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L'ocytocine dans le traitement du trouble obsessionnel: un rapport négatif à propos de deux cas

Published online by Cambridge University Press:  28 April 2020

G. Charles ,
R. Guillaume ,
M. Schittecatte ,
P. Pholien ,
J.P. Van Wettere  and
J. Wilmotte
G. Charles
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
R. Guillaume
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
M. Schittecatte
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
P. Pholien
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
J.P. Van Wettere
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
J. Wilmotte
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
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Résumé

Deux patients, un homme de 43 ans et une femme de 24 ans, répondant aux critères diagnostiques du trouble obsessionnel compulsif ont été traités par ocytocine à 10 UI/jour, en intramusculaire. L'ocytocine est un nona-peptide hypophysaire dont la propriété d'altérer la mémoire est connue chez l'animal et chez l'homme. Une rémission relative du trouble obsessionnel compulsif a récemment été signalée lors d'un traitement prolongé par ocytocine intranasale. Nous n'avons, quant à nous, observé aucune amélioration des symptômes obsessionnels compulsifs (évalués selon la liste du Maudsley Hospital) durant les 15 à 20 jours de traitement. Les implications liées au mode d'administration sont discutées, de même que le rôle joué par d'éventuelles manifestations psychopathologiques survenant en cours de traitement.

Summary

Summary

Oxytocin is known to alter memory functions in both man and animal recently, clinical improvement of an obsessive-compulsive patient under ocytocine has been reported. Two inpatients, a 24-year-old female and a 43-year-old male suffering from obsessive-compulsive disorder, were treated with oxytocin IM (10 UI/day) during 2 years and 3 weeks, respectively. We did not observe any symptomatic improvement. Symptoms were assessed according to the Maudsley Inventory. Influences of pharmacokinetic parameters of the peptide and of preexistant psychopathology are discussed.

Keywords

troubles obsessionnels-compulsifsocytocineaction négativeobsessive-compulsive disorderoxytocinnegative report
Type
Fait clinique
Information
Psychiatry and Psychobiology , Volume 4 , Issue 2 , 1989 , pp. 111 - 115
Copyright
Copyright © European Psychiatric Association 1989

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