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Olanzapine in practice: a prospective naturalistic study

Published online by Cambridge University Press:  02 January 2018

David Taylor ,
Shameem Mir  and
Shubra Mace
David Taylor*
Affiliation:
Maudsley Hospital, Denmark Hill London SE5 8AZ
Shameem Mir
Affiliation:
Maudsley Hospital, Denmark Hill London SE5 8AZ
Shubra Mace
Affiliation:
Maudsley Hospital, Denmark Hill London SE5 8AZ
*
∗Correspondence
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Abstract

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Aims and method

The study aimed to evaluate the effectiveness of the naturalistic use of olanzapine. Prescribers of olanzapine were asked to provide baseline and six-week Brief Psychiatric Rating Scale scores for 56 in-patients. Withdrawals from treatment were also noted.

Results

Olanzapine was not effective in any of the 12 patients with refractory schizophrenia and four patients worsened. In 36 patients with non-refractory schizophrenia, 16 (44%) improved and 10 (28%) were categorised as treatment failures. of eight patients with non-schizophrenic psychosis, only one improved and two were treatment failures.

Clinical implications

Olanzapine is effective in treating non-refractory schizophrenia, but appears to have no beneficial effect in refractory schizophrenia.

Type
Drug Information Quarterly
Information
Psychiatric Bulletin , Volume 23 , Issue 3 , March 1999 , pp. 178 - 180
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © 1999 The Royal College of Psychiatrists

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