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Motor effects of short-chain fatty acids and lactate in the gastrointestinal tract

Published online by Cambridge University Press:  05 March 2007

Christine Cherbut
Christine Cherbut
Affiliation:
INRA-UFDNH, BP 71627, 44316, Nantes cedex 03, France
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Abstract

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Short-chain fatty acids (SCFA) affect local and remote motility of the gastrointestinal tract by mechanisms that are not completely understood. In the large intestine where they are produced, they inhibit peristaltic activity and may stimulate tonic activity. When present in the terminal ileum as a result of reflux of colon contents, they elicit propulsive contractions. These local motor effects could involve a neuro-hormonal sensory mechanism located in the mucosa of the terminal ileum and proximal colon. Finally, through a humoral pathway probably involving polypeptide YY release, ileal and colonic SCFA modify upper motility by inducing relaxation of the proximal stomach and lower oesophageal sphincter and reducing gastric emptying. One characteristic feature of the SCFA effects is the dose-dependency of the gastrointestinal motor responses. Indeed, the effects occur only below or above a threshold of SCFA concentration in lumen contents. One putative physiological role of the motor effects of SCFA might be to maintain the physico-chemical balance of the lumen environment in the terminal ileum and proximal colon. Another role might be to co-regulate motility of the upper intestine. The clinical relevance of these effects is unclear. However, some recent findings suggest that excessive SCFA concentrations might induce adverse effects on gastrointestinal and colonic motility and sensitivity in certain diseases such as inflammatory bowel disease and gastro-oesophageal reflux disease.

Keywords

Short-chain fatty acidsGastrointestinal motor responsesLactatePolypeptide YY
Type
Session: Short-chain fatty acids
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 1 , February 2003 , pp. 95 - 99
Copyright
Copyright © The Nutrition Society 2003

References

Bicheler, V, Ropert, A, Zerbib, F, Rozé, C, Cherbut, C, Bruley, des, Varannes, S, Galmiche, JP (1999) Effect of PYY on proximal gastric tone in humans. Gastroenterology 116, A958Google Scholar
Cherbut, C, Aubé, AC, Blottière, HM, Pacaud, P, Scarpignato, C, Galmiche, JP (1996) In vitro contractile effects of short chain fatty acids in the rat terminal ileum. Gut 38, 53–58.CrossRefGoogle ScholarPubMed
Cherbut, C, Ferré, JP, Corpet, DE, Ruckebusch, Y & Delort-Laval, (1991) Alteration of intestinal microflora by antibiotics: effects on fecal excretion, transit time, and colonic motility in rats. Digestive Disease and Science 36, 1729–1734.CrossRefGoogle ScholarPubMed
Cherbut, C, Ferrier, L, Rozé, C, Anini, Y, Blottiére, HM, Lecannu, G, Galmiche, JP (1998) Short-chain fatty acids modify motility through nerves and polypeptide YY release in the rat. American Journal of Physiology 275, G1415–G1422.Google Scholar
Coffin, B, Lemann, M, Flourie, B, Jouet, P, Rambaud, JC, Jian, R (1997) Local regulation of ileal tone in healthy humans. American Journal of Physiology 272, G147–G153.Google ScholarPubMed
Cuche, G, Blat, S, Malbert, CH (2001) Desensitization of ileal vagal receptors by short-chain fatty acids in pigs. American Journal of Physiology 280, G1013–G1021.Google ScholarPubMed
Cuche, G, Cuber, JC, Malbert, CH (2000) Ileal short-chain fatty acids inhibit gastric motility by a humoral pathway. American Journal of Physiology 279, G925–G930.Google Scholar
Cuche, G, Malbert, CH (1998) Relationships between cecoileal reflux and ileal motor patterns in conscious pigs. American Journal of Physiology 274, G35–G41.Google Scholar
Cuche, G, Malbert, CH (1999) Ileal short-chain fatty acids inhibit transpyloric flow in pigs. Scandinavian Journal of Gastroenterology 34, 149–155.Google ScholarPubMed
El Oufir, L, Barry, JL, Flourie, C, Cherbut, C, Cloarec, D, Bornet, F, Galmiche, JP (2000) Relationships between transit time in man and in vitro fermentation of dietary fiber by fecal bacteria. European Journal of Clinical Nutrition 54, 603–609.CrossRefGoogle Scholar
Gorbatchef, C, Jouet, P, Coffin, B, Flourie, B, Leman, M, Franchisseur, C, Jian, R, Rambaud, JC (1998) Effects of short-chain fatty acids on the phasic and tonic motor activity in the unprepared colon of healthy humans. Gastroenterology 114 A756Google Scholar
Kamath, PS, Hoepfner, MT, Phillips, SF (1987) Short-chain fatty acids stimulate motility of the canine ileum. American Journal of Physiology 253, G427–G433.Google Scholar
Kamath, PS, Phillips, SF, O'Connor, MK, Brown, ML, Zinsmeister, AR (1990) Colonic capacitance and transit in man: modulation by luminal contents and drugs. Gut 31, 443–449.Google Scholar
Kamath, PS, Phillips, SF, Zinsmeister, AR (1988) Short chain fatty acids stimulate ileal motility in humans. Gastroenterology 95, 1496–1502.Google Scholar
Piche, T, Sacher-Huvelin, S, Bruley, des, Varannes, S, Galmiche, JP (2002) Colonic fermentation influences lower esophageal sphincter (LES) motility in gastroesophageal reflux disease (GERD). Results of a cross-over randomised study with fructo- oligosaccharides (FOS). Gastroenterology 122 A418Google Scholar
Piche, T, Zerbib, F, Bruley, des, Varannes, S, Cherbut, C, Anini, Y, Roze, C, Le Quellec, A, Galmiche, JP (2000) Modulation by colonic fermentation of LES function in humans. American Journal of Physiology 278, G578–G584.Google ScholarPubMed
Ropert, A, Cherbut, C, Rozé, C, Le Quellec, A, Hoist, JJ, Fu-Cheng, X, Bruley, des, Varannes, S, Galmiche, JP (1996) Colonic fermentation and proximal gastric tone in humans. Gastroenterology 111, 289–296.CrossRefGoogle ScholarPubMed
Squires, PE, Rumsey, RDE, Edwards, CA, Read, NW (1992) Effect of short-chain fatty acids on contractile activity and fluid flow in rat colon in vitro. American Journal of Physiology 262, G813–G817.Google Scholar
Tarrerias, AL, Millecamps, M, Alloui, A, Beaughard, C, Kemeny, JL, Bourdu, S, Bommelaer, G, Eschalier, A, Dapoigny, M, Ardid, D (2002) Short-chain fatty acid enemas fail to decrease colonic hypersensitivity and inflammation in TNBS-induced colonic inflammation in rats. Pain 100, 91–97.CrossRefGoogle ScholarPubMed
Yajima, T (1984) Effect of sodium propionate on the contractile response of the rat ileum in situ. Japanese Journal of Pharmacology 35, 265–271.Google Scholar
Yajima, T (1985) Contractile effect of short-chain fatty acids on the isolated colon of the rat. Journal of Physiology 368, 667–678.CrossRefGoogle ScholarPubMed