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XI.—The Relation of the Pituitary Gland to Muscle Creatine

Published online by Cambridge University Press:  15 September 2014

B. G. Shapiro  and
H. Zwarenstein
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Extract

Braier (1931) showed that hypophysectomised dogs on a complete diet excrete 24 per cent. less urinary creatinine than the controls, and 35 to 40 per cent. less when fasting. Schrire and Zwarenstein (1933, 1934) found that injection of anterior lobe extracts increased the urinary creatinine in rabbits.

These results afford evidence of an endocrine relationship between the anterior lobe of the pituitary and urinary creatinine. In view of the well-established relationship between urinary creatinine and muscle creatine the present authors decided to investigate the relationship of the anterior lobe to muscle creatine. An effect on phosphocreatine of muscle was reported by Marenzi (1933), who obtained a decrease of 33 per cent, following removal of the anterior lobe of the pituitary. The effect of hypophysectomy and of injections of anterior lobe extracts on muscle creatine has not been previously investigated.

Type
Proceedings
Information
Proceedings of the Royal Society of Edinburgh , Volume 56 , 1937 , pp. 164 - 168
Copyright
Copyright © Royal Society of Edinburgh 1937

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References

References to Literature

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