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Circadian rhythm of catecholaminergic binding sites on blood cells and catecholamines in plasma of healthy volunteers

Published online by Cambridge University Press:  28 April 2020

M. Fröhler ,
M. Ackenheil ,
R. Bak ,
B. Bondy ,
E. Feistenauer ,
E. Hofschuster cand. med. ,
Y. Saito ,
A. Vakis  and
D. Welter
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Summary

Circadian variations of catecholaminergic binding sites on blood cells and circulating catecholamines (CA) in serum from ten healthy volunteers, with ordinary daily activities during the investigation were examined. Simultaneously, psychological status was analysed by different tests (MMPI-Saarbrücken, EWL and BfS).

A significant increase in binding capacity (maximum at 8 p.m.) of α2-receptors with a concomitant significant decrease in affinity (minimum at 8 p.m.) was observed. β2-receptors showed a slight, but significant diurnal decrease in capacity (maximum at 8 a.m.) with no change in affinity. 3-H-spiperone binding sites on lymphocytes and circulating plasma CA did not differ significantly during 24 hours. The psychological tests showed significant diurnal variations for only the EWL-subgroups «activity» and «general inactivity» respectively with the BfS.

No correlations has been observed between biological and psychological data.

Résumé

Résumé

Les variations au cours de la journée des sites de liaisons catécholaminergiques sur les cellules sanguines et des catécholamines circulantes dans le sérum ont été analysées chez des sujets sains ne changeant rien à leurs habitudes durant la journée d'examen. Simultanément leur état psychologique a été déterminé à l‘aide de différents tests (MMPI-Saarbrücken*, EWL* et BfS*).

Une augmentation significative de la capacité de liaison (maximum à 8 heures du soir) ainsi qu’une diminution significative de l’affinité (minimum à 8 heures du soir) des récepteurs α2-adrénergiques ont pu être mises en évidence. La capacité de liaison des récepteurs β2 diminue significativement durant la journée (maximum à 8 heures du matin) tandis que leur affinité reste inchangée. Les sites de liaison du spipérone-3H sur les lymphocytes et les catéecholamines plasmatiques ne montrent pas de différence significative durant ces 24 heures. Les tests psychologiques ne montrent des variations significatives au cours de la journée que pour les sous-groupes «activité» et «inactivité générale» du test EWL et de la BfS.

Il n’existe pas de corrélations temporelles entre les variations biologiques et psychologiques.

Keywords

Catecholamine-receptorsα2-, β2- and 3-H-Spiperone Binding SitesCircadian RhythmNeurotransmitter ReceptorsPlasma catecholaminesRécepteurs catécholaminergiquesα2-, β2- et sites de liaison du spipérone-3H Rythme circadienRécepteurs des neurotransmetteursCatécholamine et plasma
Type
Research Article
Information
Psychiatry and Psychobiology , Volume 1 , Issue 4 , 1986 , pp. 309 - 317
Copyright
Copyright © European Psychiatric Association 1986

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References

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