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Regulation of cell signalling by vitamin E

Published online by Cambridge University Press:  05 March 2007

Gerald Rimbach ,
Anne Marie Minihane ,
Jonathan Majewicz ,
Alexandra Fischer ,
Josef Pallauf ,
Fabio Virgli  and
Peter D. Weinberg
Gerald Rimbach*
Affiliation:
Hugh Sinclair Human Nutrition Unit, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
Anne Marie Minihane
Affiliation:
Hugh Sinclair Human Nutrition Unit, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
Jonathan Majewicz
Affiliation:
Hugh Sinclair Human Nutrition Unit, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
Alexandra Fischer
Affiliation:
Institute of Animal Nutrition and Nutrition Physiology, Justus-Liebig-University, Giessen, Germany
Josef Pallauf
Affiliation:
Institute of Animal Nutrition and Nutrition Physiology, Justus-Liebig-University, Giessen, Germany
Fabio Virgli
Affiliation:
National Institute of Food and Nutrition Research, Rome, Italy
Peter D. Weinberg
Affiliation:
School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
*
*Corresponding author: Dr Gerald Rimbach, fax + 44 118 931 0080, email [email protected]
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Abstract

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Résumé

La vitamine E, l'antioxydant liposoluble le plus important, fut découverte à l'Université de Californie à Berkeley en 1922. Depuis sa découverte, les études sur les tocophérols et les tocotrienols que constitue cette vitamine, ont été centrées pour la plupart sur leurs propriétés antioxydantes. En 1991, le groupe de Angelo Azzi (Boscoboinik et al. 1991a,b) fut le premier à décrire les fonctions autres que les antioxydantes et de transmission de signaux de l'α-tocophérol, en démontrant la régulation par la vitamine E de l'activité de la protéine kinase C dans les cellules de muscle lisse. Au niveau de la transcription, l'²-tocophérol module l'expression de la protéine de transfert hépatique de l'α-tocophérol, ainsi que l'expression du ge`ne alpha1 du collage`ne du foie, du ge`ne de la collagénase et du ge`ne de l'α-tropomyosine. Récemment, un facteur de transcription dépendant du tocophérol (la protéine associée au tocophérol) a été découvert. Il a été démontré sur des cellules cultivées que la vitamine E inhibe l'inflammation, l'adhésion cellulaire, l'agrégation des plaquettes et la prolifération des cellules de muscle lisse. Les avancées récentes de la biologie moléculaire et des techniques génomiques ont conduit à la découverte de nouveaux ge`nes et des mécanismes de transduction des signaux sensibles à la vitamine E.

Keywords

AntioxidantsVitamin EGene expressionCell signallingCardiovascular disease
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 61 , Issue 4 , November 2002 , pp. 415 - 425
Copyright
Copyright © The Nutrition Society 2002

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