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Symposium on ‘Nutrition and health in children and adolescents’ Session 4: Obesity prevention in children and adolescents The effect of physical activity on body fatness in children and adolescents

A meeting of the Nutrition Society hosted by the Irish Section was held on 14–16 June 2006 at University College Cork, Cork, Republic of Ireland

Published online by Cambridge University Press:  21 March 2007

Kirsten L. Rennie ,
Jonathan C. K. Wells ,
Tracy A. McCaffrey  and
M. Barbara E. Livingstone
Kirsten L. Rennie*
Affiliation:
Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, ColeraineBT52 1SA, UK
Jonathan C. K. Wells
Affiliation:
MRC Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, LondonWC1N 1EH, UK
Tracy A. McCaffrey
Affiliation:
Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, ColeraineBT52 1SA, UK
M. Barbara E. Livingstone
Affiliation:
Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, ColeraineBT52 1SA, UK
*
*Corresponding author: Dr Kirsten Rennie, present address Unilever Corporate Research, Colworth House, Sharnbrook, BedfordshireMK46 4AA, UK, fax +44 1234 222161, email [email protected]
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Abstract

With the increasing prevalence of childhood obesity, there is an urgent need to identify risk factors that are amenable to preventative action. However, there is a remarkable lack of consistency between studies that have investigated the relationships between measurements of physical activity and energy expenditure and body fatness in children. This disparity could be because energy intake is a more important determinant in preventing obesity. Alternatively, some of the conflicting results could be related to methodological limitations in assessing activity and body composition. Erroneous conclusions may be drawn if physical activity energy expenditure is not adjusted for differences in body composition, or body fat is not appropriately adjusted for body size. For public health purposes it may be more informative to evaluate the amount and intensity of physical activity required to prevent fat-mass gain than to assess energy expended in physical activity. The lack of consensus in the cut-off points applied to define intensity levels is severely hindering comparisons between studies using accelerometers that have examined relationships between activity intensity and body fatness. Thus, it is not currently possible to develop a firm evidence base on which to establish physical activity recommendations until the limitations are addressed and more prospective studies undertaken. In order to turn research into effective prevention strategies a clearer understanding of the psycho-social, behavioural and environmental factors that influence activity is needed, including the interactions between physical activity and other behaviours such as time spent sedentary, sleeping and eating.

Keywords

Childhood obesityPhysical activityEnergy expenditureBody fatness
Type
Research Article
Information
Proceedings of the Nutrition Society , Volume 65 , Issue 4 , November 2006 , pp. 393 - 402
Copyright
Copyright © The Nutrition Society 2006

Abbreviations:
AEE

activity energy expenditure

DLW

doubly-labelled water

FFM

fat-free mass

HR

heart rate

HRM

HR monitoring

PAL

physical activity level

TEE

total energy expenditure

The prevalence of childhood obesity continues to rise (Lobstein et al. Reference Lobstein, Baur and Uauy2004) and there is an urgent need to identify risk factors that are amenable to intervention and preventative action. Over the medium to long term, at least, it is clear that to prevent excessive positive energy balance over and above the needs for growth, and thus excess fat-mass gain, energy intake must equal total energy expenditure (TEE). On the TEE side of the energy balance equation, physical activity is the most variable and amenable component for intervention efforts.

At present there is no compelling empirical evidence on which to base physical activity recommendations in children and adolescents in order to prevent excess weight gain. From the limited information available for children, combined with extrapolation of evidence for adults, the current general consensus is that children should undertake at least 60 min of at least moderate-intensity activity each day for general health (Department of Health, 2004). There are no objective historical data on levels of physical activity from which to compare past and present activity in children and adolescents, and thus pinpoint changes in the type and amount of activity that may be contributing to the rise in the prevalence of overweight at a population level. The evidence that children and adolescents are becoming less active has principally been based on circumstantial evidence, such as increases in the number of televisions in a household, reduced time in schools spent in physical education and increasing car use, particularly getting to and from school (Fox, Reference Fox2003).

Undoubtedly, a major constraint has been the difficulty in measuring such a complex and multi-dimensional behaviour as physical activity. Physical activity is defined as ‘any bodily movement produced by the contraction of skeletal muscles resulting in caloric expenditure’ (Caspersen et al. Reference Caspersen, Powell and Christenson1985) and therefore incorporates all daily activities. In children movement is often more sporadic and multi-dimensional, and daily activity patterns are commonly more varied than in adults. This factor, together with children's cognitive limitations on recalling their activities and evaluating time spent in such activities, means that it is virtually impossible to obtain valid self-reports of daily activity in younger age-groups (Livingstone et al. Reference Livingstone, Robson, Wallace and McKinley2003). Subjective observation of activities may be viable in infants and very young children (Puhl et al. Reference Puhl, Greaves, Baranowski, Gruben and Seale1990; Li et al. Reference Li, O'Connor, Buckley and Specker1995), but feasibility is limited. Overall, doubly-labelled water (DLW), heart-rate (HR) monitoring (HRM) and accelerometry are more feasible and are objective measurements of physical activity and/or energy expenditure for use in children and adolescents (Livingstone et al. Reference Livingstone, Robson, Wallace and McKinley2003).

Physical activity energy expenditure and body fatness

In the last two decades the DLW method has been invaluable in providing the first objective and valid measure of TEE in children and adolescents. The method is based on measuring the disappearance of two naturally-occurring stable isotopes (2H and 18O) from the body and calculating CO2 production, and thus deriving a measure of TEE (Coward & Prentice, Reference Coward and Prentice1985). Despite the expense and technical complexity of the method, its major advantage is the relatively low participant burden and the opportunity to assess TEE continuously over periods of 7–10 d in which the disappearance of the isotopes is measured from urine samples. However, the DLW method provides only an integral (average) measure of TEE and not a day-by-day measure of TEE. Also, it does not give a direct measure of energy expended in physical activity or information on the forms, frequency or intensity of physical activity undertaken. Additionally, measures of physical activity energy expenditure are derived on the basis of information known, or estimated from the other components of TEE. The two measures that are most commonly calculated are activity energy expenditure (AEE; TEE−(RMR+thermogenesis)) and physical activity level (PAL; TEE/RMR).

Intuitively, the energy expended in physical activity is pivotal in reducing the risk of excess fat-mass gain, but surprisingly there is a remarkable lack of consistency between studies that have assessed relationships between measurements of physical activity energy expenditure and body fatness. Thus, while some cross-sectional studies have reported an inverse association between measures of energy expended in physical activity (PAL and AEE) and measures of body fatness (Davies et al. Reference Davies, Gregory and White1995; Ball et al. Reference Ball, O'Connor, Abbott, Steinbeck, Davies, Wishart, Gaskin and Baur2001; DeLany et al. Reference DeLany, Bray, Harsha and Volaufova2002; Ekelund et al. Reference Ekelund, Aman, Yngve, Renman, Westerterp and Sjostrom2002; Tennefors et al. Reference Tennefors, Coward, Hernell, Wright and Forsum2003; Abbott & Davies, Reference Abbott and Davies2004; Rennie et al. Reference Rennie, Livingstone, Wells, McGloin, Coward, Prentice and Jebb2005b), just as many have observed a null association (Bandini et al. Reference Bandini, Schoeller and Dietz1990; DeLany et al. Reference DeLany, Harsha, Kime, Kumler, Melancon and Bray1995, Reference DeLany, Bray, Harsha and Volaufova2004; Goran et al. Reference Goran, Carpenter, McGloin, Johnson, Hardin and Weinsier1995, Reference Goran, Hunter, Nagy and Johnson1997; Maffeis et al. Reference Maffeis, Pinelli, Zaffanello, Schena, Iacumin and Schutz1995, Reference Maffeis, Zaffanello, Pinelli and Schutz1996; Salbe et al. Reference Salbe, Fontvieille, Harper and Ravussin1997; Treuth et al. Reference Treuth, Figueroa-Colon, Hunter, Weinsier, Butte and Goran1998). In the limited number of prospective studies assessing the same issue, the majority have reported null associations (Goran et al. Reference Goran, Shewchuk, Gower, Nagy, Carpenter and Johnson1998; Wells & Ritz, Reference Wells and Ritz2001; Treuth et al. Reference Treuth, Butte and Sorkin2003; Bandini et al. Reference Bandini, Must, Phillips, Naumova and Dietz2004), with only one study observing an inverse relationship (Salbe et al. Reference Salbe, Weyer, Harper, Lindsay, Ravussin and Tataranni2002). However, in this latter study the energy expended in physical activity explained only 1–5% of the variance observed in body fatness.

On the one hand, the lack of consistent cross-sectional and prospective associations between DLW-derived measures of physical activity energy expenditure and measures of body fatness could be, and has been, interpreted as evidence that energy intake is a more critical determinant of excess fat-mass gain. On the other hand, the inconsistency of study results could be explained by the way in which the data have commonly been analysed.

AEE tends to be expressed in analyses in absolute terms (kJ/d) and as such is highly related to the body weight of the subject, in particular the level of fat-free mass (FFM), as illustrated in Fig. 1. The assumption underlying the use of PAL is that by adjusting for RMR and expressing the data as a ratio the potential influence of body weight and composition is removed, thus allowing comparisons of the relative energy cost of physical activities between individuals and populations. Although this assumption may be valid for sedentary or low-intensity activities, PAL is not necessarily independent of body weight or FFM (Spadano et al. Reference Spadano, Must, Bandini, Dallal and Dietz2003, Reference Spadano, Bandini, Must, Dallal and Dietz2005), particularly in weight-bearing activities of moderate–vigorous intensity, such as walking and running. In such instances a heavier individual may have a higher PAL as a result of their larger weight (Spadano et al. Reference Spadano, Must, Bandini, Dallal and Dietz2003). Thus, if a child spends the majority of the time in low-intensity activity, the effect of body size may be less than if more weight-bearing moderate–vigorous activities are undertaken. Thus, it is hardly surprising that comparisons of PAL between lean and obese children have shown very inconsistent results, with many reporting no difference between the two groups (Maffeis et al. Reference Maffeis, Zaffanello, Pinelli and Schutz1996; Treuth et al. Reference Treuth, Figueroa-Colon, Hunter, Weinsier, Butte and Goran1998; DeLany et al. Reference DeLany, Bray, Harsha and Volaufova2004).

Fig. 1. Association between fat-free mass index (fat-free mass:height2; kg/m2) and log-transformed activity energy expenditure (AEE) adjusted for gender (in 100 subjects). B coefficient 1·72 (se 0·34); P<0·001.

Measuring body fatness in children, particularly comparing adiposity levels between children, is also fraught with difficulty given the differences in the stage of maturation. From a young age, before the onset of puberty, gender differences are present (Taylor et al. Reference Taylor, Gold, Manning and Goulding1997; Wells et al. Reference Wells, Fuller, Dewit, Fewtrell, Elia and Cole1999). As well as the issue of measurement error (Wells et al. Reference Wells, Fuller, Dewit, Fewtrell, Elia and Cole1999), there is also the problem of how to appropriately adjust for body size. The most common expression of body fatness used when evaluating data from DLW studies has been relative (percentage) body fat (fat mass/body weight). The rationale for dividing fat mass by body weight has been to normalise body fatness for body size. However, the conceptual difficulty of this approach has recently been highlighted (Wells et al. Reference Wells and Cole2002a; Wells & Victora, Reference Wells and Victora2005). Similar to PAL, when body fatness is expressed relative to weight, it remains highly correlated with body weight. Consequently, comparing the body fatness of individuals remains highly influenced by their body weight, and thus by their FFM. It may be more appropriate to adjust for body size by height, either as an index (fat mass/height2; Van Itallie et al. Reference Van Itallie, Yang, Heymsfield, Funk and Boileau1990) or raise height to an appropriate power to remove the effect of height (Wells et al. Reference Wells and Cole2002a).

Table 1 illustrates three hypothetical 7-year-old children and the problem in interpreting the differences in body composition between them. First, comparing genders, child A (boy), although identical in weight and height to child C (girl), has 50% more body fat in absolute terms (kg). Expressing body fat as a percentage underestimates the gender differences in body fatness (15% v. 23%) in contrast to evaluating body fatness by the fat mass index (50% higher in child C). A similar scenario occurs in relation to FFM. For the same body weight boys have a higher FFM than girls (Wells, Reference Wells2000) and therefore higher TEE in absolute terms (kJ/d; Torun et al. Reference Torun, Davies, Livingstone, Paolisso, Sackett and Spurr1996). Since the effect of FFM is not removed from the derived measures of AEE and PAL, boys will tend to have higher AEE and PAL than girls. Thus, it is inevitable that associations would be biased towards the null, given the underestimation of gender differences in body fat by using percentage body fat and the overestimation of gender differences in energy expended in physical activity. There are also implications for analyses in which data from boys and girls are combined without taking into account differences in body composition.

Table 1. Comparison of body composition measurements from three hypothetical 7-year-old children

The same issues are observed when comparing lean and overweight children. In Table 1 child B is heavier and taller and has 255% more body fat in absolute terms (kg) than child A, who is leaner. Similar to evaluating gender differences, using percentage body fat rather than the fat mass index will also underestimate the differences in body fat between the lean and obese child. The difference in interpretation is even more pronounced in the FFM measures. In evaluating the difference between child A and B percentage FFM would erroneously suggest that child A has more FFM, but the opposite conclusion is reached when adjusted body size for height in the FFM index is used. In fact, for a given body weight obese children tend to have more FFM than non-obese children (Wells et al. Reference Wells, Fewtrell, Williams, Haroun, Lawson and Cole2006), resulting in higher TEE in absolute terms (kJ/d). Thus, obese children and adolescents have higher AEE and often PAL than non-obese children. When studies evaluate associations between AEE or PAL and percentage body fat the differences between energy expended in physical activity are likely to be overestimated between leaner and fatter children and the differences in body fatness underestimated, resulting again in associations being biased towards the null. These inaccuracies may partially explain why so many studies have concluded that there were no associations between energy expended in physical activity and body fatness.

As shown in Fig. 2, this imprecision could lead to entirely different conclusions being drawn from the same dataset, depending on whether adjustment is made for differences in body composition in DLW-derived energy expenditure measures. Fig. 2(a) shows a significant positive association (P=0·01), with greater amounts of time spent being inactive or at low-intensity activity being associated with higher energy expended in physical activity. However, when this energy expenditure is normalised for FFM (Fig. 2(b)), the association is no longer apparent.

Fig. 2. (a) Activity energy expenditure (AEE) calculated from doubly-labelled water and time spent in low-intensity activity measured by heart-rate monitoring in 100 prepubertal boys (●) and girls (□; r 0·32, P=0·01) and (b) AEE adjusted for fat-free mass (kg; r 0·09, NS). AEE was normalised for fat-free mass (AEE/fat-free mass1·3; Rennie et al. Reference Rennie, Livingstone, Wells, McGloin, Coward, Prentice and Jebb2005b).

Heavier children generally have higher TEE, RMR and AEE compared with their lighter counterparts (DeLany, Reference DeLany1998; Ekelund et al. Reference Ekelund, Aman, Yngve, Renman, Westerterp and Sjostrom2002). However, when normalised for body composition, these differences in energy expenditure are removed (Treuth et al. Reference Treuth, Figueroa-Colon, Hunter, Weinsier, Butte and Goran1998; Ekelund et al. Reference Ekelund, Aman, Yngve, Renman, Westerterp and Sjostrom2002; DeLany et al. Reference DeLany, Bray, Harsha and Volaufova2004). It has frequently been concluded that the similar AEE between obese and non-obese children after adjustment for body composition reflects the lower energy efficiency in movement and/or the higher energy cost of moving a larger body mass in obese children, which results in higher overall energy expenditure in the obese children despite possibly lower physical activity (Ekelund et al. Reference Ekelund, Aman, Yngve, Renman, Westerterp and Sjostrom2002; Spadano et al. Reference Spadano, Must, Bandini, Dallal and Dietz2003). However, adjustment for body size and/or body composition is not as straightforward as it first appears. The association with AEE is not consistent but dependent on the amount of weight-bearing and non-weight-bearing activities a child undertakes. The different approaches that attempt to deal with these issues and appropriately adjust for body size in children have been described elsewhere (Lazzer et al. Reference Lazzer, Boirie, Bitar, Montaurier, Vernet, Meyer and Vermorel2003; Ekelund et al. Reference Ekelund, Yngve, Brage, Westerterp and Sjostrom2004b).

Measuring energy expended in physical activity is very informative if the purpose is to determine how much energy intake is required to keep individuals in energy balance. However, if the aim is to identify how much physical activity is necessary to prevent obesity, it is considerably more complicated. Measures of physical activity energy expenditure are not easy to interpret. Even if they can be appropriately adjusted for body composition, comparisons between populations are difficult. The level of accuracy required to determine energy imbalance that may ultimately lead to excess fat-mass gain is unattainable from the measurement instruments currently employed for both intake and expenditure and with the level of variability in both intake and expenditure from day-to-day. It is also important to note that energy expended in activity is not the same as the amount of physical activity required to prevent excess fat-mass gain. Thus, other measurement instruments are required to examine physical activity per se.

Physical activity and body fatness

Advances in technology in recent decades have resulted in objective user-friendly instruments for the measurement of physical activity that are feasible for use in studies of childhood obesity. Techniques such as HRM and accelerometry provide minute-by-minute data, making it possible to obtain not only information on the total levels of physical activity, but also the patterning of daily activity, including intensity, duration and frequency. This additional information is central to determining what aspects of physical activity in children may be important in preventing excess fat gain and for making public health recommendations.

Heart-rate monitoring

HRM has been widely used as a proxy measure of physical activity, with minute-by-minute HR data providing information on the patterning of activity or TEE. There is considerable inter-individual variability in resting HR, and HR response to activity is influenced, for example, by body weight, age and fitness level, and therefore a calibration is required to determine an individual's HR at rest and under exertion. Similarly, because of the individualised nature of the relationship between HR and {\rm V}_{{\rm O}_{\setnum{2}}}, derivation of an estimate of TEE also requires an individualised calibration (Spurr et al. Reference Spurr, Prentice, Murgatroyd, Goldberg, Reina and Christman1988). Above an empirically-derived flex HR (which distinguishes between resting and activity HR) and below maximal HR there is a good positive correlation between HR and energy expenditure, from which an estimate of AEE can be made (Spurr et al. Reference Spurr, Prentice, Murgatroyd, Goldberg, Reina and Christman1988). However, at low levels of activity around the flex point it is difficult to differentiate between modest increases in HR around this flex point that are associated with activity and those that are associated with stress or other causes (Haskell et al. Reference Haskell, Yee, Evans and Irby1993). Given the sedentary nature of most modern lifestyles it is not surprising that this factor can introduce considerable error (Rennie et al. Reference Rennie, Rowsell, Jebb, Holburn and Wareham2000), which can be particularly variable at the individual level (Livingstone et al. Reference Livingstone, Coward, Prentice, Davies, Strain, McKenna, Mahoney, White, Stewart and Kerr1992). Since time spent in low- and moderate-intensity activity may be of particular interest, and important in preventing excess fat gain in children, this imprecision represents a major limitation of the HRM method in childhood obesity research. However, studies using HRM have demonstrated associations between time spent in sedentary and light-intensity activities and body fat (Maffeis et al. Reference Maffeis, Zaffanello and Schutz1997; Rennie et al. Reference Rennie, Livingstone, Wells, McGloin, Coward, Prentice and Jebb2005b), but not all studies have found such associations with HMR measures (Rowlands et al. Reference Rowlands, Eston and Ingledew1999; Treuth et al. Reference Treuth, Butte, Adolph and Puyau2004a).

New technology that combines HRM with movement sensors enables increases in HR caused by physical activity to be distinguished from increases caused by other influences (Rennie et al. Reference Rennie, Rowsell, Jebb, Holburn and Wareham2000; Brage et al. Reference Brage, Brage, Franks, Ekelund and Wareham2005; Johansson et al. Reference Johansson, Rossander-Hulthen, Slinder and Ekblom2006). This development may allow a more accurate determination of both daily AEE and its patterning in children and adolescents in the future.

Accelerometry

Given the multi-dimensional nature and spontaneity of their movement, the direct and objective measure of body movement by accelerometry is particularly useful in children. Movement is commonly measured in one or three planes (vertical v. vertical, lateral and anterior–posterior respectively).

Only a few studies have undertaken simultaneous measurements of physical activity by accelerometry and energy expended in physical activity using the DLW method (Ekelund et al. Reference Ekelund, Aman, Yngve, Renman, Westerterp and Sjostrom2002; Abbott & Davies, Reference Abbott and Davies2004). These studies clearly illustrate that the two approaches to measuring physical activity provide different but complementary information on physical activity, especially in relation to body fatness. In a comparison of obese and non-obese adolescents Ekelund et al. (Reference Ekelund, Aman, Yngve, Renman, Westerterp and Sjostrom2002) have observed no difference in AEE or PAL between obese and non-obese groups after adjustment for differences in body composition. However, from concurrent accelerometer measures the non-obese group was shown to have significantly higher levels of physical activity compared with the obese group (P<0·001). In younger non-obese children stronger inverse associations have been observed between accelerometer measures of activity and body fatness than with PAL (Abbott & Davies, Reference Abbott and Davies2004).

One prospective study in American Indian children has reported that higher activity counts at baseline in normal-weight children are related to a decrease in body fat 3 years later (Stevens et al. Reference Stevens, Suchindran, Ring, Baggett, Jobe, Story, Thompson, Going and Caballero2004). Paradoxically, in children defined as overweight at baseline higher activity counts were found to be associated with an increase in BMI, fat mass and FFM at follow-up. However, activity measured by accelerometry was assessed only for 1 d and it is not clear whether the body size of the overweight children, being heavier and taller than their lean counterparts, affected the activity counts. The impact of height and weight on movement counts clearly needs further investigation.

By applying movement count cut-off points, minute-by-minute data from accelerometers can be summated into time spent in low-, moderate- and vigorous-intensity activity, allowing an exploration of which intensity and/or frequency of activity is the most important predictor of increases in body fatness. In adults it has been proposed that inter-individual variations in energy expenditure are largely a result of variations in moderate-intensity physical activity, with the daily proportion of time spent in vigorous-intensity activities contributing very little to the variability (Westerterp, Reference Westerterp2001). However, it is not clear whether this premise is valid in children. It has been proposed that in young children most of the variation in daily energy expenditure is associated with the proportion of time children spend in either sedentary or light-intensity activities (Montgomery et al. Reference Montgomery, Reilly, Jackson, Kelly, Slater, Paton and Grant2004). In a study of 3- and 5-year-old children that used accelerometry the majority of time (range 73–81%) was reported to be spent in sedentary activities (Reilly et al. Reference Reilly, Jackson, Montgomery, Kelly, Slater, Grant and Paton2004), leading to the conclusion that the predominance of sedentary activity may be contributing to the rise in obesity. However, in the absence of historical data, it is not clear whether there has been a secular decrease in activities of moderate–vigorous intensity in young children or whether they inherently spend much of their time at this level of activity. Equally, another study in 4–6-year-olds has observed that boys and girls engage in activities defined as moderate–vigorous intensity for 277 and 263 min/d respectively (Janz et al. Reference Janz, Levy, Burns, Torner, Willing and Warren2002). The possible explanations for these conflicting observations are discussed later.

Studies that have examined relationships between intensity of activity and measures of body fatness have also found conflicting results. A positive association between time spent in sedentary activity and measures of body fat has been observed in 9–16-year-old girls, with no such association in boys (Treuth et al. Reference Treuth, Hou, Young and Maynard2005). In the same study time spent in light-intensity activity was shown to be inversely associated with body fat measures, but only in girls (Treuth et al. Reference Treuth, Hou, Young and Maynard2005). Other studies that have evaluated light-intensity activity have reported a null association (Ekelund et al. Reference Ekelund, Aman, Yngve, Renman, Westerterp and Sjostrom2002; Ekelund et al. Reference Ekelund, Sardinha, Anderssen, Harro, Franks, Brage, Cooper, Andersen, Riddoch and Froberg2004a). Some studies have found associations between moderate–vigorous- or vigorous-intensity activity and measures of body fatness (Rowlands et al. Reference Rowlands, Eston and Ingledew1999; Ekelund et al. Reference Ekelund, Aman, Yngve, Renman, Westerterp and Sjostrom2002; Janz et al. Reference Janz, Levy, Burns, Torner, Willing and Warren2002; Abbott & Davies, Reference Abbott and Davies2004; Ekelund et al. Reference Ekelund, Sardinha, Anderssen, Harro, Franks, Brage, Cooper, Andersen, Riddoch and Froberg2004a; Gutin et al. Reference Gutin, Yin, Humphries and Barbeau2005), but not all (Treuth et al. Reference Treuth, Hou, Young and Maynard2005), and some of these studies have observed associations with vigorous-intensity activity but not with moderate-intensity activity (Janz et al. Reference Janz, Levy, Burns, Torner, Willing and Warren2002; Abbott & Davies, Reference Abbott and Davies2004). This outcome makes it difficult to draw any conclusions at present on the importance of intensity of activity on body fatness. However, two studies appear to identify an approximate threshold above which lower measures of body fatness are observed (Abbott & Davies, Reference Abbott and Davies2004; Ekelund et al. Reference Ekelund, Sardinha, Anderssen, Harro, Franks, Brage, Cooper, Andersen, Riddoch and Froberg2004a). In one study (Abbott & Davies, Reference Abbott and Davies2004) the threshold was reported to be 125 min vigorous-intensity activity/d and in the other study (Ekelund et al. Reference Ekelund, Sardinha, Anderssen, Harro, Franks, Brage, Cooper, Andersen, Riddoch and Froberg2004a) the threshold was 120 min moderate–vigorous-intensity activity/d.

The largely inconsistent results in the studies cited earlier could also reflect real differences between populations, age-groups and gender. Some studies have observed that children do not spend much time in activities that could be classed as being of vigorous intensity (Gilliam et al. Reference Gilliam, Freedson, Geenen and Shahrary1981; Bailey et al. Reference Bailey, Olson, Pepper, Porszasz, Barstow and Cooper1995; Reilly et al. Reference Reilly, Jackson, Montgomery, Kelly, Slater, Grant and Paton2004). Indeed, direct observation of 6–10-year-old children has demonstrated that they spend most of their time engaged in low-intensity activities (77%) and only small amounts of time in high-intensity activity (3%), with most of the high-intensity activity (95%) occurring for very short bursts lasting <15 s (Bailey et al. Reference Bailey, Olson, Pepper, Porszasz, Barstow and Cooper1995). However, the way in which activity data is recorded may also be contributing to this conclusion. Most data from accelerometers and HRM is recorded in 1 min epochs that may not be sensitive enough to pick up these short bursts of vigorous activity (Nilsson et al. Reference Nilsson, Ekelund, Yngve and Sjostrom2002). It is also important that activity monitoring is of sufficient duration to adequately reflect habitual activity levels in children, including both weekdays and weekend days (Trost et al. Reference Trost, Pate, Freedson, Sallis and Taylor2000).

A major, and as yet unresolved, problem of comparing studies is that there is currently no consensus in how the activity intensity cut-off points applied to data are defined (Freedson et al. Reference Freedson, Pober and Janz2005). Studies may reach wholly different conclusions on the importance of vigorous-intensity activity on levels of body fatness, which are a result, at least in part, of the cut-off point used to define vigorous intensity. Cut-off points have been developed in controlled studies with children undertaking specific activities for which the intensity or energy cost of the activity is known (Ekelund et al. Reference Ekelund, Aman, Yngve, Renman, Westerterp and Sjostrom2002; Puyau et al. Reference Puyau, Adolph, Vohra and Butte2002; Rowlands et al. Reference Rowlands, Thomas, Eston and Topping2004; Treuth et al. Reference Treuth, Schmitz, Catellier, McMurray, Murray, Almeida, Going, Norman and Pate2004b). These studies typically combine walking and running on a treadmill with other activities to establish cut-off points relating to metabolic equivalent levels (Eston et al. Reference Eston, Rowlands and Ingledew1998; Puyau et al. Reference Puyau, Adolph, Vohra and Butte2002; Rowlands et al. Reference Rowlands, Thomas, Eston and Topping2004), but in young children have involved direct observation of activity (Reilly et al. Reference Reilly, Coyle, Kelly, Burke, Grant and Paton2003). It is questionable whether essentially laboratory-based contrived cut-off points are valid for assessing the less-structured activities typical of free-living conditions. Also, most of the studies of cut-off points have only used small samples of children (frequently twenty to thirty children) and sometimes only one gender. In addition, the study samples often cover a large age-range, which inevitably introduces considerable variability in results, particularly in relation to body size. Problems arise when these cut-off points are then applied to larger study populations that include both boys and girls and different age-ranges. This issue is also relevant in the development of equations to estimate energy expenditure from accelerometry movement counts (Eston et al. Reference Eston, Rowlands and Ingledew1998; Puyau et al. Reference Puyau, Adolph, Vohra and Butte2002).

One study has found that when applying one established cut-off point for moderate–vigorous-intensity activity all children (forty-one of forty-one) achieve the current recommendations for daily physical activity (Trayers et al. Reference Trayers, Cooper, Riddoch, Ness, Fox, Deem and Lawlor2006). However, when applying another established cut-off point only 7% of the children would be defined as achieving the recommendation (three of forty-one). It is hardly surprising therefore that as a result of applying different cut-off criteria studies have reported inconsistent relationships between body fatness and daily time spent in low-, moderate- and vigorous-intensity activity. At present, therefore, it is simply not possible to be confident that the existing data on the frequency and duration of different intensities of physical activity can provide a sufficiently robust evidence base on which to formulate public health recommendations for children.

Additionally, nearly all studies have been cross-sectional, with only limited prospective data available (Stevens et al. Reference Stevens, Suchindran, Ring, Baggett, Jobe, Story, Thompson, Going and Caballero2004). Thus, it impossible to draw conclusions on cause–effect relationships; whether children are fatter as a result of being less active or whether they have changed their activity behaviour in response to their body fatness and thus their fatness inhibits their physical activity. It is clear that more prospective studies are urgently needed. There is also a dearth of studies that have examined associations between physical activity and FFM or lean tissue (Janz et al. Reference Janz, Levy, Burns, Torner, Willing and Warren2002; Stevens et al. Reference Stevens, Suchindran, Ring, Baggett, Jobe, Story, Thompson, Going and Caballero2004). Although there is some evidence that recently-measured children have less FFM than children measured 20 years earlier (Wells et al. Reference Wells, Coward, Cole and Davies2002b), probably as a result of less time spent in activity, more studies are needed to examine this aspect in more detail, particularly longitudinally.

Specific physical activity behaviours

As well as evaluating the patterning and intensity of daily physical activity, objective measures of activity can be used to evaluate the impact of specific behaviours on activity levels. For example, much emphasis has been placed on the importance of schools in enhancing levels of physical activity. Although physical education has a potentially valuable role in promoting long-term participation in recreational activity, its immediate impact on children's activity is less clear. Of particular relevance is the observational study that compared total daily activity levels of children from three schools with very different levels of time-tabled physical education (Mallam et al. Reference Mallam, Metcalf, Kirkby, Voss and Wilkin2003). Although, average total accelerometer counts were similar between the children from all three schools, it appears that children from the schools that had less time allocated to physical education actually compensated by being more active out of school. Whether this compensatory activity is typical remains to be established.

There has also been a secular change in the mode of travel to and from school, with fewer children cycling and walking to school (Dollman et al. Reference Dollman, Norton and Norton2005). Studies that have compared daily activity levels between those who walk or cycle rather than being driven to school have observed that those who walk or cycle are more active throughout the day and not just in the period of getting to and from school (Cooper et al. Reference Cooper, Page, Foster and Qahwaji2003; Alexander et al. Reference Alexander, Inchley, Todd, Currie, Cooper and Currie2005). More work is needed in this area to assess which specific activity behaviours are amenable to intervention and can impact on activity levels sufficiently to make a long-term difference to the risk of obesity.

Objective instruments, such as accelerometers, are valuable tools not only for distinguishing the amount of activity needed to prevent obesity, but also, perhaps more importantly, for evaluating the impact of community and school-based initiatives, such as ‘the walking bus’, on daily levels of physical activity.

Interactions with other factors

The effect of physical activity on body fatness cannot be considered in isolation and needs to be evaluated alongside other factors such as diet, sleep and sedentary behaviour that may influence body fatness in children and adolescents.

Sedentary behaviour

Sedentary behaviour, such as television watching, has been implicated in increasing the risk of obesity. In fact, after parental obesity, television watching has been the most consistent risk factor identified for childhood obesity (Doak et al. Reference Doak, Visscher, Renders and Seidell2006). One reason may be that it is relatively easier to quantify the amount of time a child spends watching television than, for example, the amount of time spent in unstructured play. Randomised controlled trials (Doak et al. Reference Doak, Visscher, Renders and Seidell2006) have reported that interventions to reduce television watching can reduce fat mass gain, albeit modestly. However, it is not apparent whether reducing the time spent watching television is a direct causal factor, by decreasing the time spent inactive, or whether it is an indicator of a broader set of behaviours. For example, decreasing television viewing may reduce the risk of obesity by other mechanisms such as by removing the opportunity for more eating occasions and/or exposure to advertisements for high-fat foods (Campbell et al. Reference Campbell, Crawford and Ball2006; Wiecha et al. Reference Wiecha, Peterson, Ludwig, Kim, Sobol and Gortmaker2006).

Nevertheless, sedentary behaviour, such as television viewing, is not necessarily the antithesis of being physically active. Children who spend substantial amounts of their time watching television are not necessarily less physically active than those who spend less time watching television, since they may spend the rest of their time in more vigorous-intensity activities. A meta-analytical review of the literature (Marshall et al. Reference Marshall, Biddle, Gorely, Cameron and Murdey2004) has concluded that there is only a very small inverse relationship between television viewing and physical activity. Indeed, a recent study that has examined the associations between family environment, television viewing and physical activity measured by accelerometry has observed few associations between questions about sedentary behaviours and low levels of physical activity (Salmon et al. Reference Salmon, Timperio, Telford, Carver and Crawford2005).

Sleep

Obesity research has principally focused on how children spend their waking hours, but recently cross-sectional inverse associations have been reported between time spent sleeping and odds of being obese (Sekine et al. Reference Sekine, Yamagami, Handa, Saito, Nanri, Kawaminami, Tokui, Yoshida and Kagamimori2002; von Kries et al. Reference von Kries, Toschke, Wurmser, Sauerwald and Koletzko2002; Chaput et al. Reference Chaput, Brunet and Tremblay2006), with fatter children spending less time asleep. This finding has been replicated in prospective studies, with shorter sleep duration in infancy and young childhood being a predictor of becoming overweight in childhood (Agras et al. Reference Agras, Hammer, McNicholas and Kraemer2004; Reilly et al. Reference Reilly, Armstrong, Dorosty, Emmett, Ness, Rogers, Steer and Sherriff2005).

The mechanisms by which sleep could increase the risk of excess adiposity are still emerging. Shorter sleep duration has been associated with increased time spent watching television (Van den Bulck, Reference Van den Bulck2004). However, the relationship between sleep duration and obesity has been observed to be independent of reported television viewing time (Locard et al. Reference Locard, Mamelle, Billette, Miginiac, Munoz and Rey1992; Sekine et al. Reference Sekine, Yamagami, Handa, Saito, Nanri, Kawaminami, Tokui, Yoshida and Kagamimori2002; Reilly et al. Reference Reilly, Armstrong, Dorosty, Emmett, Ness, Rogers, Steer and Sherriff2005; Chaput et al. Reference Chaput, Brunet and Tremblay2006). Time spent asleep may displace other behaviours such as eating occasions in the late evening that increase the risk of positive energy balance.

Associations between sleep time and dietary intake may also have a biological mechanism. In adults short sleep duration has been related to changes in appetite-regulation hormones, with increased hunger and appetite (Spiegel et al. Reference Spiegel, Tasali, Penev and Van Cauter2004). Another plausible mechanism is that those who are less active, and are thus less physically tired, may sleep less, which would suggest an interaction between low physical activity and low sleep duration with a risk of excess fat-mass gain. One study has reported a correlation between lower sleep time and lower activity levels measured by accelerometry in 3–4-year-old children (Agras et al. Reference Agras, Hammer, McNicholas and Kraemer2004), but physical activity was only measured for 24 h. More research is required in this area to determine whether interactions between sleep and physical activity are sustained over a longer time period, and to ascertain if lower sleep time is associated with time spent in moderate–vigorous-intensity activities and/or dietary intake.

Diet

Few studies have measured dietary intake and physical activity concurrently (Jago et al. Reference Jago, Baranowski, Baranowski, Thompson and Greaves2005) and none have examined the daily patterning and interaction of these two potential risk factors. However, evaluation of interactions between physical activity and diet is hindered by the inaccuracy in measurements of dietary intake, particularly as a result of misreporting, which tends to be higher in older age-groups and in overweight compared with lean children and adolescents (Livingstone & Black, Reference Livingstone and Black2003; Rennie et al. Reference Rennie, Jebb, Wright and Coward2005a).

Conclusions

It is only in recent years that objective measures of physical activity have become more widely available and feasible for use in large-scale studies. At the same time there is now an increased urgency to assess the impact of the duration, frequency and intensity of physical activity on the risk of obesity in children. Currently, there are major obstacles that impede the development of a firm evidence base from which physical activity recommendations can be established. First, it is essential that outcome measures of body fatness are appropriately adjusted for body size to ensure that correct conclusions are drawn from analyses. Second, a consensus is needed on intensity cut-off points from accelerometry data such that the results between studies are comparable and meaningful. Third, a real problem is how physical activity energy expenditure is appropriately adjusted for body composition differences between children so that results are not unduly biased. If these issues are addressed and applied to prospective studies, a better understanding of the role of physical activity in the prevention of obesity will be achieved. Further work is also needed to assess the impact of duration, frequency and intensity of physical activity on lean body mass and how this relationship may be a factor in reducing the risk of obesity.

Objective instruments, such as accelometers, can also be used to assess the effectiveness of interventions to change physical activity, which cannot be evaluated using self-report measures or, in the short-to-medium term, changes in body composition.

Physical activity questionnaires and diaries remain vital qualitative, if necessarily subjective, tools in studies of physical activity. Without information on the types of activity commonly undertaken and their settings it is difficult to translate findings from the objective measures of activity into public health recommendations and to find opportunities to change behaviour. For example, in changing the immediate environment to facilitate activity, such as safe routes to schools or play areas, or finding ways to encourage families to engage in more activity on a regular basis. Schools are certainly important in increasing activity in children and adolescents, but they need to be considered together with activities outside of school and the role of the family. Given the concerns of safety surrounding unsupervised travel and playing outside, implementing this change is a real challenge (Hillman, Reference Hillman1993). Thus, the designing of effective prevention studies must be complemented by research aimed at achieving a clearer understanding of the psycho-social, behavioural and environmental factors that influence physical activity (Livingstone et al. Reference Livingstone, McCaffrey and Rennie2006). Moreover, integrated prevention strategies are needed to change not only physical activity but other related behaviours, such as eating and sleeping, if the rise in childhood obesity is to be arrested.

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Figure 0

Fig. 1. Association between fat-free mass index (fat-free mass:height2; kg/m2) and log-transformed activity energy expenditure (AEE) adjusted for gender (in 100 subjects). B coefficient 1·72 (se 0·34); P<0·001.

Figure 1

Table 1. Comparison of body composition measurements from three hypothetical 7-year-old children

Figure 2

Fig. 2. (a) Activity energy expenditure (AEE) calculated from doubly-labelled water and time spent in low-intensity activity measured by heart-rate monitoring in 100 prepubertal boys (●) and girls (□; r 0·32, P=0·01) and (b) AEE adjusted for fat-free mass (kg; r 0·09, NS). AEE was normalised for fat-free mass (AEE/fat-free mass1·3; Rennie et al.2005b).