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X.—The Pigmentary System and the Dopa Reaction

Published online by Cambridge University Press:  15 September 2014

Evlyn Boyd
Evlyn Boyd
Affiliation:
University of South Africa
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Summary

1. A description of the mammalian pigmentary system is given together with an outline of the mechanism of melanin production and those factors which influence or control it.

2. The production of melanin by chemicophysical interaction between circulating 3-4-dihydroxyphenylalanine (dopa) in the blood-stream and an enzyme or enzymes of intracellular origin is accepted, but it is emphasised that in the interaction there are numerous opportunities for physiological interference which inhibit melanin formation.

3. The current theories of the origin of melanin are discussed and evidence supporting the nuclear origin of oxidising enzymes is given.

4. It is suggested that in the sheep some epidermal cells are more potentially pigment-producing than others, and that a gradation exists between the cell which cannot produce pigment and that which produces it to a maximum degree.

5. It is postulated that only one pigment exists, and that all animal colours are the result of a modification of this one pigment.

6. The results of staining sections of lamb and adult sheep skin with dopa are given.

7. A series of in vitro experiments planned to standardise the dopa reaction is described.

8. It is suggested that the dopa reaction may be used as a simple chemical test in genetic analysis whereby the pigmentogenic potentialities of a particular sheep may be analysed.

Type
Proceedings
Information
Proceedings of the Royal Society of Edinburgh , Volume 52 , 1933 , pp. 218 - 235
Copyright
Copyright © Royal Society of Edinburgh 1933

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References

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