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Plant foods for human health: research challenges

Published online by Cambridge University Press:  07 March 2007

John C. Mathers*
Affiliation:
Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
*
Corresponding author: Professor John Mathers, fax + 44 191 222 8943, email [email protected]
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Abstract

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Plants provide the major part of human food intake. Whilst advances in agronomic characteristics (improved yield and better pest and disease resistance) continue to be a very high priority, there is increasing opportunity to enhance the nutritional value of plant based diets by improving the nutritional quality of staple foods. We now have proof of principle that genetic engineering can be used to produce plant-derived human vaccines. In relation to plant foods for human health, the research challenges include understanding: (1) why certain foods cause adverse reactions in some individuals but not in others; (2) the mechanisms of action of apparently ‘protective’ foods such as fruits and vegetables. There is also a need to develop much more informative and robust methods for measuring dietary exposure to specific plant foods or food constituents, including both recent exposure, for which a metabolomics approach may be particularly helpful, and long-term exposure.

Type
Closing Lecture
Copyright
Copyright © The Nutrition Society 2006

References

Acamovic, T Brooker, JD (2005) Biochemistry of plant secondary metabolites and their effects in animals Proceedings of the Nutrition Society 64 403412.CrossRefGoogle ScholarPubMed
Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta-carotene on lung cancer incidence and other cancers in male smokers New England Journal of Medicine 330 10291035.CrossRefGoogle Scholar
Ames, BN Wakimoto, P (2002) Are vitamin and mineral deficiencies a major cancer risk? Nature Reviews Cancer 2 694704.CrossRefGoogle ScholarPubMed
Bingham, SA (2002) Biomarkers in nutritional epidemiology Public Health Nutrition 5 821827.CrossRefGoogle ScholarPubMed
Bingham, SA Gill, C Welch, A, Cassidy, A Runswick, SA Oakes, S et al. (1997) Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers International Journal of Epidemiology 26, Suppl. 1 S137S151CrossRefGoogle ScholarPubMed
Brash, DE Havre, PA (2002) New careers for antioxidants Proceedings of the National Academy of Sciences USA 99 1396913971.CrossRefGoogle ScholarPubMed
Clark, HE Allen, PE Meyers, SM, Tuckett, SE Yamamura, Y (1967) Nitrogen balances of adults consuming opaque-2 maize protein American Journal of Clinical Nutrition 20 825833.CrossRefGoogle ScholarPubMed
Collins, AR Harrington, V Drew, J, Melvin, R (2003) Nutritional modulation of DNA repair in a human intervention study Carcinogenesis 24 511515.CrossRefGoogle Scholar
Crow, JF Kermicle, J (2002) Oliver Nelson and quality protein maize Genetics 160 819821.CrossRefGoogle Scholar
European Commission (2004) Plants for the Future. Luxembourg: Office for Official Publications of the European Communities.Google Scholar
Gibbon, BC Larkins, BA (2005) Molecular genetic approaches to developing quality protein maize Trends in Genetics 21 227233.CrossRefGoogle ScholarPubMed
Gibney, MJ Walsh, M Brennan, L, Roche, HM German, B van Ommen, B (2005) Metabolomics in human nutrition: opportunities and challenges American Journal of Clinical Nutrition 82 497503.CrossRefGoogle ScholarPubMed
Haq, TA Mason, HS Clements, JD, Arntzen, CJ (1995) Oral immunization with a recombinant bacterial antigen produced in transgenic plants Science 268 714716.CrossRefGoogle ScholarPubMed
Jaenisch, R Bird, A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Nature Genetics 33 245254.CrossRefGoogle ScholarPubMed
Jood, S Singh, M (2001) Amino acid composition and biological evaluation of the protein quality of high lysine barley genotypes Plant Foods for Human Nutrition 56 145155.CrossRefGoogle ScholarPubMed
Koziel, MG Beland, GL Bowman, C Carozzi, NB Crenshaw, R Crossland, L et al. (1993) Field performance of elite transgenic maize plants expressing an insecticidal protein derived from Bacillus thuringiensis Bio-Technology 11 194200.Google Scholar
Lai, CL Ratziu, V Yuen, M-F, Poynard, T (2003) Viral hepatitis B Lancet 362 20892094.CrossRefGoogle ScholarPubMed
Liu, Y Kulesz-Martin, M (2001) p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding Carcinogenesis 22 851860.CrossRefGoogle ScholarPubMed
Martin-Orúe, SM O'Donnell, AG Ariño, J Netherwood, T, Gilbert, HJ Mathers, JC (2002) Degradation of transgenic DNA from genetically modified soya and maize in human intestinal simulations British Journal of Nutrition 87 533542.CrossRefGoogle ScholarPubMed
Mathers, JC (2003) Nutrients and apoptosis. In Molecular Nutrition, pp. 7389 [Zempleni, J and Daniel, H, editors]. Wallingford, Oxon.: CABI Publishing.CrossRefGoogle Scholar
Mathers, JC (2004a) The biological revolution – towards a mechanistic understanding of the impact of diet on cancer risk Mutation Research 551 4349.CrossRefGoogle ScholarPubMed
Mathers, JC (2004b) Chairman's introduction: what can we expect to learn from genomics? Proceedings of the Nutrition Society 63 14.CrossRefGoogle ScholarPubMed
Mazza, R Soave, M Morlacchini, M, Piva, G Marocco, A (2005) Assessing the transfer of genetically modified DNA from feed to animal tissues Transgenic Research 14 775784.CrossRefGoogle ScholarPubMed
Mertz, ET Bates, LS Nelson, OE (1964) Mutant maize that changes the protein composition and increases the lysine content of maize endosperm Science 145 279280.CrossRefGoogle ScholarPubMed
Millward, DJ (1999) The nutritional value of plant-based diets in relation to human amino acid and protein requirements Proceedings of the Nutrition Society 58 249260.CrossRefGoogle ScholarPubMed
Millward, DJ Jackson, AA (2004) Protein/energy ratios of current diets in developed and developing countries compared with safe protein/energy ratio: implications for recommended protein and amino acid intakes Public Health Nutrition 7 387405.CrossRefGoogle ScholarPubMed
Milner, JA (2004) Molecular targets for bioactive food components. Journal of Nutrition 134 2492S2498S.CrossRefGoogle ScholarPubMed
Netherwood, T Martin-Orúe, SM O'Donnell, AG Glocking, S Graham, J, Mathers, JC Gilbert, HJ (2004) Assessing the survival of transgenic plant DNA in the human gastrointestinal tract Nature Biotechnology 22 204209.CrossRefGoogle ScholarPubMed
Nielsen, KM Townsend, JP (2004) Monitoring and modelling horizontal gene transfer Nature Biotechnology 22 11101114.CrossRefGoogle ScholarPubMed
Olsen, OA (1974) Ultrastructure and genetics of the barley line hiproly Hereditas 77 287302.CrossRefGoogle ScholarPubMed
Oommen, AM Griffin, JB Sarath, G Zempleni, J (2005) Roles for nutrients in epigenetic events. Journal of Nutritional Biochemistry 16 7477.CrossRefGoogle ScholarPubMed
Padgette, SR Kolacz, KH Delannay, X Re, DB Lavallee, BJ, Tinius, CN et al. (1995) Development, identification, and characterization of a glyphosate-tolerant soybean line Crop Science 35 14511461.CrossRefGoogle Scholar
Rhodes, AP Mathers, JC (1974) Varietal differences in amino acid composition of barley grain during development and under varying nitrogen supply. Journal of the Science of Food and Agriculture 25 963972.CrossRefGoogle ScholarPubMed
Ross, AB Aman, P Kamal-Eldin, A (2004) Identification of cereal alkylresorcinol metabolites in human urine – potential biomarkers of wholegrain wheat and rye intake. Journal of Chromatography 809B 125130.Google Scholar
Rossi, F Morlacchini, M Fusconi, G, Pietri, A Mazza, R, Piva, G (2005) Effect of Bt corn on broiler growth performance and fate of feed-derived DNA in the digestive tract Poultry Science 84 10221030.CrossRefGoogle ScholarPubMed
Steele, VE (2003) Current mechanistic approaches to chemoprevention of cancer. Journal of Biochemistry and Molecular Biology 36 7881.Google ScholarPubMed
Streatfield, SJ Jilka, JM Hood, EE, Turner, DD Bailey, MR, Mayor, JM et al. (2001) Plant-based vaccines: unique advantages Vaccine 19 27422748.CrossRefGoogle ScholarPubMed
Tacket, CO Pasetti, MF Edelman, R Howard, JA Streatfield, S (2004) Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn Vaccine 22 43854389.CrossRefGoogle ScholarPubMed
Thanavala, Y Mahoney, M Pal, S, Scott, A Richter, L, Natarajan, N Goodwin, P, Arntzen, CJ Mason, HS (2005) Immunogenicity in humans of an edible vaccine for hepatitis B Proceedings of the National Academy of Sciences, USA 102 33783382.CrossRefGoogle ScholarPubMed
Trichopoulou, A Orfanos, P Norat, T, Bueno-de-Mesquita, B Ocke, MC Peeters, PH et al. (2005) Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study British Medical Journal 330 991997.CrossRefGoogle ScholarPubMed
Wei, Q Shen, H Wang, LE Duphorne, CM, Pillow, PC Guo, Z Qiao, Y, Spitz, MR (2003) Association between low dietary folate intake and suboptimal cellular DNA repair capacity Cancer Epidemiology Biomarkers and Prevention 12 963969.Google ScholarPubMed
Welch, RM Graham, RD (2004) Breeding for micronutrients in staple food crops from a human nutrition perspective. Journal of Experimental Botany 55 353364.CrossRefGoogle ScholarPubMed
World Health Organization (1996) Fighting Disease, Fostering Development. Geneva: WHO.Google Scholar
World Health Organization/Food and Agriculture Organization (2003) Diet, Nutrition and the Prevention of Chronic Diseases. WHO Technical Report Series no. 916. Geneva: WHO.Google Scholar
Ye, X Al-Babili, S Klöti, A Zhang, J Lucca, P, Beyer, P Potrykus, I (2000) Engineering provitamin A (β-carotene) biosynthetic pathway into (carotenoids-free) rice endosperm Science 287 303305.CrossRefGoogle Scholar