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Phyto-oestrogens: A potential role in the prevention of CHD?

Published online by Cambridge University Press:  28 February 2007

Aedin Cassidy  and
Bruce Griffin
Aedin Cassidy*
Affiliation:
Centre for Nutrition and Food Safety, University of Surrey, Guildford, GU2 5XH, UK
Bruce Griffin*
Affiliation:
Centre for Nutrition and Food Safety, University of Surrey, Guildford, GU2 5XH, UK
*
Corresponding author: Dr Aedin Cassidy, fax +44 (0)1483 259341, email [email protected]
Corresponding author: Dr Aedin Cassidy, fax +44 (0)1483 259341, email [email protected]
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Abstract

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CHD is a major cause of morbidity and mortality in women. The incidence of CHD in premenopausal women is low but increases substantially after the menopause, and this difference suggests that endogenous oestrogens are cardioprotective. Observational prospective studies have consistently shown that exogenous oestrogens also lower CHD risk. The biological mechanisms by which endogenous and exogenous oestrogens exert their protective effect are multifactorial, affecting lipids, carbohydrate metabolism, body fat distribution and blood pressure. The prevention of CHD with oestrogen therapy is therefore aimed both at correction of the traditional risk factors and at direct control of vessel structure and function. The wide international variation in rates of CHD together with the lower mortality in sub-groups of the population suggests that a considerable proportion of CHD may be prevented by dietary modification. Since phyto-oestrogens are structually similar to oestrogen, they have the potential to mimic its effects in vivo. The hypocholesterolaemic effects of soyabean protein (rich in phyto-oestrogen precursors) are well established, but the underlying mechanism and atherogenic potential of these changes are unknown. One isoflavone, genistein, has been shown in vitro to exert effects which may slow the development of atherosclerotic disease. However, further studies are required to determine the dose-related changes induced by phyto-oestrogens on serum lipoproteins, haemostasis and vascular function.

Keywords

Phyto-oestrogensOestrogensLignansSoyabeanCHD
Type
Micronutrient Group Symposium on ‘Dietary determinants of lipoprotein-mediated cardiovascular risk’
Information
Proceedings of the Nutrition Society , Volume 58 , Issue 1 , February 1999 , pp. 193 - 199
Copyright
Copyright © The Nutrition Society 1999

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