Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-10T04:46:06.120Z Has data issue: false hasContentIssue false
  • English
  • Français

XI.—Further Observations on the Liver Clearance of Bromo-sulphthalein in the Fowl and its Relation to Œstrogen-androgen Balance*

Published online by Cambridge University Press:  11 June 2012

J. G. Campbell
J. G. Campbell
Affiliation:
British Empire Cancer Campaign Unit at The Poultry Research Centre, Edinburgh
Get access

Synopsis

Previous work has shown a sex difference dependant upon œstrogen-androgen balance, in the rate of clearance by the fowl liver of intravenously administered sodium bromosulphthalein. Further observations reported here indicate an apparent rapid fluctuation of the Œ-A balance which takes place in immature chickens, both sexes snowing what is interpreted as hyperœstrogenization about the age of twelve weeks. Attention is drawn to other evidence that profound metabolic and hormonal changes occur at this stage. The effect of exogenous sex-hormones on the clearance rate of BSP has been further studied, particularly the influence of extra androgen on adult males with aberrant clearances unassociated with liver lesions. More evidence for the relation between the rate of BSP clearance and the Œ-A balance is provided by the study of the effect of cessation of ovulation on the clearance, and the effect of the development of virilizing tumours at the site of the rudimentary right ovary after left ovariectomy. Other changes which confirm hyperœstrogenization as assessed by the BSP clearance test are (a) decrease of the packed cell volume, (b) the development of a precipitable phospholipid in the plasma, (c) renal vascular changes, (d) adrenal cortical hyperplasia, (e) a frequent association with oviduct ligament “fibroids” and persistent cystic right oviducts.

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 67 , Issue 4 , 1960 , pp. 303 - 318
Copyright
Copyright © Royal Society of Edinburgh 1960

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

This paper was assisted in publication by a grant from the Carnegie Trust for the Universities of Scotland.

References

References to Literature

Bagget, B., Engel, L., Savard, K., and Dorfman, R. I., 1956. J. Biol. Chem., 221, 931.CrossRefGoogle Scholar
Bell, D. J., 1957. Quart. J. exp. Physiol., 42, 410.CrossRefGoogle Scholar
Bell, D. J., McIndoe, W. M., and Gross, D., 1959. Biochem.J., 71, 355.CrossRefGoogle Scholar
Blacher, L. J., 1925. Biol. Gen., 2, 346.Google Scholar
Breneman, W. R., and Mason, R. C., 1951. Endocrinology, 48, 752.CrossRefGoogle Scholar
Burrows, H., 1945. Biological Actions of Sex Hormones. Cambridge Univ. Press, P. 194.Google Scholar
Burrows, H., and Horning, E. S., 1952. Œstrogens and Neoplasia. Blackwell, Oxford.Google Scholar
Campbell, J. G., 1957 a. J. Endocrin., 15, 339.CrossRefGoogle Scholar
Campbell, J. G., 1957 b. J. Endocrin., 15, 346.CrossRefGoogle Scholar
Campbell, J. G., 1957 c. J. Endocrin., 15, 351.CrossRefGoogle Scholar
Campbell, J. G., 1960 a. Acta. Un. Int. Cancr., 16, 160.Google Scholar
Campbell, J. G., 1960. b. Proc. Roy. Soc. Edin., B, 67, 319–332.Google Scholar
Domm, L. V., Taber, E., and Davis, D. E., 1943. Proc. Soc. Exp. Biol. Med., 53, 49.CrossRefGoogle Scholar
Eschenbrenner, A. B., and Miller, E., 1945. Science, 102, 302.CrossRefGoogle Scholar
Herrick, E. H., Lockhart, C. H., Martin, E. P., and Nusser, W. L., 1954. Trans. Kans. Acad. Sci., 57, 483.CrossRefGoogle Scholar
Horning, E. S., 1958. Brit. J. Cancer, 12, 414.CrossRefGoogle Scholar
Juhn, M., and Domm, L. V., 1930. Amer.J. Physiol., 94, 610.CrossRefGoogle Scholar
Kumaran, J. D. S., and Turner, C. W., 1949. Poult. Sci., 28, 739.CrossRefGoogle Scholar
Lacassagne, A., 1939. Bull. Ass. Franç. Cancer, 28, 951.Google Scholar
McIndoe, W. M., 1959. Biochem. J., 72, 153.CrossRefGoogle Scholar
Turner, C. W., 1948. Poult. Sci., 27, 789.CrossRefGoogle Scholar
Wilkins, L., and Fleischmann, W., 1946. J. Clin. Endocrin., 6, 383.CrossRefGoogle Scholar
Wooley, G. W., Fekete, E., and Little, C. C., 1941. Endocrinology, 28, 341.CrossRefGoogle Scholar