No CrossRef data available.
Article contents
Caractéristiques cinétiques des antidépresseurs les plus récents (1975-1985)
Published online by Cambridge University Press: 28 April 2020
Résumé
Depuis 1975, 15 nouveaux antidépresseurs ont été commercialisés en France. Nous avons voulu étudier leurs caractéristiques pharmacocinétiques et les comparer à celles des antidépresseurs plus anciens.
Il faut tout d'abord noter que, bien que de structure chimique plus hétérogène que leurs prédécesseurs, ces produits possèdent tous une ou plusieurs méthodes de dosage dans le plasma, en général chromatographique.
D’un tableau regroupant les caractéristiques pharmacocinétiques, après dose unique, et après doses répétées de ces antidépresseurs de deuxième génération, nous concluons qu’ils sont peu différents à ce point de vue des antidépresseurs de première génération. Nous remarquons seulement la plus grande rapidité d‘absorption et la demi-vie plus brève de certains nouveaux produits.
De l'ensemble des études portant sur des populations particulières (personnes âgées, insuffisants rénaux, malades déprimés), il est possible de déduire quelques informations importantes concernant l‘utilisation pratique de ces produits.
Summary
Since 1975, 15 new antidepressants have become available in France. We wished to study and compare their pharmacokinetic characteristics with those of the previously available antidepressants.
Despite the more heterogeneous Chemical stmcture of these new molecules by comparison with their predecessors, they can all be assayed in human plasma by one or several methods, generally using chromatography.
A table provided in this article presents the following parameters: absorption, time to maximum concentration, first-pass effect, bioavailability, metabolites, protein binding, distribution volume, half-life, elimination, time to steady-state concentrations for maprotiline, dosulepine, viloxazine, amineptine, mianserine, quinupramine, amoxapine, demexiptiline, toloxatone, trazodone and fluvoxamine. Pharmacokinetic characteristics after single- and repeated-dose administration of these second generation antidepressants were very similar to those of the first generation drugs, although some of the new molecules showed greater rapidity of absorption and a shorter half-life.
While it is not yet possible to derive new data from the existing studies concerning the relationship between plasma concentrations and clinical effects, some studies in specific populations (elderly, physically ill and depressed patients), provide a number of important data concerning practical use of these drugs.
Keywords
- Type
- Research Article
- Information
- Copyright
- Copyright © European Psychiatric Association 1986
References
Bibliographie/References
Altamura, A.C., Colacurcio, F., Mauri, M., Terzi, A.. Vampini, C.- Age, therapeutic «milieu» and clinical response in depressive patients treated with viloxazine: a study with plasma levels 4th World Biological Psychiatry September 8-13, 1985, Philadelphia Pa, U.S. A.Google Scholar
Bayliss, P.F.C., Case, D.E.- Blood level studies with viloxazine hydrochloride in man. Br J Clin Pharmacol 1975; 2: 209–214.CrossRefGoogle ScholarPubMed
Bonin, B., Vandel, B., Jounet, J.M., Vandel, S., Raillard, P., Allers, G., Volmat, R.- Application des donnees pharmacocinétiques à un essai clinique de la viloxazine. In: Compte-rendus du congrès de psychiatrie et de neurologie de Zangue française. Barcelone. Masson ed., Paris, 1982.Google Scholar
Boutelle, W.E.- Clinical response and blood levels in the treatment of depression with a new antidepressant drug, amoxapine. Neuro-pharmacology 1980; 19: 1229–1231.Google ScholarPubMed
Bouquet, S., Lefebvre, M.A., Girault, J., Fourtillan, J.B.- Étude pharmacocinétique de la quinupramine en cross-over chez six sujets. Encéphale 1982; VIII: 449-463.Google Scholar
Boyer, P., Tsamis, M., Mahuzier, P.- Pharmacocinétique et taux plasmatique des antidépresseurs polycyeliques. Une revue générale des produits. Encéphale 1980 ; VI: 336–347.Google Scholar
Brogden, R.N., Heel, R.C., Speight, T.M., Avery, G.- Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs 1981; 21-6:401–476 (updated 1984).CrossRefGoogle ScholarPubMed
Case, D.E. - Gas-liquid chromatographic estimation in blood of ICI 58834. J Pharm Pharmac 1973; 25: 800–802.CrossRefGoogle Scholar
Crampton, L., Glass, R.C., Marchant, B., Rees, J.A.- Chemical ionisation mass fragmentographic measurement of dothiepin plasma concentrations following a single oral dose in man. J Chromatogr 1980; 183: 141–148.CrossRefGoogle ScholarPubMed
Doogan, D.P.- Fluvoxamine as an antidepressant drug. Neuro-pharmacology 1980; 19: 1215–1216.Google ScholarPubMed
Gillilan, R., Mason, W.D.- High-pressure liquid chromatographic detemination of viloxazine in human plasma and urine. J Pharm Sci 1981;70, 2: 220–221.10.1002/jps.2600700227CrossRefGoogle Scholar
Gut, M., Brohon, J., Vauterin, C.- Applications cliniques de la pharmacocinétique de la démexiptiline. In: Guelfi, J.D., Pichot, P., Sutter, J.M., ed: Symposium Deparon, Excerpta Medica, 1981.Google Scholar
Hrdina, P.D., Lapierre, Y.D., Me Intosh, B., Oyewuml, L.K.- Mianserin kinetics in depressed patients. Clin Pharmacol therapy 1983; 33, 6 : 757–762.CrossRefGoogle ScholarPubMed
Jones, R.B., Luscombe, D.K.- Single-dose study with maprotiline in normal subjects. Communication présentée au symposium Ludiomil (Malte, Novembre 1976).Google Scholar
Jue, S., Dawson, G.W., Brogden, R.N.- Amoxapine: a review of its pharmacology and efficacy in depressed States. Drugs 1982; 24: 1–23.CrossRefGoogle ScholarPubMed
Lachatre, G., Piva, C., Defrance, R., Mocaer, E., Kamoun, A., Nicot, G.- Pharmacocinétique de l’amineptine chez l’adulte jeune. Communication pcrsonnelle des auteurs (Lab. Servicr, Neuillysur- Seine), 1986.'Google Scholar
Leguay, D.. Robert, D., Garret, J.B., Turcant, A., Allain, P., Lavoisy, J.- Controlled study of I.V. viloxazine versus clomipramine double blind, blind time and plasmatic levels assay. 4th World Biological Psychiatry September 8-13, 1985, Philadelphia Pa, U.S.A.Google Scholar
Luscombe, D.K., Mathur, G.N., Wright, J.- Plasma concentrations of maprotiline in depressive patients following an incremental dosage regime. Br J Clin Pract (Symp Suppl) New Perspectives in Depressive Illness 1979: 36–41.Google Scholar
Maguire, J.P., Bunows, G.D., Norman, T.R., Scoggins, B.A.- Metabolism and pharmacokinetics of dothiepin. Br J Pharmacol 1981; 12: 405409.Google ScholarPubMed
Maguire, K.P., Norman, T.R.. Burrows, G.D., Scoggins, B.A.- A pharmacokinetic study of mianserin. Eur J Clin Pharmacol 1982; 21: 517–520.CrossRefGoogle ScholarPubMed
Maguire, K.P., Norman, T.R., Mc Intyre I., Burrows G.D.- Clinical pharmacokinetics of dothiepin. Clin Pharmacokinet 1983; 8:179–185.CrossRefGoogle ScholarPubMed
Malnoe, A., Strolin Benedetti, M.- Pharmacokinetics and metabolism of a new antidepressant drug, 3-(3-methylphenil)- 5-hydroxy-methyl-2-oxazolidinone (Toloxatone), in the rat, dog and man. Sixth international cong pharmacol (july 20-25, Helsinki), 1975, Abst. 317.Google Scholar
MARSH, B.D., Rees, J.A.- Considérations métaboliques et cliniques de l’administration d’une dose unique journalière de prothiaden, antidépresseur tricyclique. Colloque sur la dépression, Prague, 5-8 mai 1977, l'Expansion scientifique, Paris, 155 p., 1978.Google Scholar
Mendlewicz, J., Linkowski, P” Rees, J.A.- A double-blind comparison of dothiepine and amitriptyline in patients with primary affective disorder: serum levels and clinical response. Br J Psychiatry 1980; 136: 154–160.CrossRefGoogle Scholar
Michel, J.P., Nicot, G., Lachatre, C., Bertrandias, F., Mottier, D., Riche, C., Mocaer, E.- Pharmacokinetics of the antidepressant amineptine in elderly patients. CINP, San Juan Puerto Rico, December 14-17, 1986.Google Scholar
Montgomery, S.A., Mc Asley, R., Montgomery, D.B., Dawling, S” Braithwaite, R.A.- Clinical efficacy, side effects and plasma concentrations of maprotiline and amitriptyline. Br J Clin pract (Symp Suppl) New Perspectives in Depressive Illness 1979:60–66.Google Scholar
Norman, T.R., Burrows, G.D., Davies, B.M., Maguire, K.P., Wurrme, J.M.E.- Viloxazine plasma concentrations and clinical response. J Affective Disord 1980; 2: 157–164.10.1016/0165-0327(80)90002-6CrossRefGoogle ScholarPubMed
Olivier, P., Robert, H.- HPLC assay of viloxazine in plasma for drug monitoring. J Pharmacol Clin 1986; 5. 1; 23–34.Google Scholar
Overmans, H., Scherpenisse, P.M., Post, L.C.- Fluvoxamine maleate: metabolism in man. Eur J Drug Metab and Pharmacokinet 1983; 18, 3: 269–280.CrossRefGoogle Scholar
Pinder, R.M., Brogden, R.N., Speight, T.M., Avery, G.S.- Maprotiline: a review of its pharmacological properties and therapeutic efficacy in mental depressive States. Drugs 1977; 13:321–352.CrossRefGoogle ScholarPubMed
Pinder, R.M., Van Delft, A.M.L.- Pharmacological aspeets of mianserin. Acta Psychiatr Scand 1983; suppl. 302:59–71.CrossRefGoogle Scholar
Pinder, R.M., Van Delft, A.M.L.- The potential therapeutic role of the enantionners and metabolites of mianserin. Br J Clin Pharmacol 1983; 15: 269S–276S.10.1111/j.1365-2125.1983.tb05875.xCrossRefGoogle ScholarPubMed
Putzolu, S., Pecknold, J.G., Baiocchi, L.et al.- Trazodone clinical and biochemical studies II blood levels and therapeutic responsiveness. Psychopharmacol Bull 1976; 12 :40–41Google ScholarPubMed
Rovei, V., Vajta, S., Le Moing, J.P., Strolin Benedetti, M.- Metabolism of toloxatone in man. Encephale 1983 ; IX (suppl 1, fasc.2), Abst. B18, 92A.Google Scholar
Sbarra, C., Castelli, M.G., Noseda A” Fanelli R.- Pharmacokinetics of amineptine in man. Eur J Drug Metab Pharmacokinet 1981; 6, 2: 123–126.CrossRefGoogle ScholarPubMed
Shami, M., Elliott, H.L., Kelman, A.W., Whiting, B.- The pharmacokinetics of mianserin. Br J Clin Pharmacol 1983; 15: 3 135-3225.CrossRefGoogle ScholarPubMed
Strolin Benedetti, M., Rovei, V., Dencker, S.J., Nagy, A., Johansson, R - Pharmacokinetics of toloxatone in man following intravenous and oral administration. Arzneim-Forsch 1982; 32: 276–280.Google Scholar
Suckow, R.F., Cooper, T.B., Quitkin, F. M., Stewart, J.W.- Determination of mianserin and metabolites in plasma by liquid chromatography with electrochemical detection. J Pharm Sci 1982; 71,8: 889–892.CrossRefGoogle ScholarPubMed
Vajta, S., Le Moing, J.P , Rovei, V.- Gas-liquid chromatographic detemination of toloxatone in human plasma. J Chromatogr 1983; 274: 139–148.CrossRefGoogle Scholar
Vandel, B., Vandel, SJounet, J.M., Blum, D - Pharmacokinetics of viloxazine hydrochloride in man. Eur J Drug Metab Pharmacokinet 1982; 1, 7: 65–68.CrossRefGoogle Scholar
Van Riezen, H , Pinder, R.M., Nickolson, V.J., Hobbelen, P., Zayed, I., Van Der Veen, F.- Chlorydrate de miansérine. In : Goldberg, M.E. EdT propriétés pharmacologiqucs et biochimiques des produits pharmaceutiques, vol 3, American Pharmaceutical Association, 1981.Google Scholar
Comments
No Comments have been published for this article.