The present paper is the first step in an attempt to combine study of the genetics of coat colour in dogs with histological examination of the hairs and pigmentation, so that a picture may eventually be formed of the genetic relations of the various phenotypes, and of the processes by which the various colours are produced. Work along similar lines has been carried out by other workers on various mammals, e.g. on the mouse (Dry, 1926, 1928; Dunn, 1936; Einsele, 1937), guinea-pig (Wright and Hunt, 1918; Russel, 1939; Heidenthal, 1940), and in cattle (Bogart and Ibsen, 1938).