We answer a question of Takesaki by showing that the following can be derived from the thesis of Shen: if A and B are σ-unital hereditary C*-subalgebras of C such that ‖p – q‖ < 1, where p and q are the corresponding open projections, then A and B are isomorphic. We give some further elaborations and counterexamples with regard to the σ-unitality hypothesis. We produce a natural one-to-one correspondence between complete order isomorphisms of C*-algebras and invertible left multipliers of imprimitivity bimodules. A corollary of the above two results is that any complete order isomorphism between σ-unital C*-algebras is the composite of an isomorphism with an inner complete order isomorphism. We give a separable counterexample to a question of Akemann and Pedersen; namely, the space of quasi-multipliers is not linearly generated by left and right multipliers. But we show that the space of quasi-multipliers is multiplicatively generated by left and right multipliers in the σ-unital case. In particular, every positive quasi-multiplier is of the form T*T for T a left multiplier. We show that a Lie theory consequence of the negative result just stated is that the map sending T to T*T need not be open, even for very nice C*-algebras. We show that surjective maps between σ-unital C*-algebras induce surjective maps on left, right, and quasi-multipliers. (The more significant similar result for multipliers is Pedersen's non-commutative Tietze extension theorem.) We elaborate the relations of the above with continuous fields of Hilbert spaces and in so doing answer a question of Dixmier and Douady. We discuss the relationship of our results to the theory of perturbations of C*-algebras.