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Le cortisol salivaire: une alternative au dosage du cortisol plasmatique

Published online by Cambridge University Press:  28 April 2020

JP Kahn ,
N de Talance ,
C Michaux ,
P Witkowski ,
C Burlet ,
L Mejean  and
M Laxenaire
JP Kahn
Affiliation:
Service de psychologie médicale (Pr M Laxenaire), Centre hospitalier régional de Nancy, hôpital Jeanne-d’Arc, BP 303, 54201Toul Cedex
N de Talance
Affiliation:
Laboratoire d‘explorations fonctionnelles (Pr M Boulange), Centre hospitalier régional de Nancy, hôpital de Brabois, 54500Vandœuvre, France
C Michaux
Affiliation:
INSERM - Unité 308 «Mécanismes de régulation des comportements alimentaires» (Pr JP Nicolas), 38, rue Lionnois, 54000Nancy
P Witkowski
Affiliation:
Service de psychologie médicale (Pr M Laxenaire), Centre hospitalier régional de Nancy, hôpital Jeanne-d’Arc, BP 303, 54201Toul Cedex
C Burlet
Affiliation:
INSERM - Unité 308 «Mécanismes de régulation des comportements alimentaires» (Pr JP Nicolas), 38, rue Lionnois, 54000Nancy
L Mejean
Affiliation:
INSERM - Unité 308 «Mécanismes de régulation des comportements alimentaires» (Pr JP Nicolas), 38, rue Lionnois, 54000Nancy
M Laxenaire
Affiliation:
Service de psychologie médicale (Pr M Laxenaire), Centre hospitalier régional de Nancy, hôpital Jeanne-d’Arc, BP 303, 54201Toul Cedex
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Résumé

L’étude de la fonction hypothalamo-hypophyso-cortico-surrénalienne (HHS) occupe une place de choix dans l’étude du stress, de l’anxiété et d’autres pathologies psychiatriques telle la dépression. Mais les procédures d’investigation actuellement utilisées sont difficiles à mettre en œuvre et susceptibles d’interférer avec les phénomènes étudiés. Les auteurs présentent ici l’adaptation et les applications du dosage du cortisol dans la salive dans diverses conditions statiques et dynamiques chez des patients et des sujets sains qui devraient permettre une approche fructueuse dans l’étude des corrélations clinico-biologiques en psychiatrie et en psychobiologie.

Summary

Summary

The hypothalamo-pituitary-adrenal (HPA) function has been the focus of interest for many years in an attempt to understand the pathophysiology of stress, anxiety and other psychiatric disorders such as depression. The various procedures which are traditionally used may, however, present several drawbacks: their use is often cumbersome and they may interfere with the variables which are investigated. The authors adapted a radioimmunoassay for salivary cortisol and present its main interests and applications under various static and dynamic conditions in patients and healthy subjects. Direct determination of cortisol in the saliva may prove useful to assist in the future development of research strategies in psychobiology and contribute to a better understanding of the biological correlations and pathophysiology of stress, anxiety and other psychiatric disorders such as depression.

Keywords

dosage RIA du cortisol salivairevolontaires sainspsychobiologiestressanxiété normale et pathologiquedépressionsalivary cortisol radioimmunoassaynormal volunteerspsychobiologystressnormal and pathological anxietydepression
Type
Article original
Information
Psychiatry and Psychobiology , Volume 5 , Issue 2 , 1990 , pp. 129 - 136
Copyright
Copyright © European Psychiatric Association 1990

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References

Références

Al-Ansari, AAKPerry, LASmith, DSLandon, J (1982) Salivary cortisol determination : adaptation of a commercial serum cortisol kit. Ann Clin Biol 19, 163–166CrossRefGoogle ScholarPubMed
Angeli, A (1978) The binding of glucocorticoids to human plasma proteins. In: The Endocrine Function of the Human Adrenal Cortex (James, VHT, ed). Academic Press, London, 155Google Scholar
Ansseau, MSulon, JDoumont, ACerfontaine, JLLegros, JJSodoyez, JCDemey-Ponsart, E (1984) Use of saliva cortisol in the dexamethasone suppression test. Psychiatry Res 13, 203–211CrossRefGoogle ScholarPubMed
Asnis, GMSachar, EJHalbreich, USwani-Nathan, ROstrow, LHalpern, FS (1981) Cortisol secretion and dexamethasone response in depression. Am J Psychiatry 138, 1218–1221Google ScholarPubMed
Burke, PMReichler, RJSmith, EDugaw, KMcCauley, EMitchell, J (1985) Correlation between serum and salivary cortisol levels in depressed and non-depressed children and adolescents. Am J Psychiatry 142, 1065–1067Google Scholar
Carroll, BJMartin, FIRDavies, BM (1968) The resistance to suppression by dexamethasone of plasma II-OHCS levels in severe depressive illness. Br Med J 3, 285–287CrossRefGoogle ScholarPubMed
Carroll, BJCurtis, GCMendels, J (1976) Neuroendocrine regulation in depression. I. Adreno-cortical dysfunction. Arch Gen Psychiatry 33, 1039–1044CrossRefGoogle Scholar
Carroll, BJFeinberg, MGreden, JFTarika, JAlbala, AAHaskett, RFJames, NMKronfol, ZLohr, NSteiner, MDe Vigne, PYoung, E (1981) A specific laboratory test for the diagnosis of melancholia. Arch Gen Psychiatry 38, 15–22CrossRefGoogle Scholar
Charney, DSRedmond, DE (1983) Neurobiological mechanisms in human anxiety: evidence supporting central noradrenergic hyperactivity. Neuropharmacology 22, 1531–1536CrossRefGoogle ScholarPubMed
Cherek, DRSmith, JELane, JDBrauchi, JT (1982) Effects of cigarettes on saliva cortisol levels. Clin Pharmacol Ther 32, 765–768CrossRefGoogle ScholarPubMed
Cook, NHarris, BWalker, RHailwood, RJones, EJohns, SRiad-Fahmy, D (1986) Clinical utility of the dexamethasone suppression test assessed by plasma and salivary cortisol determinations. Psychiatry Res 18, 143–150CrossRefGoogle ScholarPubMed
DSM III: American Psychiatric Association (1983) Manuel diagnostique et statistique des troubles mentaux. Masson, ParisGoogle Scholar
Ferguson, DBPrice, DAWallace, S (1980) Effects of physiological variable on the concentrations of cortisol in human saliva. Adv Physiol Sci 28, 301–313Google Scholar
Gibbons, JL (1964) Cortisol secretion rates in depressive illness. Arch Gen Psychiatry 10, 572–575CrossRefGoogle Scholar
Hiramatsu, R (1981) Direct assay of cortisol in human saliva by solid phase radioimmunoassay and its clinical applications. Clin Chim Acta 117, 239–249Google ScholarPubMed
Kahn, JPRubinow, DRDavis, CLKling, MPost, RM (1988) Salivary cortisol: a practical method for evaluation of adrenal function. Biol Psychiatry 23, 335–349CrossRefGoogle ScholarPubMed
Katz, FHShannon, IL (1964) Identification and significance of parotid fluid corticosteroids. Acta Endocrinol 46, 393–404CrossRefGoogle ScholarPubMed
Laudat, MHCerdas, SFournier, CGuiban, DGuilhaume, BLuton, JP (1988) Salivary cortisol measurement: a practical approach to assess pituitary-adrenal function. J Clin Endocrinol & Metab 66, 343–348CrossRefGoogle ScholarPubMed
McVie, RLevine, LNew, MI (1979) The biological significance of the aldosterone concentration in saliva. Pediatr Res 13, 755–759CrossRefGoogle Scholar
Piollet, ILepine, JPGuechot, JPhilip, ERouillon, FFiet, JLajeunesse, CVillette, JMDreux, CLemperière, TRance, JRZarifian, E (1984) DST plasmatique et salivaire dans la dépression: applications cliniques et approche cinétique. Encéphale X, 279–280Google Scholar
Poland, RERubin, RT (1982) Saliva cortisol levels following dexamethasone administration in endogenously depressed patients. Life Sci 30, 177–181CrossRefGoogle ScholarPubMed
Riad-Fahmy, DRead, GFWalker, RJGriffiths, K (1982) Steroids in saliva for assessing endocrine function. Endocr Rev 3, 367–395CrossRefGoogle ScholarPubMed
Rodbard, D (1978) Statistical estimation of the minimal detectable concentration, sensitivity for radioligand assays. Anal Biochem 90, 1–12CrossRefGoogle ScholarPubMed
Rubinow, DRPost, RMGold, PWBallenger, JCWolff, EA (1983) The relationship between cortisol and clinical phenomenology of affective illness. In: Neurobiology of Mood Disorders, vol 1 (Post, RMBallenger, JC, eds). Williams and Wilkins, Baltimore, 519–528Google Scholar
Sachar, EJHellman, LRoffwarg, HPHalpern, FSFukushima, DKGallagher, TF (1973) Disrupted 24-hour patterns of cortisol secretion in psychotic depression. Arch Gen Psychiatry 28, 19–24CrossRefGoogle ScholarPubMed
Seyle, H (1936) A syndrome produced by diverse noxious agents. Nature (Lond) 128, 32CrossRefGoogle Scholar
Shannon, ILBeering, SCKatz, FH (1966a) Parotid fluid steroid response to ACTH in surgically confirmed cases of Cushing's syndrome. J Clin Endocrinol 26, 11–13CrossRefGoogle Scholar
Shannon, ILBeering, SCJenson, RL (1966) Dexamethasone suppression tests employing parotid fluid. J Clin Endocrinol 26, 967–969CrossRefGoogle ScholarPubMed
Stahl, FDorner, G (1982) Responses of salivary cortisol levels to stress situations. Endokrinologie 80, 158–162Google ScholarPubMed
Umeda, THiramatsu, RIwaoka, TShimada, TMura, FSato, T (1981) Use of saliva for monitoring unbound free cortisol levels in serum. Clin Chim Acta 110, 245–253Google ScholarPubMed
Ursin, HBaade, ELevine, S (1984) Psychobiology of stress. Academie Press, New YorkGoogle Scholar
Vining, RFMcGinley, RASymons, RC (1983) Hormones in saliva: mode of entry and consequent implications for clinical interpretation. Clin Chem 29, 1752–1756CrossRefGoogle ScholarPubMed
Wahby, VGiller, EMason, J (1984) Use of saliva in the DST. XVth International Congress of the ISPNE, 14 (abstr)Google Scholar
Walker, RFRiad-Fahmy, DRLlewelyn, DE (1978) A direct radioimmunoassay for cortisol in parotid fluid and saliva. J Endocrinol 77, 26P–27PGoogle ScholarPubMed
Walker, RF (1984) Salivary cortisol determination in the assessment of adrenal activity. In: Steroid Hormones in Saliva. Front Oral Physiol, vol 5 (Ferguson, DB, ed). Karger, Manchester, 33–50Google Scholar
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