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Clinical Trials in Dementia

Published online by Cambridge University Press:  13 June 2006

Encarnita Raya-Ampil  and
Jeffrey L. Cummings
Encarnita Raya-Ampil
Affiliation:
Department of Neurology and Psychiatry, University of Santo Tomas, Manila, Philippines; Email: [email protected]
Jeffrey L. Cummings
Affiliation:
Departments of Neurology and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Email: [email protected]
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Extract

ABSTRACT

Dementia, particularly Alzheimer's disease (AD), is increasing by patient population included in clinical trials. The methodology for trials of AD patients have been defined in terms of outcomes, standard measures and analytic techniques. Trial methodology is evolving with experience as new potential therapies become available. Screening criteria, instrumentation choices, duration of trials and analytic strategies may have a profound impact on the conclusions that can be derived from trials. The components of AD trials are reviewed in detail in this chapter.

Type
Review Article
Information
Progress in Neurotherapeutics and Neuropsychopharmacology , Volume 2 , Issue 1 , March 2007 , pp. 39 - 78
Copyright
© 2007 Cambridge University Press

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