We introduce the totally multiplicatively prime algebras as those normed algebras for which there exists a positive number K such that K‖F‖‖a‖ ≤ ‖WF,a‖ for all F in M(A) (the multiplication algebra of A) and a in A, where WF,a denotes the operator from M(A) into A defined by WF,a(T) = FT(a) for all T in M(A). These algebras are totally prime and their multiplication algebra is ultraprime. We get the stability of the class of totally multiplicatively prime algebras by taking central closure. We prove that prime H*-algebras are totally multiplicatively prime and that the ℓ1-norm is the only classical norm on the free non-associative algebras for which these are totally multiplicatively prime.