, S. I. (1984 a). Electrophysiological and haemodynamic changes with trazodone, amitriptyline and placebo in depressed out-patients. Current Medical Research and Opinion 9, 339–352.Google Scholar
van de Merwe, T. J., Silverstone, T., Ankier, S. I., Warrington, S. J. & Turner, P. (1984 b). A double-blind non-crossover placebocontrolled study between group comparison of trazodone and amitriptyline on cardiovascular function in major depressive disorder. Psychopathology 17, Suppl. 2, 64–76.Google Scholar
Veith, R. C., Friedel, R. O., Bloom, V. & Bielski, R. (1980). Electrocardiogram changes and plasma desipramine levels during treatment of depression. Clinical Pharmacology and Therapeutics 27, 796–802.Google Scholar
Veith, R. C., Bloom, V., Bielski, R. & Friedel, R. O. (1982 a). ECG effects of comparable plasma concentrations of desipramine and amitriptyline. Journal of Clinical Psychopharmacology 2, 394–398.Google Scholar
Veith, R. C., Raskind, M. A., Caldwell, J. H., Barnes, R. F., Gumbrecht, G. & Ritchie, J. L. (1982 b). Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease. New England Journal of Medicine 306, 954–959.Google Scholar
Vohra, J. K., Burrows, G. D., Hunt, D. & Sloman, G. (1975 a). The effect of toxic and therapeutic doses of tricyclic anti-depressant drugs on intracardiac conduction. European Journal of Cardiology 3, 219–227.Google Scholar
Vohra, J., Burrows, G. D. & Sloman, J. G. (1975 b). Assessment of cardiovascular side effects of therapeutic doses of tricyclic antidepressant drugs. Australian and New Zealand Journal of Medicine 5, 7–11.Google Scholar
Vohra, J. K., Burrows, G. D., McIntyre, I. & Davies, B. (1978). Cardiovascular effects of nomifensine. Lancet ii, 902–903.Google Scholar
Warrington, S. (1984). Cardiovascular effects of lofepramine. International Medicine Suppl. 10, 23–26.Google Scholar
Weld, F. M. & Bigger, J. T. Jr (1980). Electrophysiological effects of imipramine on ovine cardiac Purkinje and ventricular muscle fibers. Circulation Research 46, 167–175.Google Scholar
Weld, F. M., Bigger, J. T. Jr, Swistel, D. & Bordiuk, J. (1978). Effects of imipramine hydrochloride on electrophysiological properties of sheep cardiac Purkinje fibers. American Journal of Cardiology 41 386.Google Scholar
Wenger, T. L. & Stern, W. C. (1983). The cardiovascular profile of bupropion. Journal of Clinical Psychiatry 44, 176–182.Google Scholar
Wenger, T. L., Cohn, J. B. & Bustrack, J. A. (1983). Comparison of the effects of bupropion and amitriptyline on cardiac conduction in depressed patients. Journal of Clinical Psychiatry 44, 174–175.Google Scholar
Wester, H. A. (1982). The question of negative inotropicity of viloxazine and amitriptyline. Therapiewoche 32, 3806–3810.Google Scholar
Wester, H. A. (1983 a). Computer-assisted comparative echocardiographic examinations on the question of the negative inotropic effect of ‘Vivalan’ (viloxazine) and amitriptyline. International Symposium on ‘Vivalan’, Cambridge 22–24 September, Abstract 6–7.Google Scholar
Wester, H. A. (1983 b). A comparison of zimelidine and amitriptyline on cardiovascular effects in healthy volunteers. Acta Psychiatrica Scandinavica 68, Suppl. 308, 131–134.Google Scholar
Wester, H. A. & Siegers, C. P. (1980 a). Echocardiographic study in volunteers taking mianserin and amitriptyline. Current Medical Research and Opinion 6, 29–34.Google Scholar
Wester, H. A. & Siegers, C. P. (1980 b). Cardiovascular effects of mianserin and amitriptyline in healthy volunteers. International Journal of Clinical Pharmacology, Therapy and Toxicology 18, 513–517.Google Scholar
Whiteford, H., Klug, P. & Evans, L. (1984). Disturbed cardiac function possibly associated with mianserin therapy. Medical Journal of Australia 140 166–167.Google Scholar
Williams, P. (1980). Recent trends in the prescribing of psychotropic drugs. Health Trends 12 6–7.Google Scholar
Wilson, J. R., Kraus, E. S., Bailas, M. M. & Rakita, L. (1976). Reversible sinus-node abnormalities due to lithium carbonate therapy. New England Journal of Medicine 294, 1223–1224.Google Scholar
Winsberg, B. G., Goldstein, S., Yepes, L. E. & Perel, J. M. (1975). Imipramine and electrocardiographic abnormalities in hyperactive children. American Journal of Psychiatry 132 542–545.Google Scholar
Winsor, T. & Zarco, P. (1960). Monoamine oxidase inhibitors and angina pectoris. Angiology 11, 67–75.Google Scholar
Wolf, W. A. & Kuhn, D. A. (1984). Effects of L-tryptophan on blood pressure in normotensive and hypertensive rats. Journal of Pharmacology and Experimental Therapeutics 230, 324–329.Google Scholar
Wright, S. P. (1978). Hazards with monoamine oxidase inhibitors: a persistent problem. Lancet i, 284–285.Google Scholar
Young, R. C., Alexopoulos, G. S., Shamoian, C. A., Dhar, A. K. & Kutt, H. (1984). Heart failure associated with high plasma 10-hydroxynortriptyline levels. American Journal of Psychiatry 141, 432–433.Google Scholar
Young, R. C., Alexopoulos, G. S., Shamoian, C. A., Kent, E., Dhar, A. K. & Kutt, H. (1985). Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients. American Journal of Psychiatry 142, 866–868.Google Scholar
Zachariah, P. K. & Rosenbaum, A. H. (1982). Stabilization of high blood pressure with tricyclic antidepressants and lithium combinations in hypertensive patients. Mayo Clinic Proceedings 57, 625–628.Google Scholar
Zavodnick, S. (1981). Atrial flutter with amoxapine: a case report. American Journal of Psychiatry 138, 1503–1504.Google Scholar
Ziegler, V. E., Co, B. T. & Biggs, J. T. (1977 a). Plasma nortriptyline and ECG findings. American Journal of Psychiatry 134, 441–443.Google Scholar
Ziegler, V. E., Co, B. T. & Biggs, J. T. (1977 b). Electrocardiographic findings in patients undergoing amitriptyline treatment. Diseases of the Nervous System 38, 697–699.Google Scholar
Zisook, S. (1984). Side effects of isocarboxazid. Journal of Clinical Psychiatry 45, 53–58.Google Scholar