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III.—New Developments in Large-scale Plasma Fractionation

Published online by Cambridge University Press:  05 December 2011

J. G. Watt ,
J. K. Smith ,
W. Grant  and
C. Turnbull
J. G. Watt
Affiliation:
Scottish National Blood Transfusion Association, Protein Fractionation Centre, Royal Infirmary, Edinburgh.
J. K. Smith
Affiliation:
Scottish National Blood Transfusion Association, Protein Fractionation Centre, Royal Infirmary, Edinburgh.
W. Grant
Affiliation:
Scottish National Blood Transfusion Association, Protein Fractionation Centre, Royal Infirmary, Edinburgh.
C. Turnbull
Affiliation:
Scottish National Blood Transfusion Association, Protein Fractionation Centre, Royal Infirmary, Edinburgh.
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Extract

‘Selective transfusion of appropriate blood components is preferable to the routine use of whole blood.’ (American Association of Blood Banks. Physicians' Handbook of Blood Component Therapy, 1969).

The rational use of donor blood in the environment of modern blood transfusion revolves around a series of developments in the field of component therapy. The fractionation of plasma, i.e. the separation of plasma into a series of subdivisions each containing one or other of the constituent proteins in varying degrees of purity and concentration, was one of the first of these developments to become established.

Early fractionation of plasma was applied in various ways to the purification of animal antisera; initially to antipneumococcal serum for therapeutic use. These sera frequently provoked reactions in patients until Sabin showed that absorption with Fullers earth could abolish these side-effects by removing complexed molecules.

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 71 , supplement S1 , 1972 , pp. s15 - s34
Copyright
Copyright © Royal Society of Edinburgh 1972

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References

References to Literature

Adam, E. and Škařvil., F., 1965. The use of placental gamma globulins stabilised with epsilonaminocaproic acid for the prevention of measles. Arch. Ges. Virusforsch., 16, 220.CrossRefGoogle ScholarPubMed
Barandun, S., Kistler, P., Jennet, F. and Isliker, H., 1962. Intravenous administration of human γ-globulin. Vox Sang., 7, 157.Google ScholarPubMed
Blatrix, Ch. and Soulier, J. P., 1959. Preparation d'une fraction riche en prothrombine, proconvertine, factuer Stuart et facteur anti-hemophilique B (Fraction PPB). Path. Biol., Paris, 7, 2477.Google Scholar
Blomback, M., 1958. Purification of antihaemophilic Globulin. Ark. Kemi, 12, 387.Google Scholar
Blumbert, B. S., Gerstley, B. J., Hungerford, D. A., London, W. T. and Sutnick, A. J., 1967. A serum antigen (Australia antigen) in Down's syndrome, leukemia and hepatitis. Ann. Intern. Med., 66, 924.CrossRefGoogle Scholar
Clarke, C. A., 1969. Prevention of Rhesus iso-immunisation. Semin. Hemat., 6, 201.Google ScholarPubMed
Cohn, E. J., Strong, L. E., Hughes, W. L. Jr., Mulford, D. J., Ashworth, J. N., Melin, M. and Taylor, H. L., 1946. Preparation and properties of serum and plasma proteins. IV. A system for the separation into fractions of the protein and lipoprotein components of biological tissues and fluids. J. Am. Chem. Soc., 68, 459.CrossRefGoogle Scholar
Connell, G. E. and Painter, R. H., 1966. Fragmentation of immunoglobulin during storage. Can. J. Biochem. Physiol., 44, 371.Google ScholarPubMed
Cosine, W., 1971. Cited by Bier, M., pp. 233–266. In Membrane Processes in Industry and Biomedicine (Ed. Bier, M.). New York: Plenum Press.Google Scholar
Crain, J. D., Rosen, F. S. and Janeway, C. A., 1970. Clinical experiences with intravenous fragmented gamma globulins. In Immunoglobulin, p. 179 (Ed. Merler, E.). Washington: Natn. Acad. Sci.Google Scholar
Cuatrecasus, P. And Parikh, I., 1971. The application of affinity chromatography to plasma fractionation. Vox Sang., in press.Google Scholar
Didisheim, P., Loeb, J. Blatrix, Ch. and Soulier, J. P., 1959. Preparation of a human plasma fraction rich in prothrombin, proconvertin, Stuart factor and P.T.C. and a study of its toxicity in rabbits and man. J. Lab. Clin. Med., 53, 322.Google Scholar
Duncan, G. G., Christian, H. A., Stokes, J. Rexer, W. F., Nicolson, J. T. and Edgar, A., 1947. An evaluation of immune serum globulins as a prophylactic agent against homologous serum hepatitis. Am. J. Med. Sci., 213, 53.CrossRefGoogle ScholarPubMed
Ellis, E. F. and Henney, C. S., 1969. Adverse reaction following administration of human gammaglobulin. J. Allergy, 43, 45.CrossRefGoogle Scholar
Finn, R., 1960. Symposium on the role of inheritance in common diseases. Erythroblastosis. Lancet, 1, 526.Google Scholar
Fleetwood, H. G. and Milne, G. R., 1968. The separation of plasma proteins and related sub-stances by multi-membrane electrodecanter. In Protides of Biological Fluids, 15, 545. Amsterdam: Elsevier.Google Scholar
Frame, M. and Mollison, P. L., 1969. Charge differences between human IgG isoantibodies associated with specificity. Immunology, 16, 277.Google ScholarPubMed
Gitlin, D. and Janeway, C. A., 1956. Agammaglobulinemia. Congenital, acquired and transient forms. Prog. Hemat, 1, 318.Google ScholarPubMed
Grossman, E. B., Stewart, S. G. and Stokes, J., 1945. Post-transfusion hepatitis in battle casualties and study of its prophylaxis by means of human immune serum globulin. J. Am. Med. Ass., 129, 991.CrossRefGoogle ScholarPubMed
Henney, C. S. and Ellis, E. F., 1968. Antibody production to aggregated human γ-G-globulin in acquired hypogammaglobulinemia. New Engl. J. Med., 278, 1144.CrossRefGoogle ScholarPubMed
Hink, J. H. Jr., Hidalgo, J., Seeberg, V. P. and Johnson, F. F. 1957. Preparation and properties of a heat-treated human plasma protein fraction. Vox Sang., 2, 174.Google ScholarPubMed
Holland, P. V., Robinson, R. M. Morrow, A. G. and Schmidt, P. J., 1966. Gamma-globulin in the prophylaxis of post-transfusion hepatitis. J. Am. Med. Ass., 196, 471.CrossRefGoogle Scholar
Hoppe, H. H., Krebs, H-J., Mester, Th., and Hennig, W., 1967. Herstellung von Anti-Rh-Gamma-globulin zur Immunisierungs-Prophylaxe. Munch. Med. Wschr., 109, 1749.Google Scholar
James, K., Henney, C. S. and Stanworth, D. R., 1964. Structural changes occurring in 7S γ-globulins. Nature, Lond., 202, 563.CrossRefGoogle ScholarPubMed
Johnson, A. J., Karpatkin, M. H. and Newman, J., 1969. Preparation of and clinical experiences with antihemophilic factor concentrates. Thromb. Diath. Haemorrh., Suppl., 35, 49.Google Scholar
Johnson, A. J., Newman, H., Howell, M. B. and Puszkin, S., 1966. Two large-scale procedures for purification of human antihemophilic factor (A.H.F.). Blood, 28, 1011.Google Scholar
Krijnen, H. W., Brummelhuis, H. G. J. and Beentjes, S. P., 1970. Production of specific antibody concentrates. In Immunoglobulins, p. 332 (Ed. Merler, E.). Washington: Natn. Acad. Sci.Google Scholar
Levine, L. Wyman, L. and Mccomb, J. A., 1967. Tetanus immunoglobulin from selected human plasmas: six years experience with a screening method. J. Am. Med. Ass., 200, 341.CrossRefGoogle ScholarPubMed
Macrae, A. D., Mogford, H. and Reid, D., 1970. Studies of the effect of immunoglobulin on rubella in pregnancy. Br. Med. J., 2, 497.Google Scholar
Medical Research Council, 1969. Hypogammaglobulinaemia in the United Kingdom. Spec. Rep. Ser., 310.Google Scholar
Mirik, G. S., Ward, R. and Mccollum, R. W., 1955. Modification of post-transfusion hepatitis by gamma globulin. New Engl. J. Med. 273, 59.CrossRefGoogle Scholar
Mosley, I. W. and Brachott, D. 1970. Variations in effectiveness of gamma globulin preparations for prophylaxis against infectious hepatitis. In Immunoglobulins, p. 234 (Ed. Merler, E.). Washington: Natn. Acad. Sci.Google Scholar
Oncley, J. L., Melin, M., Richert, D. A., Cameron, J. W. and Gross, P. M. Jr., 1949. The separation of the antibodies, isoagglutinins, prothrombin, plasminogen and β1-lipoprotein into subfractions of human plasma. J. Am. Chem. Soc., 71, 541.CrossRefGoogle ScholarPubMed
Painter, R. H. 1967. Instability of immune serum globulin solutions. Vox Sang., 13, 57.Google ScholarPubMed
Pool, J. G., 1967. Cryoprecipitated Factor VIII concentrate. Thromb. Diathes. Haemorrh., Suppl., 35, 35.Google Scholar
Pool, J. G. and Robinson, J., 1959. Observations on plasma banking and transfusion procedures for haemophilic patients using a quantitative assay for antihaemophilic globulin (A.H.G.). Br. J. Haemat., 5, 24.CrossRefGoogle Scholar
Prince, A. M., 1968. An antigen detected in the blood during the incubation period of serum hepatitis. Proc. Natn. Acad. Sci., U.S.A., 60, 814.CrossRefGoogle ScholarPubMed
Schiff, P., Sutherland, S. K. and Lane, W. R., 1968. The preparation, testing and properties of human gamma globulin for intravenous administration. Aust. Paediat. J., 4, 121.Google Scholar
Schroeder, D. D., and Mozen, M. M., 1970. Australia antigen. Distribution during Cohn ethanol fractionation of human plasma. Science, N.Y., 168, 1462.CrossRefGoogle ScholarPubMed
Schultze, H. E. and Schwick, H. G., 1962. Uber neue Möglichkeiten intravenöser gammaglobulin-applikation.” Dtsch. Med. Wschr., 87, 1643.CrossRefGoogle Scholar
Schwick, H. G., 1970. Pepsindisaggregated gamma globulin. In Immunoglobulins, p. 184 (Ed. Merler, E.) Washington: Natn. Acad. Sci.Google Scholar
Schwick, H. G., 1971. A survey of the production of plasma derivatives for clinical use. Vox Sang., in press.Google Scholar
Schwick, H. G., Fischer, J. and Geiger, H., 1970. Human immunoglobulins A and M for clinical use. In Immunoglobulins, p. 116 (Ed. Merler, E.). Washington: Natn. Acad. Sci.Google Scholar
Sgouris, J., 1971. The current status of plasma fractionation. Vox Sang., in press.Google Scholar
Škvařil, F., 1970. Fragmentation of gamma globulin preparations. In Immunoglobulins, p. 159 (Ed. Merler, E.). Washington: Natn. Acad. Sci.Google ScholarPubMed
Smith, J. K. and Robinson Sarah, M., 1971. Concentrates of human coagulation Factors II, IX and X from Cohn supernatent I.II Congress, Int. Soc. Thrombosis, in press.Google Scholar
Smith, J. K., Watt, J. G., Watson, C. N. and Mastenbroek, G. G. A., 1972. Alternatives to freezedrying for the removal of ethanol from plasma proteins. I. Vacuum distillation of human albumin. Vox Sang., 22, 120.Google ScholarPubMed
Stiehm, E. R. and Fudenberg, H. H., 1965. Antibody to gamma globulin in infants and children exposed to isologous gamma globulin. Pediatrics, Springfield, 35, 229.CrossRefGoogle ScholarPubMed
Stokes, J., Blanchard, M., Neefe, J. R., Gellis, S. S. and Wade, G. R., 1948. Methods of protection against serum hepatitis. J. Am. Med. Ass., 138, 336.CrossRefGoogle ScholarPubMed
Wagner, R. H., 1962. Purification of anti-hemophilic factor (A.H.F.) by precipitation with aliphatic amino acids. Proc. 9th Int. Hemat. Congr. Mexico City.Google Scholar
Watt, J. G., 1970 a. Methods associated with the routine preparation of anti-Rh immunoglobulin. In The Rh Problem, p. 16. Proc. Int. Symp. (Ed. Robertson, J. G. and Dambrosio, F.).Google Scholar
Watt, J. G., 1970 b. Recovery of anti-D antibody from human plasma by forced flow electrophoresis. W.H.O. Conference on Prevention of Rh Immunisation, London.Google Scholar
Watt, J. G., 1971. The automation of plasma fractionation. Vox Sang., in press.Google Scholar