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Regulation of liver gene expression by glucose

Published online by Cambridge University Press:  05 March 2007

Franck Rencurel  and
Jean Girard
Franck Rencurel*
Affiliation:
Endocrinologie Moléculaire, CNRS, 9 rue Jules Hetzel, F-92190 Meudon, France
Jean Girard
Affiliation:
Endocrinologie Moléculaire, CNRS, 9 rue Jules Hetzel, F-92190 Meudon, France
*
*Corresponding author: Dr F. Rencurel, fax +44 (0)1382 345514
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Abstract

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Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 57 , Issue 2 , May 1998 , pp. 265 - 275
Copyright
Copyright © The Nutrition Society 1998

Footnotes

†

Department of Anatomy and Physiology, The Old Medical School University of Dundee, Small Wynd, Dundee DDI 4HN, UK.

References

Agius, L (1994) Control of glucokinase translocation in rat hepatocytes by sorbitol and the cytosolic redox state. Biochemical Journal 298, 237–243.Google Scholar
Agius, L & Peak, M (1993) Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin. Biochemical Journal 296, 785–796.Google Scholar
Antoine, B, Levrat, F, Vallet, V, Berbar, T, Cartier, N & Kahn, A (1992) Gene expression in hepatocyte-like cell lines established by targeted carcinogenesis in transgenic mice. Experimental Cell Research 200, 175–185.CrossRefGoogle ScholarPubMed
Argaud, D, Kirby, TL, Newgard, CB & Lange, AJ (1997) Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate. Journal of Biological Chemistry 272, 12854–12861.Google Scholar
Argaud, D, Lange, AJ, Becker, TC, Okar, DA, Raafat El-Maghrabi, M, Newgard, CB & Pilkis, S (1995) Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Journal of Biological Chemistry 270, 24229–24236.Google Scholar
Asano, T, Katagiri, H, Tsukuda, K, Lin, J-L, Ishihara, H & Oka, Y (1992) Upregulation of GLUT2 mRNA by glucose, mannose, and fructose in isolated rat hepatocytes. Diabetes 41, 22–25.Google Scholar
Bergot, MO, Diaz-Guerra, MJM, Puzenat, N, Raymondjean, M & Kahn, A (1992) Cis-regulation of the L-type pyruvate kinase gene promoter by glucose, insulin and cyclic AMP. Nucleic Acid Research 20, 1871–1878.Google Scholar
Bessell, E & Thomas, P (1973) The effect of substitution at C-2 of D-glucose-6-phosphate on the rate of dehydrogenation by glucose-6-phosphate dehydrogenase (from yeast and from rat liver). Biochemical Journal 131, 83–89.CrossRefGoogle ScholarPubMed
Bonny, C, Thompson, N, Nicod, P & Waeber, G (1995) Pancreatic-specific expression of the glucose transporter type 2 (GLUT2) gene: identification of cis-elements and islet-specific trans-acting factors. Molecular Endocrinology 9, 1413–1426.Google ScholarPubMed
Bontemps, F, Hue, L & Hers, H-G (1978) Phosphorylation of glucose in isolated rat hepatocytes. Sigmoidal kinetics explained by the activity of glucokinase alone. Biochemical Journal 174, 603–611.CrossRefGoogle ScholarPubMed
Bossard, P, Decaux, JF, Juanes, M & Girard, J (1994) Initial expression of glucokinase gene in cultured-hepatocytes from suckling rats is linked to the synthesis of an insulin-dependent protein. European Journal of Biochemistry 223, 371–380.CrossRefGoogle Scholar
Brichard, S, Desbuquois, B & Girard, J (1993 a) Vanadate treatment of diabetic rats reverses the impaired expression of genes involved in hepatic glucose metabolism. Effects on glycolytic and gluconeogenic enzymes and on glucose transporter GLUT2. Molecular and Cellular Endocrinology 91, 91–97.Google Scholar
Brichard, S, Henquin, JC & Girard, J (1993 b) Phlorizin treatment of diabetic rats partially reversed the impaired expression of genes involved in hepatic metabolism. Diabetologia 36, 292–298.CrossRefGoogle Scholar
Brown, KS, Kalinowski, SS, Megill, JR, Durham, SK & Mookhtiar, KA (1997) Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus. Diabetps 46, 179–1 86.CrossRefGoogle ScholarPubMed
Brun, T, Roche, E, Kirn, K-H & Prentki, M (1993) Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic β-cell line (INS-1). Journal of Biological Chemistry 268, 18905–18911.Google Scholar
Burcelin, R, Eddouks, M, Kandé, J, Assan, R & Girard, J (1992) Evidence that GLUT2 mRNA and protein concentrations are decreased by hyperinsulinemia and increased by hyperglycemia in liver of diabetic rats. Biochemical Journal 288, 675–679.CrossRefGoogle ScholarPubMed
Cederbaum, AI & Dicker, E (1979) The effect of acetaldehyde on gluconeogenesis from xylitol, sorbitol, and fructose by isolated rat liver cells. Archives of Biochemistry and Biophysics 197, 415–423.Google Scholar
Clarke, SD & Abraham, S (1992) Gene expression: nutrient control of pre-and posttranscriptional events. FASEB Journal 6, 3146–3152.CrossRefGoogle ScholarPubMed
Cuif, M, Cognet, M, Boquet, D, Tremp, G, Kahn, A & Vaulont, S (1992) Elements responsible for hormonal control and tissue specificity of L-type pyruvate kinase gene expression in transgenic mice. Molecular and Cellular Biology 12, 4852–4861.Google ScholarPubMed
Daniel, S & Kim, KH (1996) Spl mediates glucose activation of the acetyl-CoA carboxylase promoter. Journal of Biological Chemistry 271, 1385–1392.Google Scholar
Decaux, JF, Antoine, B & Kahn, A (1989) Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture. Journal of Biological Chemistry 264, 11584–11590.Google Scholar
Decaux, JF, Marcillat, O, Pichard, AL, Henry, J & Kahn, A (1991) Glucose-dependent and -independent effect of insulin on gene expression. Journal of Biological Chemistry 266, 3432–3438.Google Scholar
Diaz Guerra, M, Bergot, M, Martinez, A, Cuif, M, Khan, A & Raymondjean, M (1993) Functional characterization of the L-type pyruvate kinase gene glucose response complex. Molecular and Cellular Biology 13, 7125–7733.Google Scholar
Doiron, B, Cuif, M-H, Chen, R & Kahn, A (1996) Respective roles of glucose, fructose, and insulin in the regulation of the liver-specific pyruvate kinase gene promoter. Journal of Biological Chemistry 271, 1–4.Google Scholar
Doiron, B, Cuif, M-H, Khan, A & Diaz-Guerra, MJM (1994) Transcriptional glucose signaling through the glucose response element is mediated by pentose phosphate pathway. Journal of Biological Chemistry 269, 10213–10216.Google Scholar
Ferre, T, Riu, E, Bosch, F & Valera, A (1996) Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver. FASEB Journal 10, 1213–1218.Google Scholar
Foufelle, F, Girard, J & Ferré, P (1996) Regulation of lipogenic enzyme expression by glucose in liver and adipose-tissue – a review of the potential cellular and molecular mechanisms. Advances in Enzyme Regulation 36, 199–226.Google Scholar
Foufelle, F, Gouhot, B, Pégorier, JP, Perdereau, D, Girard, J & Ferré, P (1992) Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue. A role for glucose-6-phosphate. Journal of Biological Chemistry 267, 20543–20547.Google Scholar
Foufelle, F, Lepetit, N, Bosc, D, Morin, J, Raymondjean, M & Ferre, P (1995) DNase I hypersensitivity sites and nuclear protein binding on the fatty acid synthase gene: identification of an element with properties similar to known glucose-responsive elements. Biochemical Journal 308, 521–527.Google Scholar
Gancedo, JM (1992) Carbon catabolite repression in yeast. European Journal of Biochemistry 206, 297–313.Google Scholar
German, M, Ashcroft, S, Docherty, K, Edlund, H, Edlund, T, Goodison, S, Imura, H, Kennedy, G, Madsen, O, Melloul, D, Moss, L, Olson, K, Permutt, MA, Philippe, J, Robertson, RP, Rutter, WJ, Serup, P, Stein, R, Steiner, D, Tsai, M & Walker, MD (1995) The insulin gene promoter. Diabetes 44, 1002–1004.CrossRefGoogle ScholarPubMed
German, M & Wang, J (1994) The insulin gene contains multiple transcriptional elements that respond to glucose. European Journal of Biochemistry 14, 4061–4075.Google ScholarPubMed
Girard, J, Ferré, P & Foufelle, F (1997) Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes. Annual Review of Nutrition 17, 325–352.Google Scholar
Gould, GW & Bell, GI (1990) Facilitative glucose transporters :an expanding family. Trends in Biological Sciences 15, 18–23.CrossRefGoogle ScholarPubMed
Gould, GW & Holman, G (1993) The glucose transporter family: structure, function and tissue-specific expression. Biochemical Journal 295, 329–341.Google Scholar
Gregor, P, Sawadago, M & Roeder, R (1990) The adenovirus Major Late Transcription Factor USF is a member of the helix loop helix group of regulatory proteins and binds to DNA as a dimer. Genes and Development 4, 1730–1740.CrossRefGoogle ScholarPubMed
Hers, HG & Van Schaftingen, E (1982) Fructose 2,6-bisphosphate 2 years after its discovery. Biochemical Journal 206, 1–12.Google Scholar
Iritani, N, Fukuda, H & Matsumura, Y (1993) Regulation of hepatic lipogenic enzyme gene expression by diet quantity in rats fed a fat-free, high carbohydrate diet. Journal of Biochemistry 113, 519–525.Google Scholar
Issad, T, Fed, P, Pastor-Anglada, M, Baudon, MA & Girard, J (1989) Development of insulin-sensitivity at weaning in the rat. Role of the nutritional transition. Biochemical Journal 264, 217–222.Google Scholar
Iynedjian, PB, Gjinovci, A & Renold, AE (1988) Stimulation by insulin of glucokinase gene transcription in liver of diabetic rats. Journal of Biological Chemistry 263, 740–744.Google Scholar
Iynedjian, PB, Jottterand, D, Nouspikel, T, Asfari, M & Pilot, PR (1989) Transcriptional regulation of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system. Journal of Biological Chemistry 264, 21824–21829.Google Scholar
Iynedjian, PB, Möbius, G, Seitz, HJ, Wollheim, CB & Renold, AE (1986) Tissue-specific expression of glucokinase: Identification of the gene product in liver and pancreatic islets. Proceedings of the National Academy of Sciences USA 83, 1998–2001.CrossRefGoogle ScholarPubMed
Jacob, F & Monod, J (1961) Genetic regulatory mechanisms in the synthesis of proteins. Journal of Molecular Biology 3, 318.Google Scholar
Jenkins, AB, Furler, SM & Kraegen, EW (1986) 2-Deoxy-D-glucose metabolism in individual tissues of the rat in vivo. International Journal of Biochemistry 18, 311–318.Google Scholar
Jump, DB, Bell, A, Lepar, G & Hu, D (1990) Insulin rapidly induces rat liver S14 gene transcription. Molecular Endocrinology 4, 1655–1660.Google Scholar
Kang, R, Yamada, K, Tanaka, T, Lu, T & Noguchi, T (1996) Relationship between the concentrations of glycolytic intermediates and expression of the L-type pyruvate kinase gene in cultured hepatocytes. Journal of Biochemistry 119, 162–166.CrossRefGoogle ScholarPubMed
Kaytor, EN, Shih, H & Towle, HC (1997) Carbohydrate regulation of hepatic gene expression. Evidence against a role for the upstream stimulatory factor. Journal of Biological Chemistry 272, 7525–7531.Google Scholar
Kinlaw, WB, Church, JL, Harmon, J & Mariash, C (1995) Direct evidence for a role of the ‘Spot 14’ protein in the regulation of lipid synthesis. Journal of Biological Chemistry 270, 16615–16618.Google Scholar
Lee, FK, Lee, AYW, Lin, CXF, Chung, SS & Chung, SK (1995) Cloning, sequencing, and determination of the sites of expression of mouse sorbitol dehydrogenase cDNA. European Journal of Biochemistry 230, 1059–1065.Google Scholar
Lefrançois-Martinez, AM, Diaz-Guerra, MJM, Vallet, V, Kahn, A & Antoine, B (1994) Glucose-dependent regulation of the L-type pyruvate kinase gene in hepatoma cell line independent of insulin and cyclic AMP. FASEB Journal 8, 89–96.Google Scholar
Lefrançois-Martinez, A-M, Martinez, A, Antoine, B, Raymondjean, M & Kahn, A (1995) Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter. Journal of Biological Chemistry 270, 2640–2643.Google Scholar
Leibiger, B & Leibiger, IB (1995) Functional analysis of DNA-elements involved in transcriptional control of the human glucose transporter 2 (GLUT2) gene in the insulin-producing cell line βTC-3. Diabetologia 38, 112–115.CrossRefGoogle Scholar
Lindstad, RI, Hermansen, LF & McKinley-McKee, JS (1992) The kinetic mechanism of sheep liver sorbitol dehydrogenase. European Journal of Biochemistry 210, 641–647.Google Scholar
Liu, Z, Thompson, KS & Towle, HC (1993) Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family. Journal of Biological Chemistry 268, 12787–12795.Google Scholar
Lopez-Casillas, F & Kim, KH (1989) Heterogeneity at the 5′ end of rat acetyl-coenzyme A carboxylase mRNA. Journal of Biological Chemistry 264, 7176–7184.Google Scholar
Magnusson, MA, Andreone, TL, F'rintz, RL, Koch, S & Granner, DK (1989) Rat glucokinase gene: Structure and regulation by insulin. Proceedings of the National Academy of Sciences USA 86, 4838–4342.Google Scholar
Marshak, S, Totary, H, Cerasi, E & Melloul, D (1996) Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proceedings of the National Academy of Sciences USA 96, 15057–15062.Google Scholar
Meienhofer, MC, De Medicis, E, Cognet, M & Kahn, A (1987) Regulation of genes for glycolytic enzymes in cultured rat hepatoma cell lines. European Journal of Biochemistry 169, 237–243.Google Scholar
Melloul, D, Ben-Neriah, Y & Cerasi, E (1993) Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoter. Proceedings of the National Academy of Sciences USA 90, 3865–3869.Google Scholar
Melloul, D & Cerasi, E (1994) Transcription of the insulin gene. Towards defining the glucosesensitive cis-element and trans-acting factors. Diabefologia 7, S3–S10.Google Scholar
Mourrieras, F, Foufelle, F, Foretz, M, Morin, J, Bouche, S & Ferre, P (1997) Induction of fatty acid synthase and S 14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucosed-phosphate concentration. Biochemical Journal 326, 345–349.Google Scholar
Munnich, A, Besmond, C, Darquy, S, Reach, G, Vaulont, S, Dreyfus, JC & Kahn, A (1985a) Dietary and hormonal regulation of aldolase B gene exression. Journal of Clinical Investigation 75, 1045–1052.Google Scholar
Munnich, A, Lyonnet, S, Chauvet, D, Van Schaftingen, E & Kahn, A (1985b) Differential effect of glucose and fructose on liver L-type pyruvate kinase gene expression in vivo. Journal of Biological Chemistry 262, 17065–17071.Google Scholar
Narkewicz, MR, Iynedjian, PB, Ferré, P & Girard, J (1990) Insulin and triiodothyronine induce glucokinase mRNA in primary cultures of neonatal rat hepatocytes. Biochemical Journal 271, 585–589.Google Scholar
Nishimura, M, Fedorov, S & Uyeda, K (1994) Glucose-stimulated synthesis of fructose2,6-bisphosphate in rat liver. Journal of Biological Chemistry 269, 26100–26106.Google Scholar
Noguchi, T, Inoue, H & Tanaka, T (1985) Transcriptional and post-transcriptional regulation of L-type pyruvate kinase in diabetic rat liver by insulin and dietary fructose. Journal of Biological Chemistry 260, 14393–14397.Google Scholar
Ohlsson, H, Karlsson, K & Edlund, T (1993) IPFI, a homeodomain-containing transactivator of the insulin gene. EMBO Journal 12, 4251–4259.CrossRefGoogle Scholar
Oka, Y, Assano, T, Shibasaki, Y, Lin, Y-L, Tsukuda, K, Akanuma, Y & Takaku, F (1990) Increased liver glucose-transporter protein and mRNA in streptozotocin-induced diabetic rats. Diabetes 39, 441–446.Google Scholar
Pilkis, SJ & Granner, DK (1992) Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annual Review of Physiology 54, 885–909.Google Scholar
Postic, C, Burcelin, R, Rencurel, F, Pegorier, JP, Loizeau, M, Girard, J & Leturque, A (1993) Evidence for a transient inhibitory effect of insulin on GLUT2 expression in the liver: studies in vivo and in vitro. Biochemical Journal 293, 119–124.Google Scholar
Printz, RL, Magnusson, MA & Granner, DK (1993) Mammalian glucokinase. Annual Review of Nutrition 13, 463–496.Google Scholar
Prip-Buus, C, Perdereau, D, Foufelle, F, Maury, J, Ferré, P & Girard, J (1995) Induction of fatty-acid-synthase gene expression by glucose in primary culture of rat hepatocytes. European Journal of Biochemistry 268, 309–315.Google Scholar
Rencurel, F, Waeber, G, Antoine, B, Rocchiccioli, F, Maulard, P, Girard, J & Leturque, A (1996) Requirement of glucose metabolism for regulation of glucose transporter type 2 (GLUT2) gene expression in liver. Biochemical Journal 314, 903–909.Google Scholar
Rencurel, F, Waeber, G, Bonny, C, Antoine, B, Maulard, P, Girard, J & Leturque, A (1997) cAMP prevents the glucose-mediated stimulation of GLUT2 gene transcription in hepatocytes. Biochemical Journal 322, 441–448.Google Scholar
Salas, J, Salas, M, Vinuela, E & Sols, A (1965) Glucokmase of rabbit liver. Journal of Biological Chemistry 240, 1014–1018.Google Scholar
Shih, H, Liu, Z & Towle, HC (1995) Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription. Journal of Biological Chemistry 270, 21991–21997.Google Scholar
Shih, H & Towle, HC (1992) Definition of the carbohydrate response element of the rat S14 gene. Journal of Biological Chemistry 267, 13222–13228.Google Scholar
Shih, H & Towle, HC (1994) Definition of the carbohydrate response element of the rat S14 gene. Journal of Biological Chemistry 269, 9380–9387.Google Scholar
Sibrowski, W & Seitz, HJ (1984) Rapid action of insulin and cyclic AMP in the regulation of functional messenger RNA for glucokinase in rat liver. Journal of Biological Chemistry 259, 343–346.Google Scholar
Sirito, M, Lin, Q, Maity, T & Sawadogo, M (1994) Ubiquitous expression of 43- and 44-kDA forms of transcription factor USF in mammalian cells. Nucleic Acid Research 22, 427–433.Google Scholar
Thompson, KS & Towle, HC (1991) Localization of the carbohydrate response element of the rat L-type pyruvate kinase gene. Journal of Biological Chemistry 266, 8679–8682.Google Scholar
Thorens, B, Flier, JS, Lodish, HF & Kahn, BB (1990) Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment. Diabetes 39, 712–719.Google Scholar
Thorens, B, Sarkar, HK, Kaback, HR & Lodish, HF (1988) Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and P-pancreatic islet cells. Cell 55, 281–290.CrossRefGoogle Scholar
Valera, A, Rodriguez-Gil, JE & Bosch, F (1993) Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats. Journal of Clinical Investigation 92, 4–11.Google Scholar
Van Schaftingen, E (1989) A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate. European Journal of Biochemistry 179, 179–184.Google Scholar
Van Schaftingen, E, Detheux, M & Veiga Da Cunha, M (1994) Short-term control of glucokinase activity: role of regulatory protein. FASEB Journal 8, 414–419.Google Scholar
Vaulont, S, Puzenat, N, Levrat, F, Cognet, M, Kahn, A & Raymondjean, M (1989) Analysis by cell-free transcription of the liver-specific pyruvate kinase gene promoter. Journal of Molecular Biology 209, 205–219.Google Scholar
Vincent, MF, Van Den Berghe, G & Hers, H-G (1989) D-Xyhlose-induced depletion of ATP and Pi in isolated rat hepatocytes. FASEB Journal 3, 1855–1861.Google Scholar
Waeber, G, Pedrazzini, T, Bonny, O, Bonny, C, Steinmann, M, Nicod, P & Haefliger, J-A (1995) A 338 bp proximal fragment of the glucose transporter type 2 (GLUT2) promoter drives reporter gene expression in the pancreas islets of transgenic mice. Molecular and Cellular Endocrinology 114, 205–215.Google Scholar
Waeber, G, Thompson, N, Haefliger, JA & Nicod, P (1994) Characterization of the murine high Km glucose transporter GLUT2 gene and its transcriptional regulation by glucose in a differentiated insulin-secreting cell line. Journal of Biological Chemistry 269, 26912–26919.Google Scholar
Walker, DG & Holland, G (1965) The development of hepatic glucokinase in the neonatal rat. Biochemical Journal 97, 845–854.Google Scholar
Walker, DG & Rao, S (1964) The role of glucokinase in the phosphorylation of glucose by rat liver. Biochemical Journal 90, 360–368.Google Scholar
Waeber, A, Marie, J, Cottreau, D, Simon, MP, Besmond, C, Dreyfus, JC & Kahn, A (1984) Dietary control of aldolase B and L-type pyruvate kinase mRNAs in rat. Journal of Biological Chemistry 259, 1798–1802.Google Scholar