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Why do people get fat: is adipose tissue guilty?

Published online by Cambridge University Press:  28 February 2007

Margaret Ashwell
Margaret Ashwell
Affiliation:
British Nutrition Foundation, 15 Belgrave Square, London SWIX 8PG
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Abstract

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Type
Symposium on ‘The manipulation of adiposity’
Information
Proceedings of the Nutrition Society , Volume 51 , Issue 3 , December 1992 , pp. 353 - 365
Copyright
Copyright © The Nutrition Society 1992

References

REFERENCES

Ashwell, M. (1975). The tendency to fatness. Health Education Journal 34, 81–87.CrossRefGoogle Scholar
Ashwell, M. (1978). The ‘fat cell pool’ concept. International Journal of Obesity 2, 69–72.Google ScholarPubMed
Ashwell, M. (1979). How can research into fat cells and fat distribution help the treatment oi obesity? International Journal of Obesity 3, 188–189.Google Scholar
Ashwell, M. (1985 a). Is there a continuous spectrum of the adipose tissues in animals and man? In Metabolic Complications of Human Obesities, pp. 265–274 [J., Vague, editor]. London: Elsevier Science Publishers.Google Scholar
Ashwell, M. (1985 b). The use of the adipose tissue transplantation technique to demonstrate that abnormalities in adipose tissue metabolism of genetically obese mice are due to extrinsic rather than intrimic factors. International Journal of Obesity 9, Suppl. 1, 77–82.Google ScholarPubMed
Ashwell, M. (1987). Transplantation of white and brown adipose tissue in experimental animals. In Biology of the Adipocyte: Research Approaches, pp. 255–280 [Hausman, G. J. and Martin, R. J., editors] New York: Van Nostrand Reinholdt Co Inc.Google Scholar
Ashwell, M. & Dunnett, S. B. (1985). Fluorescent histochemical demonstration of catecholamines in brown adipose tissue from obese (ob/ob) and lean mice acclimated at different temperatures. Journal of the Autonomic Nervous System 14, 377–386.CrossRefGoogle ScholarPubMed
Ashwell, M., Holt, S., Jennings, G., Stirling, D. M., Trayhurn, P. & York, D. A. (1985). Measurement of radioimmunoassay of the mitochondria1 uncoupling protein from brown adipose tissue of obese (ob/ob) mice and Zucker (fa/fa) rats at different ages. FEBS Letters 179, 233–237.CrossRefGoogle Scholar
Ashwell, M. & Meade, C. J. (1978). Obesity: do fat cells from genetically obese mice (C57B1/6J/ ob/ob) have an innate capacity for increased fat storage? Diabetologia 15, 465–470.CrossRefGoogle Scholar
Ashwell, M. & Meade, C. J. (1979). Adipose tissue in genetically obese rodents. In Animal Models of Obesity, pp. 107–130 [Festing, M. F. W., editor]. London: Macmillan.CrossRefGoogle Scholar
Ashwell, M., Meade, C. J., Medawar, P. B. M. & Sowter, C. (1977). Adipose tissue: contributions of nature and nurture to the obesity of an obese mutant mouse. Proceedings of the Royal Society of London 195B, 343–353.Google Scholar
Ashwell, M., Stirling, D., Freeman, S. & Holloway, B. (1987). Transformations within the continuous spectrum of the adipose tissues. In Recent Advances in Obesity Research, vol. 5, pp. 151–157 [Berry, E. M., Blondheim, S. H, Elliahou, H. E and Shafrir, E., editors]. London: John Libbey.Google Scholar
Ashwell, M.. Wells, C. & Dunnett, S. B. (1986). Brown adipose tissue: contributions of nature and nurture to the obesity of an obese mutant mouse (ob/ob). International Journal of Obesity 10, 355–373.Google Scholar
Barker, D. J. P. (1991). Programming of cardiovascular disease in fetal life and infancy. In Early Diet, Later Consequtwces, pp. 29–37 [Conning, D. M, editor]. London: British Nutrition Foundation.Google Scholar
Bjorntorp, P. (1990). Criteria of obesity. In Progress in Obesity Research 1990, pp. 655–657 [Oomura, Y., Tarui, S., Inone, S. and Shimazu, T., editors]. London: John Libbey.Google Scholar
Bouchard, C. (1990). Variation in human fat: the contribution of the genotype. In Obesity: Towards a Molecular Approach, pp. 17–28 [Bouchard, C., editor]. New York: Alan Liss Inc.Google Scholar
British Nutrition Foundation (1992). Briefing Paper on The Nature and Risks of Obesity. London: British Nutrition Foundation.Google Scholar
Cannon, B., Nedergaard, J., Romert, L., Sundin, U. & Srartergren, J. (1978). Biochemical mechanism of thermogenesis in brown adipose tissues. In Strategies in Cold–Colon Natural Torpidity and Thermogenesb, pp. 567–594 [Wang, L. C and Hudson, J. W, editors]. New York: Academic Press.Google Scholar
Cryer, A., Williams, S. E. & Cryer, J. (1992). Dietary and other factors involved in the proliferation, determination and differentiation of adipocyte precursor cells. Proceedings of the Nutrition Sociey 51, 379–385.CrossRefGoogle ScholarPubMed
Department of Health (1992). The Health of the Nation. London: H.M. Stationery Office.Google Scholar
Enser, M. (1975). Desaturation of stearic acid by liver and adipose tissue from obese-hyperglycaemic mice (ob/ob). Biochemical Journal 148, 551–555.CrossRefGoogle ScholarPubMed
Enser, M. (1979). The role of insulin in the regulation of stearic and desaturase activity in liver and adipose tissue from obese-hyperglycaemic (ob/ob) and lean mice. Biochemical Journal 180, 551–558.CrossRefGoogle ScholarPubMed
Enser, M. & Ashwell, M. (1983). Fatty acid composition of triglycerides from adipose tissue transplanted between obese and lean mice. Lipids 18, 776–780.CrossRefGoogle ScholarPubMed
Hartrampf, R. & Loffler, G. (1992). Culture of mature human adipocytes: evidence for cell division induced by growth factors. Experimental Cell Research (In the Press).Google Scholar
Himms-Hagen, J. (1985). Brown adipose tissue metabolism and thermogenesis. Annual Review of Nutrition 5, 69–94.CrossRefGoogle ScholarPubMed
Hirsch, J. & Batchelor, B. (1976). Adipose tissue cellularity in human obesity. Clinics in Endocrinology and Metabolism 5 (Suppl. II), 299–311.CrossRefGoogle ScholarPubMed
Knight, I. (1983). The Heights and Weights of Adults in Great Britain. London: H.M. Stationery Office.Google Scholar
Lean, M. E. J. (1992). Brown adipose tissue and obesity. In Obesity: Basic Concepts and Clinical Aspects, vol.11. Front Diabetes, pp. 37–49 [Belfiace, F., Jeanrenaud, B. and Papalia, D., editors]. Basel: Karger.Google Scholar
Lean, M. E. J., Branch, W. J., James, W. P. T., Jennings, G. & Ashwell, M. (1983). Measurement of rat brown adipose tissue mitochondria1 uncoupling protein by radioimmunoassay: increased concentration after cold acclimation. Bioscience Reports 3, 61–71.CrossRefGoogle Scholar
Meade, C. J., Ashwell, M. & Sowter, C. (1979). Is genetically transmitted obesity due to an adipose tissue defect? Proceedings of the Royal Society, London 205B, 395–410.Google Scholar
Medawar, P. B. (1979). Advice to a Young Scientist. New York: Harper and Row.Google Scholar
Poskitt, E. M. E. (1991). Early diet, later obesity? In Early Diet, Later Consequences, pp. 38–44 [Conning, D. M, editor]. London: British Nutrition Foundation.Google Scholar
Rath, E. A. & Thenan, S. (1980). Influence of age and genetic background on in vivo fatty acid synthesis in obese (ob/ob) mice. Biochimica et Siophysica Acta 618, 18–27.CrossRefGoogle ScholarPubMed
Roberts, J. C., Ashwell, M. & Enser, M. (1986). Fatty acids of brown adipose tissue of obese and lean mice: effect of transplantation. Biochemical Society Transactions 14, 279.CrossRefGoogle Scholar
Salans, L. B., Cushman, S. W. & Weismann, R. E. (1973). Studies of human adipose tissue. Adipose cell size and number in non-obese and obese patients. Journal of Clinical Investigation 52, 929–941.CrossRefGoogle Scholar
Stunkard, A. J., Harris, J. K., Pedersen, N. C. & McCleam, G. E. (1990). The body mass index of twins who have been reared apart. New England Journal of Medicine 322, 1483–1487.CrossRefGoogle ScholarPubMed
Trayhum, P. (1986). Brown adipose tissue and energy balance. In Brown Adipose Tissue, pp. 299–338 [Trayhurn, P. and Nicholls, D. G, editors]. London: Edward Arnold.Google Scholar
Trayhurn, P. (1990). Energy expenditure and thermogenesis: animal studies on brown adipose tissue. International Journal of Obesity 14, Suppl. 1, 17–29.Google ScholarPubMed
Trayhurn, P. & Ashwell, M. (1987). Control of white and brown adipose tissues by the autonomic nervous system. Proceedings of the Nutrition Society 47, 135–142.CrossRefGoogle Scholar
Vague, J. (1946). Le Traitment des Obesities. Marseille Medicine 83, 210–225.Google Scholar
Widdowson, E. M. & Shaw, W. T. (1973). Full and empty fat cells. Lancet ii, 905.CrossRefGoogle Scholar