Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-23T07:34:56.316Z Has data issue: false hasContentIssue false
  • English
  • Français

Douleur chronique, dépression et sérotonine

Published online by Cambridge University Press:  28 April 2020

F Boureau ,
C Gay  and
A Combes
F Boureau
Affiliation:
Centre d’évaluation et de traitement de ta douteur, hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012Paris
C Gay
Affiliation:
Service hospitalo-universitaire de santé mentale et de thérapeutique (Pr H Loo), hôpital Sainte-Anne, 1, rue Cabanis, 75014Paris, France
A Combes
Affiliation:
Centre d’évaluation et de traitement de ta douteur, hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012Paris
Get access

Résumé

Les relations entre douleur chronique et dépression ont été soulignées de longue date, suggérant la possible intervention de variables biologiques ou psychologiques communes. Dans cette revue, trois catégories d’informations nous aideront à étudier ces relations: la prévalence de la dépression chez les malades douloureux chroniques, I’efficacité analgésique des antidépresseurs, I’hypothèse de perturbations neurobiologiques communes à la dépression et à la douleur chronique. Les études cliniques se heurtent à des difficultés d’ordre nosographique. Ainsi, la douleur chronique peut correspondre à des symptomatologies variées où it peut être difficile de faire la part des facteurs organiques (initiaux ou persistants) et des facteurs psychologiques, notamment dépressifs. Divers problèmes méthodologiques peuvent être invoqués pour expliquer la disparité des observations actuellement disponibles. L’efficacité analgésique des antidépresseurs est actuellement démontrée par de nombreux essais cliniques contrôlés, comportant des comparaisons à des molécules de références ou à un placebo. De nombreuses publications aboutissent à la conclusion que l’effet analgésique des antidépresseurs s’observe indépendamment de la présence d’une symptomatologie dépressive associée. Cette notion est importante car elle interdit désormais d’interpréter la réponse positive à un traitement antidépresseur comme un argument en faveur de I’origine dépressive d’une douleur. Diverses études neurobiologiques ont tente de chercher chez les patients douloureux chroniques des perturbations supposées caractériser certains états dépressifs. En particulier, l’hypothèse sérotoninergique a souvent été privilégiée.

Summary

Summary

The relationship between chronic pain and depression have been emphasized since a long time suggesting the possible participation of common biological or psychological mechanisms. Our review focuses on 3 types of information: the prevalence of depression among chronic pain patients, the analgesic efficacy of antidepressants. and the search for common neurobiological perturbations to chronic pain and depression. Nosographical difficulties avose from clinical studies on this topic. Chronic pain may include various symptomatologies and it may often be difficult to distinguish between the respective roles of physical and psychological (ie depressive) factors. Various explanations can be suggested to explain the discrepancy of the available literature. Clinical trials with placebo or reference substance controls have demonstrated the analgesic efficacy of antidepressants. Numerous studies concluded that the analgesic effect is unrelated to a depressive state. This notion is important since it is now impossible to use antidepressant responsiveness as a diagnostic index for depression. Various neurobiological studies have attempted to characterise a common serotoninergic dysfunction to depression and chronic pain.

Keywords

douleur chroniquedépressionsérotoninechronic paindépressionserotonin
Type
Revue
Information
Psychiatry and Psychobiology , Volume 5 , Issue 3 , 1990 , pp. 169 - 178
Copyright
Copyright © European Psychiatric Association

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Références

Alcoff, J, Jones, E, Rust, P (1982) Controlled Trial of Imipramine for Chronic Lovv Back pain. J Fam Pract 14, 841–846Google ScholarPubMed
Almay, BGL, Haggendal, J, von Knorring, L, Oreland, L (1987) 5-H1AA and HVA in CSF in Patients with Idiopathic Pain Disorders Biol Psychiatry 22, 403–412CrossRefGoogle Scholar
Basbaum, Al, Fields, HL (1984) Endogenous Pain Controls Systems Brainstem Spinal Pathwys and Endorphin Circuits. Ann Rev Neurosci 7, 309–338CrossRefGoogle Scholar
Black, RG (1980) The Clinical Syndrome of Chronic Pain. In: Pain, Discomfort and Humanitarian Care (Ng, Bonica, ed), Elsevier, North Holland, 207–219Google Scholar
Bradley, JJ (1963) Severe Localized Pain Associated with the Dépressive Syndrome. Br J Psychialry 109, 741–745CrossRefGoogle ScholarPubMed
Blumer, D, Heilbronn, M (1982) Chronic Pain as a Variant of Depressive Disease. The Pain-Prone Disorder. J Nerv Ment Dis 170, 381–406CrossRefGoogle ScholarPubMed
Blumer, D, Heilbronn, M, Rosenbaum, A (1984) Antidepressant Treatment of the Pain Prone Disorder. Psychopharmacol Bull 20, 531–535Google ScholarPubMed
Boureau, F, Doubrere, JF (1988) Le concept de douleur. Du symptôme au syndrome. Douleur et Analgésie 1, 11–17CrossRefGoogle Scholar
Boureau, F, Gay, C, Doubrere, JF, Luu, M (1983) Symptomatologies douloureuses chronique et dépressive: rôle possible de la sérotonine. Psychol Med 15, 519–522Google Scholar
Butler, SH (1984) Présent Status of Tricyclic Antidepressants in Chronic Pain Therapy. In: Benedetti, C, Chapman, CR, Moricca, G, (eds) Adv Pain Res Ther 7, Raven Press, New York, 177-192Google Scholar
Butler, SH, Well-Fugazza, J, Godefroy, F, Besson, JM (1985) Réduction of Arthritis and Pain Behaviour Following Chronic Administration of Amitriptyline or Imipramine in Rats with Adjuvant-Induced Arthritis. Pain 23 159-175CrossRefGoogle ScholarPubMed
Chapman, CR, Butler, SH (1978) Effects of Doxepin on Perception of Laboratory-Induced Pain in Man. Pain 5, 253–262CrossRefGoogle ScholarPubMed
Couch, JR, Ziegler, DK, Hassanein, R (1976) Amitriptyline in the Prophylaxia of Migraine. Neuroiogy 26, 121–127Google Scholar
Davidoff, G, Guarracini, M, Roth, E, Sliwa, J, Yarkony, G (1987) Trazodone Hydrochloride in the Treatment of Dysesthetic Pain in Traumatic Myelopathy: a Randomized, Double-Blind, Placebo-Controlled Study. Pain 29, 151–161CrossRefGoogle ScholarPubMed
Diamond, S, Baltes, B.I (1971) Chronic Tension Headache Treated with Amitriptyline, a Double- Blind Study. Headache 11, 110–116CrossRefGoogle ScholarPubMed
Delaplaine, R, Ifabumuyl, OI, Merskey, H, Zarfas, J (1978) Significance of Pain in Psychiatrie Hospital Patients. Pain 4, 361–366CrossRefGoogle Scholar
Eberhard, G, von Knorring, L, Nilsson, HL, Sundequist, U, Bjorling, G, Linder, H, Svard, KO, Tysk, L (1988) A Double Blind Randomized Study of Clomipramine versus Maprotiline in Patients with Idiopathic Pain Syndromes. Neuropsychobiol 19, 25–34CrossRefGoogle ScholarPubMed
Engel, G (1959) «Psychogenic» Pain and the Pain- Prone Patient. Am J Med 26, 425–428CrossRefGoogle ScholarPubMed
Eschalier, A, Fialip, J, Marty, H (1988) Utilisation des antidépresseurs dans les syndromes douloureux. Douleur et Analgésie 1, 111–120CrossRefGoogle Scholar
Eschalier, A, Montrastruc, JL, Devolze, JL, Rigal, F, Gallard-Plaza, G, Pechadre, JC (1981) Influence of Naloxone and Methysergide on the Analgésie Effect of Clomipramine in Rats. Eur J Pharmacol 74, 1—7CrossRefGoogle Scholar
Evans, W, Gensler, F, Blackwell, B, Galbrecht, C (1973) The Effects of Antidepressant Drugs on Pain Relief and Mood in the Chronically 111. A Double-Blind Study. Psychosomatics 14, 214–219CrossRefGoogle Scholar
Feinmann, C (1985) Pain Relief by Antidepressants: Possible Modes of Action. Pain 23, 1–8CrossRefGoogle ScholarPubMed
Feinmann, C, Harris, M, Cawley, R (1984) Psychogenic Pain: Présentation and Treatment. Br Med J 228, 436–438CrossRefGoogle Scholar
Fishbain, DA, Goldgerg, M, Meaghe, BR, Steele, R, Rosomoff, H (1986). Male and Female Chronic Pain Patients Categorized by DSM-III Psychiatrie Diagnostic Criteria. Pain 26, 181–197CrossRefGoogle Scholar
Frank, RG, Kashani, JH, Parker, JC, Beck, NC, Brownlee-Duffeck, M, Ellitt, TR, Haut, AE, Atwood, C, Smith, E, Kay, DR (1988) Antidepressant Analgesia in Rheumatoid Arthritis. J Rheumatol 15, 1632–1638Google ScholarPubMed
France, RD, Krishnan, KRR, Trainor, M, Pelton, S (1987). Chronic Pain and Dépréssion IV. DST as a Discriminator between Chronic Pain and Dépréssion. Pain 28, 39–44CrossRefGoogle ScholarPubMed
Ganvir, P, Beaumont, G, Seldrug, J (1980) A Comparative Trial of Clomipramine and Placebo: an Adjunctive Therapy in Arthralgia.J Int Med Res 8, 60–66Google Scholar
Glick, EN, Fowler, PD (1979) Imipramine in Chronic Arthritis. Pharm Med 1, 94–96Google Scholar
Gomersall, JD, Stuart, A (1973) Amitriptyline in Migraine Prophylaxia. J Neurol Neurosurg Psychiatry 36, 684–690CrossRefGoogle Scholar
Gourlay, GK, Cherry, DA, Cousins, MJ, Love, BL, Graham, JR, McLachlan, MO (1986) A Controlled Study of a Serotonin Reuptake Blocker, Zimelidine, in the Treatment of Chronic Pain. Pain 25, 35–52CrossRefGoogle ScholarPubMed
Gringas, M (1976) A Clinical Trial of Tofranil in Rheumatic Pain in General Practice. J Int Med Res 4 (suppl 2), 41–49Google Scholar
Haley, WE, Turner, JA, Romano, JM (1985) Dépréssion in Chronic Pain Patients: Relation to Pain, Activity and Sex Différences. Pain 23, 337–343CrossRefGoogle ScholarPubMed
Hameroff, SR, Cork, RC, Scherer, K, Crago, BR, Neuman, C, Womble, JR, Davis, TP (1962) Doxepin Effects on Chronic Pain, Dépréssion and Plasma Opioids. J Clin Psychialry 43, 22–27Google Scholar
Hameroff, SR, Weiss, JL, Lerman, JC, Cork, RC, Watts, KS, Crago, BR (1984) Doxepin's Effects on Chronic Pain and Dépréssion: a Controlled Study. J Clin Psychialry 45, 47–52Google ScholarPubMed
Jenkins, DG, Ebbutt, AF, Evans, CD (1976) Imipramine in the Treatment of Low Back Pain. J Int Med Res 4, 28–40Google ScholarPubMed
Johansson, F, Von, Knorring L (1979) A Double-Blind Controlled Study of a Serotonin Uptake Inhibitor (zimelidine) versus Placebo in Chronic Pain Patients. Pain 7, 69–78CrossRefGoogle ScholarPubMed
Katon, W, Egan, K, Miller, D (1985). Chronic Pain: Life-Time Psychiatrie diagnoses and Family History. Am J Psychialry 142, 1156–1160Google Scholar
Kramlinger, KG, Swanson, DW, Maruta, T (1983)Are Patients with Chronic Pain Depressed? Am J Psychiatry 140, 747–749Google ScholarPubMed
Krishnan, KRR, France, RD, Pelton, S, McCann, UD, Davidson, J, Urban, BJ (1985). Chronic Pain and Dépréssion. 1. Classification of Dépréssion in Chronic Low Back Pain Patients. Pain 22, 279–287CrossRefGoogle Scholar
Kvinesdal, B, Molin, J, Froland, A, Gram, LF (1984) Imipramine Treatment of Painful Diabetic Neuropathy. JAMA 251, 1727–1730CrossRefGoogle ScholarPubMed
Lance, JW, Curran, DA (1964) Treatment of Chronic Tension Headache. Lancet 1, 1236–1239CrossRefGoogle ScholarPubMed
Langhor, F.D, Stohr, M, Petruch, F (1982) An Open and Double-Blind Cross-Over Study on the Efficacy of Clomipramine (Anafranil) in Patients with Painful mono- and Polyneuropathies. Eur Neurol 21, 309–317CrossRefGoogle Scholar
Lascelles, RG (1966) Atypical Facial Pain and Dépréssion. Br J Psychiatry 112, 651–659CrossRefGoogle ScholarPubMed
MacDonald, Scott WA (1967) The Relief of Pain with an Antidepressant in Arthritis. Practitioner 202, 802–806Google Scholar
MacNeil, AL, Dick, WC (1976) Imipramine and Rheumatoid Factor. J Int Med Res 4 (suppl 2), 23–27Google Scholar
Magni, G (1984) Chronic Low Back Pain and Dépréssion. An Epidemiologie Survey. Acta psychiatr Scand 70, 614–617CrossRefGoogle Scholar
Magni, G (1987) On the Relationship between Chronic Pain and Dépréssion when There is no Organic Lésion. Pain 31, 1–21CrossRefGoogle ScholarPubMed
Magni, G, Talamo, Rossi R, Stella, A, Mottaran, R, Salar, G (1989) DST in Chronic Pain Patients not Suffering front Major Dépréssion. Pharmacopsychiatria 22, 8–10CrossRefGoogle ScholarPubMed
Martucci, N, Agnoli, A, Manna, V, Boccola, V (1984) Fleadache and Noradrenergic Involvement: Study with Alpha-2 Stimulants and Blockers. Clin Neuropharmacol 7, 654–655CrossRefGoogle Scholar
Maruta, T, Swanson, DW, Swenson, WM (1976). Pain as a Psychiatrie Symptom: Comparison between Low Back Pain and Dépréssion. Psychosomatics 17, 123–127CrossRefGoogle Scholar
Max, MB, Culnane, M, Schafer, SC, Gracely, RH, Walther, DJ, Smoller, B, Dubner, R (1987) Amitriptyline Relieves Neuropathy Pain in Patients with Normal or Depressed Mood. Neurology 37, 589–596CrossRefGoogle ScholarPubMed
Merskey, H, Spear, FG (1967) Pain: Psychological and Psychiatrie Aspects. Baillère, Tindall Cassell, Londres. Morland TJ (1979) Doxepin in the Treatment of Mixed Vascular and Tension Headache. Headache 19, 382–383Google Scholar
Nick, J, Contamin, F (1969) Traitement de douleurs observées en milieu neurologique par l’association de médicaments antidépresseurs et neuroleptiques. Vie Méd 35, 4285–4291Google Scholar
Okasha, A, Ghalet, HA, Sadek, A (1973) A Double Blind Trial for the Clinical Management of Psychogenic Headache. Br J Psychiatry 122, 181–185CrossRefGoogle ScholarPubMed
Paoli, F, Darcourt, G, Cossa, P (1960) Note préliminaire sur l’action de l’imipramine dans les états douloureux. Rev Neurol 102, 503–504Google Scholar
Pilowsky, I (1988) Affective Disorders and Pain. In: Proceedings of the Vth World Congress on Pain (Dubner, R, Gebhart, GF, Bond, M, eds) Elsevier, Amsterdam, 263-275Google Scholar
Pilowsky, I, Bassett, DL (1982) Pain and Dépréssion. Br J Psychiatry 141, 30–36CrossRefGoogle ScholarPubMed
Pilowsky, I, Chapman, CR, Bonica, JJ (1977). Pain, Dépréssion and lllness Behaviour in a Pain Clinic Population. Pain 4, 183–192CrossRefGoogle Scholar
Pilowsky, I, Halletts, EC, Bassett, DL, Thomas, PG, Perhall, RK (1982) A Controlled Study of Amitriptyline in the Treatment of Chronic Pain. Pain 14, 169–179CrossRefGoogle ScholarPubMed
Ranga, Rama Krishnan K, France, RD, Pelton, S, MvDann, UD, Davidson, J, Urban, BJ (1985) Chronic Pain and Dépréssion 1. Classification of Dépréssion in Chronic Low Back Pain Patients. Pain 22, 279–287Google Scholar
Ranga, Rama Krishnan K, France, RD, Pelton, S, Mc, Dann UD, Davidson, J, Urban, BJ (1985) Chronic Pain and Dépréssion IL Symptoms of Anxiety in Chronic Low Back Pain Patients and their Relationship to Subtypes of Dépréssion. Pain 22, 289–294Google Scholar
Reddy, SVR, Maderbrut, JL, Yaksh, TL (1980) Spinal Cord Pharmacology of Adrenergic Agonist- Mediated Antinociception J Pharmacol Exp Ther 213, 525–533Google ScholarPubMed
Reich, J, Tupin, JP, Abramowitz, SI (1983). Psychiatrie Diagnosis of Chronic Pain Patients. Am J Psychiatry 140, 1495–1498Google Scholar
Sarzi, Puttini P, Cazzola, M, Boccassinni, L, Ciniselli, G, Santandrea, S, Caruso, I, Benvenuti, C (1988) A Comparison of Dothiepin versus Placebo in the Treatment of Pain in Rheumatoid Arthritis and the Assocation of Pain with Dépréssion. J Intern Med Res 16, 331–337Google Scholar
Schaffer, CB, Donlong, PT, Bittle, RM (1980). Chronic Pain and Dépréssion : a Clinical and Family History Survey. Am J Psychiatry 137, 118–120Google ScholarPubMed
Sharav, Y, Singer, E, Schmidt, E, Dionne, RA, Dubner, R (1987) The Analgésie Effect of Amitripytline on Chronic Facial Pain 31, 199–209CrossRefGoogle Scholar
Sternbach, RA (1974) Pain Patients. Traits and Treatment. Academie press, New YorkGoogle Scholar
Swanson, DW (1984) Chronic Pain as a Third Pathologie Emotion. Am J Psychiatry 141, 210–214Google Scholar
Thorpe, P, Marchant-Williams, R (1974) The Rôle of an Antidepressant Dibenzepin (Noveril), in the Relief of Pain in Chronic Arthritic States. Med J Aust 1, 264–266CrossRefGoogle Scholar
Turkington, RW (1980) Dépréssion Masquering as Diabetic Neuropathy. JAMA 243, 1147–1150CrossRefGoogle Scholar
Turner, JA, Romano, JM (1984) Review of Prevalence ol Coexisting Chronic Pain and Dépréssion. In: Adv Pain Res Ther (Benedetti et al, eds) 7, 123–130Google Scholar
Valdès, M, Garcia, L, Treserra, J, de Pablo, J, de Flores, T (1989) Psychogenic Pain and Dépressive Disorders: an Emperical Study. J Affec Dis 16, 21–25CrossRefGoogle Scholar
Ventafridda, V, Caraceni, A, Saita, L, Bonezzi, C, De Conno, F, Guarise, G, Ramella, G, Sivani, V, Tantburini, M, Toscani, F (1988) Trazodone for Différentiation Pain. Comparison with Amitriptyline. Psychopharmacology 95, S44–S49CrossRefGoogle Scholar
Von Knorring, L, Perris, C, Elsemann, M, Eriksson, U, Perris, H (1983) Pain as a Symptom in Dépressive Disorders I. Relationship to Diagnostic Subgroup and Dépressive Symptomatology. Pain 15, 19–26CrossRefGoogle Scholar
Ward, NG, Bloom, VL, Friedel, RO (1979) The Effectiveness of Tricyclic Antidepressants in the Treatment of Coexisting Pain and Dépréssion. Pain 7, 331–341CrossRefGoogle ScholarPubMed
Ward, N, Bokan, JA, Philipps, M, Benedetti, C, Butler, S, Spengler, D (1984) Antidepressants in Concomitant Chronic Back Pain and Dépréssion: Doxepin and Desipramine Compared. J Clin Psychiatry 45, 54–57Google ScholarPubMed
Watson, CPN, Evans, RJ, Reed, K, Merskey, H, Goldsmith, L, Warsh, J (1982) Amitriptyline versus Placebo in Postherpetic Neuralgia. Neurology 32, 671–673CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.