Hostname: page-component-6bf8c574d5-j5c6p Total loading time: 0 Render date: 2025-03-09T16:50:34.902Z Has data issue: false hasContentIssue false
  • English
  • Français

Skin response to protein A

Published online by Cambridge University Press:  05 December 2011

M. I. White  and
W. C. Noble
M. I. White
Affiliation:
The Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London E9 6BX
W. C. Noble
Affiliation:
The Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London E9 6BX
Get access

Synopsis

The cutaneous reactions induced in the skin of human volunteers by protein A from Staphylococcus aureus have been studied. This cell wall protein induces no response when applied in solution to intact skin. In contrast a vigorous inflammatory reaction is seen if it is injected intradermally or applied to skin from which the stratum corneum has been partially removed. This study demonstrates that the intact epidermis is an important protection against this microbial product.

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 79 , Issue 1-3: Surface ecosystems and the interactions within them which overcome skin defence mechanisms , 1980 , pp. 43 - 46
Copyright
Copyright © Royal Society of Edinburgh 1980

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Forsgren, A., Svedjelund, A. and Wigzell, H., 1976. Lymphocyte stimulation by protein A of Staphylococcus aureus. Euro. J. IMmun., 6, 207–213.Google Scholar
Martin, R. R., Crowder, J. G. and White, A., 1967. Human reactions to staphylococcal antigens. J. Immun., 99, 269–275.CrossRefGoogle ScholarPubMed
Sjöquist, J. and Stålenheim, G., 1969. Protein A from Staphylococcus aureus. Complement fixing activity of protein A–IgG complexes. J. Immun., 103, 467–473.CrossRefGoogle ScholarPubMed