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Manipulation of adiposity by somatotropin and β-adrenergic agonists: a comparison of their mechanisms of action

Published online by Cambridge University Press:  28 February 2007

Terry D. Etherton  and
Isabelle Louveau
Terry D. Etherton
Affiliation:
Department of Dairy and Animal Science, Pennsylvania State University, University Park, PA 16802, USA
Isabelle Louveau
Affiliation:
Department of Dairy and Animal Science, Pennsylvania State University, University Park, PA 16802, USA
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Abstract

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Type
Symposium on ‘The manipulation of adiposity’
Information
Proceedings of the Nutrition Society , Volume 51 , Issue 3 , December 1992 , pp. 419 - 431
Copyright
Copyright © The Nutrition Society 1992

References

REFERENCES

Bauman, D. E., Dunshea, F. R., Boixlair, Y. R., McGuire, M. A., Harris, D. M. & Houseknecht, K. L. (1989). Regulation of nutrient partitioning: Homeostasis, homeorhesis and exogenous somatotropin. In Proceedings Seventh International Conference of Production Disease in Farm Animals, pp. 306–323 [Kallfelz, F. A., editor]. Ithaca, NY, USA: Cornell University Press.Google Scholar
Bauman, D. E., Peel, C. J., Steinhour, W. D., Reynolds, P. J., Tyrrell, H. F., Brown, A. C. G. & Haaland, G. L. (1988). Effect of bovine somatotropin on metabolism of lactating dairy cows: Influence on rates of irreversible loss and oxidation of glucose and nonesterified fatty acids. Journal of Nutrition 118, 1031–1040.CrossRefGoogle ScholarPubMed
Beermann, D. H., Butler, W. R., Hogue, D. R., Fishell, V. K., Dalrymple, R. H., Ricks, C. A. & Scanes, C. G. (1987). Cimaterol-induced muscle hypertrophy and altered endocrine status in lambs. Journal of Animal Science 63, 1314–1524.Google Scholar
Bierring, E. & Nielsen, E. (1932). CXX. The composition of the tissues of albino rats treated with alkaline anterior pituitary extracts. Biochemical Journal 26, 1015–1021.CrossRefGoogle Scholar
Birnbaum, M. J. (1989). Identification of a novel gene encoding an insulin-responsive glucose transporter protein. Cell 57, 305–315.CrossRefGoogle ScholarPubMed
Boyd, R. D. & Bauman, D. E. (1989). Mechanisms of action for somatotropin in growth. In Current Concepts of Animal Growth Regulation, pp. 257–293 [Campion, D. R., Hausman, G. J. and Martin, R. J., editors]. New York: Plenum Publishing Company.CrossRefGoogle Scholar
Campbell, R. G., Johnson, R. J., King, R. H. & Taverner, M. R. (1990). Effects of gender and genotype on the response of growing pigs to exogenous administration of porcine growth hormone. Journal of Animal Science 68, 2674–2681.CrossRefGoogle ScholarPubMed
Campbell, R. G., Steele, N. C., Caperna, T. J., McMurty, J. P., Solomon, M. B. & Mitchell, A. D. (1989). Interrelationships between sex and exogenous growth hormone administration on performance, body composition and protein and fat accretion of growing pigs. Journal of Animal Science 67, 177–186.CrossRefGoogle ScholarPubMed
Campbell, R. M. & Scanes, C. G. (1985). Adrenergic control of lipogenesis and lipolysis in the chicken in vitro. Comparative Biochemistry and Physiology 82c, 137–142.Google Scholar
Charron, M. J. & Kahn, B. B. (1990). Divergent molecular mechanisms for insulin-resistant glucose transport in muscle and adipose cells in vivo. Journal of Biological Chemistry 265, 7994–8000.CrossRefGoogle ScholarPubMed
Chung, C. S., Etherton, T. D. & Wiggins, J. P. (1985). Stimulation of swine growth by porcine growth hormone. Journal of Animal Science 60, 118–130.CrossRefGoogle ScholarPubMed
Cusin, I., Terrettaz, J., Rohner-Jeanrenaud, F., Zarjevski, N., Assimacopoulous-Jeannet, F. & Jeanrenaud, B. (1990). Hyperinsulinaemia increases the amount of GLUT4 mRNA in white adipose tissue and decreases that of muscles: a clue for increased fat depot and insulin resistance. Endocrinology 127, 3246–3248.CrossRefGoogle ScholarPubMed
Doglio, A., Dani, C., Grimaldi, P. & Ailhaud, G. (1989). Growth hormone stimulate c-fos gene expression by means of protein kinase C without increasing inositol lipid turnover. Proceedings of the National Academy of Sciences, USA 86, 1148–1152.CrossRefGoogle ScholarPubMed
Downs, W. G. (1930). An experimental study of the growth effects of the anterior lobe of the hypophysis on the teeth and other tissues and organs. Journal of Dental Research 10, 601–654.CrossRefGoogle Scholar
Dunshea, F. R., Harris, D. M., Bauman, D. E., Boyd, R. D. & Bell, A. W. (1992 b). Effect of somatotropin on nonesterified fatty acid and glycerol metabolism in growing pigs. Journal of Animal Science 70, 132–140.CrossRefGoogle ScholarPubMed
Dunshea, F. R., Harris, D. M., Bauman, D. E., Boyd, R. D. & Bell, A. W. (1992 b). Effect of porcine somatotropin on in vivo glucose kinetics and lipogenesis in growing pigs. Journal of Animal Science 70, 141–151.CrossRefGoogle ScholarPubMed
Duquette, P. F. & Muir, L. A. (1985). Effect of the beta adrenergic agonists isoproterenol, clenbuterol, L-640-033 and BRL 35135 on lipolysis and lipogenesis in rat adipose tissue in vitro. Journal of Animal Science 61, Suppl. 1, 265.Google Scholar
Eisemann, J. H., Hammond, A. C., Bauman, D. E., Reynolds, P. J., McCutcheon, S. N., Tyrrell, H. F. & Haaland, G. L. (1986). Effect of bovine growth hormone administration on metabolism of growing Hereford heifers: Protein and lipid metabolism and plasma concentrations of metabolites and hormones. Journal of Nutrition 116, 2504–2515.CrossRefGoogle ScholarPubMed
Eisemann, J. H., Huntington, G. B. & Ferrell, C. L. (1988). Effects of dietary clenbuterol on metabolism of the hindquarters in steers. Journal of Animal Science 66, 342–353.CrossRefGoogle ScholarPubMed
Etherton, T. D. (1989 b). Mechanisms by which porcine growth hormone (pGH) and insulin-like growth factors (IGFs) regulate pig growth performance: Approaches from the pGH and IGF receptors to the whole animal. In Biotechnology for Control of Growth and Product Quality in Swine. Implications and Acceptability, pp. 111–125 [P., van der Wal, Nieuwhof, G. J. and Politiek, R. D., editors]. Wageningen: Pudoc Wageningen.Google Scholar
Etherton, T. D., Evock, C. M. & Kensinger, R. S. (1987 a). Native and recombinant bovine growth hormone antagonize insulin action in cultured bovine adipose tissue. Endocrinology 121, 699–703.CrossRefGoogle ScholarPubMed
Etherton, T. D. & Kensinger, R. S. (1984). Endocrine regulation of fetal and postnatal meat animal growth. Journal of Animal Science 59, 511–528.CrossRefGoogle ScholarPubMed
Etherton, T. D. & Smith, S. B. (1991). Somatotropin and P-adrenergic agonists: Their efficacy and mechanisms of action. Journal of Animal Science 69, Suppl. 2, 2–26.CrossRefGoogle Scholar
Etherton, T. D. & Walton, P. E. (1986). Hormonal and metabolic regulation of lipid metabolism in domestic animals. Journal of Animal Science 63, Suppl. 1, 76–88.Google Scholar
Etherton, T. D., Wiggins, J. P., Chung, C. S., Evock, C. M., Rebhun, J. F. & Walton, P. E. (1986). Stimulation of pig growth performance by porcine growth hormone and growth-hormone-releasing factor. Journal of Animal Science 63, 1389–1399.CrossRefGoogle ScholarPubMed
Etherton, T. D., Wiggins, J. P., Evock, C. M., Chung, C. S., Rebhun, J. F., Walton, P. E. & Steele, N. C. (1987 b). Stimulation of pig growth performance by porcine growth hormone: Determination of the dose-response relationship. Journal of Animal Science 64, 433–443.CrossRefGoogle ScholarPubMed
Evock, C. M., Etherton, T. D., Chung, C. S. & Ivy, R. E. (1988). Pituitary porcine growth hormone (pGH) and a recombinant pGH analog stimulate pig growth performance in a similar manner. Journal of Animal Science 66, 1928–1941.CrossRefGoogle Scholar
Farese, R. V. (1988). Phospholipid signaling systems in insulin action. American Journal of Physiology 85. Suppl. 5A. 36–43.Google ScholarPubMed
Foster, C. M., Shafer, J. A., Rozsa, F. W., Wang, X., Lewis, S. D., Renken, D. A., Natale, J. E., Schwartz, J. & Carter-Su, C. (1988). Growth hormone promoted tyrosyl phosphorylation of growth hormone receptors in murine 3T3-F442A fibroblasts and adipocytes. Biochemistry 27, 326–334.CrossRefGoogle ScholarPubMed
Fukumoto, H., Kayano, T., Buse, J. B., Edwards, Y., Pilch, P. F., Bell, G. I. & Seino, S. (1989). Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. Journal of Biological Chemistry 264, 7776–7779.CrossRefGoogle ScholarPubMed
Giles, D. D. (1942). An experiment to determine the effect of the growth hormone of the anterior lobe of the pituitary gland on swine. American Journal of Veterinary Research 3, 77–85.Google Scholar
Glieman, J. & Rees, W. D. (1983). The insulin-sensitive hexose transport system in adipocytes. Current Topics in Membrane Transport 18, 339–379.CrossRefGoogle Scholar
Greenbaum, A. L. (1953). Changes in body composition and respiratory quotient of adult female rats treated with purified growth hormone. Biochemical Journal 54, 400–407.CrossRefGoogle ScholarPubMed
Henricson, B. & Ullberg, S. (1960). Effects of pig growth hormone on pigs. Journal of Animal Science 19. 1002–1008.CrossRefGoogle Scholar
James, D. E., Strube, M. & Mueckler, M. (1989). Molecular cloning and characterization of an insulin- regulatable glucose transporter. Nature 338, 83–87.CrossRefGoogle ScholarPubMed
Johnson, R. M., Napier, M. A., Cronin, M. J. & King, K. L. (1990). Growth hormone stimulates the formation of sn-l,2-diacylglycerol in rat hepatocytes. Endocrinology 127, 2099–2103.CrossRefGoogle Scholar
Kris-Etherton, P. M., Krummel, D., Russell, M. E., Dreon, D., Mackey, S., Borchers, J. & Wood, P. D. (1988). The effect of diet on plasma lipids, lipoproteins and coronary heart disease. Journal of the American Dietetic Association 88, 1373–1400.CrossRefGoogle ScholarPubMed
Lawrence, J. C., Hiken, J. F. & James, D. E. (1990). Stimulation of glucose transport and glucose transporter phosphorylation by okadaic acid in rat adipocytes. Journal of Biological Chemistry 265, 19768–19776.CrossRefGoogle ScholarPubMed
Lee, M. O. & Schaffer, N. K. (1934). Anterior pituitary growth hormone and the composition of growth. Journal of Nutrition 7, 337–363.CrossRefGoogle Scholar
Li, C. H., Evans, H. M. & Simpson, M. E. (1945). Isolation and properties of the anterior hypophyseal growth hormone. Journal of Biological Chemistry 159, 353–366.CrossRefGoogle Scholar
Li, C. H., Simpson, M. E. & Evans, H. M. (1948). The gigantism produced in normal rats by injection of the pituitary growth hormone. III. Main chemical components of the body. Growth 12, 39–42.Google Scholar
Liu, C. Y., Boyer, J. L. & Mills, S. E. (1989). Acute effects of beta-adrenergic agonists on porcine adipocyte metabolism in vitro. Journal of Animal Science 67, 2930–2936.CrossRefGoogle ScholarPubMed
Lobie, P. E., Barnard, R. & Waters, M. J. (1991). The nuclear growth hormone receptor binding protein. Antigenic and physiochemical characterization. Journal of Biological Chemistry 266, 22645–22652.CrossRefGoogle Scholar
Louveau, I., Chaudhuri, S. & Etherton, T. D. (1991). An improved method for isolating RNA from porcine adipose tissue. Analytical Biochemistry 196, 308–310.CrossRefGoogle ScholarPubMed
Machlin, L. (1972). Effect of porcine growth hormone on growth and carcass composition of the pig. Journal of Animal Science 35, 794–800.CrossRefGoogle ScholarPubMed
McLaren, D. G., Bechtel, P. J., Grebner, G. L., Novakofski, J., McKeith, F. K., Jones, R. W., Dalrymple, R. H. & Easter, R. A. (1990). Dose response in growth of pigs injected daily with porcine somatotropin from 57 to 103 kilograms. Journal of Animal Science 68, 640–651.CrossRefGoogle ScholarPubMed
Magri, K. A., Adamo, M., LeRoith, D. & Etherton, T. D. (1990). The inhibition of insulin action and glucose metabolism by porcine growth hormone in porcine adipocytes is not the result of any decrease in insulin binding or insulin receptor kinase activity. Biochemical Journal 266, 107–113.CrossRefGoogle ScholarPubMed
Mersmann, H. J. (1989). Inhibition of porcine adipose tissue lipogenesis by β-adrenergic agonists. Comparative Biochemistry and Physiology 94C, 619–623.Google Scholar
Mildner, A. M. & Clarke, S. D. (1991). Porcine fatty acid synthase: cloning of complementary DNA, tissue distribution of its mRNA and suppression of expression by somatotropin and dietary protein. Journal of Nutrition 121, 900–907.CrossRefGoogle ScholarPubMed
Miller, M. F., Garcia, D. K., Coleman, M. E., Ekeren, P. A., Lunt, D. K., Wagner, K. A., Procknor, M., Welsh, T. H. & Smith, S. B. (1988). Adipose tissue, longissimus muscle and anterior pituitary growth and function in clenbuterol fed heifers. Journal of Animal Science 66, 12–20.CrossRefGoogle ScholarPubMed
Mills, S. E. & Liu, C. Y. (1990). Sensitivity of lipolysis and lipogenesis to dibutyryl-CAMP and β-adrenergic agonists in swine adipocytes in vitro. Journal of Animal Science 68, 1017–1023.CrossRefGoogle ScholarPubMed
Moloney, A., Allen, P., Joseph, R. & Tarrant, V. (1991). Influence of β-adrenergic agonists and similar compounds on growth. In Growth Regulation in Meat Animals, pp. 455–513 [Pearson, A. M. and Dutson, T. R., editors]. London: Elsevier Applied Science.Google Scholar
O'Brien, R. M. & Granner, D. K. (1991). Regulation of gene expression by insulin. Biochemical Journal 278, 609–619.CrossRefGoogle ScholarPubMed
Peel, C. J. & Bauman, D. E. (1987). Somatotropin and lactation. Journal of Dairy Science 70, 474–486.CrossRefGoogle ScholarPubMed
Peterla, T. A. & Scanes, C. G. (1990). Effect of β-adrenergic agonists on lipolysis and lipogenesis by porcine adipose tissue in vitro. Journal of Animal Science 68, 1024–1029.CrossRefGoogle ScholarPubMed
Rogers, S. A. & Hammerman, M. R. (1989). Growth hormone activates phospholipase C in proximal tubular basolateral membranes from canine kidney. Proceedings of the National Academy of Sciences, USA 86, 6363–6366.CrossRefGoogle ScholarPubMed
Roupas, P., Chou, S. Y., Towns, R. J. & Kostyo, J. L. (1991). Growth hormone inhibits activation of phosphatidylinositol phospholipase C in adipose plasma membranes: Evidence for a growth hormone-induced change in G protein function. Proceedings of the National Academy of Sciences, USA 88, 1691–1695.CrossRefGoogle ScholarPubMed
Rule, D. C., Smith, S. B. & Mersmann, H. J. (1987). Effects of adrenergic agonists and insulin on porcine adipose tissue metabolism in vitro. Journal of Animal Science 65, 136–149.CrossRefGoogle ScholarPubMed
Saltiel, A. R. & Cuatrecasas, P. (1988). In search of a second messenger for insulin. American Journal of Physiology 255, C1–C11.CrossRefGoogle ScholarPubMed
Sechen, S. J., Bauman, D. E., Tyrrell, H. F. & Reynolds, P. J. (1989). Effect of somatotropin on kinetics of nonesterified fatty acids and partition of energy, carbon and nitrogen in lactating dairy cows. Journal of Dairy Science 72, 59–67.CrossRefGoogle ScholarPubMed
Simpson, I. A. & Cushman, S. W. (1986). Hormonal regulation of mammalian glucose transport. Annual Reviews in Biochemistry 55, 1059–1089.CrossRefGoogle ScholarPubMed
Sivitz, W. I., DeSautel, S. L., Kayano, T., Bell, G. I. & Pessin, J. E. (1990). Regulation of glucose transport messenger RNA levels in rat adipose tissue by insulin. Molecular Endocrinology 4, 583–588.CrossRefGoogle ScholarPubMed
Slootweg, M. C., De Groot, R. P., Herrmann-Erlee, M. P. M., Koornneff, I., Kruijer, W. & Kramer, Y. M. (1991). Growth hormone induces expression of c-jun and jun B oncogenes and employs a protein kinase C signal transduction pathway for the induction of c-fos oncogene expression. Journal of Molecular Endocrinology 6, 179–188.CrossRefGoogle Scholar
Smal, J. & De Meyts, P. (1987). Role of kinase C in the insulin-like effects of human growth hormone in rat adipocytes. Biochemical and Biophysical Research Communications 147, 1232–1240.CrossRefGoogle ScholarPubMed
Stred, S. E., Stubbart, J. R., Argetsinger, L. S., Shafer, J. A. & Carter-Su, C. (1990). Demonstration of growth hormone (GH) receptor-associated tyrosine kinase activity in GH-responsive cell types. Endocrinology 127, 2506–2516.CrossRefGoogle ScholarPubMed
Stubbart, J. R., Barton, D. F., Tai, P. K., Stred, S. E., Gorin, E., Goodman, H. M. & Carter-Su, C. (1991). Antibodies to cytoplasmic sequences of cloned liver growth hormone (GH) receptors recognize GH receptors associated with tyrosine kinase activity. Endocrinology 129, 1659–1670.CrossRefGoogle ScholarPubMed
Tollet, P., Legraverend, C., Gustafsson, J. & Mode, A. (1991). A role for protein kinases in the growth hormone regulation of cytochrome P4502C12 and insulin-like growth factor-I messenger RNA expression in primary adult rat hepatocytes. Molecular Endocrinology 5, 1351–1358.CrossRefGoogle ScholarPubMed
Turman, E. J. & Andrews, F. N. (1955). Some effects of purified anterior pituitary growth hormone on swine. Journal of Animal Science 14, 7–18.CrossRefGoogle Scholar
Vernon, R. G. (1982). Effects of growth hormone on fatty acid synthesis in sheep adipose tissue. International Journal of Biochemistry 14, 255–258.CrossRefGoogle ScholarPubMed
Vernon, R. G. & Flint, D. J. (1989). Role of growth hormone in the regulation of adipocyte growth and function. In Biotechnology in Growth Regulation, pp. 57–71 [Heap, R. B., Prosser, C. G. and Lamming, G. E., editors]. London: Butterworths.CrossRefGoogle Scholar
Walton, P. E. & Etherton, T. D. (1986). Stimulation of lipogenesis by insulin in swine adipose tissue: Antagonism by porcine growth hormone. Journal of Animal Science 62, 1584–1595.CrossRefGoogle ScholarPubMed
Walton, P. E. & Etherton, T. D. (1987). The culture of adipose tissue explants in serum-free medium. Journal of Animal Science 65, Suppl. 2, 25–30.CrossRefGoogle Scholar
Walton, P. E., Etherton, T. D. & Chung, C. S. (1987). Exogenous pituitary and recombinant growth hormones include insulin and insulin-like growth factor-I resistance in pig adipose tissue. Domestic Animal Endocrinology 4, 183–189.CrossRefGoogle Scholar
Walton, P. E., Etherton, T. D. & Evock, C. M. (1986). Antagonism of insulin action in cultured pig adipose tissue by pituitary and recombinant porcine growth hormone: Potentiation by hydrocortisone. Endocrinology 118, 2577–2581.CrossRefGoogle ScholarPubMed
Yang, Y. T. & McElligott, M. A. (1989). Multiple actions of β-adrenergic agonists on skeletal muscle and adipose tissue. Biochemical Journal 261, l–10.CrossRefGoogle ScholarPubMed
Yoon, J. B., Berry, S. A., Seelig, S. & Towle, H. C. (1990). An inducible nuclear factor binds to a growth hormone-regulated gene. Journal of Biological Chemistry 265, 19947–19954.CrossRefGoogle ScholarPubMed