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XIV.—Abiogenic Information Coupling between Nucleic Acid and Protein, or, how Protein and DNA were married*

Published online by Cambridge University Press:  11 June 2012

Melvin Calvin
Melvin Calvin
Affiliation:
Honorary Fellow, Royal Society of Edinburgh, and Foreign Member, Royal Society of London, Physical Chemistry Laboratory, Oxford University
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Extract

The title to the talk this afternoon, “Abiogenic Information Coupling, or, How protein and DNA were married”, is, indeed, an excerpt from the much broader subject to which your President referred, namely chemical evolution of life on the surface of the earth, with some speculation about elsewhere as well. Actually, the “elsewhere” portion is more than a hopeful addition because it may provide a check on the speculations on the origin of life on the surface of the earth, which is very difficult to obtain inany other way.

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 70 , Issue 4 , 1969 , pp. 273 - 294
Copyright
Copyright © Royal Society of Edinburgh 1969

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Footnotes

‡Eastman Professor, Oxford University, Oxford, England, 1967–1968.
‡Permanent address: Laboratory of Chemical Biodynamics, University of California, Berkeley. The preparation of this paper was sponsored, in part, by the United States Atomic Energy Commission.
*

Address to the Royal Society of Edinburgh, June 17, 1968.

References

References to Literature

1. For reviews of the theory of chemical evolution see:

a. Bernal, J. D., 1967. The Origin of Life. London, Weidenson and Nicolson.Google Scholar
b. Calvin, Melvin, 1961. Chemical Evolution. Eugene, Univ. Oregon Press.Google Scholar
c. Calvin, Melvin, 1965. “Chemical Evolution (The Bakerian Lecture)”, Proc. Roy. Soc., 288A, 441.Google Scholar
d. Calvin, Melvin, 1969. Chemical Evolution. Oxford, Clarendon Press.Google ScholarPubMed
e. Fox, S. W., 1965. The Origins of Prebiological Systems and of Their Molecular Matrices. New York, Academic Press.Google Scholar
f. Oparin, A. I., 1963. The Origin of Life on Earth. (3rd English edition, trans, by Synge, Ann), London, Oliver and Boyd.Google Scholar
g. Steinman, G., and Kenyon, D. H., 1969. Biochemical Predestination. New York, McGraw-Hill.Google Scholar
a. Lemmon, R. M., 1969. “Abiogenic Synthesis of Biologically Relevant Organic Compounds”, Chem. Rev. [In press.]Google Scholar
b. Ponnamperuma, C. A., and Gabel, N. W., 1968. “Current Status of Chemical Studies of the Origin of Life”, Space Life Sci., 1, 64.Google ScholarPubMed
3. Waddington, C. H., 1968. “Towards a Theoretical Biology”, Nature, Lond., 218, 525.CrossRefGoogle ScholarPubMed
4. Khorana, H. G., 1961. Some Recent Developments in the Chemistry of Phosphate Esters of Biological Interest. New York, Wiley.Google Scholar
5. Steinman, Gary D., “Protobiochemistry: Dehydration Condensation in Aqueous Solution”, Ph.D. thesis, University of California, Berkeley December 1965. Univ. Calif. Lawrence Radiat. Lab. Rep., UCRL 16566.Google Scholar
6. Steinman, G., Kenyon, D. H., and Calvin, M., 1965. “Dehydration Condensation in Aqueous Solutions”, Nature, Lond., 206, 707.CrossRefGoogle Scholar
7. Fox, S. W., 1968. “How Did Life Begin?” Sci. Technol., Lond., Feb., 61.Google Scholar
8. a. Steinman, G., Lemmon, R. M., and Calvin, Melvin, 1964.. “Cyanamide: A Possible Key Compound in Chemical Evolution”, Proc. Natn. Acad. Sci. U.S.A., 52, 27.Google ScholarPubMed
b. Schimpl, A., Lemmon, R. M., and Calvin, M., 1965. “Formation of Cyanamide under ‘Primitive Earth’ Conditions”, Science, N.Y., 147, 148.CrossRefGoogle ScholarPubMed
c. Steinman, G., Lemmon, R. M., and Calvin, M., 1965. “Dicyanamide: Possible Role in Peptide Synthesis during Chemical Evolution”, Science, N.Y., 147, 574.CrossRefGoogle Scholar
9. Kenyon, D. H., Steinman, G., and Calvin, Melvin, 1966. “The Mechanism and Protobiochemical Relevance of Dicyanamide-Mediated Peptide Synthesis”, Biochim. Biophys. Ada., 124, 339.Google Scholar
10. Steinman, G., and Cole, M. N., 1967. “Synthesis of Biologically Pertinent Peptides under Possible Primordial Conditions”, Proc. Natn. Acad. Sci. U.S.A., 58, 735.Google ScholarPubMed
11. Eck, R. V., and Dayhoff, M. O., 1967. Atlas of Protein Structure and Function, 1966, Nat. Biomed. Res. Found., Silver Springs, Maryland.Google Scholar
12. Allen, D. E., and Gillard, R. D., 1967. “Stereoselective Effects in Peptide Complexes”, Chem. Commun., 1091.Google Scholar
13. An actual experimental observation of spontaneous generation of optically active material which involves these principles of equilibrium and relative autocatalytic rates was made some fifteen years ago. Havinga, E., 1954. “Spontaneous Formation of Optically Active Substances”, Biochim. Biophys. Ada., 13, 171.CrossRefGoogle ScholarPubMed
14. Collman, J. P., and Kumura, E., 1967. “The Formation of Peptide Bonds in Co-ordination Sphere of Cobalt (III)”, J. Am. Chem. Soc., 89, 6096.CrossRefGoogle Scholar
15. Schramm, G., Grotsch, W., and Pollman, W., 1962. “Nonenzymatic Synthesis of Polysaccharides, Nucleosides, Nucleic Acids and the Origin of Self-Reproducing Systems”, Angew. Chem. (Int. Ed.,) 1, 1.CrossRefGoogle Scholar
16. Naylor, R., and Gilham, P. H., 1966. “Study of Interactions and Reactions of Oligonucleotides in Aqueous Solution”, Biochemistry, N.Y., 8, 2722CrossRefGoogle Scholar
17. a. Akabori, S., 1959. “The Origin of the Fore-Protein”. In The Origin of Life on the Earth, ed. Oparin, A. I., pp. 189–196. London, Pergamon Press.Google Scholar
b. Bernal, J. D., 1959. “The Problem of Stages in Biopoesis”. In The Origin of Life on the Earth, ed. Oparin, A. I., pp. 38–53. London, Pergamon Press.CrossRefGoogle Scholar
c. Cairns-Smith, A. G., 1966. “The Origin of Life and the Nature of the Primitive Gene”, J. Theor. Biol., 10, 35.CrossRefGoogle ScholarPubMed
18. Harpold, M. A., and Calvin, M., 1968. “AMP on an Insoluble Solid Support”, Nature, Lond., 219, 486.CrossRefGoogle Scholar
19. Harpold, M. A., “Amino-Acid Nucleotide Interactions on an Insoluble Solid Support. I. A Simple Model of the Amino Acid Acceptor Terminus of at RNA”, unpublished manuscript.Google Scholar