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The nutritional value of plant-based diets in relation to human amino acid and protein requirements

Published online by Cambridge University Press:  28 February 2007

D. Joe Millward
D. Joe Millward*
Affiliation:
Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
*
*Corresponding author: Professor D. Joe Millward, fax +44 (0)1483 259297, email [email protected]
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Abstract

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The adequacy of plant-based diets in developed and developing countries as sources of protein and amino acids for human subjects of all ages is examined. Protein quantity is shown not to be an issue. Digestibility is identified as a problem for some cereals (millet (Panicum miliaceum) and sorghum (Sorghum sp.)) and generally is poorly understood. Direct measurements of biological value in children are reviewed and scoring is consid-ered. Various existing requirement values for amino acids and especially lysine are reviewed, and it is concluded that stable-isotope studies do not yet provide adequate alternative values to N balance data, which for lysine are robust after recalculation and adjustment. A new maintenance requirement pattern is developed, with higher values than those of Food and Agriculture Organization/World Health Organization/United Nations University (1985) but lower values than the Massachusetts Institute of Technol-ogy pattern (Young et al. 1989). Calculations of age-related amino acid requirements are based on most recent estimates of human growth and maintenance protein requirements, a tissue amino acid pattern and the new maintenance amino acid pattern. These values appear valid when used to score plant proteins, since they indicate values similar to or less than the biological value measured directly in young children. When used to score plant-based diets in India, no marked deficiencies are identified. All regions score > 1 for adults, whilst for children scores range from > 1, (Tamil Nadhu) from 6 months of age to 0.78 (West Bengal), rising to 0.9 in the 2–5 year old, consistent with reports that high-lysine maize supports similar weight and height growth to that of casein. Inadequate amino acid supply is not an issue with most cereal-based diets.

Keywords

LysineProtein scoringPlant-based dietsChildren
Type
Meat or wheat for the next millennium? Plenary Lecture
Information
Proceedings of the Nutrition Society , Volume 58 , Issue 2 , May 1999 , pp. 249 - 260
Copyright
Copyright © The Nutrition Society 1999

References

Benevenga, NJ, Gahl, MJ, Crenshaw, TD & Fink, MD (1994) Protein and amino acid requirements for maintenance and growth of laboratory rats. Journal of Nutrition 124, 451–453.CrossRefGoogle ScholarPubMed
Bingham, SA (1997) Urine nitrogen as an independent validatory measure of protein intake. British Journal of Nutrition 77, 144–148.Google ScholarPubMed
Bolourchi, S, Friedeman, CM & Mickelson, O (1968) Wheat flour as a source of protein for adult human subjects. American Journal of Clinical Nutrition 21, 827–835.CrossRefGoogle ScholarPubMed
Bressani, R, Viteri, F & Elias, LG (1973) The usefulness of results in human beings of standardised rat assays. In Protein in Human Nutrition, pp. 293–316 [Porter, JWG and Rolls, BA, editors]. London: Academic Press.Google Scholar
Cassidy, A (1996) Physiological effects of phyto-oestrogens in relation to cancer and other human health risks. Proceedings of the Nutrition Society 55, 399–417.CrossRefGoogle ScholarPubMed
Clark, HE, Reitz, LL, Vacharotayan, TS & Mertz, ET (1962) Effect of certain factors on nitrogen retention and lysine requirements of adult human subjects. Journal of Nutrition 78, 173–178.CrossRefGoogle ScholarPubMed
Davis, TA, Nguyen, HV, Garcia-Bravo, R, Fiorotto, ML, Jackson, EM, Lewis, DS, Lee, DR & Reeds, PJ (1994) Amino acid composition of human milk is not unique. Journal of Nutrition 124, 1126–1132.CrossRefGoogle Scholar
Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 41. London: H. M. Stationery Office.Google Scholar
Dewey, KG, Beaton, G, Fjeld, C, Lonnerdal, B & Reeds, P (1996) Protein requirements of infants and children. European Journal of Clinical Nutrition 50, Suppl. 1, S119–S147.Google ScholarPubMed
Duncan, AM, Ball, RO & Pencharz, PB (1996) Lysine requirement of adult males is not affected by decreasing dietary protein. American Journal of Clinical Nutrition 64, 718–725.CrossRefGoogle Scholar
Edwards, CH, Booker, LK, Rumph, CH, Wright, WG, Ganapathy, MS & Ganapathy, S (1971) Utilization of wheat by adult man: nitrogen metabolism, plasma amino acids and lipids. American Journal of Clinical Nutrition 24, 181–193.CrossRefGoogle ScholarPubMed
Food and Agriculture Organization/World Health Organization (1973) Energy and Protein Requirements. Report of a Joint FAO/WHO ad hoc Expert Committee. WHO Technical Report Series no. 522. Geneva: WHO.Google Scholar
Food and Agriculture Organization/World Health Organization (1991) Protein Quality Evaluation. Report of a Joint FAO/WHO Expert Consultation. FAO Food and Nutrition Paper no. 51. Rome: FAO.Google Scholar
Food and Agriculture Organization/World Health Organization/United Nations University (1985) Energy and Protein Requirements. Report of a Joint Expert Consultation. WHO Technical Report Series no. 724. Geneva: WHO.Google Scholar
Fuller, MF & Garlick, PJ (1994) Human amino acid requirements: can the controversy be resolved? Annual Review of Nutrition 14, 217–241.CrossRefGoogle ScholarPubMed
Fuller, MF, McWilliam, R, Wang, TC & Giles, LR (1989) The optimum dietary amino acid pattern for growing pigs; requirements for maintenance and for tissue protein accretion. British Journal of Nutrition 62, 255–267.CrossRefGoogle ScholarPubMed
Fuller, MF, Milne, A, Harris, CI, Reid, TM & Keenan, R (1994) Amino acid losses in ileostomy fluid on a protein-free diet. American Journal of Clinical Nutrition 59, 70–73.CrossRefGoogle ScholarPubMed
Gibson, NR, Ah-Sing, E, Badalloo, A, Forrester, T, Jackson, A & Millward, DJ (1997) Transfer of 15N from urea to the circulating dispensable and indispensable amino acid pool in the human infant. Proceedings of the Nutrition Society 56, 79A.Google Scholar
Golden, MHN (1997) Protein–energy interactions in the management of severe malnutrition. Clinical Nutrition 16, Suppl. 1, 19–23.CrossRefGoogle ScholarPubMed
Graham, GG, Lembcke, J & Morales, E (1990) Quality-protein maize as the sole source of dietary protein and fat for rapidly growing young children. Pediatrics 85, 85–91.CrossRefGoogle ScholarPubMed
Graham, GG, Morales, E, Placko, RP & Maclean, WC (1997) Nutritive value of brown and black beans for infants and small children. American Journal of Clinical Nutrition 32, 2362–2366.CrossRefGoogle Scholar
Health Education Authority (1996) The Balance of Good Health. London: Health Education Authority.Google Scholar
Hegsted, DM (1963) Variation in requirements of nutrients: amino acids. Federation Proceedings 22, 1424–1430.Google ScholarPubMed
Hegsted, DM (1976) Balance studies. Journal of Nutrition 106, 307–311.CrossRefGoogle Scholar
Jackson, AA & Margetts, BM (1993) Protein intakes in the adult population of the UK. International Journal of Food Science and Nutrition 44, 95–104.CrossRefGoogle Scholar
Jepson, MM, Bates, PC & Millward, DJ (1988) The role of insulin and thyroid hormones in the regulation of muscle growth and protein turnover in response to dietary protein. British Journal of Nutrition 59, 397–415.Google ScholarPubMed
Jones, EM, Bauman, CA & Reynolds, MS (1956) Nitrogen balances in women maintained on various levels of lysine. Journal of Nutrition 60, 549–559.CrossRefGoogle Scholar
MacFarlane, G & Cummings, JH (1991) The colonic flora, fermentation, and large bowel digestive function. In The Large Intestine: Physiology, Pathophysiology and Disease, pp. 51–92 [Phillips, S, Pemberton, JH and Shorter, RG, editors]. New York: Raven Press.Google Scholar
Maclean, WC, De Romana, GL, Placko, RP & Graham, GG (1981) Protein quality and digestibility of sorghum in pre school children: balance studies and plasma free amino acids. Journal of Nutrition 111, 1928–1936.CrossRefGoogle Scholar
Malcolm, LA (1970) Growth retardation in a New Guinea boarding school and its response to supplementary feeding. British Journal of Nutrition 24, 297–305.CrossRefGoogle Scholar
Marchini, JS, Cortiella, J, Hiramatsu, T, Chapman, TE & Young, VR (1993) Requirements for indispensable amino acids in adult humans: longer-term amino acid kinetic study with support for the adequacy of the Massachusetts Institute of Technology amino acid requirement pattern. American Journal of Clinical Nutrition 58, 670–683.CrossRefGoogle ScholarPubMed
Meakins, TS & Jackson, AA (1996) Salvage of endogenous urea nitrogen enhances nitrogen balance in normal men consuming marginally inadequate protein diets. Clinical Science 90, 215–225.CrossRefGoogle ScholarPubMed
Meredith, CN, Wen, Z-M, Bier, DM, Matthews, DE & Young, VR (1986) Lysine kinetics at graded lysine levels in young men. American Journal of Clinical Nutrition 43, 787–794.CrossRefGoogle Scholar
Millward, DJ (1994) Can we define indispensable amino acid requirements and assess protein quality in adults? Journal of Nutrition 124, 1509–1516.CrossRefGoogle ScholarPubMed
Millward, DJ (1997) Human amino acid requirements. Journal of Nutrition 127, 1842–1846.CrossRefGoogle ScholarPubMed
Millward, DJ (1998 a) Quality and utilization of plant proteins in human nutrition. In Plant Proteins from European Crops: Food and Non-Food Applications, pp. 169–176 [Gueguen, J and Popineau, Y, editors]. Berlin: Springer–Verlag.CrossRefGoogle Scholar
Millward, DJ (1998 b) Metabolic demands for amino acids and the human dietary requirement: Millward and Rivers (1988) revisited. Journal of Nutrition (In the Press).CrossRefGoogle ScholarPubMed
Millward, DJ, Jackson, AA, Price, G & Rivers, JPW (1989) Human amino acid and protein requirements: Current dilemmas and uncertainties. Nutrition Research Reviews 2, 109–132.CrossRefGoogle ScholarPubMed
Millward, DJ, Price, G, Pacy, PJH & Halliday, D (1991) Whole body protein and amino acid turnover in man: what can we measure with confidence? Proceedings of the Nutrition Society 50, 195–214.CrossRefGoogle ScholarPubMed
Millward, DJ & Rivers, JPW (1988) The nutritional role of indispensable amino acids and the metabolic basis for their requirements. European Journal of Clinical Nutrition 42, 367–393.Google ScholarPubMed
Millward, DJ & Roberts, SR (1996) Protein requirement of older individuals. Nutrition Research Reviews 9, 67–88.CrossRefGoogle ScholarPubMed
Pacy, PJ, Price, GM, Halliday, D, Quevedo, MR & Millward, DJ (1994) Nitrogen homeostasis in man: the diurnal responses of protein synthesis and degradation and amino acid oxidation to diets with increasing protein intakes. Clinical Science 86, 103–116.CrossRefGoogle ScholarPubMed
Pellett, PL (1996) World essential amino acid supply with special attention to South-East Asia. Food and Nutrition Bulletin 17, 204–234.CrossRefGoogle Scholar
Price, GM, Halliday, D, Pacy, PJ, Quevedo, MR & Millward, DJ (1994) Nitrogen homeostasis in man: 1. Influence of protein intake on the amplitude of diurnal cycling of body nitrogen. Clinical Science 86, 91–102.CrossRefGoogle ScholarPubMed
Quevedo, MR, Price, GM, Halliday, D, Pacy, PJ & Millward, DJ (1994) Nitrogen homeostasis in man: 3. Diurnal changes in nitrogen excretion, leucine oxidation and whole body leucine kinetics during a reduction from a high to a moderate protein intake. Clinical Science 86, 185–193.CrossRefGoogle ScholarPubMed
Rose, WC (1957) The amino acid requirements of adult man. Nutrition Abstracts and Reviews 27, 631–647.Google ScholarPubMed
Rosegrant, MW (1999) Alternative futures for world cereal and meat consumption. Proceedings of the Nutrition Society 58, 219–234.CrossRefGoogle ScholarPubMed
Scrimshaw, NS (1996) Human protein requirements: a brief update. Food and Nutrition Bulletin 17, 185–190.CrossRefGoogle Scholar
Tolbert, B & Watts, JH (1963) Phenylalanine requirements of women consuming a minimal tyrosine diet and the sparing effect of tyrosine on the phenylalanine requirement. Journal of Nutrition 80, 111–117.Google ScholarPubMed
Waterlow, JC (1992) Protein-Energy Malnutrition. London: Edward Arnold.Google Scholar
Waterlow, JC (1996) The requirements of adult man for indispensable amino acids. European Journal of Clinical Nutrition 50, Suppl.1, S151–S176.Google ScholarPubMed
Waterlow, JC, Garlick, PJ & Millward, DJ (1978) Protein Turnover in Mammalian Tissues and the Whole Body. Amsterdam: North Holland Elsevier.Google Scholar
Young, VR (1986) Nutritional balance studies: Indicators of human requirements or adaptive mechanisms. Journal of Nutrition 116, 700–703.CrossRefGoogle ScholarPubMed
Young, VR, Bier, DM & Pellet, PL (1989) A theoretical basis for increasing current estimates of the amino acid requirements in adult man with experimental support. American Journal of Clinical Nutrition 50, 80–92.CrossRefGoogle ScholarPubMed
Young, VR & El-Khoury, AE (1996) Human amino acid requirements: a re-evaluation. Food and Nutrition Bulletin 17, 191–203.CrossRefGoogle Scholar
Young, VR, Fajardo, L, Murray, E, Rand, WM & Scrimshaw, NS (1975) Protein requirements of man: comparative nitrogen balance response within the submaintenance-to-maintenance range of intakes of wheat and beef proteins. Journal of Nutrition 105, 534–544.CrossRefGoogle ScholarPubMed
Young, VR & Pellet, PL (1990) Current concepts concerning indispensable amino acid needs in adults and their implications for international nutrition planning. Food and Nutrition Bulletin 12, 289–300.CrossRefGoogle Scholar
Young, VR & Pellet, PL (1994) Plant proteins in relation to human protein and amino acid nutrition. American Journal of Clinical Nutrition 59, Suppl., 1203S–1212S.CrossRefGoogle ScholarPubMed
Zello, GA, Pencharz, PB & Ball, RO (1993) Dietary lysine requirement of young adult males determined by oxidation of L-[1-13C]phenylalanine. American Journal of Physiology 264, E677–E685.Google Scholar