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Liquid Fluoxetine versus Placebo for Repetitive Behaviors in Childhood Autism

Published online by Cambridge University Press:  15 February 2006

Eric Hollander ,
Erika Swanson ,
Evdokia Anagnostou ,
Ann Phillips ,
William Chaplin  and
Stacey Wasserman
Eric Hollander
Affiliation:
Seaver & New York Autism Center of Excellence, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY
Erika Swanson
Affiliation:
Seaver & New York Autism Center of Excellence, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY
Evdokia Anagnostou
Affiliation:
Seaver & New York Autism Center of Excellence, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY
Ann Phillips
Affiliation:
Seaver & New York Autism Center of Excellence, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY
William Chaplin
Affiliation:
Department of Psychology, Saint John's University, Jamaica, New York
Stacey Wasserman
Affiliation:
Seaver & New York Autism Center of Excellence, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY
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Abstract

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Keywords

Autismliquid fluoxetinerepetitive behaviorsneurotherapeuticsclinical trialsYale-Brown Obsessive Compulsion Scale
Type
Review Article
Information
Progress in Neurotherapeutics and Neuropsychopharmacology , Volume 1 , Issue 1 , January 2006 , pp. 105 - 113
Copyright
© 2006 Cambridge University Press

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References

American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Washington, DC: American Psychiatric Association.
Chugani, D.C., Muzik, O., Rothermel, R., Behen, M., Chakraborty, P., Mangner, T., da Silva, E.A., & Chugani, H.T. (1997). Altered serotonin synthesis in the dentathalmocortical pathway in autistic boys. Annals of Neurology, 42, 666–669.Google Scholar
Chugani, D.C., Muzik, O., Behen, M., Rothermel, R., Janisse, J.J., Lee, J., & Chugani, H.T. (1999). Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Annals of Neurology, 45, 287–295.Google Scholar
Fatemi, S.H., Realmuto, G.M., Khan, L., & Thuras, P. (1998). Fluoxetine in treatment of adolescent patients with autism: a longitudinal open trial. Journal of Autism and Developmental Disorders, 28, 303–307.Google Scholar
Fombonne, E. (1988). Epidemiology of the pervasive developmental disorders. Trends in Evidence-Based Neuropsychiatry, 5, 29–36.Google Scholar
Gaspar, P., Cases, O., & Maroteaux, L. (2003). The developmental role of serotonin: news from mouse molecular genetics. Nature Reviews Neuroscience, 4, 1002–1012.Google Scholar
Gordon, C.T., State, R.C., Nelson, J.E., Hamburger, S.D., & Rapoport, J.L. (1993). A double-blind comparison of clomiprimine, despramine, and placebo in the treatment of autistic disorder. Archives of General Psychiatry, 50, 441–447.Google Scholar
Hollander, E., Phillips, A.T., & Yeh, C. (2003a). Targeted treatments for symptom domains in child and adolescent autism. Lancet, 362, 222–252.Google Scholar
Hollander, E., King, A., Delaney, K., Smith, C.J., & Silverman, J.M. (2003b). Obsessive–compulsive behaviors in parents of multiplex autism families. Psychiatry Research, 117, 11–16.Google Scholar
Hollander, E., Anagnostou, E., Chaplin, W., Esposito, K., Haznedar, M.M., Licalzi, E., Wasserman, S., Soorya, L., & Buchsbaum, M. (2005a). Striatal volume on magnetic resonance imaging and repetitive behaviors in autism. Biological Psychiatry, 58, 226–232.Google Scholar
Hollander, E., Phillips, A., Chaplin, W., Zagursky, K., Novotny, S., Wasserman, S., & Iyengar, R. (2005b). A placebo-controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism. Neuropsychopharmacology, 30, 582–589. Reprinted with permission.Google Scholar
Markowitz, P.I. (1992). Effect of fluoxetine on self-injurious behavior in the developmentally disabled: a preliminary study. Journal of Clinical Psychopharmacology, 12, 27–31.Google Scholar
McDougle, C.J., Kresch, L.E., Goodman, W.K., Naylor, S.T., Volkmar, F.R., Cohen, D.J., & Price, L.H. (1995). A case controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive–compulsive disorder. American Journal of Psychiatry, 152, 772–777.Google Scholar
McDougle, C.J., Naylor, S.T., Cohen, D.J., Aghajanian, G.K., Heninger, G.R., & Price, L.H. (1996a). Effects of tryptophan depletion in drug-free adults with autistic disorder. Archives of General Psychiatry, 53, 993–1000.Google Scholar
McDougle, C.J., Naylor, S.T., Cohen, D.J., Volkmar, F.R., Heninger, G.R., & Price, L.H. (1996b). A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Archives of General Psychiatry, 53, 1001–1008.Google Scholar
McDougle, C.J., Kresch, L.E., & Posey, D.J. (2000). Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitors. Journal of Autism and Developmental Disorders, 30, 427–435.Google Scholar
Novotny, S., Hollander, E., Allen, A., Mosovich, S., Aronowitz, B., Cartwright, C., DeCaria, C., & Dolgoff-Kaspar, R. (2000). Increased growth hormone response to sumatriptan challenge in adult autistic disorders. Psychiatry Research, 94, 173–177.Google Scholar
Research Units on Pediatric Psychopharmacology Autism Network. (2002). Risperidonein children with autism and serious behavioral problems. New England Journal of Medicine, 347, 314–321.Google Scholar
Scarone, S., Colombo, C., Livian, S., Abbruzzese, M., Ronchi, P., Locatelli, M., Scotti, G., & Smeraldi, E. (1992). Increased right caudate nucleus size in obsessive–compulsive disorder: detection with magnetic resonance imaging. Psychiatry Research, 45, 115–121.Google Scholar