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New insights into the development of obesity: obese genes and the leptin system

Published online by Cambridge University Press:  28 February 2007

Paul Trayhurn
Paul Trayhurn
Affiliation:
Molecular Physiology Group, Division of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB
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Abstract

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Type
‘Predisposition to obesity: metabolic and/or behavioural factors’ Symposium 1
Information
Proceedings of the Nutrition Society , Volume 55 , Issue 3 , November 1996 , pp. 783 - 791
Copyright
Copyright © The Nutrition Society 1996

References

Becker, D. J., Ongemba, L. N., Brichard, V., Henquin, J.-C. & Brichard, S. M. (1995). Diet-and diabetes-induced changes of ob gene expression in rat adipose tissue. FEBS Letters 371, 324–328.Google Scholar
Billington, C. J., Briggs, J. E., Grace, M. & Levine, A. E. (1991). Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. American Journal of Physiology 260, R321–R327.Google ScholarPubMed
Bing, C., Wang, Q., Pickavance, L. & Williams, G. (1996). The central regulation of energy homeostasis: role of neuropeptide Y and other brain peptides. Biochemical Society Transactions 24, 559–565.CrossRefGoogle Scholar
Bouchard, C. & Pérusse, L. (1993). Genetics of obesity. Annual Reviews of Nutrition 13, 337–354.CrossRefGoogle ScholarPubMed
Bray, G. A. (1991). Weight homeostasis. Annual Reviews of Medicine 42, 205–216.CrossRefGoogle ScholarPubMed
Bray, G. A. & York, D. A. (1979). Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiological Reviews 59, 719–809.CrossRefGoogle ScholarPubMed
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R. & Burn, P. (1995). Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546–549.CrossRefGoogle ScholarPubMed
Cassard-Doulcier, A. M., Bouillaud, F., Chagnon, M., Gelly, C., Dionne, F. T., Oppert, J. M., Bouchard, C., Chagnon, Y. & Ricquier, D. (1996). The BcI I polymorphism of the human uncoupling protein (ucp) gene is due to a point mutation in the 5'-flanking region. International Journal of Obesity 20, 278–279.Google Scholar
Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., Moore, K. J., Breitbart, R. E., Duyk, G. M., Tepper, R. I. & Morgenstern, J. P. (1996). Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell 84, 491–495.CrossRefGoogle ScholarPubMed
Chua, S. C., Chung, W. K., Wu-peng, X. S., Zhang, Y., Liu, S.-M., Tartaglia, L. & Leibel, R. L. (1996). Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271, 994–996.CrossRefGoogle ScholarPubMed
Coleman, D. L. (1978). Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14, 141–148.CrossRefGoogle ScholarPubMed
Coleman, D. L. & Eicher, E. M. (1990). Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. Journal of Heredity 81, 424–427.CrossRefGoogle ScholarPubMed
Considine, R. V., Considine, E. L., Williams, C. J., Nyce, M. R., Magosin, S. A., Bauer, T. L., Rosato, E. L., Colberg, J. & Caro, J. F. (1995). Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. Journal of Clinical Investigation 95, 2986–2988.CrossRefGoogle ScholarPubMed
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., Mckee, L. J., Bauer, T. L. & Caro, J. F. (1996). Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334, 292–295.CrossRefGoogle ScholarPubMed
De vos, P., Saladin, R., Auwerx, J. & Staels, B. (1995). Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. Journal of Biological Chemistry 270, 15958–15961.CrossRefGoogle Scholar
Egawa, M., Yoshimatsu, H. & Bray, G. A. (1991). Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue in rats. American Journal of Physiology 260, R328–R334.Google ScholarPubMed
Frederich, R. C., Löllmann, B., Hamann, A., Napolitano-rosen, A., Kahn, B. B., Lowell, B. B. & Flier, J. S. (1995). Expression of ob mRNA and its encoded protein in rodents: impact of nutrition and obesity. Journal of Clinical Investigation 96, 1658–1663.CrossRefGoogle Scholar
Funahashi, T., Shimomura, I., Hiraoka, H., Arai, T., Takahashi, M., Nakamura, T., Nozaki, S., Yamashita, S., Takemura, K., Tokunaga, K. & Matsuzawa, Y. (1995). Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Biochemical and Biophysical Research Communications 211, 469–475.CrossRefGoogle ScholarPubMed
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K. & Friedman, J. M. (1995). Weight-reducing effects of the plasma-protein encoded by the obese gene. Science 269, 543–546.CrossRefGoogle ScholarPubMed
Hamilton, B. S., Paglia, D., Kwan, A. Y. M. & Deitel, M. (1995). Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Medicine 1, 953–956.CrossRefGoogle ScholarPubMed
Kadowaki, H., Yasuda, K., Iwamoto, K., Otabe, S., Shimokawa, K., Silver, K., Walston, J., Yoshinaga, H., Kosaka, K., Yamada, N., Saito, Y., Hagura, R., Akanuma, Y., Shuldiner, A., Yazaki, Y. & Kadowaki, T (1995). A mutation in th β-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects. Biochemical and Biophysical Research Communications 215, 555–560.CrossRefGoogle Scholar
Kennedy, G. G. (1953). The role of depot fat in the hypothalamic control of food intake in the rat. Proceedings of the Royal Society of London 140B, 578–592.Google Scholar
Klebig, M. L., Wilkinson, J. E., Geisler, J. G. & Woychik, R. P. (1995). Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proceedings of the National Academy of Sciences, USA 92, 4728–4732.CrossRefGoogle ScholarPubMed
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I. & Friedman, J. M. (1996). Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632–635.CrossRefGoogle ScholarPubMed
Leroy, P., Dessolin, S., Villageois, P., Moon, B. M., Friedman, J. M., Ailhaud, G. & Dani, C. (1996). Expression of ob gene in adipose cells. Regulation by insulin. Journal of Biological Chemistry 271, 2365–2368.CrossRefGoogle Scholar
Lönnqvist, F., Arner, P., Nordfors, L. & Schalling, M. (1995). Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Medicine 1, 950–953.CrossRefGoogle ScholarPubMed
Macdougald, O. A., Hwang, C.-S., Fan, H. & Lane, M. D. (1995). Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-Ll adipocytes. Proceedings of the National Academy of Sciences, USA, 92, 9034–9037.CrossRefGoogle Scholar
Madej, T., Boguski, M. S. & Bryant, S. H. (1995). Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Letters 373, 13–18.CrossRefGoogle ScholarPubMed
Maffei, M., Fei, H., Lee, G.-H., Dani, C., Leroy, P., Zhang, Y., Proenca, R., Negrel, R., Ailhaud, G. & Friedman, J. M. (1995 a). Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proceedings of the National Academy of Sciences, USA 92, 6957–6960.CrossRefGoogle Scholar
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., Kern, P. A. & Friedman, J. M. (1995 b). Leptin levels in human and rodent: measurement of plasma leptin and ob mRNA in obese and weight-reduced subjects. Nature Medicine 1, 1155–1161.CrossRefGoogle Scholar
Manne, J., Argeson, A. C. & Siracusa, L. D. (1995). Mechanisms for the pleiotropic effects of the agouti gene. Proceedings of the National Academy of Sciences, USA 92, 4721–4724.CrossRefGoogle ScholarPubMed
Masuzaki, H., Ogawa, Y., Isse, N, Satoh, N., Okazaki, T., Shigemoto, M., Mori, K., Tamura, N., Hosoda, K., Yoshimasa, Y., Jingami, H., Kawada, T. & Nakao, K. (1995). Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44, 855–858.CrossRefGoogle ScholarPubMed
Mercer, S. W., Hoggard, N., Williams, L. M., Lawrence, C. B., Hannah, L. T., Morgan, P. J. & Trayhurn, P. (1996). Co-expression of preproncuropeptide Y and leptin receptor mRNA in arcurate nucleus of mouse hypothalamus. Journal of Neuroendocrinology 8 (In the Press).CrossRefGoogle Scholar
Murakami, T., Iida, M. & Shima, K. (1995). Dexamethasone regulates obese expression in isolated rat adipocytes. Biochemical and Biophysical Research Communications 214, 1260–1267.CrossRefGoogle ScholarPubMed
Murakami, T. & Shima, K. (1995). Cloning of rat obese cDNA and its expression in obese rats. Biochemical and Biophysical Research Communications 209, 944–952.CrossRefGoogle ScholarPubMed
Naggert, J. K., Fricker, L. D., Varlamov, O., Nishina, P. M., Rouille, Y., Steiner, D. F., Carroll, R. J., Paigen, B. J. & Leiter, E. H. (1995). Hyperproinsulinaemia in obese fatlfat mice associated with a carboxypeptidase-E mutation which reduces enzyme-activity. Nature Genetics 10, 135–142.CrossRefGoogle ScholarPubMed
Nasto, B. (1996). Millenium makes gains in 'fat drug' race. Biotechnology 14, 134–135.Google Scholar
Noben-trauth, K., Naggert, J. K., North, M. A. & Nishina, P. M. (1996). A candidate gene for the mouse mutation tubby. Native 380, 534–538.Google ScholarPubMed
Ogawa, Y., Masuzaki, H., Isse, N., Okazaki, T., Mori, K., Shigemoto, M., Satoh, N., Tamura, N., Hosoda, K., Yoshimasa, Y., Jingami, H., Kawada, T. & Nakao, K. (1995). Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (falfa) rats. Journal of Clinical Investigation 96, 1647–1652.CrossRefGoogle Scholar
Oppert, J.-M., Vohl, M.-C., Chagnon, M., Dionne, F. T., Cassard-Doulcier, A.-M., Ricquier, D., Pérusse, L. & Bouchard, C. (1994). DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. International Journal of Obesity 18, 526–531.Google ScholarPubMed
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T. & Collins, F. (1995). Effects of the obese gene-product on body weight regulation in oblob mice. Science 269, 540–543.CrossRefGoogle Scholar
Prentice, A. M. & Jebb, S. A. (1995). Obesity in Britain: gluttony or sloth? British Medical Journal 311, 437–439.CrossRefGoogle ScholarPubMed
Rentseh, J. & Chiesi, M. (1996). Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Letters 379, 55–59.CrossRefGoogle Scholar
Saladin, R., De Vos, P., Guerre-Millo, M., Leturque, A., Girard, J., Staels, B. & Auwerx, J. (1995). Transient increase in obese gene expression after food intake or insulin administration. Nature 377, 527–529.CrossRefGoogle ScholarPubMed
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffman, J., Hsiung, H. M., Kriauciunas, A., MacKellar, W., Rosteck, P. R. Jr, Schoner, B., Smith, D., Tinsley, F. C., Zhang, X.-Y. & Heiman, M. (1995). The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530–532.CrossRefGoogle ScholarPubMed
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. I., Smutko, J. E., Mays, G. G., Woolf, E. A., Monroe, C. A. & Tepper, R. I. (1995). Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1–20.CrossRefGoogle ScholarPubMed
Trayhurn, P. (1984). The development of obesity in animals: the role of genetic susceptibility. Clinics in Endocrinology and Metabolism 13, 451–474.CrossRefGoogle ScholarPubMed
Trayhurn, P. (1992). Genetics of obesity in animal models and in humans. In Obesity in Europe 1991, pp. 77–80 [Ailhaud, G., Guy-Grand, B., Lafontan, M. and Ricquier, D., editors]. Paris: John Libbey.Google Scholar
Trayhurn, P., Duncan, J. S. & Rayner, D. V. (1995 a). Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochemical Journal 311, 729–733.CrossRefGoogle Scholar
Trayhurn, P., Thomas, M. E. A., Duncan, J. S. & Rayner, D. V. (1995 b). Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (oblob) mice. FEBS Letters 368, 488–490.Google ScholarPubMed
Weaver, J. U., Kopelman, P. G. & Hitman, G. A. (1992). Glucose transporter (Glut 1) as a possible candidate gene for obesity. In Obesity in Europe 1991, pp. 89–93 [Ailhaud, G., Guy-Grand, B., Lafontan, M. and Ricquier, M., editors]. Paris: John Libbey.Google Scholar
Williams, G., McKibben, P. E. & McCarthy, H. D. (1991). Hypothalamic regulatory peptides and the regulation of food intake and energy balance: signals or noise? Proceedings of the Nutrition Society 50, 527–544.CrossRefGoogle ScholarPubMed
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. & Friedman, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432.CrossRefGoogle ScholarPubMed