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Genetic Research in Psychiatry: Update from the Society of Biological Psychiatry and the American Psychiatric Association, New York, May 1990

Published online by Cambridge University Press:  28 April 2020

MA Crocq ,
F Duval  and
JP Macher
MA Crocq
Affiliation:
Centre Hospitalier Spécialisé, 68250Rouffach, France
F Duval
Affiliation:
Centre Hospitalier Spécialisé, 68250Rouffach, France
JP Macher
Affiliation:
Centre Hospitalier Spécialisé, 68250Rouffach, France

Summary

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A stimulating variety of papers on genetic and clinical research in psychiatry was discussed at the latest meeting of the American Psychiatric Association and the Society of Biological Psychiatry in May 1990 in New York. Conflicting results point out that extreme caution must be taken in interpreting linkage studies of psychiatric disorders. Difficulties stem from complex models on inheritance as well as the genetic heterogeneity of psychiatric disorders. Progress has been made in the approach to the regulation of receptor genes that have been implicated in the pathogenesis of psychiatric disorders. In some cases, gene regulation may be tissue-dependent, as is suggested by the alternative splicing of D2 receptor mRNA.

Résumé

Résumé

Les congrès annuels de l'association américaine de psychiatrie et de la société américaine de psychiatrie biologique se sont tenus en mai 1990 à New York. Les recherches génétiques (études de liaison, études chez des jumeaux, biologie moléculaire des gènes des récepteurs impliqués dans les maladies mentales) ont occupé une place de choix. Les controverses se poursuivent autour des liaisons qui ont été rapportées antérieurement entre la psychose maniaco-dépressive, la schizophrénie, la maladie d’Alzheimer, et des marqueurs génétiques. Ces difficultés sont expliquées par des caractères en partie propres à la psychiatrie, tels que la complexité des modes de transmission génétique, l‘hétérogénéité génétique et clinique des troubles, la difficulté de définir les phénotypes et la révélation tardive de certaines affections. La connaissance de la régulation des gènes impliqués dans les maladies mentales, notamment celle des gènes des récepteurs D2, a aussi progressé notablement.

Keywords

geneticslinkagemanic-depressive illnessAmishAlzheimer's diseaseschizophreniaD2 receptorsAmerican Psychiatric AssociationSociety of Biological Psychiatrygénétiqueliaisonpsychose maniaco-dépressiveAmishmaladie d’Alzheimerschizophrénierécepteurs D2association américaine de psychiatriesociété américaine de psychiatrie biologique
Type
Editorial
Information
Psychiatry and Psychobiology , Volume 5 , Issue 5 , 1990 , pp. 283 - 287
Copyright
Copyright © European Psychiatric Association 1990

References

Berrettini, WH, Detera-Wadleigh, S, Goldin, L, Martinez, M, Hsieh, WT, Gershon, E (1990) Systematic genomic mapping of genes for manic-depressive disease : studies of chromosomes 5 and 11. Biol Psychiatry Suppl, 27, 9A, p 46AGoogle Scholar
Breitner, JCS, Murphy, EA, Silverman, JM, Mohs, RC, Davis, KL (1988) Age-dependent expression of familial risk in Alzheimer's disease. Am J Epidemiol 128 : 3, 536-548CrossRefGoogle ScholarPubMed
Breitner, JCS, Magruder-Habib, KM (1989) Criteria for onset critically influence the estimation of familial risk in Alzheimer's disease. Genet Epidemiol 6, 663-669CrossRefGoogle ScholarPubMed
Breitner, JCS, Welsh, K, Magruder-Habib, K, Churchill, C, Robinette, CD, Folstein, M, Priolo, CC, Brandt, J (1990) Pilot studies suggest 60% concordance for Alzheimer's disease in MZ twin pairs. Biol Psychiatry Suppl, 27, 9A, p 43AGoogle Scholar
Bunzow, JR, Van, Tol HHM, Grandy, DK, Albert, P, Salon, J, Christie, M, Machida, CA, Neve, KA, Civelli, O (1988) Cloning and expression of a rat D2 dopamine receptor cDNA. Nature 336, 783-787CrossRefGoogle ScholarPubMed
Byerley, WF, Leppert, M, Holik, J, Lubbers, AM, Jensen, S, White, R (1990) Mapping genes for manie depression and schizophrenia. APA 143rd Artnual Meeting. New Research Abstracts. NR206, p 126Google Scholar
Egeland, JA, Gerhard, DS, Pauls, DL, Sussex, JN, Kidd, KK, Allen, CR, Hostetter, AM, Houseman, DE (1987) Bipolar affective disorder linked to DNA markers on chromosome 11. Nature 325, 783—787CrossRefGoogle ScholarPubMed
Gershon, ES (1990) Genetics. In: Manic-Depressive Illness (Goodwin, FK, Jamison, KR, eds) Oxford University Press, pp 373-401Google ScholarPubMed
Goate, AM, Owen, MJ, James, LA, Mullan, MJ, Rossor, MN, Haynes, AR, Farrall, M, Lai, LYC, Roques, P, Williamson, R, Hardy, J (1989) Predisposing locus for Alzheimer's disease on chromosome 21. Lancet i, 352–355CrossRefGoogle Scholar
Gurling, H (1990) Genetic linkage and psychiatrie disease. Nature 344, 298CrossRefGoogle Scholar
Haroutuninan, V, Braider, S, Snyder, L, Sealfon, S, Roberts, JL, Davis, KL (1990) Regulation of dopamine D2 receptor mRNA by chronic haloperidol treatment. Biol Psychiatry Suppl, 27, 9A, p 141AGoogle Scholar
Kelsoe, JR, Ginns, EI, Egeland, JA, Gerhard, DS, Goldstein, AM, Bale, SJ, Pauls, DL, Long, RT, Kidd, KK, Conte, G, Housman, DE, Paul, SM (1989) Re-evaluation of the linkage relationship between chromosome llp loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 342, 238-243CrossRefGoogle Scholar
Kelsoe, JR, Ginns, EI, Egeland, JA, Goldstein, AM, Bale, SJ, Pauls, DL, Long, RT, Conte, G, Gerhard, DS, Housman, DE, Paul, SM (1990) Bipolar Affective Disorder in the Old Order Amish In: Proceedings, APA 143rd Annual Meeting, 83B, p 244Google Scholar
Kennedy, JL, Giuffra, LA, Moises, HW, Cavalli-Sforza, LL, Pakstis, AJ, Kidd, JR, Castiglione, CM, Sjogren, B, Wetterberg, L, Kidd, KK (1988) Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 336, 167-170CrossRefGoogle Scholar
Kennedy, JL, Giuffra, L, Wetterberg, L, Sjogren, B, Cavalli-Sforza, LL, Moises, HW, Gelernter, JE, Pakstis, AJ, Castiglione, CM, Kidd, KK, Kidd, JR (1990) Genetic linkage studies of schizophrenia. In: Proceedings, APA I43rd Annual Meeting, 83D, p 244Google Scholar
Lentes, KU, Hôhe, MR, Berrettini, WH, Goldin, LR, Gershon, ES (1989) Eine Kopplungsanalyse beta-adrenerger Rezeptoren bei manisch-depressiver Krankheit mit molekulargenetischen Methoden. Biologische Psychiatrie 515–519Google Scholar
Meador-Woodruff, JH, Mansour, A, Bunzow, JR, Van, Tol HHM, Watson, SJ, Civelli, O (1989) Distribution of D2 receptor mRNA in rat brain. Proc Natl Acad Sci USA 86, 7625-7628CrossRefGoogle ScholarPubMed
Meador-Woodruff, JH, Mansour, A, Healy, DJ, Civelli, O, Watson, SJ (1990) Dopamine D2 receptor mRNA in brain. In: Procedings, APA I43rd Annual Meeting, 56E, p 206Google Scholar
Meador-Woodruff, JH, Mansour, A, Healy, DJ, Watson, SJ (1990) Distribution of dopamine D2 receptor mRNA in primate brain : an in-situ hybridization study. Biol Psychiatry Suppl 27, 9A, p 141AGoogle Scholar
Pericak-Vance, MA, Yamaoka, LH, Haynes, CS, Speer, MC, Haines, JL, Gaskell, PC, Hung, WY, Clark, CM, Heyman, AL, Trofatter, JA, Eisenmenger, JP, Gilbert, JR, Lee, JE, Alberts, MJ, Dawson, DV, Bartlett, RJ, Earl, NL, Siddique, T, Vance, JM, Conneally, PM, Roses, AD (1988) Genetic linkage studies in Alzheimer's disease families. Exp Neurol 102, 271-279CrossRefGoogle ScholarPubMed
Polymeropoulos, MH, Xiao, H, Delisi, L, Weber, LJ, Merril, RC (1990) Use of (AC)N repeat polymorphisms in schizophrenia. APA I43rd Annual Meeting, New Research Abstracts. NR205, p 126Google Scholar
Robakis, NK, Mohamadi, M, Fu, D, Refolo, LM (1990) Cloning and characterization of two cDNA's encoding the human D2 receptor. Biol Psychiatry Suppl, 27, 9A, p 79AGoogle Scholar
Roses, AD, Bebout, J, Yamaoka, L, Gaskell, PC, Hung, WY, Alberts, MJ, Clark, C, Welsh, K, Earl, N, Heyman, A (1990) Linkage studies in familial Alzheimer's disease: Application of the affected pedigree member method. Neurology 40 (Suppl 1) 275Google Scholar
St, George-Hyslop PH, Tanzi, RE, Polinsky, RJ (1987) The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 235, 885-890Google Scholar
Schellenberg, GD, Bird, TD, Wijsman, EM (1988) Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science 241, 1507-1510CrossRefGoogle ScholarPubMed
Sherrington, R, Brynjolfsson, J, Petursson, H, Potter, M, Dudleston, K, Barraclough, B, Wasmulh, J, Dods, J, Gurling, H (1988). Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336, 164-167CrossRefGoogle ScholarPubMed
Todd, RD, Mack, K, Gandelman, K-Y, O’Malley, KL (1990) Organization and expression of a dopamine D2 receptor gene. Biol Psychiatry Suppl, 27, 9A, p 140AGoogle Scholar
Welsch, K, Breitner, JCS, Magruder-Habib, KM, Churchill, CM, Robinette, CD, Folstein, MF (1990) Sixty percent concordance for Alzheimer's disease in monozygotic twin pairs. APA I43rd Annual Meeting, New Research Abstracts. NR201, p 124Google Scholar
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