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Immunohistochemical expression of oestrogen receptor in normal breast tissue

Published online by Cambridge University Press:  05 December 2011

Sarah Carpenter ,
Gregory Georgiade ,
Kenneth S. McCarty Sr.  and
Kenneth S. McCarty Jr.
Sarah Carpenter
Affiliation:
Department of Pathology and Medicine, Duke University Medical Center, Box 3712, Durham, NC 27710, U.S.A.
Gregory Georgiade
Affiliation:
Department of Plastic Surgery, Duke University Medical Center, Durham, NC 27710, U.S.A.
Kenneth S. McCarty Sr.
Affiliation:
Department of Biochemistry, Box 3711, Duke University Medical Center, Durham, NC 27110, U.S.A.
Kenneth S. McCarty Jr.
Affiliation:
Department of Pathology and Medicine, Duke University Medical Center, Box 3712, Durham, NC 27710, U.S.A.
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Synopsis

The human breast undergoes profound changes during the menstrual cycle. The development of monocloiial antibodies to oestrogen-receptors (ER) allows study of receptor content and distribution in individual components of breast tissue. Forty-one specimens from premenopausal patients who underwent bilateral mastectomy for benign conditions were evaluated. The patients were categorised into early follicular, late follicular, early luteal, late luteal, and menstrual phases. An HSCORE, a semiquantitative evaluation of the intensity and distribution of receptor antigen localisation, was evaluated for the ductal and lobular epithelia as a tissue mean HSCORE. ER localised to the nuclei of the epithelium and was not observed in stromal elements. Receptor concentration was greater for ER in the follicular phase but this finding was not as striking as differences between lobules in a single breast and even between breasts. This heterogeneous expression between lobules was in contrast to the relatively uniform expression of receptor within a lobule of a given specimen.

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 95: Oestrogen and the Human Breast , 1989 , pp. 59 - 66
Copyright
Copyright © Royal Society of Edinburgh 1989

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