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The use of clozapine plasma levels in optimising therapy

Published online by Cambridge University Press:  02 January 2018

David Taylor  and
Denise Duncan
David Taylor
Affiliation:
The Maudsley Hospital, Denmark Hill, London SE5 8AZ
Denise Duncan
Affiliation:
The Maudsley Hospital, Denmark Hill, London SE5 8AZ
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Clozapine is well known to be an effective treatment for neuroleptic-resistant schizophrenia. However, its use is complicated by a variable and delayed response and by a range of troublesome adverse effects. Current practice is usually to increase the dose initially to around 450 mg/day and then by small increments to a maximum of 900 mg/day according to response and tolerability. While this method is often successful, it has been suggested that a better way of optimising the dose of clozapine might be to monitor plasma concentrations of the drug.

Type
Drug Information Quarterly
Information
Psychiatric Bulletin , Volume 19 , Issue 12 , December 1995 , pp. 753 - 755
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © Royal College of Psychiatrists, 1995

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