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Génétique et psychiatrie : une nouvelle approche de l’étiopathogénie des maladies mentales ?

Published online by Cambridge University Press:  28 April 2020

M. Leboyer  and
F. Clerget-Darpoux
M. Leboyer
Affiliation:
Unité de génétique épidémiologique, INSERM U 155, Château de Longchamp, Bois de Boulogne, 75016Paris, France
F. Clerget-Darpoux
Affiliation:
Unité de génétique épidémiologique, INSERM U 155, Château de Longchamp, Bois de Boulogne, 75016Paris, France

Résumé

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Jusqu’à présent, différentes méthodes ont été utilisées pour mettre en évidence l’influence de facteurs de risque d’origine génétique: comparaison du taux de concordance chez des jumeaux monozygotes et dizygotes, études d’adoption, analyse de ségrégation et analyse de linkage. Le développement explosif de la biologie moléculaire, fournissant un nombre grandissant de marqueurs génétiques, rend particulièrement prometteuse l’application des techniques de linkage. Néanmoins, il faut être conscient que l’application de cette stratégie aux maladies psychiatriques se heurte à des difficultés spécifiques: critères diagnostiques, âge de début variable, hétérogénéité probable, corrélations intrafamiliales environnementales.

Summary

Summary

Until recently, different methods have been used to show the role of risk factors in the etiopathology of psychiatric diseases: comparison of concordance rates of monozygote and dizygote twins, adoption studies, segregation analysis, linkage analysis. This last approach has become an exciting one with the growing number of genetic markers due to progress in molecular genetics. Nevertheless, we must be aware of the fact that linkage strategy applied to psychiatric disease has toface specific problems: diagnostic criteria, variable age of onset, possible heterogeneity, environmental intrafamilial correlations.

Keywords

génétiqueétiopathogénie des maladies mentalesgeneticsetiopathology of psychiatric diseases
Type
Editorial
Information
Psychiatry and Psychobiology , Volume 3 , Issue 2 , 1988 , pp. 69 - 72
Copyright
Copyright © European Psychiatric Association 1988

References

Références

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