Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-23T00:43:53.901Z Has data issue: false hasContentIssue false

The π-helix translates structure into function

Published online by Cambridge University Press:  01 January 2000

TODD M. WEAVER
Affiliation:
University of Wisconsin La Crosse, Department of Chemistry, La Crosse, Wisconsin 54601
Get access

Abstract

A search for the occurrence of the rare π-helix was performed with Iditis from the Oxford Molecular Group upon the Protein Data Bank. In 8 of the 10 confirmed crystal structures that harbor the π-helix, its unique conformation has been linked directly to the formation or stabilization of a specific binding site within the protein. In the discussion to follow, the role for each of these eight π-helices will be addressed in regard to protein function. It is clear upon closer examination that the conformation of the π-helix has evolved to provide unique structural features within a variety of proteins.

Type
FOR THE RECORD
Copyright
© 2000 The Protein Society

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)