Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-22T22:00:15.022Z Has data issue: false hasContentIssue false
  • English
  • Français

Fenetyline as possible treatment in non-responder depressive patients

Published online by Cambridge University Press:  28 April 2020

F Lang ,
J Pellet  and
B Estour
F Lang
Affiliation:
Service de psychiatrie adultes ethôpital de Bellevue, CHU, 42000Saint-Etienne, France
J Pellet
Affiliation:
Service de psychiatrie adultes ethôpital de Bellevue, CHU, 42000Saint-Etienne, France
B Estour
Affiliation:
Service d'endocrinologie, hôpital de Bellevue, CHU, 42000Saint-Etienne, France
Get access

Summary

The authors report the case of a 45-yr-old male who presented from 1979 to 1986 with several severe depressive episodes. The patient fulfilled Feighner criteria for major depression, Newcastle criteria for endogenous depression: the depressive episodes were all classified as severe recurrent depression without melancholia according to DSM III. The patient was resistant to different types of treatment (ECT, tricyclic and MAOI drugs, lithium, sleep deprivation). With a treatment of 10 cg/day of fenetyline, reduced to 5 cg/day after 6 months, (atypical manic episode), the patient improved considerably for 20 rnonths. The therapeutic response decreased after this period but after a month of withdrawal, the patient again responded. The authors cannot explain the duration of this therapeutic response.

Résumé

Résumé

Les auteurs rapportent le cas d'un homme de 45 ans ayant présenté de 1979 à 1986 plusieurs épisodes de dépression majeure selon les critères de Feighner, à caractère endogène selon les critères de Newcastle, correspondant à la dépression majeure récurrente sans caractère mélancolique du DSM III. Après avoir constaté l'inefficacité des thérapeutiques habituelles (électrochocs, tricycliques, IMAO, lithium, privation de sommeil), la prescription de fénétylline à la dose de 10 puis de 5 cg, du fait de manifestation d'excitation, a entraîné une amélioration considérable pendant 20 mois au total, qui s'est ensuite épuisée. La reprise du traitement après une interruption de l mois a de nouveau entraîné une amélioration identique à la précédente. Les auteurs ne peuvent expliquer la durée de cet effet.

Keywords

fenetylinenon-respondersevere depressionfénétyllinenon-répondeursdépression majeure
Type
Original article
Information
Psychiatry and Psychobiology , Volume 5 , Issue 1 , 1990 , pp. 29 - 30
Copyright
Copyright © European Psychiatric Association 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abou, Samra ABDechaud, MEstour, BChalendar, DFesre-Montange, MPugeat, MTourniaire, J (1985) Beta lipotropin and cortisol responses to an intravenous infusion dexamethasone suppression test in Cushing's syndrome and obesity. J Clin Endocrinol & Metab 61, 116–119Google Scholar
American, Psychiatric association (1980) Diagnostic and Statistical Manual of Mental Disorders DSM III Washington, DC, 3rd ed, French translation (Guelfi, JDet al) Manuel Diagnostique et Statistique des Troubles Mentaux, Masson, Paris, 1983Google Scholar
Crocq, LSailhan, M (1983) Névroses actuelles (neurasthénie; psychasthénie; névrose d'angoisse; hypochondrie), Encycl Méd-Chir (Paris) Psychiatrie 37330 A 10, 2-1983Google Scholar
Feighner, JPRobins, EGuze, SBWoodruff, RAWinokur, GMunoz, R (1972) Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry 26, 57–63CrossRefGoogle ScholarPubMed
Hamilton, M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23, 56–62CrossRefGoogle ScholarPubMed
Lecrubier, Y (1983) Le ralentissement : une limite biologique des états dépressifs. In: Le Ralentissement dépressif (Widlôcher, D, ed). PUF, 71-86Google Scholar
Montgomery, SAAsberg, M (1979) A New depression scale designed to be sensitive to change. Br J Psychiatry 134, 382–389CrossRefGoogle ScholarPubMed
Roth, MGarside, RSGurney, C (1976) Classification of depressive disorders.In: Classification and Prediction of Outcome of Depression. FK Shattauer Verlag, Stuttgart3–26Google Scholar
Satel, LNelson, JP (1989) Stimulants in the treatment of depression: a critical overview. J Clin Psychiatry 50, 241–249Google ScholarPubMed
Winer, N (1985) Norepinephrine, epinephrine and the sympaticomimetic amines in the pharmacological basis of therapeutic (Goodman, LSGilman, A, eds). MacMillan New York, 7th ed, 145–180Google Scholar
Submit a response

Comments

No Comments have been published for this article.