In the house of philosophy of science are many mansions, and Marjorie Grene has lived — or at least taken rooms — in most of them. She has done everything from studies of concepts and presuppositions within particular sciences, chiefly the biological sciences, to analyses of notions such as explanation and reduction, which cut across many sciences, to extended reflections on scientific knowledge and practice Uberhaupt. In an important sense, however, Marjorie Grene is not a “philosopher of science” at all, if one means by that a practitioner of some technical specialty, but simply a philosopher — or, as she likes to put it, a “teacher of the history of philosophy” — who takes scientific inquiry seriously. Indeed, one of her major contributions has precisely been to insist that renewal in philosophy of science is inseparable from a fundamental re-thinking of the tradition of modern philosophy generally. It is this rethinking that has occupied her over more than three decades.