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Wholegrain cereals and cancer in Italy

Published online by Cambridge University Press:  05 March 2007

Carlo La Vecchia ,
Liliane Chatenoud ,
Eva Negri  and
Silvia Franceschi
Carlo La Vecchia*
Affiliation:
Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62, 20157, Milan, Italy Istituto di Statistica Medico e Biometria, Universitd degli Studi di Milano, Via Venezian, 1, Milan, Italy
Liliane Chatenoud
Affiliation:
Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62, 20157, Milan, Italy
Eva Negri
Affiliation:
Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62, 20157, Milan, Italy
Silvia Franceschi
Affiliation:
Field and Intervention Studies Unit, International Agency for Research on Cancer, Lyon Cedex, France
*
*Corresponding author:Dr Carlo La Vecchia, fax +39 02 33200231, [email protected]
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Abstract

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The relationship between frequency of consumption of whole-grain foods and cancer risk has been analysed using data from an updated series of case-control studies conducted in Northern Italy between 1983 and 1997. The overall dataset included the following incident histologically-confirmed neoplasms: oral cavity and pharynx 524, oesophagus 410, stomach 745, colon 955, rectum 625, liver 435, gallbladder 65, pancreas 402, larynx 388, soft tissue sarcomas 217, breast 3412, endometrium 750, ovary 971, prostate 127, bladder 431, kidney 190, thyroid 428, Hodgkin's disease 201, non-Hodgkin's lymphomas 529, multiple myelomas 185. Controls were 10 058 patients admitted to hospital for acute non-neoplastic conditions unrelated to long-term modifications in diet, tobacco or alcohol use. The multivariate odds ratios for the highest category of whole-grain cereal consumption were 0.3–0.5 for upper digestive tract and respiratory neoplasms and colon, 0.6 for rectum and liver, 0.4 for gallbladder, 0.8 for pancreas, 0.2 for soft tissue sarcomas, 0.9 for breast and endometrium, 0.7 for ovary, 0.7 for prostate, 0.4 for bladder and kidney, 1.1 for thyroid and about 0.5 for lymphomas and 0.6 for myelomas. In this population whole-grain food consumption is an indicator of reduced risk of several neoplasms.

Keywords

Wholegrain cereal consumptionCancer riskCase-control studiesDietEpidemiologyFibre
Type
Session: Whole cereal grains, fibre and human cancer
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 1 , February 2003 , pp. 45 - 49
Copyright
Copyright © The Nutrition Society 2003

References

Augustin, LSA, Dal, Maso, L, La, Vecchia, C, Parpinel, M, Negri, E, Vaccarella, S, Kendall, CWC, Jenkins, DJA, Franceschi, S (2001) Dietary glycemic index and glycemic load, and breast cancer risk: A case-control study. Annals of Oncology 12, 1533–1538.CrossRefGoogle ScholarPubMed
Bosetti, C, Franceschi, S, Negri, E, Talamini, R, Tomei, F, La Vecchia, C (2001) Changing socioeconomic correlates for cancers of the upper digestive tract. Annals of Oncology 12, 327–330.CrossRefGoogle ScholarPubMed
Breslow, NE, Day, NE (1980) Statistical Methods in Cancer Research, Vol. 1 Lyon, France International Agency for Research on Cancer IARC Scientific Publication no. 32Google Scholar
Chatenoud, L, La Vecchia, C, Franceschi, S, Tavani, A, Jacobs, DR Jr, Parpinel, MT, Soler, M & Negri, E (1999) Refined-cereal intake and risk of selected cancers in Italy. American Journal of Clinical Nutrition 70, 1107–1110.CrossRefGoogle ScholarPubMed
Chatenoud, L, Tavani, A, La Vecchia, C, Jacobs, DR Jr, Negri, E, Levi, F & Franceschi, S (1998) Whole grain food intake and cancer risk. International Journal of Cancer 77, 24–28.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Franceschi, S, Bidoli, E, Negri, E, Zambon, P, Talamini, R, Ruol, A, Parpinel, MT, Levi, F, Simonato, L, La Vecchia, C (2000) Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus. International Journal of Cancer 86, 626–631.Google Scholar
Franceschi, S, Dal, Maso, L, Augustin, L, Negri, E, Parpinel, M, Boyle, P, Jenkins, DJA, La, Vecchia, C (2001) Dietary glycemic load and colo-rectal cancer risk. Annals of Oncology 12, 173–178.Google Scholar
Gallus, S, Bosetti, C, Franceschi, S, Levi, F, Simonato, L, Negri, E, La Vecchia, C (2001) Oesophageal cancer in women: Tobacco, alcohol, nutritional and hormonal factors. British Journal of Cancer 85, 341–345.CrossRefGoogle ScholarPubMed
Giovannucci, E (1995) Insulin and colon cancer. Cancer Causes Control 6, 164–169.CrossRefGoogle ScholarPubMed
Hill, MJ (1997) Cereals, cereal fibre and colo-rectal cancer risk: a review of the epidemiological literature. European Journal of Cancer Prevention 6, 219–225.CrossRefGoogle Scholar
Hu, FB, Rimm, EB, Stampfer, MJ, Ascherio, A, Spiegelman, D, Willett, WC (2000) Prospective study of major dietary patterns and risk of coronary heart disease in men. American Journal of Clinical Nutrition 72, 912–921.CrossRefGoogle ScholarPubMed
Jacobs, DR, Marquart, L, Slavin, J, Kushi, LH (1998) Whole-grain intake and cancer: an expanded review and meta-analysis. Nutrition and Cancer 30, 85–96.CrossRefGoogle ScholarPubMed
Jacobs, DR Jr, Slavin, J, Marquart, L (1995) Whole grain intake and cancer: a review of the literature. Nutrition and Cancer 24, 221–229.CrossRefGoogle Scholar
La Vecchia, C (2001) Diet and human cancer: a review. European Journal of Cancer Prevention 20, 177–181.Google Scholar
La Vecchia, C, Chatenoud, L (1998) Fibres, whole-grain foods and breast and other cancers. European Journal of Cancer Prevention 7, S25–S28 Suppl. 2Google Scholar
La Vecchia, C, Chatenoud, L, Franceschi, S, Soler, M, Parazzini, F, Negri, E (1999) Vegetables and fruit and human cancer: Update of an Italian study. International Journal of Cancer 82, 151–152.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
La Vecchia, C, Negri, E, D'Avanzo, B, Franceschi, S, Decarli, A & Boyle, P (1990) Dietary indicators of laryngeal cancer risk. Cancer Research 50, 4497–4500.Google ScholarPubMed
La Vecchia, C, Negri, E, Decarli, A, D'Avanzo, B & Franceschi, S (1987) A case-control study of diet and gastric cancer in Northern Italy. International Journal of Cancer 40, 484–489.Google Scholar
Levi, F, Pasche, C, Lucchini, F, Chatenoud, L, Jacobs, DR, Jr, La, Vecchia, C (2000) Refined and whole grain cereals and the risk of oral, oesophageal and laryngeal cancer. European Journal of Clinical Nutrition 54, 487–489.Google Scholar
Liu, S, Stampfer, MJ, Hu, FB, Giovannucci, E, Rimm, E, Manson, JE, Hennekens, CH, Willett, WC (1999) Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study. American Journal of Clinical Nutrition 70, 412–19.Google Scholar
Negri, E, Franceschi, S, Bosetti, C, Levi, F, Conti, E, Parpinel, M, La Vecchia, C (2000) Selected micronutrients and oral and pharyngeal cancer. International Journal of Cancer 86, 122–127.3.0.CO;2-2>CrossRefGoogle ScholarPubMed
Negri, E, Franceschi, S, Parpinel, M, La Vecchia, C (1998) Fiber intake and risk of colorectal cancer. Cancer Epidemiology, Biomarkers and Prevention 7, 667–671.Google Scholar
Peters, RK, Garabrant, DH, Yu, MC, Mack, TM (1989) A case-control study of occupational and dietary factors in colo-rectal cancer in young men by subsite. Cancer Research 49, 5459–5468.Google Scholar
Potter, JD, Steinmetz, K (1996) Vegetables, fruit and phyto-estrogens as preventive agents. In Principles of Chemo-prevention. IARC Scientific Publication, no. 139 pp.61–90[Stewart, BW, Mcgregor, D, Kleihues, O, editors]. Lyon: International Agency for Research on Cancer.Google Scholar
Slattery, ML, Potter, JD, Coates, A, Ma, K-N, Berry, TD, Duncan, DM, Caan, BJ (1997) Plant foods and colon cancer: an assessment of specific foods and their related nutrients (United States). Cancer Causes and Control 8, 575–590.CrossRefGoogle ScholarPubMed
Slavin, JL, Martini, MC, Jacobs, DR, Marquart, L (1999) Plausible mechanisms for the protectiveness of whole grains. American Journal of Clinical Nutrition 70, 4598–638.CrossRefGoogle ScholarPubMed
Trichopoulos, D, Ouranos, G, Day, NE, Tzonou, A, Manousos, O, Papadimitriou, Ch, Trichopoulos, A (1985) Diet and cancer of the stomach: a case-control study in Greece. International Journal of Cancer 36, 291–297.CrossRefGoogle ScholarPubMed
Truswell, AS (2002) Cereal grains and coronary heart disease. European Journal of Clinical Nutrition 56, 1–14.Google Scholar
Tuyns, AJ, Kaaks, R, Haelterman, M (1988) Colorectal cancer and the consumption of foods: a case-control study in Belgium. Nutrition and Cancer 11, 189–204.Google Scholar
Yu, H, Rohan, H (2000) Role of insulin-like growth factor family in cancer development and progression. Journal of the National Cancer Institute 92, 1472–1489.CrossRefGoogle ScholarPubMed