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Tocopherol transport and absorption

Published online by Cambridge University Press:  28 February 2007

William Cohn
Affiliation:
Departments of Vitamin and Nutrition Research
Peter Gross
Affiliation:
Departments of Vitamin and Nutrition Research
Hugo Grun
Affiliation:
Departments of Vitamin and Nutrition Research
Francine Loechleiter
Affiliation:
Departments of Vitamin and Nutrition Research
David P. R. Muller
Affiliation:
Departments of Institute of Child Health, London WC1
Martin Zulauf
Affiliation:
Departments of Pharmaceutical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basle, Switzerland
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Abstract

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Type
Symposium on ‘Micronutrient transport processes’
Copyright
Copyright © The Nutrition Society 1992

References

Aviram, M., Bierman, E. L. & Oram, J. F. (1989). High density lipoprotein stimulates sterol translocation between intracellular and plasma membrane pools in human monocyte-derived macrophages. Journal of Lipid Research 30, 6576.CrossRefGoogle ScholarPubMed
Behrens, W. A. & Madere, R. (1982). Transfer of a-tocopherol to microsomes mediated by a partially purified liver a-tocopherol binding protein. Nutrztion Research 2, 611618.CrossRefGoogle Scholar
Behrens, W. A., Thompson, J. N. & Madere, R. (1982). Distribution of a-tocopherol in human plasma lipoproteins. American Journal of Clinical Nutrition 35, 691696.CrossRefGoogle Scholar
Bennett, M. & Medwadowski, B. (1967). Vitamin A, vitamin E and lipids in serum of children with cystic fibrosis or congenital heart defects compared with normal children. American Jozcrnal of Clinical Nutrition 20, 415421.CrossRefGoogle ScholarPubMed
Bjorneboe, A., Bjorneboe, G. E. A., Bodd, E., Hagen, B. F., Kveseth, N. & Drevon, C. A. (1986). Transport and distribution of a-tocopherol in lymph, serum and liver cells in rats. Biochimica et Biophysica Acta 889, 310315.CrossRefGoogle Scholar
Bjorneboe, A., Bjorneboe, G. E. A., Hagen, B. F., Nossen, J. O. & Drevon, C. A. (1987). Secretion of a-tocopherol from cultured rat hepatocytes. Biochimica et Biophysica Acra 922, 199205.CrossRefGoogle Scholar
Bjornson, L. K., Kayden, H. J., Miller, E. & Moshell, A. N. (1976). The transport of a-tocopherol and β-carotene in human blood. Journal of Lipid Research 17, 343352.Google Scholar
Carey, M. C. & Small, D. M. (1970). The characteristics of mixed micellar solutions with particular reference to bile. American Journal of Medicine 49, 590608.CrossRefGoogle ScholarPubMed
Carey, M. C. & Small, D. M. (1978). The physical chemistry of cholesterol solubility in bile. Journal of Clinical Investigation 61, 9981026.Google Scholar
Catignani, G. L. & Bieri, J. G. (1977). Rat liver a-tocopherol binding protein. Biochimica et Biophysica Acta 497, 349357.CrossRefGoogle Scholar
Cohn, W., Goss-Sampson, M. A., Grun, H. & Muller, D. P. R. (1992). Plasma clearance and net uptake of α-tocopherol and low density lipoprotein by tissues in WHHL and control rabbits. Biochemical Journal (In the Press).CrossRefGoogle ScholarPubMed
Cohn, W. & Kuhn, H. (1989). The role of the low density lipoprotein receptor for α-tocopherol delivery to tissues. Annals of the New York Academy of Sciences 570, 6171.CrossRefGoogle ScholarPubMed
Cohn, W., Loechleiter, F. & Weber, F. (1988). α-Tocopherol is secreted from rat liver in very low density lipoproteins. Journal of Lipid Research 29, 13591366.CrossRefGoogle ScholarPubMed
Davies, T., Kelleher, J. & Losowsky, M. (1969). Interrelation of serum lipoprotein and tocopherol levels. Clinica Chimica Acta 24, 431436.Google Scholar
Esterbauer, H., Jurgens, G., Quehenberger, O. & Koller, E. (1987). Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. Journal of Lipid Research 28, 495509.Google Scholar
Farrell, P. (1980). Deficiency states, pharmacological effects, and nutrient requirements. In Vitamin E: A Comprehensive Treatise, pp. 520620 [Machlin, L. J., editor]. New York: Marcel Dekker Inc.Google Scholar
Gallo-Torres, H. (1970). Obligatory role of bile for the intestinal absorption of vitamin E. Lipids 5, 379384.CrossRefGoogle ScholarPubMed
Gallo-Torres, H. E. (1980). Absorption. In Vitamin E: A Comprehensive Treatise, pp. 170192 [Machlin, L. J., editor]. New York: Marcel Dekker Inc.Google Scholar
Gallo-Torres, H. E. & Miller, O. N. (1969). A modified Bollman's technique for cannulation of the rat's thoracic duct: Lymph flow standardization. Proceedings of the Society for Experimental Biology and Medicine 130, 552555.CrossRefGoogle ScholarPubMed
Gotto, A. M., Pownall, H. J. &; Havel, R. J. (1986). Introduction to the plasma lipoproteins. In Methods in Enzymology, vol. 128, pp. 341 [J., Segrest and J., Albers, editors]. Orlando: Academic Press Inc.Google Scholar
Granot, E., Tamir, I. & Deckelbaum, R. J. (1988). Neutral lipid transfer protein does not regulate α-tocopherol transfer between human plasma lipoproteins. Lipids 23, 1721.CrossRefGoogle Scholar
Harries, J. T. & Muller, D. P. R. (1971 a). Absorption of vitamin E in children with biliary obstruction. Gut 12, 579584.CrossRefGoogle ScholarPubMed
Harries, J. T. & Muller, D. P. R. (1971 b). Absorption of different doses of fat soluble and water miscible preparations of vitamin E in children with cystic fibrosis. Archives of Disease in Childhood 46, 341344.CrossRefGoogle ScholarPubMed
Havel, R. J. (1987). Origin, metabolic fate, and function of plasma lipoproteins. In Hypercholesterolemia and Atherosclerosis, Pathogenesis and Prevention, pp. 117141 [D., Steinberg and Olefsky, J. M., editors]. New York: Churchill Livingston.Google Scholar
Hollander, D. & Dadufalza, V. (1989). Lymphatic and portal absorption of vitamin E in aging rats. Digestive Diseases and Sciences 34, 768772.Google Scholar
Hollander, D., Rim, E. & Muralidhara, K. S. (1975). Mechanism and site of small intestinal absorption of α-tocopherol in the rat. Gastroenterology 68, 14921499.CrossRefGoogle ScholarPubMed
Holt, P. R. & Dominguez, A. A. (1980). Triton-induced hyperlipidemia: a model for studies of intestinal lipoprotein production. American Journal of Physiology 238, G453G457.Google Scholar
Horwitt, M. K., Harvey, C. C., Dahrn, D. H. & Searcy, M. T. (1972). Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy. Annals of the New York Academy of Sciences 203, 223236.CrossRefGoogle ScholarPubMed
MacMahon, M. T., Neale, G. & Thompson, G. R. (1971). Lymphatic and portal venous transport of α-tocopherol and cholesterol. European Journal of Clinical Investigation 1, 288294.CrossRefGoogle ScholarPubMed
MacMahon, M. T. & Thompson, G. R. (1970). Comparison of the absorption of a polar lipid, oleic acid and a non-polar lipid, α-tocopherol from mixed micellar solutions and emulsions. European Journal of Clinical Investigation 1, 161166.CrossRefGoogle Scholar
Mahley, R. W. (1988). Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240, 622–430.CrossRefGoogle ScholarPubMed
Massey, J. B. (1984). Kinetics of transfer of a-tocopherol between model and native plasma lipoproteins. Biochimica et Biophysica Acta 793, 387392.CrossRefGoogle Scholar
Muller, D. P. R., Manning, J. A., Mathias, P. M. & Harries, J. T. (1976). Studies on the hydrolysis of tocopheryl esters. International Journal for Vitamin and Nutrition Research 46, 207210.Google ScholarPubMed
Muralidhara, K. S. & Hollander, D. (1977). Intestinal absorption of α-tocopherol in the unanaesthetized rat. The influence of luminal constituents on the absorptive process. Journal of Laboratory and Clinical Medicine 90, 8591.Google Scholar
Nelsson-Ehle, P., Garfinkel, A. S. & Schotz, M. C. (1980). Lipolytic enzymes and plasma lipoprotein metabolism. Annual Review of Biochemistry 49, 667693.Google Scholar
Oram, J. F., Brinton, E. A. & Bierman, E. L. (1983). Regulation of high density lipoprotein receptor activity in cultured human skin fibroblasts and human arterial smooth muscle cells. Journal of Clinical Investigation 72, 16111621.CrossRefGoogle ScholarPubMed
Otway, S. & Robinson, D. S. (1967 a). The effect of a non-ionic detergent (Triton WR-1339) on the removal of triglyceride fatty acids from the blood of the rat. Journal of Physiology 190, 309319.Google Scholar
Otway, S. & Robinson, D. S. (1967 b). The use of a non-ionic detergent (Triton WR-1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions. Journal of Physiology 190, 321332.CrossRefGoogle ScholarPubMed
Pearson, C. K., & Legge, A. M. (1972). Uptake of vitamin E by rat small intestinal slices. Biochimica et Biophysica Acta 288, 404412.Google Scholar
Risser, T. R., Reaven, G. M. & Reaven, E. P. (1978). Intestinal contribution to secretion of very low density lipoproteins into plasma. American Journal of Physiology 234, E277E281.Google Scholar
Sokol, R. J., Heubi, J. E., Butler-Simon, N., McClung, H. J., Lilly, J. R. & Silverman, A. (1987). Treatment of vitamin E deficiency during chronic childhood cholestasis with oral D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS). I. Intestinal absorption, efficacy and safety. Gastroenterology 93, 975985.CrossRefGoogle Scholar
Stead, R. J., Muller, D. P. R., Matthews, S., Hodson, M. E. & Batten, J. C. (1986). Effect of abnormal liver function on vitamin E status and supplementation in adults with cystic fibrosis. Gut 27, 714718.CrossRefGoogle ScholarPubMed
Thellman, C. A. & Shireman, R. B. (1985). In vitro uptake of [3H]-α-tocopherol from low density lipoprotein by cultured human fibroblasts. Journal of Nutrition 115, 16731679.Google Scholar
Thomson, B. R. & Dietschy, J. M. (1981). Intestinal lipid absorption: major extracellular and intracellular events. Physiology of the Gastrointestinal Tract 2, 11471220.Google Scholar
Tozuka, M. & Fidge, N. (1989). Purification and characterization of two high density lipoprotein binding proteins from rat and human liver. Biochemical Journal 261, 239244.CrossRefGoogle ScholarPubMed
Traber, M. G., Burton, G. W., Ingold, K. U. & Kayden, H. J. (1990 a). RRR- and SRR-a-tocopherols are secreted without discrimination in human chylomicrons, but RRR-a-tocopherol is preferentially secreted in very low density lipoproteins. Journal of Lipid Research 31, 675–485.Google Scholar
Traber, M. G., Goldberg, I., Davidson, E., Lagmay, N. & Kayden, H. J. (1990 b). Vitamin E uptake by human intestinal cells during lipolysis in vitro. Gastroenterology 98, 96103.Google Scholar
Traber, M. G. & Kayden, H. J. (1984). Vitamin E is delivered to cells via the high affinity receptor for low density lipoprotein. American Journal of Clinical Nutrition 40, 747751.CrossRefGoogle ScholarPubMed
Traber, M. G., Kayden, H. J., Green, J. B. & Green, M. H. (1986). Absorption of water-miscible forms of vitamin E in a patient with cholestasis and in rats. American Journal of Clinical Nutrition 44, 914923.Google Scholar
Traber, M. G., Olivecrona, T. & Kayden, H. J. (1985). Bovine milk lipoprotein lipase transfers tocopherol to human fibroblasts during triglyceride hydrolysis in vitro. Journal of Clinical Investigation 75, 17291734.Google Scholar
Traber, M. G., Rudel, L. L., Burton, G. W., Hughes, L., Ingold, K. U. & Kayden, H. J. (1990 c). Nascent VLDL from liver perfusions of cynomolgus monkeys are preferentially enriched in RRR- compared with SRR-α-tocopherol. Studies using deuterated tocopherols. Journal of Lipid Research 31, 687694.CrossRefGoogle ScholarPubMed
Traber, M. G., Sokol, R. J., Burton, G. W., Ingold, K. U., Papas, A. M., Huffaker, J. E. & Kayden, H. J. (1990 d). Impaired ability of patients with familial isolated vitamin E deficiency to incorporate α-tocopherol into lipoproteins secreted by the liver. Journal of Clinical Investigation 85, 397407.Google Scholar
Traber, M. G., Thellman, C. A., Rindler, M. J. & Kayden, H. J. (1988). Uptake of intact TPGS (D-a-tocopheryl polyethylene glycol 1000 succinate) a water-miscible form of vitamin E by human cells in vitro. American Journal of Clinical Nutrition 48. 605–411.CrossRefGoogle Scholar
Weisgraber, K. H., Innerarity, T. L. & Mahley, R. W. (1978). Role of lysine residues of lipoproteins in high affinity binding to cell surface receptors on human fibroblasts. Journal of Biological Chernistry 253, 90539062.Google Scholar
Yamamoto, T., Bishop, R. W., Brown, M. S., Goldstein, J. L. & Russel, D. W. (1986). Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science 232, 12301237Google Scholar