Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-20T03:32:51.222Z Has data issue: false hasContentIssue false

Modulating the metabolic response to injury and infection

Published online by Cambridge University Press:  28 February 2007

Stephen F. Lowry
Affiliation:
Laboratory of Surgical Metabolism, Department of Surgery, New York Hospital-Cornell Medical Center, New York, NY10021, USA
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Symposium on ‘New strategies for manipulating the metabolic reponse to severe illness’
Copyright
Copyright © The Nutrition Society 1992

References

Auron, P. E., Warner, S. J., Webb, A. C., Cannon, J. G., Bernheim, H. A., McAdam, K. J., Rosenwasser, L. J., LoPreste, G., Mucci, S. F. & Dinarello, C. A. (1987). Studies on the molecular nature of human interleukin-1. Journal of Immunology 138, 14471456.CrossRefGoogle ScholarPubMed
Barber, A. E., Coyle, S. M., Fong, Y., Fischer, E., Marano, M. A., Calvano, S. E., Moldawer, L. L., Shires, G. T. & Lowry, S. F. (1990). Impact of hypercortisolemia on the metabolic and hormonal responses to endotoxin in man. Surgical Forum 41,7477.Google Scholar
Beaufrere, B., Horber, F. F., Schwenk, W. F., Marsh, H. M., Matthews, D., Gerich, J. E., Haymond, M. W. (1989). Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans. American Journal of Physiology 257, E712E721.Google ScholarPubMed
Bernardini, R., Kamilaris, T. C., Calogero, A. E., Johnson, E. O., Gomez, M. T., Gold, P. W. & Chrousos, G. P. (1990). Interactions between tumor necrosis factorα, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin secretion in the rat. Endocrinology 126,28762881.CrossRefGoogle ScholarPubMed
Bessey, P. G., Watters, J. M., Aoki, T. T. & Wilmore, D. W. (1984). Combined hormonal infusion stimulates the metabolic response to injury. Annals of Surgery 200, 264281.CrossRefGoogle Scholar
Beutler, B., Krochnin, N., Milsark, I. W., Luedke, C. & Cerami, A. (1986). Control of cachectin (tumor necrosis factor) synthesis: mechanisms for endotoxin resistance. Science 232,977980.CrossRefGoogle ScholarPubMed
Brandt, M. R., Fernandes, A., Mordhorst, R. & Kehlet, H. (1978). Epidural analgesia improves postoperative nitrogen balance. British Medical Journal 1, 11061108.CrossRefGoogle ScholarPubMed
Cerra, F. B. (1987). Hypermetabolism, organ failure, and metabolic support. Surgery 101, 114.Google ScholarPubMed
Cerra, F. B., McPherson, J. P., Konstantinides, F. N., Konstantinides, N. N. & Teasley, K. M. (1988). Enteral nutrition does not prevent multiple organ failure syndrome (MOFS) after sepsis. Surgery 104,727733.Google Scholar
Edwards, C. K. III, Lorence, R. M., Dunham, D. M., Arkins, S., Yunger, L. M., Greager, J. A., Walter, R. J., Dantzer, R. & Kelley, K. W. (1991). Hypophysectomy inhibits the synthesis of tumor necrosis factor a by rat macrophages: partial restoration by exogenous growth hormone or interferon v. Endocrinology 128,989996.CrossRefGoogle ScholarPubMed
Fong, Y., Albert, J. D., Tracey, K. J., Hesse, D. G., Calvano, S., Matthews, D. E. & Lowry, S. F. (1991). The influence of substrate background on the acute metabolic response to epinephrine and cortisol. Journal of Trauma (In the Press).CrossRefGoogle Scholar
Fong, Y., Marano, M. A., Barber, A., Wei, H., Moldawer, L. L., Bushman, E. D., Coyle, S. M., Shires, G. T. & Lowry, S. F. (1989). Total parenteral nutrition and bowel rest modify the metabolic response to endotoxin in man. Annals of Surgery 210,449457.CrossRefGoogle Scholar
Fong, Y., Marano, M. A., Moldawer, L. L., Wei, H., Calvano, S. E., Kenney, J. S., Allison, A. C., Cerami, A., Shires, G. T. & Lowry, S. F. (1990 b). The acute splanchnic and peripheral tissue metabolic response to endotoxin in man. Journal of Clinical Investigation 85,18961904.CrossRefGoogle Scholar
Fong, Y., Moldawer, L. L., Shires, G. T. & Lowry, S. F. (1990 a). The biological characteristics of cytokines and their implication in surgical injury. Surgery, Gynecology & Obstetrics 170, 363378.Google ScholarPubMed
Fong, Y., Tracey, K. J., Hesse, D. G., Albert, J. D., Barie, P. S. & Lowry, S. F. (1990 c). Influence of enterectomy on peripheral tissue glutamine efflux in critically ill patients. Surgery 107, 321326.Google ScholarPubMed
Gelfand, R. A., Matthews, D. E., Bier, D. M. & Sherwin, R. S. (1984). Role of counterregulatory hormones in the catabolic response to stress. Journal of Clinical Investigation 74, 22382248.CrossRefGoogle ScholarPubMed
Goldstein, S. A. & Elwyn, D. H. (1989). The effects of injury and sepsis on fuel utilization. Annual Review of Nutrition 9, 445473.CrossRefGoogle ScholarPubMed
Herndon, D. N., Stein, M. D., Rutan, T. C., Abston, S. & Linares, H. (1987). Failure of TPN supplementation to improve liver function, immunity, and mortality in thermally injured patients. Journal of Trauma 21, 195204.CrossRefGoogle Scholar
Horber, F. F. & Haymond, M. W. (1990). Human growth hormone prevents the protein catabolic side effects of prednisone in humans. Journal of Clinical Investigation 86, 265272.CrossRefGoogle ScholarPubMed
Jahoor, F., Shangraw, R. E., Miyoshi, H., Wallfish, H., Herndon, D. N. & Wolfe, R. R. (1989). Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis. American Journal of Physiology 257, E323E331.Google ScholarPubMed
Keogh, C. V., Fong, Y., Barber, A., Marano, M. A., Wei, H., Minei, J., Lowry, S. F. & Moldawer, L. L. (1990). Identification of a novel cell-associated murine tumor necrosis factor. Archives of Surgery 125, 7985.CrossRefGoogle Scholar
Klasing, K. C. (1988). Nutritional aspects of leukocytic cytokines. Journal of Nutrition 118, 14361446.CrossRefGoogle ScholarPubMed
Kraenzlin, M. E., Keller, U., Keller, A., Thklin, A., Arnaud, M. J. & Stauffacher, W. (1989). Elevation of plasma epinephrine concentrations inhibits proteolysis and leucine oxidation in man via P-adrenergic mechanisms. Journal of Clinical Investigation 84,388393.CrossRefGoogle Scholar
Kriegler, M., Perez, C., DeFay, K., Albert, I. & Lu, S. D. (1988). A novel form of TNFkachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell 53, 4553.CrossRefGoogle ScholarPubMed
Lee, M. D., Zentella, A., Pekala, P. H. & Cerami, A. (1987). Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6. Proceedings of the National Academy of Science, USA 84, 25902594.CrossRefGoogle ScholarPubMed
Lowry, S. F. (1986). The host metabolic response to injury. In Host Defenses, vol. 6, pp. 169180 [Shires, G. T. and Davis, J. M., editors]. New York: Academic Press.Google Scholar
Lowry, S. F. (1990). The route of feeding influences injury responses. Journal of Trauma 30, 510515.Google ScholarPubMed
Luger, A., Graf, H., Schwarz, H.-P., Stummvoll, H.-K. & Luger, T. A. (1986). Decreased serum interleukin 1 activity and monocyte interleukin 1 production in patients with fatal sepsis. Critical Care Medicine 14, 458461.CrossRefGoogle ScholarPubMed
Matthews, D. E., Pesola, G. & Campbell, R. G. (1990). Effect of epinephrine on amino acid and energy metabolism in humans. American Journal of Physiology 258, E948E956.Google ScholarPubMed
Wolff, S. M. & Wilmore, D. W. (1988 a).Detection of circulating tumor necrosis factor after endotoxin administration. New England Journal of Medicine 318, 14811486.Google Scholar
Michie, H. R., Spriggs, D. R., Manogue, K. R., Sherman, M. L., Revhaug, A., O'Dwyer, S. T., Arthur, K., Dinarello, C. A., Cerami, A., Wolff, S. M., Kufe, D. W. & Wilmore, D. W. (1988 b). Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings. Surgery 104, 280286.Google ScholarPubMed
Moldawer, L. L., Lowry, S. F. & Cerami, A. (1988). Cachectin: Its impact on metabolism and nutritional status. Annual Review of Nutrition 8, 585609.CrossRefGoogle ScholarPubMed
Möller-Loswick, A.-C., Zachrisson, H., Bennegård, K., Sandström, R. & Lundholm, K. (1991). Insufficient effect of total parenteral nutrition to improve protein balance in peripheral tissues of surgical patients. Journal of Parenteral and Enteral Nutrition 15, 669–475.CrossRefGoogle ScholarPubMed
Moore, F. A., Moore, E. E., Jones, T. N., McCroskey, B. L. & Peterson, V. M. (1989). TEN versus TPN following major abdominal trauma -Reduced septic morbidity. Journal of Trauma 29, 916923.CrossRefGoogle ScholarPubMed
Pitkänen, O., Takala, J., Pöyhönen, M. & Kari, A. (1991). Nitrogen and energy balance in septic and injured intensive care patients: response to parenteral nutrition. Clinical Nutrition 10, 258265.CrossRefGoogle ScholarPubMed
Rock, C. S., Barber, A. E., Ng, E., Jones, W. G., Roth, M. S., Moldawer, L. L. & Lowry, S. F. (1990). TPN vs. oral feeding: Bacterial translocation, cytokine response and mortality following E. coli LPS administration. Surgical Forum 41, 1416.Google Scholar
Schattner, A., Steinbock, M., Tepper, R., Schonfeld, A., Vaisman, N. & Hahn, T. (1990). Tumour necrosis factor production and cell-mediated immunity in anorexia nervosa. Clinical Experimental Immunology 79, 6266.CrossRefGoogle ScholarPubMed
Shaw, J. H. F., Galler, L., Holdaway, I. M. & Holdaway, C. M. (1987 a). The effect of extradural blockage upon glucose and urea kinetics in surgical patients. Surgery, Gynecology & Obstetrics 165, 260266.Google ScholarPubMed
Shaw, J. H. F., Holdaway, C. M. & Humberstone, D. A. (1988). Metabolic intervention in surgical patients: The effect of α- or β-blockade on glucose and protein metabolism in surgical patients receiving total parenteral nutrition. Surgery 103, 520525.Google ScholarPubMed
Shaw, J. H. F., Wildbore, M. & Wolfe, R. R. (1987 b). Whole body protein kinetics in severely septic patients. Annals of Surgery 205, 288294.CrossRefGoogle ScholarPubMed
Shaw, J. H. F & Wolfe, R. R. (1985). Alanine, urea, and glucose interrelationship in normal subjects and patients with sepsis with stable isotope tracers. Surgery 97, 557567.Google Scholar
Shaw, J. H. F. & Wolfe, R. R. (1987). Fatty acid and glycerol kinetics in septic patients and in patients with gastrointestinal cancer. Annals of Surgery 205, 368376.CrossRefGoogle ScholarPubMed
Shaw, J. H. F. & Wolfe, R. R. (1989). An integral analysis of glucose, fat, and protein metabolism in severely traumatized patients. Annals of Surgery 209, 6372.CrossRefGoogle ScholarPubMed
Spengler, R. N., Allen, R. M., Remick, D. G., Strieter, R. M. & Kunkel, S. L. (1990). Stimulation of α-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. Journal of Immunology 145, 14301434.CrossRefGoogle ScholarPubMed
Starnes, H. F., Warren, R. A., Jeevanandam, M., Gabrilove, J. L., Larchian, W. & Oettgen, H. F. & Brennan, M. F. (1988). Tumor necrosis factor and the acute metabolic response to tissue injury in man. Journal of Clinical Investigation 82, 13211325.CrossRefGoogle ScholarPubMed
Tracey, K. J., Fong, Y., Hesse, D., Manogue, K. R., Lee, A., Kuo, G. C., Calvano, S. E., Moldawer, L. L., Marano, M., Shires, G. T., Cerami, A. & Lowry, S. F. (1988). Cachectin (tumor necrosis factor-α, TNF-α) participates in the metabolic derangements induced by gram-negative bacteremia. Surgical Forum 39, 810.Google Scholar
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F. & Cerami, A. (1987 a). Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteremia. Nature 330,662664.CrossRefGoogle Scholar
Tracey, K. J. & Lowry, S. F. (1989). The role of cytokines in septic shock. In Advances in Surgery, pp. 2156 [Tompkins, R. K., editor]. Chicago II: Yearbook Medical Publishers.Google Scholar
Tracey, K. J., Lowry, S. F., Fahey, T. J., Albert, J. D., Fong, Y., Hesse, D., Beutler, B., Manogue, K., Calvano, S. E., Wei, H., Cerami, A.Shires, G. T. (1987 b). Cachectin/tumor necrosis factor induces lethal septic shock and stress hormone responses in the dog. Surgery, Gynecology & Obstetrics 164, 415422.Google ScholarPubMed
van der Poll, T., Romijn, J. A., Endert, E., Borm, J. J. J., Biiller, H. R. & Sauenvein, H. P. (1991). Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans. American Journal of Physiology 261, E457E465.Google ScholarPubMed
van der Poll, T., Romijn, J. A., Wiersinga, W. M. & Sauenvein, H. P. (1990). Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man. Journal of Clinical Endocrinology and Metabolism 71, 15671572.CrossRefGoogle ScholarPubMed
Warren, R. S., Donner, D. B., Starnes, H. F. Jr. & Brennan, M. F. (1987 a). Modulation of endogenous hormone action by recombinant human tumor necrosis factor. Proceedings of the National Academy of Science USA 84, 86198622.CrossRefGoogle ScholarPubMed
Warren, R. S., Stames, H. F. Jr, Gabrilove, J. L., Oettgen, H. F. & Brennan, M. F. (1987 b). The acute metabolic effects of tumor necrosis factor administration in humans. Archives of Surgery 122, 13961400.CrossRefGoogle ScholarPubMed
Wilmore, D. W. (1991). Catabolic illness. New England Journal of Medicine 325, 695702.Google ScholarPubMed
Wolfe, R. R., Hemdon, D. N., Jahoor, F., Miyoshi, H. & Wolfe, M. (1987). Effect of severe burn injury on substrate cycling by glucose and fatty acids. New England Journal of Medicine 317, 403408.CrossRefGoogle ScholarPubMed
Ziegler, E. J., Fisher, C. J. Jr, Sprung, C. L., Straube, R. C., Sadoff, J. C., Foulke, G. E., Wortel, C. H., Fink, M. P., Dellinger, R. P., Teng, N. N. H., Allen, I. E., Berger, H. J., Knatterud, G. L., LoBuglio, A. F., Smith, C. R. and the HA-1A Sepsis Study Group (1991). Treatment of gram-negative bacteremia and septic shock with HA-IA monoclonal antibody against endotoxin: a randomized, double-blind, placebo-controlled trial. New England Journal of Medicine 324, 429436.CrossRefGoogle Scholar