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Asymptotic stability of spatial homogeneity in a haptotaxis model for oncolytic virotherapy

Part of: Equations of mathematical physics and other areas of application Partial differential equations Parabolic equations and systems Physiological, cellular and medical topics

Published online by Cambridge University Press:  08 January 2021

Youshan Tao  and
Michael Winkler
Youshan Tao
Affiliation:
School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai200240, P.R. China ([email protected])
Michael Winkler
Affiliation:
Institut für Mathematik, Universität Paderborn, Paderborn, 33098, Germany ([email protected])
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Abstract

This study considers a model for oncolytic virotherapy, as given by the reaction–diffusion–taxis system

\[\begin{eqnarray*} \left\{ \begin{array}{l} u_t = \Delta u - \nabla (u\nabla v)-\rho uz, \\ v_t = - (u+w)v, \\ w_t = D_w \Delta w - w + uz, \\ z_t = D_z \Delta z - z - uz + \beta w, \end{array} \right. \end{eqnarray*}\]
in a smoothly bounded domain Ω ⊂ ℝ2, with parameters Dw > 0, Dz > 0, β > 0 and ρ ⩾ 0.

Previous analysis has asserted that for all reasonably regular initial data, an associated no-flux type initial-boundary value problem admits a global classical solution, and that this solution is bounded if β < 1, whereas whenever β > 1 and $({1}/{|\Omega |})\int _\Omega u(\cdot ,0) > 1/(\beta -1)$, infinite-time blow-up occurs at least in the particular case when ρ = 0.

In order to provide an appropriate complement to this, the current study reveals that for any ρ ⩾ 0 and arbitrary β > 0, at each prescribed level γ ∈ (0, 1/(β − 1)+) one can identify an L∞-neighbourhood of the homogeneous distribution (u, v, w, z) ≡ (γ, 0, 0, 0) within which all initial data lead to globally bounded solutions that stabilize towards the constant equilibrium (u∞, 0, 0, 0) with some u∞ > 0.

Keywords

Haptotaxisboundednessstabilitycooperative parabolic system

MSC classification

Primary: 35B40: Asymptotic behavior of solutions
Secondary: 35B33: Critical exponents 35K57: Reaction-diffusion equations 35Q92: PDEs in connection with biology and other natural sciences 92C17: Cell movement (chemotaxis, etc.)
Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh Section A: Mathematics , Volume 152 , Issue 1 , February 2022 , pp. 81 - 101
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of The Royal Society of Edinburgh

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