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Short-term changes in human metabolism following a 5-hour delay of the light-dark and behavioural cycle

Published online by Cambridge University Press:  01 October 2024

A. Flanagan ,
L.C. Ruddick-Collins ,
B. Fielding ,
B. Middleton ,
J. von Gerichten ,
M. Short ,
V. Revell ,
J. Mendis ,
C.D. Mayer  and
P.J. Morgan
...Show all authors
A. Flanagan
Affiliation:
Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK Section of Molecular Medicine, Food and Macronutrients, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
L.C. Ruddick-Collins
Affiliation:
The Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK
B. Fielding
Affiliation:
Section of Molecular Medicine, Food and Macronutrients, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
B. Middleton
Affiliation:
Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
J. von Gerichten
Affiliation:
Section of Molecular Medicine, Food and Macronutrients, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
M. Short
Affiliation:
Department of Chemical and Process Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
V. Revell
Affiliation:
Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, Guildford, Surrey GU2 7XP, UK
J. Mendis
Affiliation:
Surrey Clinical Trials Unit, Faculty of Health and Medical Sciences, Guildford, Surrey GU2 7XP, UK
C.D. Mayer
Affiliation:
Biomathematics and Statistics Scotland, University of Aberdeen, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK
P.J. Morgan
Affiliation:
The Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK
A.M. Johnstone
Affiliation:
The Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK
J.D. Johnston
Affiliation:
Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
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Abstract

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The circadian timing system regulates many aspects of metabolic physiology, including the postprandial response to meals(1). Experimental inversion of circadian and behavioural rhythms by 12 hours adversely effects markers of metabolic health(2). We investigated effects of a more modest 5hour delay in behavioural cycles.

Fourteen participants completed an 8-day in-patient laboratory protocol, with controlled sleepwake opportunities, light-dark cycles, and diet. The 5-hour delay in behavioural cycles was induced by delaying sleep opportunity. We measured: melatonin to confirm central circadian phase; fasting markers and postprandial metabolism; energy expenditure; subjective sleepiness; and appetite, throughout the waking period.

After the phase delay, there was slower gastric emptying at breakfast, lower fasting plasma glucose, higher postprandial plasma glucose and triglycerides, and lower thermic effect of feeding. Any changes were abolished or attenuated within 48-72 hours. Further, we show no difference in 16 h waking energy expenditure.

These data extend our previous findings, which showed no time-of-day effect on energy expenditure in healthy adults.

Type
Abstract
Information
Proceedings of the Nutrition Society , Volume 83 , Issue OCE3: Scottish Section Conference 2024, 26-27 March 2024, Circadian rhythms in health and disease , July 2024 , E244
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

References

Flanagan, A, Bechtold, DA, Pot, GK et al. (2021) J Neurochem 157, 53–72.10.1111/jnc.15246CrossRefGoogle Scholar
Scheer, FAJL, Hilton, MF, Mantzoros, CS et al (2009) PNAS 106, 4453–4458.10.1073/pnas.0808180106CrossRefGoogle Scholar