Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-23T16:45:57.808Z Has data issue: false hasContentIssue false

Public health aspects of food fortification: a question of balance

Published online by Cambridge University Press:  07 March 2007

Reginald J. Fletcher*
Affiliation:
Kellogg Europe, Talbot Road, Manchester, M16 0PU, UK
Ian P. Bell
Affiliation:
Kellogg Europe, Talbot Road, Manchester, M16 0PU, UK
Janet P. Lambert
Affiliation:
Lambert Nutrition Consultancy, 5 Britwell Road, Watlington, OX49 5JS, UK
*
*Corresponding author: Reginald J. Fletcher, fax +44 161 869 2103, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Micronutrient malnutrition is widespread throughout the world, with important health and economic consequences. Tools to address this situation include food fortification, supplementation and dietary diversification, each having different and complementary roles. Fortification (mandatory and voluntary) has been practised over several decades in Western countries as well as in developing countries. Iodised salt was introduced in the USA in 1924 to reduce severe I deficiency. In 1938 voluntary enrichment of flours and breads with niacin and Fe was initiated to reduce the incidence of pellagra and Fe-deficiency anaemia respectively. Micronutrient intakes in European countries appear to be generally adequate for most nutrients. However, a number of population subgroups are at higher risk of suboptimal intakes (below the lower reference nutrient intake) for some micronutrients, e.g. folate, Fe, Zn and Ca in children, adolescents and young women. Dietary surveys indicate that fortified foods play a role in mitigating such risks for several important nutrients. The number of foods suited to fortification are considerably limited by several factors, including technological properties (notably moisture, pH and O2 permeability), leading to unacceptable taste and appearance, as well as cost and consumer expectations. In countries in which voluntary fortification is widely practised micronutrient intakes are considerably below tolerable upper intake levels. Concerns about safety are addressed in relation to the potentially increased level or proportion of fortified foods (e.g. following potential EU legislation), for nutrients with relatively low tolerable upper intake levels and where the potential benefit and risks are in different subpopulations (e.g. folic acid). Recent models for assessing these issues are discussed.

Type
Symposium on ‘Micronutrient interactions and public health’
Copyright
Copyright © The Nutrition Society 2004

References

Act of Parliament (1995) Statutory Instrument 1995 no. 3116 The Spreadable Fats (Marketing Standards) Regulations 1995. London: H.M. Stationery Office; available at www.hmso.gov.uk/si/si1995/Uksi_19953116_en_1.htmGoogle Scholar
Act of Parliament (1998) Statutory Instrument 1998 no. 141. Bread and Flour Regulations 1998. London: H.M. Stationery Office; available at www.legislation.hmso.gov.uk/si/si1998/19980141.htmGoogle Scholar
ACC/SCN (2000) Fourth Report on the World Nutrition Situation.Geneva:WHO.Google Scholar
Allen, LH (2003) Interventions for micronutrient deficiency control in developing countries: past, present and future. Journal of Nutrition 133, 3875S3878S.CrossRefGoogle ScholarPubMed
American, Dietetic Association (2001) Position of the American Dietetic Association: Food fortification and dietary supplements. Journal of the American Dietetic Association 101, 115125Google Scholar
Bernier, JJ (1995) Rapport sur les Limites de Sécurité dans les Consommations Alimentaires des Vitamines et Mineraux (Report on the Safe Limits for Food Intakes of Vitamins and Minerals) Paris, France: Conseil Supérieur d'Hygiène Publique de FranceGoogle Scholar
Bertrais, S, Polo, ML, Preziosi, P, Fieux, B, Torra, De M, Galan, P, Hercberg, S (2000) Contribution of ready-to-eat cereals to nutrition intakes in French adults and relations with corpulence. Annals of Nutrition and Metabolism 44, 249255CrossRefGoogle ScholarPubMed
Blum, M (1997) Status Paper: Food Fortification, a Key Strategy to End Micronutrient Malnutrition. NUTRIVIEW 97/Special Issue Basel, Switzerland: Vitamin Division, F. Hoffmann-La Roche LtdGoogle Scholar
Bollet, AJ (1992) Politics and pellagra: the epidemic of pellagra in the U.S. in the early twentieth century. Yale Journal of Biological Medicine 65, 211221Google ScholarPubMed
Brussaard, JH, Brants, HAM, Lowik, MRH (1997) Nutritional status among adults with special reference to micronutrients. European Journal of Clinical Nutrition 51, Suppl. 4. S1S66Google Scholar
Choi, SW, Mason, JB (2002) Folate status: effects on pathways of colorectal carcinogenesis. Journal of Nutrition 135 2413S – 2418SGoogle Scholar
Commission of, the European Communities (2003) COM 671, Proposal for a Regulation of the European Parliament and of the Council, on the Addition of Vitamins and Minerals and of Certain Other Substances to Foods Brussels, Belgium Commission of the European CommunitiesGoogle Scholar
Confederation of, the Food and, Drink Industries, of the, European Union (1999) Addition of Nutrients to Food Brussels, Belgium: CIAAGoogle Scholar
Cuskelly, GJ, McNulty, H, Scott, JM (1996) Effect of increasing dietary folate on red cell folate: implications for the prevention of neural tube defects. Lancet 347, 657659CrossRefGoogle ScholarPubMed
Darnton-Hill, I, Nalubola, R (2002) Fortification strategies to meet micronutrient needs: successes and failures. Proceedings of the Nutrition Society 61, 231241Google Scholar
De, Groot, LC, Hautvast, JG van Staveren, WA (1992) Nutrition and health of elderly people in Europe: the EURONUT-SENECA Study. Nutrition Reviews 50, 185194Google Scholar
Department of HealthDepartment of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 41. London: H.M. Stationery Office.Google Scholar
European Community (2002) Articles 28 and 30 of the Treaty establishing the European Community (TEC), consolidated version. Official Journal of the European Communities. C325.Google Scholar
Essama-Tjani, JC, Guilland, JC, Potier, de G, Fuchs, F, Richard, D (2000) Folate status worsens in recently institutionalized elderly people without evidence of functional deterioration. Journal of the American College of Nutrition 19, 392404CrossRefGoogle ScholarPubMed
Expert Group, on Vitamins, and Minerals (2003) Safe Upper Limits for Vitamins and Minerals. London: Food Standards Agency.Google Scholar
Finch, S, Doyle, W, Lowe, C, Bates, CJ, Prentice, A, Smithers, G, Clarke, PC (1998) National Diet and Nutrition Survey: People Aged 65 Years and Over. 1: Report of the Diet and Nutrition Survey London The Stationery OfficeGoogle Scholar
Flynn, A, Moreiras, O, Stehle, P, Fletcher, RJ, Muller, DJG, Rolland, V (2003) Vitamins and minerals: a model for safe addition to foods. European Journal of Nutrition 42, 118130Google Scholar
Food and, Agriculture Organization (1996) Food Fortification: Technology and Quality Control. Rome: FAO.Google Scholar
Food and, Drug Administration (1996) Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Federal Register 61, 87818797Google Scholar
Galvin, MA, Kiely, M, Flynn, A (2003) Impact of ready-to-eat-breakfast cereal (RTEBC) consumption on adequacy of micronutrient intakes and compliance with dietary recommendations in Irish adults. Public Health Nutrition 6, 351363CrossRefGoogle ScholarPubMed
Gibson, S (2003) Micronutrient intakes, micronutrient status and lipid profiles among young people consuming different amounts of breakfast cereals: further analysis of data from the National Diet and Nutrition Survey of Young People aged 4 to 18 years. Public Health Nutrition 6, 815820Google Scholar
Gibson, SA, O'Sullivan, K (1995) Breakfast cereal consumption patterns and nutrient intakes of British schoolchildren. Journal of the Royal Society of Health 115, 366370CrossRefGoogle ScholarPubMed
Gregory, J, Lowe, S (2000) National Diet and Nutrition Survey: Young People Aged 4 to 18 Years. 1: Report of the Diet and Nutrition Survey. London: The Stationery Office.Google Scholar
Gregory, JR, Collins, DL, Davies, PSW, Hughes, J, Clarke, PC (1995) National Diet and Nutrition Survey: Children Aged 1.5 to 4.5 Years. 1: Report of the Diet and Nutrition Survey. London: H.M. Stationery Office.Google Scholar
Hallberg, L (1995) Results of surveys to assess iron status in Europe. Nutrition Reviews 11, 314322Google Scholar
Hannon, EM, Kiely, M, Harrington, KE, Robson, PJ, Strain, JJ, Flynn, A (2001) The North/South Ireland Food Consumption Survey: mineral intakes in 18–64-year-old adults. Public Health Nutrition 4, 10811088CrossRefGoogle ScholarPubMed
Henderson, L, Irving, K, Gregory, J (2003) The National Diet and Nutrition Survey: Adults Aged 19 to 64 Years3 London: The Stationery OfficeGoogle Scholar
Hercberg, S, Preziosi, P, Galan, P, Yacoub, N, Kara, G, Deheeger, M (1996) La consommation du petit déjeuner dans l‘étude du Val-de-Marne 3. La valeur nutritionnelle du petit déjeuner et ses relations avec l’équilibre nutritionnel global et le statut minéral et vitaminique (Consumption at breakfast in the Val-de-Marne Study 3. The nutritional value of breakfast and its relationship with the overall nutritional balance and the mineral and vitamin status) Cahiers de Nutrition et de Dietetique Suppl. 1 1825Google Scholar
Honein, MA, Paulozzi, LJ, Mathews, TJ, Erickson, JD, Wong, LY (2001) Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. Journal of the American Medical Association 285, 30223023Google ScholarPubMed
Institute of MedicineInstitute of Medicine (1997) Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press.Google Scholar
Institute of MedicineInstitute of Medicine (1998) Dietary Reference Intakes: Folate, Other B Vitamins, and Choline. Washington, DC: National Academy Press.Google Scholar
Institute of MedicineInstitute of Medicine (2000 a) Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline. Washington, DC: National Academy Press.Google Scholar
Institute of MedicineInstitute of Medicine (2000 b) Dietary Reference Intakes for Vitamin C, Selenium, and Carotenoids. Washington, DC: National Academy Press.Google Scholar
Institute of MedicineInstitute of Medicine (2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press.Google Scholar
Kiely, M, Flynn, A, Harrington, KE, Robson, PJ, O'Connor, N, Hannon, EM, O'Brien, MM, Bell, S, Strain, JJ (2001) The efficacy and safety of nutritional supplement use in a representative sample of adults in North/South Ireland Food Consumption Survey. Public Health Nutrition 4, 10891097CrossRefGoogle Scholar
Lanska, DJ (1996) Stages in recognition of epidemic pellagra in the United States: 1865–1960. Neurology 47, 829834Google Scholar
Lee, K, Bradley, R, Dwyer, J, Lee, Sl (1999) Too much versus too little: the implications of the current iodine intake in the United States. Nutrition Reviews 57, 177181Google Scholar
McNulty, H, Eaton-Evans, J, Cran, G, Woulahan, G, Boreham, C, Savage, JM, Fletcher, R, Strain, JJ (1996) Nutrient intakes and impact of fortified breakfast cereals in schoolchildren. Archives of Disease in Childhood 75, 474481CrossRefGoogle ScholarPubMed
Mejia, LA (1994) Fortification of foods: Historical development and current practices. Food and Nutrition Bulletin 15 – available at http://www.unu.edu/unupress/food/8F154e/8F154E00.htmCrossRefGoogle Scholar
Mills, JL, Von Kohorn, I, Conley, MR, Zeller, JA, Cox, C, Williamson, RE, Dufour, DR (2003) Low vitamin B-12 concentrations in patients without anemia: the effect of folic acid fortification of grain. American Journal of Clinical Nutrition 77, 14741477CrossRefGoogle ScholarPubMed
Ministry of Agriculture, Fisheries and Food (2000) National Food Survey 1999 (Annual Report on Food Expenditure, Consumption and Nutrient Intakes). London: H.M. Stationery Office.Google Scholar
O'Brien, MM, Kiely, M, Harrington, KE, Robson, PJ, Strain, JJ, Flynn, A (2001) The North/South Ireland Food Consumption Survey: vitamin intakes in 18–64-year-old adults. Public Health Nutrition 4, 10691079Google Scholar
Ortega, RM, Requejo, AM, Redondo, R, Lopez-Sobaler, AM, Andres, P, Ortega, A, Gaspar, MJ, Quintas, E, Navia, B (1996) Influence of the intake of fortified breakfast cereals on dietary habits and nutritional status of Spanish schoolchildren. Annals of Nutrition and Metabolism 40, 146156CrossRefGoogle ScholarPubMed
Ottaway, B (1995) The Technology of Vitamins in Food Glasgow Blackie Academic and ProfessionalGoogle Scholar
Ovesen, L, Andersen, R, Jakobsen, J (2003) Geographical differences in vitamin D status, with particular reference to European countries. Proceedings of the Nutrition Society 62, 813821CrossRefGoogle ScholarPubMed
Preziosi, P, Galan, P, Deheeger, M, Jacob, N, Drewnowski, A, Hercberg, S (1999) Breakfast type, daily nutrient intakes and vitamin and mineral status of French children, adolescents and adults. Journal of the American College of Nutrition 18, 171178CrossRefGoogle ScholarPubMed
Renwick, AG, Flynn, A (2004) Risk benefit analysis of micronutrients Food and Chemical ToxicologyGoogle Scholar
Richardson, DP (1990) Food fortification. Proceedings of the Nutrition Society 49, 3950Google Scholar
Richardson, DP (1997) The addition of nutrients to food. Proceedings of the Nutrition Society 56, 807825Google Scholar
Schneider, R, Eberhardt, W, Heseker, H, Kubler, W (1995) Vitamin intake and status in Germany. Bibliotheca Nutritio et Dieta 52, 116127Google Scholar
Scientific Committee on FoodScientific Committee on Food (2000) Guidelines of the Scientific Committee on Food for the development of tolerable upper intake levels for vitamins and minerals. SCF/CS/NUT/UPPLEV/11 Final, 28 November 2000. http://europa.eu.int/comm/food/fs/sc/scf/out80a_en.pdfGoogle Scholar
SCOOP Task, 7.1.1 Working Group (1997) Scientific Considerations for Development of Measures on the Addition of Vitamins and Minerals to Foodstuffs Zeist, The Netherlands: TNO Food and Nutrition ResearchGoogle Scholar
Sebrell, WH (1974) Past experience in fortification of processed foods. In Nutrients in Processed Foods, pp. 95100 [White, PL, Fletcher, DC, Ellis, M and the American Medical Association, editors]. Acton, MA: Publishing Science Group.Google Scholar
Serra-Majem, L (2001) Vitamin and mineral intakes in European children. Is food fortification needed. Public Health Nutrition 4, 101107Google Scholar
Serra-Majem, L, Ortega, R, Aranceta, J, Entrala, A, Gil, A (2001) Fortified foods. Criteria for vitamin supplementation in Spain. Public Health Nutrition 4, 13311334CrossRefGoogle ScholarPubMed
Tucker, KL, Olson, B, Bakun, P, Dallal, GE, Selhub, J, Rosenberg, IH (2004) Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. American Journal of Clinical Nutrition 79, 805811Google Scholar
Van, der, Wielen, RPJ, Löwik, MRH, van, den, Berg, H, de, Groot, CPGM, Haller, J, Moreiras, O, van Staveren WA (1995) Serum vitamin D concentrations among elderly people in Europe. Lancet 346, 207210Google Scholar